Optimal culture conditions for the generation of natural killer cell-induced dendritic cells for cancer immunotherapy
作者机构：Research Center for Cancer ImmunotherapyChonnam National University Hwasun HospitalJeollanamdoKorea Department of Hematology-OncologyChonnam National University Hwasun HospitalJeollanamdoKorea Vaxcell-Bio TherapeuticsJeollanamdoKorea The Brain Korea 21 ProjectCenter for Biomedical Human Resources at Chonnam National UniversityGwangjuKorea
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2012年第9卷第1期
页 面：45-53页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：grant no.RTI05-01-01 from the Regional Technology Innovation Program of the Ministry of Commerce Industry and Energy Republic of Korea
主 题：cancer immunotherapy dendritic cells natural killer cells signal
摘 要：Dendritic cell(DC)-based vaccines continue to be considered an attractive tool for cancer *** require an additional signal from the environment or other immune cells to polarize the development of immune responses toward T helper 1(Th1)or Th2 *** play a role in natural killer(NK)cell activation,and NK cells are also able to activate and induce the maturation of *** investigated the types of NK cells that can induce the maturation and enhanced function of DCs and the conditions under which these interactions *** that were activated by resting NK cells in the presence of inflammatory cytokines exhibited increased expression of several costimulatory molecules and an enhanced ability to produce *** cell-stimulated DCs potently induced Th1 polarization and exhibited the ability to generate tumor antigen-specific cytotoxic T lymphocyte *** data demonstrate that functional DCs can be generated by coculturing immature DCs with freshly isolated resting NK cells in the presence of Toll-like receptor agonists and proinflammatory cytokines and that the resulting DCs effectively present antigens to induce tumor-specific T-cell responses,which suggests that these cells may be useful for cancer immunotherapy.
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