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Relationship between methylation and colonic inflammation in inflammatory bowel disease

World Journal of Gastroenterology 2014年第30期20卷 10591-10598页

作者： Triana Lobaton Daniel Azuara Francisco rodriguez-Moranta Carolina Loayza Xavier Sanjuan javier de Oca Ana Fernandez-Robles Jordi Guardiola Gabriel Capella Department of Gastroenterology University Hospital of BellvitgeIDIBELLHospitalet de Llobregat08907 BarcelonaSpain Translational Research Laboratory Catalan Institute of OncologyIDIBELLHospitalet de Llobregat08907 BarcelonaSpain Department of Pathology University Hospital of BellvitgeIDIBELLHospitalet de Llobregat08907 BarcelonaSpain Department of Surgery Colorectal UnitUniversity Hospital of BellvitgeIDIBELLHospitalet de Llobregat08907 BarcelonaSpain

AIM:To investigate the relationship between the methylation status in the SLIT2 and TGFB2 promoters and colonic inflammation in inflammatory bowel disease ***:We evaluated the methylation status of 2genes(SLIT2 and TGFB2)in 226 biopsies taken from62 colonoscopies of 38 patients(29 ulcerative colitis and 9 Crohn’s colitis)using methylation-specific melting curve *** relationships between methylation status and clinical,biological,endoscopic and histological activities were ***-three of the 38patients had a second colonoscopy and were included in a longitudinal *** results were given as the means±SD of the sample and range,except when *** t analysis,U Mann Whitney and ANOVA factor were used to compare the *** results were based on theχ2 ***:SLIT2 methylation was more frequent in samples with endoscopic activity than with endoscopic remission(55%vs 18%,P<0.001).SLIT2 methylation was also higher in samples with acute inflammation(56.5%)than in samples with chronic(24%)or absent inflammation(15%)(P<0.001).For TGFB2methylation,the correlation was only significant with endoscopic *** was higher in the distal colon for both genes(P<0.001 for SLIT2 and P=0.022for TGFB2).In the multivariate analysis,only inflammation status(and not disease duration or extension)was independently associated with SLIT2 methylation[OR=6.6(95%CI:1.65-27.36),P=0.009].In the longitudinal analysis,the maintenance of endoscopic remission was protective for ***:Endoscopic and histological inflammation are predictive for SLIT2 methylation.

关键词： Colonic inflammation Inflammatory bowel disease Aberrant methylation Dysplasia Colitis associated colorectal cancer

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αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

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Protein & Cell 2020年第3期11卷 219-226页

作者： Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityCambridgeMA 02115USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Integrative Genomics and Bioinformatics Core Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Universidad Catolica San Antonio de Murcia(UCAM) Campus de los JeronimosNo 1351230107 GuadalupeSpain Hospital Clinic of Barcelona Career Villarroel17008036 BarcelonaSpain Department of Traumatology and Research Unit Clinica CEMTRO28035 MadridSpain National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China Translational Medical Center for Stem Cell Therapy Shanghai East HospitalTongji University School of MedicineShanghai 200120China

Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular *** regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with *** aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016).

关键词： aging treatment critical

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Hippocampal Pallium and Map-Like Memories through Vertebrate Evolution

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Journal of Behavioral and Brain Science 2015年第3期5卷 109-120页

作者： C. Broglio I. Martin-Monzon F. M. Ocana A. gomez E. Duran C. Salas F. rodriguez Laboratory of Psychobiology. University of Sevilla Campus Santiago Ramon y Cajal Sevilla Spain

The hippocampus in humans and other mammals is essential for episodic and relational memories. Comparative evidence indicates that a hippocampal pallium homologue is present in birds, reptiles, amphibians, ray-finned fishes, cartilaginous fishes and agnathans. Some of their characteristics, such as the topological position and the pattern of connectivity, appear remarkably well conserved. We review here substantial data showing that in all the vertebrate groups studied up to date, from fish to mammals, the hippocampus plays a fundamental role in spatial memory. In these vertebrates groups, the hippocampal pallium homologue is involved in the use of map-like, relational representations of the objective space that provide stable allocentric frames of reference, thus allowing flexible navigation. These similarities suggest a common evolutionary ancestry and indicate that the functional properties of the hippocampus appear early in the vertebrate phylogenesis and are retained through the independent evolution of the vertebrate lineages.

关键词： Hippocampus Spatial Memory Amniotes Anamniotes Vertebrate Brain Evolution

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New Developments in Speciation of Metal-Humic Substances Complexes by using Different Polyacrylamide Gel Electrophoresis（PAGE）Techniques and LA-ICP-MS

New Developments in Speciation of Metal-Humic Substances Com...

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第三十五届国际光谱会议

作者： J.R.Castillo M.T.gomez M.S.Jimenez L.rodriguez R.Velarte Analytical Spectroscopy and Sensors Group（GEAS） Sciences Faculty University of Zaragoza Zaragoza 50009Spain Analytical Spectroscopy and Sensors Group（GEAS） Sciences Faculty University of Zaragoza Zaragoza 50009Spain Analytical Spectroscopy and Sensors Group（GEAS） Sciences Faculty University of Zaragoza Zaragoza 50009Spain Analytical Spectroscopy and Sensors Group（GEAS） Sciences Faculty University of Zaragoza Zaragoza 50009Spain Analytical Spectroscopy and Sensors Group（GEAS） Sciences Faculty University of Zaragoza Zaragoza 50009Spain

＜正＞Compost obtained from the organic fraction of municipal solid waste and from other selected waste biomasses can sometimes be used effectively as an organic fertilizer on agricultural *** presence of organic and inorganic contaminants in compost,may, however,constitute a danger to the *** is the heavy metal content and metal mobility and bioavailability which are the main factors leading to restricted agricultural use of *** acids （HAs）,the predominant fractions of humic substances （HSs）

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DNA and RNA oxidative damage in hepatocellular carcinoma patients and mortality during the first year of liver transplantation

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World Journal of Hepatology 2022年第6期14卷 1182-1189页

作者： Leonardo Lorente Sergio T rodriguez Pablo Sanz Agustín F González-Rivero Antonia Pérez-Cejas javier Padilla Dácil Díaz Antonio González María M Martín Alejandro Jiménez Purificación Cerro Julián Portero Manuel A Barrera Department ofIntensive Care Hospital Universitario de CanariasLa Laguna 38320TenerifeSpain Intensive Care Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain Department of Surgery Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010Spain Department of Laboratory Hospital Universitario de CanariasLa Laguna 38320Spain Department of Digestive Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de Tenerife 38010Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320Spain Transplant Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain Department of Radiology Hospital Universitario Nuestra Señora CandelariaSanta Cruz de Tenerife 38010Spain

BACKGROUND Oxidative damage of DNA and RNA has been associated with mortality of patients with different ***,there is no published data on the potential use of DNA and RNA oxidative damage to predict the prognosis of patients with hepatocellular carcinoma(HCC)undergoing liver transplantation(LT).AIM To determine whether patients with increased DNA and RNA oxidative damage prior to LT for HCC have a poor LT *** Patients with HCC who underwent LT were included in this observational and retrospective *** levels of all three oxidized guanine species(OGS)were measured prior to LT since guanine is the nucleobase that forms DNA and RNA most prone to *** mortality at 1 year was the end-point *** Surviving patients(n=101)showed lower serum OGS levels(P=0.01)and lower age of the liver donor(P=0.03)than non-surviving patients(n=13).An association between serum OGS levels prior to LT and 1-year LT(odds ratio=2.079;95%confidence interval=1.356-3.189;P=0.001)was found in the logistic regression *** The main new finding was that high serum OGS concentration prior to LT was associated with the mortality 1 year after LT in HCC patients.

关键词： DNA oxidative damage Hepatocellular carcinoma Liver transplantation Mortality Oxidized guanine species

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Air pollution and heart failure: Relationship with the ejection fraction

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World Journal of Cardiology 2013年第3期5卷 49-53页

作者： Alberto Dominguez-rodriguez javier Abreu-Afonso Sergio Rodríguez Ruben A Juarez-Prera Eduardo Arroyo-Ucar Yenny Gonzalez Pedro Abreu-Gonzalez Pablo Avanzas Department of Cardiology Hospital Universitario de Canarias Universidad Europea de Canarias Facultad de Ciencias de la Salud Instituto Universitario de Tecnologías Biomédicas Department of Applied Physics Universidad de Valencia Center for Atmospheric Research Izaa AEMET-CSIC Department of Physiology Universidad de la Laguna Department of Cardiology Hospital Universitario Central de Asturias

AIM: To study whether the concentrations of particulate matter in ambient air are associated with hospitaladmission due to heart failure in patients with heart failure with preserved ejection fraction and reduced ejection fraction. METHODS: We studied 353 consecutive patients admitted into a tertiary care hospital with a diagnosis of heart failure. Patients with ejection fraction of ≥ 45% were classified as having heart failure with preserved ejection fraction and those with an ejection fraction of < 45% were classified as having heart failure with reduced ejection fraction. We determined the average concentrations of different sizes of particulate matter (< 10, < 2.5, and < 1 μm) and the concentrations of gaseous pollutants (carbon monoxide, sulphur dioxide, nitrogen dioxide and ozone) from 1 d up to 7 d prior to admission. RESULTS: The heart failure with preserved ejection fraction population was exposed to higher nitrogen dioxide concentrations compared to the heart failure with reduced ejection fraction population (12.95 ± 8.22 μg/m 3 vs 4.50 ± 2.34 μg/m 3 , P < 0.0001). Multivariate analysis showed that nitrogen dioxide was a significant predictor of heart failure with preserved ejection fraction (odds ratio ranging from (1.403, 95%CI: 1.003-2.007, P = 0.04) to (1.669, 95%CI: 1.043-2.671, P = 0.03). CONCLUSION: This study demonstrates that shortterm nitrogen dioxide exposure is independently associated with admission in the heart failure with preserved ejection fraction population.

关键词： Air pollution Heart failure Preserved ejection fraction Reduced ejection fraction Nitrogen dioxide

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Botulinum Toxin A, Effect on Tensile Strength of Skin Wounds;Animal Study

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Journal of Biosciences and Medicines 2020年第2期8卷 17-24页

作者： Carlos A. Gonzalez-Alvarado Juan Garzon-Muvdi Roxanna Perez-Garmendia Victoria Ramirez Luz Graciela Cervantes Adriana rodriguez-gomez Rodrigo Davila-Diaz Cuahutemoc Marquez-Espriella Plastic and Reconstructive Surgery Division Hospital Central Sur de alta Especialidad de Petroleos Mexicanos Mexico City Mexico Experimental Surgery Department Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubiran Mexico City Mexico Pharmacology Department Instituto Nacional de Cardiologia Ignacio Chavez Mexico City Mexico Pathology Department Hospital Angeles del Pedregal Mexico City Mexico

Wound healing and cicatrization is a process that involves several phases. The main goal of a surgeon and specially the plastic surgeon is to achieve the best cosmetic results and avoid complications. Several tools are available to achieve the best result. One of the tools recently studied is the use of Botulinum toxin. The use of Botulinum toxin has showed to be a useful aid by improving macroscopic cosmetic changes, as histopathologic ones. The increase of the tensile strength is also one of the positive changes that come with the use of botulinum toxin.

关键词： Botulinum Toxin Wound Tensile Strength

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Effects of Microselective Neurotomy on Focal Spasticity and Description of the Surgical Technique

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Open Journal of Modern Neurosurgery 2021年第3期11卷 144-156页

作者： Sergio A. Sacchettoni Joyce Bolaños Napoleon Torres Juan P. Abud Penelope Mantilla Luis Salazar Maria-Fernanda Vargas Julio rodriguez-Wulff Randy Balladares Ricardo gomez Service of Neurosurgery Hospital Vargas de Caracas Caracas Venezuela Service of Neurosurgery Centro Medico Docente La Trinidad Caracas Venezuela Neurological Unit “NeuroQX” Centro Médico Integra Caracas Venezuela Université Grenoble Alpes Grenoble France

We studied the microselective neurotomy (MSN) and its advantages to alleviate disabling spasticity. The best indication for MSN is focal spasticity. We performed 298 MSN, 87 nerves on the upper limb, 211 nerves on the lower limb) in 68 patients. The initial causes were: stroke, cranial trauma, postoperative complications and multiple sclerosis. MSN procedures were performed on the median nerve (n = 40) for wrist and finger flexion;musculo-cutaneus nerve (n = 38) for elbow flexion;ulnaris nerve (n = 9) for cubital deviation of the hand;gastrocnemius nerve (n = 98) and soleus nerve (n = 49) for equinus foot, tibial posterior nerve (n = 45) for varus foot, and fascicles (or bundles) of the flexor digitorum for “claw” toes (n = 19). The main preoperative test to identify the responsible nerve was a neuromuscular block with local anesthesia (lidocaine or bupivacaine) injected into the site of the nerve connecting the spastic muscle. During surgery, the identified nerve was exposed and its epineurium opened. Nerve bundles were teased apart into individual rootlets and a number of rootlets cut were previously planned, according to the spasticity. Follow-up was performed for up to 10 years, with a mean period of 29 months. Results demonstrated a reduction of limb spasticity of 2 to 3 points: modified Ashworth scale (MAS). Pain and clonus were also diminished in the affected limb. In some cases, voluntary movement was once again possible. MSN is a useful alternative in those cases of focal spasticity where physiotherapy and nerve block with botulinum toxin or phenol no longer produce satisfactory results.

关键词： Focal Spasticity Microselective Neurotomy Neurosurgery of Spasticity

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Postoperative radiotherapy in resected non-small cell lung cancer:The never-ending story

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World Journal of Clinical Oncology 2021年第10期12卷 833-844页

作者： javier Serrano Patricia Calvo Crespo Begoña Taboada Ana Alvarez Gonzalez Rafael Garcia García Antonio gomez Caamaño Juan Carlos Trujillo Reyes Xabier Mielgo-Rubio Felipe Couñago Department of Radiation Therapy Clinica Universidad de NavarraMadrid 28027Spain Department of Radiation Oncology Hospital Clínico Universitario Santiago de CompostelaSantiago de Compostela 15706Spain Department of Radiation Oncology HGU Gregorio MarañónMadrid 28007Spain Department of Radiation Oncology Hospital Ruber InternacionalMadrid 28034Spain Department of Radiation Oncology Hospital Clínico Universitario Santiago de CompostelaA Coruña 15706Spain Department of Thoracic Surgery Hospital de La Santa Creu I Sant PauBarcelona 08026Spain Department of Medical Oncology Hospital Universitario Fundación AlcorcónMadrid 28922Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28223Spain

This manuscript collects in a joint and orderly manner the existing evidence at the present time about postoperative treatment with radiotherapy in non-small cell lung *** also systematically reviews the current evidence,the international recommendations in the most relevant guidelines,the most controversial aspects in clinical and pathological staging,the specific technical aspects of radiotherapy treatment,and also collects all the potential risk factors that have been postulated as significant in the prognosis of these patients,evaluating the possibility of segmenting a particularly sensitive subpopulation with a high risk of relapse on which an adjuvant treatment with radiotherapy could have an impact on their clinical ***,currently active trials that aspire to provide more evidence on this topic are reviewed.

关键词： Non-small lung cancer Radiotherapy Postoperative Lung cancer

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Effectiveness and safety of first-generation protease inhibitors in clinical practice:Hepatitis C virus patients with advanced fibrosis

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World Journal of Gastroenterology 2015年第30期21卷 9163-9174页

作者： javier Salmeron Carmen Vinaixa Ruben Berenguer Juan Manuel Pascasio Juan Jose Sanchez Ruano Miguel angel Serra Ana Gila Moises Diago Manuel Romero-gomez Jose Maria Navarro Milagros Testillano Conrado Fernandez Dolores Espinosa Isabel Carmona Jose Antonio Pons Francisco Jorquera Francisco javier rodriguez Ramon Perez Jose Luis Montero Rafael Granados Miguel Fernandez Ana Belen Martin Paloma Munoz de Rueda Rosa Quiles CIBERehd Instituto de Salud Carlos Ⅲ28029 MadridSpain Unit for Clinical Management of Digestive Diseases Complejo Hospitalario Universitario de Granada Instituto de Investigacion Biosanitaria de Granada University Hospital Politecnico La Fe Unit for Clinical Management of Digestive Diseases University Hospital Virgen Del Rocio Hospital Toledo University Clinic Hospital of Valencia University General Hospital of Valencia Unit for Clinical Management of Digestive Diseases University Hospital Nuestra Senora de Valme Department of Gastroenterology and Hepatology Agencia Sanitaria Costa del Sol University Hospital Cruces Gastroenterology Unit University Hospital Fundacion Alcorcon University Hospital Virgen Macarena University Hospital Virgen de la Arrixaca Hospital of Leon University General Hospital Reina Sofia Department Gastroenterology and Hepatology University Hospital Central de Asturias University Hospital Reina Sofia University Hospital De Gran Canaria Dr. Negrin Hospital San Pedro de Alcantara

AIM:To evaluates the effectiveness and safety of the first generation,NS3/4A protease inhibitors(PIs) in clinical practice against chronic C virus,especially in patients with advanced fibrosis. METHODS:Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis C genotype 1,treatment-na?ve(TN) or treatment-experienced(TE),who underwent triple therapy with the first generation NS3/4A protease inhibitors,boceprevir(BOC) and telaprevir(TVR),in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow ***:One thousand and fifty seven patients were included,405(38%) were treated with BOC and 652(62%) with TVR. Of this total,30%(n = 319) were TN and the remaining were TE:28%(n = 298) relapsers,12%(n = 123) partial responders(PR),25%(n = 260) null-responders(NR) and for 5%(n = 57) with prior response unknown. The rate of sustained virologic response(SVR) by intention-to-treatment(ITT) was greater in those treated with TVR(65%) than in those treated with BOC(52%)(P < 0.0001),whereas by modified intention-to-treatment(m ITT) no were found significant differences. By degree of fibrosis,56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients,both TN and TE. In the analysis by groups,the TN patients treated with TVR by ITT showed a higher SVR(P = 0.005). However,by m ITT there were no significant differences between BOC and TVR. In the multivariate analysis by m ITT,the significant SVR factors were relapsers,IL28 B CC and non-F4; the type of treatment(BOC or TVR) was not significant. The lowest SVR values were presented by the F4-NR patients,treated with BOC(46%) or with TVR(45%). 28% of the patients interrupted the treatment,mainly by non-viral response(51%):this outcome was

关键词： Hepatitis C Boceprevir Telaprevir First-generation protease inhibitors Advanced fibrosis

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