Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring
作者机构：Functional Bio-integrated Electronics and Energy Management LabSchool of Electrical and Electronic EngineeringYonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Center for BiomaterialsBiomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Fusion Research and CollaborationBiomedical Research InstituteSeoul National University HospitalSeoul 03080Republic of Korea School of Electrical Engineering and Computer Science(EECS)Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea PA1Foundry BusinessSamsung Electronics1 Samsungjeonja-roHwaseong-siGyeonggi-doRepublic of Korea R&D Center DNA LabPharmaresearchSeongnam 13486Republic of Korea KU-KIST Graduate School of Converging Science and TechnologyKorea UniversitySeoul 136-705Republic of Korea School of Materials Science and EngineeringEnergy Materials for Soft Electronics LaboratoryPusan National UniversityBusan 46241Republic of Korea IEN Center for Human-Centric Interfaces and Engineering and George W.Woodruff School of Mechanical EngineeringGeorgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical EngineeringGeorgia Institute of Technology and Emory University School of MedicineAtlantaGA 30332USA Institute for Robotics and Intelligent MachinesParker H.Petit Institute for Bioengineering and BiosciencesInstitute for MaterialsNeural Engineering CenterGeorgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Electronic EngineeringYU-Korea Institute of Science and Technology(KIST)InstituteYonsei University50Yonsei-roSeodaemun-guSeoul 03722Republic of Korea
出 版 物：《npj Flexible Electronics》 (npj-柔性电子（英文）)
年 卷 期：2023年第7卷第1期
页 面：119-130页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：3D Rat Anatomy Software Korean Fund for Regenerative Medicine Ministry of Science, ICT and Future Planning, MSIP Ministry of Health and Welfare, MOHW, (21A0504L1–11) Ministry of Health and Welfare, MOHW National Research Foundation of Korea, NRF, (2023R1A2C3004531, NRF-2019R1A2C2086085) National Research Foundation of Korea, NRF
主 题：optoelectronic enable battery
摘 要：Photodynamic therapy(PDT)is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues,exhibit fewer side effects,and lack pain during *** PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive *** implantable PDT systems,however,are not able to perform multiple functions simultaneously,such as modulating light intensity,measuring,and transmitting tumor-related data,resulting in the complexity of cancer ***,we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in *** system exploits micro inorganic light-emitting diodes(μ-LED)that emit light with a wavelength of 624 nm,designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity ofμ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation(2–3 weeks).The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments,ray-tracing simulation results,and a tumor xenograft mouse model in *** all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.
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