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Fabrication and Applications of Micro/Nanostructured Devices for Tissue Engineering

Nano-Micro Letters 2017年第1期9卷 1-13页

作者： Tania Limongi Luca Tirinato Francesca Pagliari Andrea Giugni Marco Allione gerardo Perozziello Patrizio Candeloro Enzo Di Fabrizio SMILEs Lab Physical Science and Engineering(PSE)and Biological and Environmental Sciences and Engineering(BESE)DivisionsKing Abdullah University of Science and TechnologyThuwal 23955-6900Kingdom of Saudi Arabia Department of Biological and Environmental Sciences and Engineering(BESE) King Abdullah University of Science and TechnologyThuwal 23955-6900Kingdom of Saudi Arabia Laboratory of Nanotechnology BioNEM Department of Experimental and Clinical MedicineUniversity"Magna Graecia"of CatanzaroViale Europa-Loc.Germaneto88100 CatanzaroItaly

Nanotechnology allows the realization of new materials and devices with basic structural unit in the range of1–100 nm and characterized by gaining control at the atomic, molecular, and supramolecular level. Reducing the dimensions of a material into the nanoscale range usually results in the change of its physiochemical properties such as reactivity,crystallinity, and solubility. This review treats the convergence of last research news at the interface of nanostructured biomaterials and tissue engineering for emerging biomedical technologies such as scaffolding and tissue regeneration. The present review is organized into three main sections. The introduction concerns an overview of the increasing utility of nanostructured materials in the field of tissue engineering. It elucidates how nanotechnology, by working in the submicron length scale, assures the realization of a biocompatible interface that is able to reproduce the physiological cell–matrix interaction. The second, more technical section, concerns the design and fabrication of biocompatible surface characterized by micro- and submicroscale features, using microfabrication, nanolithography, and miscellaneous nanolithographic *** the last part, we review the ongoing tissue engineering application of nanostructured materials and scaffolds in different fields such as neurology, cardiology, orthopedics, and skin tissue regeneration.

关键词： Nanomaterials Nanostructures Microfabrication Nanofabrication Device Tissue engineering

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Modelling extraordinary floods and sedimentological processes in a large channel-floodplain system of the Lower Paran River(Argentina)

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International Journal of Sediment Research 2015年第2期30卷 150-159页

作者： Marina L.Garcia Pedro A.Basile gerardo A.Riccardi José F.Rodriguez Hydraulics Department School of Civil EngineeringFaculty of Exact SciencesEngineering and Land SurveyingNational University of Rosario Centre for Hydro-Environmental Research Faculty of Exact SciencesEngineering and Land SurveyingNational University of Rosario Research Council of National University of Rosario(CIUNR) Civil Surveying and Environmental EngineeringUniversity of Newcastle

A quasi-2D unsteady flow and sediment transport model suitable for the simulation of large lowland river systems,including their floodplains,is *** water flow and sediment equations are discretised using an interconnected irregular cells scheme,in which different simplifications of the 1D de Saint Venant equations are used to define the discharge laws between ***-distributed transport and deposition of fine sediments throughout the river-floodplain system are *** model is applied over a 208-km reach of the Parana River between the cities of Diamante and Ramallo（Argentina） comprising a river-floodplain area of 8100 km;.After calibration and validation,the model is applied to predict water and sediment dynamics during synthetically generated extraordinary floods of100,1000,and 10,000 years return *** potential impact of a 56-km long road embankment constructed across the entire floodplain is simulated and compared to model results without the *** embankment results in increases in upstream water levels,inundation extent,flow duration,and sediment deposition.

关键词： Fluvial hydraulics Numerical modelling Floodplain sedimentation Lowland rivers Parana River

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Tests （Ch2） As Primary Screening Test In One Of The Hospitals Of The Hospitals Of The Mexican Departament Of Health （Secretaria De Salud,Mexico）.

Tests （Ch2） As Primary Screening Test In One Of The Hospit...

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24th International Papillomavirus Conference and Clinical Workshop

作者： Maria Esther Dragustinovis ruiz Carlos Vargas Carriche Laura Tirado Gomez gerardo Lara Figueroa Genaro Valerio Tello Genaro Valerio Tello Genaro Valerio Tello Genaro Valerio Tello

＜正＞Background Among Latin American countries such as Mexico and the rest of the world,there is a great discrepancy in the screening Methods used on the general population for prevention cervical cancer;there is a 30 to 50% error margin in the diagnostic Methods used today（Cytology 50%-70%,Colposcopy 40%-60%）.The implementation of new techniques and Methods based in molecular biology（HC2）that comply with the cultural,social,and economic level of each country to manage

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Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis

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World Journal of Gastroenterology 2011年第48期17卷 5305-5309页

作者： Ron Benyair Maria Kondratyev Elena Veselkin Sandra Tol-chinsky Marina Shenkman Yoav Lurie gerardo Z Lederkremer Department of Cell Research and Immunology George Wise Faculty of Life Sciences Tel Aviv University Liver Unit Department of Gastroenterology Tel Aviv Sourasky Medical Center

AIM: To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum. METHODS: Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentration of sH2a in human sera of individuals of both sexes and a wide range of ages. RESULTS: The recombinant protein was produced successfully and a specific ELISA assay was developed. The levels of sH2a in sera from 62 healthy individuals variedminimally (147 ± 19 ng/mL). In contrast, 5 hepatitis C patients with cirrhosis showed much decreased sH2a levels (50 ± 9 ng/mL). CONCLUSION: Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals. This constant level and the decrease with cirrhosis suggest a diagnostic potential.

关键词： Asialoglycoprotein receptor Hepatitis C vi-rus Liver function Cirrhosis Liver diagnosis

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Simulation of erosion-deposition processes at basin scale by a physically-based mathematical model

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International Journal of Sediment Research 2010年第2期25卷 91-109页

作者： Pedro A. BASILE gerardo A. RICCARDI Erik D. ZIMMERMANN Hernán R. STENTA Hydraulics Department School of Civil EngineeringNational University of Rosario Research Scientist Centre for Hydro-Environmental ResearchNational University of Rosario Research Scientist Research Council of National University of Rosario(CIUNR) Research Scientist National Council of Scientific and Technical Research(CONICET)

The development and application of the physically-based and spatially-distributed mathematical model CTSS8-SED is presented. The model simulates hydrologic-hydraulic processes produced by storm events and related soil erosion and sediment transport processes at basin scale in lowland areas. The model simulates (i) storm runoff,(ii) soil detachment by raindrop impact and overland flow (gross sediment yield),(iii) sediment transport by overland flow and associated erosion-deposition processes and (iv) sediment transport by stream flow and riverbed erosion-deposition processes. A quasi two-dimensional representation of water flow and sediment transport routing is made by means of interconnected cells approach. The model is applied to simulate two flooding events in the Luduea Creek basin (Santa Fe, Argentina) occurred in April 1994 and March 2007 due to extraordinary rainfalls.

关键词： Mathematical modeling Erosion Sedimentation Ludue?a Creek Argentina

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Autoimmune liver diseases and SARS-CoV-2

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World Journal of Gastroenterology 2023年第12期29卷 1838-1851页

作者： Costantino Sgamato Alba Rocco Debora Compare Stefano Minieri Stefano Andrea Marchitto Simone Maurea gerardo Nardone Department of Clinical Medicine and Surgery University of Naples Federico ⅡNaples 80131Italy Department of Advanced Biomedical Sciences University of Naples Federico ⅡNaples 80131Italy

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing coronavirus disease 2019(COVID-19),can trigger autoimmunity in genetically predisposed individuals through hyperstimulation of immune response and molecular *** we summarise the current knowledge about autoimmune liver diseases(AILDs)and SARS-CoV-2,focusing on:(1)The risk of SARS-CoV-2 infection and the course of COVID-19 in patients affected by AILDs;(2)the role of SARS-CoV-2 in inducing liver damage and triggering AILDs;and(3)the ability of vaccines against SARS-CoV-2 to induce autoimmune responses in the *** derived from the literature suggest that patients with AILDs do not carry an increased risk of SARS-Cov-2 infection but may develop a more severe course of COVID-19 if on treatment with steroids or *** SARSCoV-2 infection can lead to the development of several autoimmune diseases,few reports correlate it to the appearance of de novo manifestation of immunemediated liver diseases such as autoimmune hepatitis(AIH),primary biliary cholangitis(PBC)or AIH/PBC overlap *** case series of an AIHlike syndrome with a good prognosis after SARS-CoV-2 vaccination have been *** the causal link between SARS-CoV-2 vaccines and AIH cannot be definitively established,these reports suggest that this association could be more than coincidental.

关键词： Autoimmune liver disease SARS-CoV-2 COVID-19 COVID-19 vaccine Autoimmune hepatitis

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On Boolean Lattices of Module Classes

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Algebra Colloquium 2018年第2期25卷 285-294页

作者： Alejandro Alvarado-Garcia Cesar Cejudo-Castilla Hugo Alberto Rincon-Mejia Ivan Fernando Vilchis-Montalvo Manuel gerardo Zorrilla-Noriega Facultad de Ciencias Universidad Nacional Autonoma de Mexico Circuito Exterior C.U. C.P. 04510 Ciudad de Mexico Mexico Facultad de Ciencias Fisico Matemdticas Benemerita Universidad Autonoma de Puebla Av. San Claudio y 18 Sur Col. San Manuel Ciudad Universitaria C.P. 72570 Puebla Mexico Facultad de Ciencias Universidad Nacional Autonoma de Mexico Circuito Exterior C.U. C.P. 04510 Ciudad de Mdxico Mdxico Facultad de Ciencias Ffsico Matematicas Benemerita Universidad Autonoma de Puebla Av. San Claudio y 18 Sur Coi. San Manuel Ciudad Universitaria C.P. 72570 Puebla Mexico

Some properties of and relations between several （big） lattices of module classes are used in this paper to obtain information about the ring over which modules are taken. The authors reach characterizations of triv... 详细信息

关键词： torsion theories hereditary pretorsion classes natural classes conaturalclasses boolean lattice

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Surgical treatment of locally advanced anal cancer after male-to-female sex reassignment surgery

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World Journal of Gastroenterology 2009年第23期15卷 2918-2919页

作者： Marco Caricato Fabio Ausania Giovanni Francesco Marangi Ilaria Cipollone gerardo Flammia Paolo Persichetti Lucio Trodella Roberto Coppola Department of General Surgery Campus Bio Medico University of Rome Rome 00139 Italy Plastic and Reconstructive Surgery Campus Bio Medico University of Rome Rome 00139 Italy Radiation Oncology Campus Bio Medico University of Rome Rome 00139 Italy

We present a case of a transsexual patient who underwent a partial pelvectomy and genital reconstruction for anal cancer after chemoradiation. This is the first case in literature reporting on the occurrence of anal cancer after male-to-female sex reassignment surgery. We describe the surgical approach presenting our technique to avoid postoperative complications and preserve the sexual reassignment.

关键词： Sex reassignment Pelvic surgery Analcancer

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Non-Specific Factors Involved in the Treatment： Its Influence on Treatment Adherence

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Journal of Pharmacy and Pharmacology 2017年第6期5卷 340-348页

作者： gerardo A. Fridman Corrientes Pharmacy Santa Fe 1294 City of Corrientes 3400 Argentina

Introduction： The effectiveness of treatment depends on the efficacy of the therapy and the level of compliance of the patient. NF （non-specific factors） involved in treatment are all those effects that do not depend on the pharmacological properties of the drug. Materials and Methods： The job lasted a year. The sample consisted of patients with mental health disorders and was divided into two groups. Treatment compliance was measured with the Morisky-Green Test. Results were compared using the chi square test and relative risk. Results and Discussion： Group A had 23 patients ending 91.3% of them and group B of 22 patients, ending the 77.27%. At the beginning of the study, we found in the group A 0.86 NF/patients while in the group B 0.82 NF/patient. At the end of the study there was a 54.65% decrease in group A while in group B the proportion remained. At the beginning of the study both groups had approximately 40% of compliant patients. Data that remained in the control group rose to 80.95% in group A at the end of the study. Conclusions： The work demonstrates the negative influence of these factors on adherence to treatment.

关键词： Adhesion to treatment nonspecific factors influencing treatment health professional patient family environment.

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Resource manipulation reveals flexible allocation rules to growth and reproduction in a Mediterranean evergreen oak

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Journal of Plant Ecology 2014年第1期7卷 77-85页

作者： Fernando Pulido gerardo Moreno Eustolia García José J.Obrador Raúl Bonal Mario Díaz Grupo de Investigación Forestal Ingeniería Forestal y del Medio NaturalUniversidad de ExtremaduraE-10600 PlasenciaCáceresSpain Colegio de Postgraduados Campus TabascoMX-86500 CárdenasTabascoMexico Instituto de Investigación en Recursos Cinegéticos (CSIC-UCLM-JCCM)University of Castilla-La ManchaCiudad RealSpain Department of Biogeography and Global Change(BCG-MNCN) Museo Nacional de Ciencias NaturalesCSICE-28006 MadridSpain

Aims In plants,resource allocation to growth and reproduction may depart from trade-off expectations if(i)investment in growth and reproduction relies on different resource pools,(ii)allocation to reproduction is dependent upon reaching some growth threshold or(iii)reproduction is developmentally linked to growth,both functions relying on the same resource *** examined the effects of enhanced resource level on patterns of resource allocation to growth and reproduction in holm oak(Quercus ilex ***),a Mediterranean evergreen *** In the experimental year(2003),we manipulated the amount of soil nutrients in autumn(to increase nutrient uptake during shoot elongation in the following spring)and soil water in summer(to increase water uptake during acorn growth).Indicators of growth and male and female reproduction were estimated in the preexperimental(2002),experimental(2003)and post-experimental(2004)*** Findings Fertilized trees produced significantly longer shoots,but the number of female flowers per shoot was not affected by *** production of male catkins was also enhanced by *** did not affect the production of female flowers or abortion *** and female reproduction showed no consistent relationship in untreated trees,but resource addition elicited a growth-female reproduction trade-off in the experimental *** sign of this significant relationship changed in the post-experimental year,indicating the existence of lagged effects of resource manipulation on acorn ***,patterns of allocation to growth and reproduction varied as a function of sex,resource availability and year,a result consistent with extreme allocational plasticity in holm oak.

关键词： acorn abortion allocational plasticity dehesa growthreproduction trade-offs nutrient addition Quercus ilex resource allocation

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