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Optimal culture conditions for the generation of natural killer cell-induced dendritic cells for cancer immunotherapy

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Cellular & Molecular Immunology 2012年第1期9卷 45-53页

作者： Thanh-Nhan Nguyen-Pham Deok-Hwan Yang Truc-Anh Thi Nguyen Mi-Seon Lim Cheol Yi Hong Mi-Hyun Kim Hyun Ju lee Youn-Kyung lee Duck Cho Soo-Young Bae Jae-Sook Ahn yeo-Kyeoung Kim Ik-Joo Chung Hyeoung-Joon Kim Je-Jung lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalJeollanamdoKorea Department of Hematology-Oncology Chonnam National University Hwasun HospitalJeollanamdoKorea Vaxcell-Bio Therapeutics JeollanamdoKorea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National UniversityGwangjuKorea

Dendritic cell(DC)-based vaccines continue to be considered an attractive tool for cancer *** require an additional signal from the environment or other immune cells to polarize the development of immune responses toward T helper 1(Th1)or Th2 *** play a role in natural killer(NK)cell activation,and NK cells are also able to activate and induce the maturation of *** investigated the types of NK cells that can induce the maturation and enhanced function of DCs and the conditions under which these interactions *** that were activated by resting NK cells in the presence of inflammatory cytokines exhibited increased expression of several costimulatory molecules and an enhanced ability to produce *** cell-stimulated DCs potently induced Th1 polarization and exhibited the ability to generate tumor antigen-specific cytotoxic T lymphocyte *** data demonstrate that functional DCs can be generated by coculturing immature DCs with freshly isolated resting NK cells in the presence of Toll-like receptor agonists and proinflammatory cytokines and that the resulting DCs effectively present antigens to induce tumor-specific T-cell responses,which suggests that these cells may be useful for cancer immunotherapy.

关键词： cancer immunotherapy dendritic cells natural killer cells signal

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Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists

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Cellular & Molecular Immunology 2011年第4期8卷 341-347页

作者： Thanh-Nhan Nguyen-Pham Mi-Seon Lim Truc Anh Thi Nguyen Youn-Kyung lee Chun-Ji Jin Hyun Ju lee Cheol Yi Hong Jae-Sook Ahn Deok-Hwan Yang yeo-Kyeoung Kim Ik-Joo Chung Byoung Chul Park Hyeoung-Joon Kim Je-Jung lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalJeollanamdoKorea Department of Hematology-Oncology Chonnam National UniversityGwangjuKorea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National UniversityGwangjuKorea Vaxcell-Bio Therapeutics JeollanamdoKorea Korea Research Institute of Bioscience and Biotechnology(KRIBB) DaejeonKorea

The major limitation for the maturation of dendritic cells(DCs)using Toll-like receptor(TLR)agonists is their decreased ability to migrate into lymph nodes compared with conventional ***38 can be used as a multifunctional marker to modulate migration,survival and Th1 responses of ***74 has been shown to negatively regulate DC *** goal of this study was to investigate the combinations of TLR agonists and interferons(IFNs)that most effectively regulate CD38 and CD74 expression on *** TLR agonist stimulation in combination with IFN-a and IFN-c was the best method for regulating CD38 and CD74 expression and inducing the highest secretion of *** in vitro migration assay showed that DCs treated with this combination had significantly enhanced migratory ability,similar to that observed in cells expressing CD38,CD74 and *** results of this study suggest that an alternative maturation protocol in which two TLR ligands are combined with type I and II IFNs generates potent DCs that have both a high migratory capacity and high IL-12p70 production.

关键词： CD38 CD74 dendritic cells interferon Toll-like receptor

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Experimental Study on Flow Characteristic in Sloping Weir

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Engineering（科研） 2014年第7期6卷 329-337页

作者： Joongu Joongu Kang Sungjoong Kim Hongkoo yeo Namjoo lee Kyungsung University Busan Korea Water Resource Research Department Korea Institute of Construction Technology Goyang Korea

Drop structure is a key hydraulic structure used in river improvement projects for flood control purposes. However, as demand for riparian construction techniques with environmental considerations is increasing both domestically and internationally, discontinuation of aquatic organisms as a result of high head is raised as a serious issue associated with the existing drop structures. Accordingly, it has become necessary to install a drop structure with a mild slope rather than the existing drop structures with high head, so that the structure can function as a migration channel for fish, which is severed by the existing drop structures, and also improve surrounding landscapes. In this study, which was initiated based on the necessity as such, a drop structure of mild slope was defined as sloping weir and flow characteristics under different conditions were analyzed through a hydraulic experiment. Focusing on efficiency according to energy dissipation that takes place according to different gradients of sloping weir, particle sizes of riverbed materials and the effect of hydraulic jump occurring at the downstream of a structure, this study aimed at identifying flow characteristics according to the conditions of sloping weirs. Thehydraulic experimentwas carried out on a variable-slope channel measuring 0.6 m in width and 20.0 m in length. As for riverbed materials, materials with two particle sizes (16 mm and 25 mm) were selected. For the experiment, models with different slope ratios to the structure, such as 1V:2H, 1V:3H and 1V:4H, were created. For flow conditions and hydraulic jump locations, an amount of water satisfying four water level conditions by stage was flown according to water level at the inlet area. Then, eight points were selected from inlet area, drop area, jet flow area and downstream area by controlling water level at the downstream area and adjusting the location of hydraulic jump occurrence. Water level (y), flow velocity (V), length of hydraulic

关键词： Drop Structure Sloping Weir Energy Dissipation Hydraulic Jump

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Traditional Chinese medicine in psychiatry： the fruit-basket-problem

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Journal of Integrative Medicine 2016年第4期14卷 239-240页

作者： Peggy Bosch Peter de Rover Sujung yeo Sook-Hyun lee Sabina Lim Maurits van den Noort Donders Center for Cognition Radboud University Nijmegen 6525 HR Nijmegen The Netherlands Psychiatric Research Institute LVR-Klinik Bedburg-Hau 47551 Bedburg-Hau Germany Division of Acupuncture & Meridian WHO Collaborating Center for Traditional Medicine East-West Medical Research Institute and School of Korean Medicine Kyung Hee University Seoul 130-701Korea Karel de Grote Hoge School 2018 Antwerp Belgium Department of Acupuncture & Meridian of Oriental Medicine Sang Ji University Wonju 26339 Korea Brussels Institute for Applied Linguistics Free University of Brussels 1050 Brussels Belgium

Traditional Chinese medicine （TCM） is gaining popularity in the treatment of psychiatric disorders that can be described and treated from either an Eastern or a Western perspective. In Eastern medicine, the disorders are described according to five diagnostic methods that are used in TCM： inspection, auscultation, olfaction, inquiry, and palpation, including tongue and pulse diagnosis.

关键词： medicine Chinese traditional diagnostic methods psychiatry

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Soft wearable flexible bioelectronics integrated with an anklefoot exoskeleton for estimation of metabolic costs and physical effort

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npj Flexible Electronics 2023年第1期7卷 535-544页

作者： Jihoon Kim Prakyath Kantharaju Hoon Yi Michael Jacobson Hyungkeun Jeong Hojoong Kim Jinwoo lee Jared Matthews Nathan Zavanelli Hyeonseok Kim Heejin Jeong Myunghee Kim Woon-Hong yeo IEN Center for Human-Centric Interfaces and Engineering and George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Department of Mechanical and Industrial Engineering the University of Illinois at ChicagoChicagoIL 60607USA Department of Mechanical Roboticsand Energy EngineeringDongguk UniversitySeoulRepublic of Korea Human Systems Engineering The Polytechnic SchoolIra A.Fulton Schools of EngineeringArizona State UniversityMesaAZ 85212USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of MedicineAtlantaGA 30332USA Institute for Robotics and Intelligent Machines Parker H.Petit Institute for Bioengineering and BiosciencesInstitute for MaterialsNeural Engineering CenterGeorgia Institute of TechnologyAtlantaGA 30332USA

Activities and physical effort have been commonly estimated using a metabolic rate through indirect calorimetry to capture breath *** physical effort represents the work hardness used to optimize wearable robotic ***,personalization and rapid optimization of the effort are *** respirometry is the gold standard for estimating metabolic costs,this method requires a heavy,bulky,and rigid system,limiting the system’s field ***,this paper reports a soft,flexible bioelectronic system that integrates a wearable ankle-foot exoskeleton,used to estimate metabolic costs and physical effort,demonstrating the potential for real-time wearable robot adjustments based on *** from a set of activities,including walking,running,and squatting with the biopatch and exoskeleton,determines the relationship between metabolic costs and heart rate variability root mean square of successive differences(HRV-RMSSD)(R=−0.758).Collectively,the exoskeleton-integrated wearable system shows potential to develop a field-deployable exoskeleton platform that can measure wireless real-time physiological signals.

关键词： skeleton wear estimation

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Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

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npj Flexible Electronics 2023年第1期7卷 119-130页

作者： Kiho Kim In Sik Min Tae Hee Kim Do Hyeon Kim Seungwon Hwang Kyowon Kang Kyubeen Kim Sangun Park Jongmin lee Young Uk Cho Jung Woo lee Woon-Hong yeo Young Min Song Youngmee Jung Ki Jun Yu Functional Bio-integrated Electronics and Energy Management Lab School of Electrical and Electronic EngineeringYonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Fusion Research and Collaboration Biomedical Research InstituteSeoul National University HospitalSeoul 03080Republic of Korea School of Electrical Engineering and Computer Science(EECS) Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea PA1 Foundry BusinessSamsung Electronics1 Samsungjeonja-roHwaseong-siGyeonggi-doRepublic of Korea R&D Center DNA Lab PharmaresearchSeongnam 13486Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 136-705Republic of Korea School of Materials Science and Engineering Energy Materials for Soft Electronics LaboratoryPusan National UniversityBusan 46241Republic of Korea IEN Center for Human-Centric Interfaces and Engineering and George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of MedicineAtlantaGA 30332USA Institute for Robotics and Intelligent Machines Parker H.Petit Institute for Bioengineering and BiosciencesInstitute for MaterialsNeural Engineering CenterGeorgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Photodynamic therapy(PDT)is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues,exhibit fewer side effects,and lack pain during *** PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive *** implantable PDT systems,however,are not able to perform multiple functions simultaneously,such as modulating light intensity,measuring,and transmitting tumor-related data,resulting in the complexity of cancer ***,we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in *** system exploits micro inorganic light-emitting diodes(μ-LED)that emit light with a wavelength of 624 nm,designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity ofμ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation(2–3 weeks).The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments,ray-tracing simulation results,and a tumor xenograft mouse model in *** all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.

关键词： optoelectronic enable battery

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Neurons in the hippocampal CA1 region,but not the dentate gyrus,are susceptible to oxidative stress in rats with streptozotocin-induced type 1 diabetes

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Neural Regeneration Research 2015年第3期10卷 451-456页

作者： Sang Gun lee Dae Young Yoo Hyo Young Jung Sung Min Nam Jong Whi Kim Jung Hoon Choi Sun Shin Yi Moo-Ho Won yeo Sung Yoon In Koo Hwang Seung Myung Moon Departments of Neurosurgery Dongtan Sacred Heart HospitalCollege of MedicineHallym University Department of Anatomy and Cell Biology College of Veterinary Medicineand Research Institute for Veterinary ScienceSeoul National University Department of Anatomy College of Veterinary MedicineKangwon National University Department of Biomedical Laboratory Science College of Medical SciencesSoonchunhyang University Department of Neurobiology School of MedicineKangwon National University

In this study, we investigated the effects of streptozotocin-induced type 1 diabetes on antioxi- dant-like protein-1 immunoreactivity, protein carbonyl levels, and malondialdehyde formation, a marker for lipid peroxidation, in the hippocampus. For this study, streptozotocin （75 mg/kg） was intraperitoneally injected into adult rats to induce type 1 diabetes. The three experimental pa- rameters were determined at 2, 3, 4 weeks after streptozotocin treatment. Fasting blood glucose levels significantly increased by 20.7-21.9 mM after streptozotocin treatment. The number of antioxidant-like protein-1 immunoreactive neurons significantly decreased in the hippocampal CA1 region, but not the dentate gyrus, 3 weeks after streptozotocin treatment compared to the control group. Malondialdehyde and protein carbonyl levels, which are modified by oxidative stress, significantly increased with a peak at 3 weeks after malondialdehyde treatment, and then decreased 4 weeks after malondialdehyde treatment. These results suggest that neurons in the hippocampal CA1 region, but not the dentate gyrus, are susceptible to oxidative stress 3 weeks after malondialdehyde treatment.

关键词： nerve regeneration hippocampus dentate gyrus lipid peroxidation type 1 diabetes malondialdehyde neurons neural regeneration

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3D-printed gelatin methacrylate (GelMA)/ silanated silica scaffold assisted by two-stage cooling system for hard tissue regeneration

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Regenerative Biomaterials 2021年第2期8卷 50-63页

作者： Eunjeong Choi Dongyun Kim Donggu Kang Gi Hoon Yang Bongsu Jung MyungGu yeo Min-Jeong Park SangHyun An KyoungHo lee Jun Sik Kim Jong Chul Kim Woonhyeok Jeong Hye Hyun Yoo Hojun Jeon Research Institute of Additive Manufacturing and Regenerative Medicine Baobab Healthcare Inc55 Hanyangdaehak-RoAnsanGyeonggi-do 15588South Korea Department of Mechanical Engineering Korea Polytechnic UniversitySangidaehak-roSiheungGyeonggi-do 15073South Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF)80Cheombok-roDong-guDaegu 41061South Korea Laboratory Animal Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF)80 Cheombok-roDong-guDaegu 41061South Korea Department of Plastic and Reconstructive Surgery Dongsan Medical CenterKeimyung University College of Medicine1035 Dalgubeol-daeroDalseo-guDaegu 42601South Korea Institute of Pharmaceutical Science and Technology College of PharmacyHanyang University55 Hanyangdaehak-RoAnsanGyeonggi-Do 15588South Korea

Among many biomaterials,gelatin methacrylate(GelMA),a photocurable protein,has been widely used in 3D bioprinting process owing to its excellent cellular responses,biocompatibility and ***,GelMA still shows a low processability due to the severe temperature dependence of *** overcome this obstacle,we propose a two-stage temperature control system to effectively control the viscosity of *** optimize the process conditions,we evaluated the temperature of the cooling system(jacket and stage).Using the established system,three GelMA scaffolds were fabricated in which different concentrations(0,3 and 10 wt%)of silanated silica particles were *** evaluate the performances of the prepared scaffolds suitable for hard tissue regeneration,we analyzed the physical(viscoelasticity,surface roughness,compressive modulus and wettability)and biological(human mesenchymal stem cells growth,western blotting and osteogenic differentiation)***,the composite scaffold with greater silica contents(10 wt%)showed enhanced physical and biological performances including mechanical strength,cell initial attachment,cell proliferation and osteogenic differentiation compared with those of the *** results indicate that the GelMA/silanated silica composite scaffold can be potentially used for hard tissue regeneration.

关键词： 3D bioprinting gelatin methacrylate silanated silica cooling system human mesenchymal stem cells

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3D Printing of Polylactic Acid Bioplastic–Carbon Fibres and Twisted Kevlar Composites Through Coextrusion Using Fused Deposition Modeling

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Journal of Renewable Materials 2020年第12期8卷 1671-1680页

作者： J.Y.Tey W.H.yeo Y.J.King W.O.Ding Department of Mechanical and Material Engineering Lee Kong Chian Faculty of Engineering and ScienceUniversiti Tunku Abdul RahmanJalan Sungai LongBandar Sungai LongCheras43000 KajangSelangorMalaysia

Polylactic acid(PLA)bioplastic is a common material used in Fused Deposition Modeling(FDM)3D *** is biodegradable and environmentally friendly biopolymer which made out of ***,it exhibits weak mechanical properties which reduced its usability as a functional prototype in a real-world *** the present study,two PLA composites are created through coextruded with 3K carbon fibres and twisted Kevlar string(as core fibre)to form a fibre reinforced parts(FRP).The mechanical strength of printed parts was examined using ASTM D638 standard with a strain rate of 1 mm/*** has been demonstrated that the FRPs coextruded with 3K carbon fibres had achieved significant improvement in Young’s modulus(+180.6%,9.205 GPa),ultimate tensile strength(+175.3%,103 MPa)and maximum tensile strain(+21.6%,1.833%).Although the Young’s modulus of Kevlar FRP was found to be similar to as compared to unreinforced PLA(~3.29 GPa),it has gained significant increment in terms of maximum tensile strain(+179.7%,104.64 MPa),and maximum tensile strain(+257%,5.384%).Thus,this study revealed two unique composite materials,in which the 3K carbon FRP can offer stiff and high strength structure while Kevlar FRP offers similar strength but at a higher elasticity.

关键词： 3D printing Kevlar fibre 3K carbon fibre coextruded reinforced plastic polylactic acid bioplastic

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Residue patterns of indoxacarb and pyridalyl in treated cauliflower

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Agricultural Sciences 2013年第3期4卷 111-116页

作者： Ji-Young Yoon Jae-Hun Park Hye-Ree Moon guk-Tak Han Kyu-Seung lee Department of Bio-Environmental Chemistry Chungnam National University Daejeon Republic of Korea National Agriculture Product Quality Management Service Chungnam Division Branch Office Daejeon Republic of Korea

The biological half-life and final residue levels of indoxacarb and pyridalyl were determined in cauliflower over a 10-day cultivation period following applications of a standard (100 g ***–1 and 200 g a.i.·ha–1, respectively) and double dose (200 g a.i.·ha–1 and 400 g a.i.·ha–1, respectively). The residue levels were analyzed by gas chromatography with recovery ranging from 92.1% to 109.7%. The biological half-lives of indoxacarb and pyridalyl were 6.33 and 7.74 days for the standard dose, and 6.26 and 7.44 days for the double dose, respectively. The initial and persisting concentrations of indoxacarb and pyridalyl were all below the Korean maximum residue limits for broccoli of 1.0 mgkg–1 and 3.0 mgkg–1, respectively.

关键词： Biological Half-Life Cauliflower Indoxacarb Pyridalyl Residue

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