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Self-assemblies of plasmonic gold/layered double hydroxides with highly efficient antiviral effect against the hepatitis B virus

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Nano Research 2015年第11期8卷 3512-3523页

作者： gabriela Carja Elena Florentina Grosu Catalina Petrarean Norica Nichita Department of Chemical Engineering Faculty of Chemical Engineering and Environmental Protection Technical University 'Gh. Asachi' of lasi Bd. Mangeron No. 71 lasi 700554 Romania Department of Viral Glycoproteins Institute of Biochemistry of the Romanian Academy Splaiul Independentei 296 Bucharest 060031 Romania

Engineering complex nanocomposites that specifically target the hepatitis B virus （HBV） and overcome the limitations of current therapies such as limited efficacy and serious side effects is very challenging. Here, for the first time, the antiviral effect of engineered plasmonic gold and layered double hydroxide self-assemblies （AuNPs/LDHs） is demonstrated, using HBV as a model virus and hepatoma-derived HepG2.2.215 ceils for viral replication, assembly, and secretion of infectious virions and subviral particles. AuNPs/LDHs were obtained by a simple, cost-effective procedure in which small AuNPs （-3.5 nm） were directly obtained and organized on the surface of larger LDH nanoparticles （-150 nm） by exploiting the capability of MgLDH, ZnLDH, and MgFeLDH to manifest their ＂structural memory＂ in the aqueous solution of Au（O2CCH3）3. The self-assembly approach of AuNPs and LDHs was assessed by transmission electron microscopy （TEM）, X-ray photoelectron spectroscopy （XPS）, powder X-ray diffraction （PXRD）, and UV-Vis analysis （UV-Vis）. All AuNPs/LDHs tested reduced the amount of viral and subviral particles released from treated cells by up to 80% and exhibited good cytocompatibility. AuNPs/MgFeLDH showed the highest antiviral HBV response with more than 90% inhibition of HBV secretion for the whole concentration range. Preliminary studies on the mechanism of HBV inhibition reveals that in the presence of AuNPs/LDHs, HBV particles are sequestered within the treated cells. The antiviral and low cytotoxic plasmonic properties of these Au/LDH nanocomposites indicate that they hold significant potential to be tailored as novel efficient therapeutics for the treatment of hepatitis B.

关键词： plasmonic gold layered double hydroxides layered double hydroxide (LDH) antiviral effect HBV hepatitis cytotoxicity

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Mapping flood and flooding potential indices： a methodological approach to identifying areas susceptible to flood and flooding risk. Case study： the Prahova catchment （Romania）

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Frontiers of Earth Science 2017年第2期11卷 229-247页

作者： Liliana ZAHARIA Romulus COSTACHE Remus PRAVALIE gabriela IOANA-TOROIMAC Faculty of Geography University of Bucharest 1 Nieolae Balcescu Str. 010041 Bucharest Romania National Institute of Hydrology and Water Management 97 Bucuresti-Ploiesti Str. District 1 Bucharest Romania

Given that floods continue to cause yearly significant worldwide human and material damages, flood risk mitigation is a key issue and a permanent challenge in developing policies and strategies at various spatial scales. Therefore, a basic phase is elaborating hazard and flood risk maps, documents which are an essential support for flood risk management. The aim of this paper is to develop an approach that allows for the identification of flash-flood and flood-prone susceptible areas based on computing and mapping of two indices： FFPI （Flash-Flood Potential Index） and FPI （Flooding Potential Index）. These indices are obtained by integrating in a GIS environment several geographical variables which control runoff（in the case of the FFPI） and favour flooding （in the case of the FPI）. The methodology was applied in the upper （mountainous） and middle （hilly） catchment of the Prahova River, a densely populated and socioeconomically well-developed area which has been affected repeatedly by water-related hazards over the past decades. The resulting maps showing the spatialization of the FFPI and FPI allow for the identification of areas with high susceptibility to flash- floods and flooding. This approach can provide useful mapped information, especially for areas （generally large） where there are no flood/hazard risk maps. Moreover, the FFPI and FPI maps can constitute a preliminary step for flood risk and vulnerability assessment.

关键词： flash-flood flooding Flash-flood/FloodingPotential Index Prahova River catchment Romania

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Hydrogen evolution kinetics on Ni cathodes modified by spontaneous deposition of Ag or Cu

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Journal of Energy Chemistry 2017年第3期26卷 466-475页

作者： Esteban A.Franceschini gabriela I.Lacconi Horacio R.Corti INFIQC-CONICET Departamento de Fisicoquímica–Facultad de Ciencias QuímicasUniversidad Nacional de CórdobaCiudad Universitaria5000 CórdobaArgentina Departamento de Física de la Materia Condensada Centro Atómico ConstituyentesComisión Nacional de Energía AtómicaAv.Gral.Paz 1499(B1650KNA)San MartínBuenos AiresArgentina INQUIMAE-CONICET Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresCiudad UniversitariaPabellón IIC1428EHABuenos AiresArgentina

Nickel modification by spontaneous deposition of transition metals such as Ag and Cu is shown as an economic and simple alternative for the activation of hydrogen evolution reaction（HER） on cathodes in alkaline media. The kinetics of HER is studied on Ni/Ag and Ni/Cu catalysts by cyclic voltammetry and electrochemical impedance spectroscopy（EIS） using a rotating disk electrode（RDE）. Freshly synthesized catalysts, as well as catalysts subjected to a short chronoamperometric ageing procedure, are analyzed and the kinetic and thermodynamic parameters of the HER are obtained. The nickel surface modified with transition metals with an outer shell electronic configuration [xd;（x+1）s;], such as Cu(3d;4s;)and Ag(4d;5s;), shows an improved activity for the HER compared to bare nickel. Furthermore, the Ni/Cu catalyst presents a decreased onset potential. The hydrogen evolution rate, measured as current density at –1.5 V（vs. SCE）, is similar on Ni/Cu and Ni/Ag electrodes.

关键词： Hydrogen evolution reaction Spontaneous deposition Nickel/Silver Nickel/Copper Electrochemical impedance spectroscopy

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Ursane derivatives isolated from leaves of Hylocereus undatus inhibit glycation at multiple stages

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Chinese Journal of Natural Medicines 2018年第11期16卷 856-865页

作者： ROSA MARTHA Pérez-Gutiérrez SUSANA gabriela Enriquez-Alvirde Research Laboratory of Natural Products School of Chemical Engineering and Extractive Industries National Polytechnic Institute

The present study was designed to evaluate the therapeutic potential of bioactive compounds from chloroform extract of the leaves of Hylocereus undatus in the formation of advanced glycation end products(AGEs) in vitro. Bioactivity-guided fractionation of chloroform extract from Hylocereus undatus afforded two novel 12-ursen-type triterpenes, 3β, 16α, 23-trihydroxy-urs-12-en-28-oic acid(1) and 3β, 6β, 19α, 22α-tetrahydroxy-urs-12-en-28-oic acid(2), as well as four known triterpenes 2α, 3β, 23-tetrahydroxy-urs-11-en-28-oic acid(3), 3β-acetoxy-28-hydroxyolean-12-ene(4), 3β, 16α-dihidroxyolean-12-ene(5) and 3β-acetoxy-olean-12-ene(6). Our results revealed that triterpenes 1–3 were able to inhibit the formation of AGEs in all tested assays. The data indicated that the triterpenes had inhibitory activity at the múltiple stages of glycation and that there might be a high potential for decreasing protein oxidation and protein glycation that can enhance glycative stress in diabetic complications.

关键词： Hylocereus undatus Advanced glycation end product Triterpenes

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A demand side management approach to increase self-consumption in buildings

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Building Simulation 2023年第2期16卷 317-335页

作者： Carlos Fernández Bandera gabriela Bastos Porsani María Fernández-Vigil Iglesias School of Architecture University of Navarra31009 PamplonaSpain

There is a growing interest in increasing the presence of renewable energy in the electric *** production from grid-connected systems is leading this growth in terms of *** this development,concern about network security has emerged,because excesses of intermittent renewable energy on the grid could exceed voltage ***-consumption,understood as the capacity of the producer to consume his or her own production,can partially solve these *** controllable loads,such as heating and cooling,represent 50%of the total amount of energy consumed by buildings;the proper allocation of these loads could be a driving force for *** this study,a demand side management strategy is proposed based on a building energy model equipped with an inverter heat pump coupled with a photovoltaic *** goal is to maximize the use of local energy from the photovoltaic plant(self-consumption),reducing the export and import of energy to and from the *** goal is achieved by optimizing the set-points in each *** array of optimal set-points over six years is *** results show the capacity of the methodology to match similar values of self-consumption(70%in winter and 50%in summer)obtained by strategies based on chemical *** findings are shown in an energy matching chart at different levels of detail(yearly and monthly).Color bubbles are added to the matching chart to help visualize the unmatched energy of the system *** comparison with actual model predictive control technologies,this study’s strategy offers great simplicity and a large saving in computational time.

关键词： sensor data internal thermal mass energy simulation EnergyPlus inverse model

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Low concentrations of atrazine,glyphosate,2,4-dichlorophenoxyacetic acid,and triadimefon exposures have diverse effects on Xenopus laevis organ morphogenesis

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Journal of Environmental Sciences 2010年第9期22卷 1305-1308页

作者： Jenny R.Lenkowski gabriela Sanchez-Bravo Kelly A.McLaughlin Department of Biology Tufts University

Many chemicals are released into the environment, and chemical contamination has been suggested as a contributing factor to amphibian declines. To add to a growing body of knowledge about the impact of individual chemicals on non-target organisms, we examined the specificity of deformities induced by exposure to four pesticides （atrazine, 2,4-dichloropheoxyacetic acid （2,4-D）, triadimefon, and glyphosate） in the model amphibian species, Xenopus laevis. We focused on the period of organ morphogenesis, as it is frequently found to be particularly sensitive to chemical exposure yet also commonly overlooked. We found similar levels of intestine malformations and edemas, as well as disruption of skeletal muscle, in atrazine and triadimefon exposed tadpoles. The effects of 2,4-D were only apparent at the highest concentrations we examined; glyphosate did not induce dramatic malformations at the concentrations tested. While researchers have shown that it is important to understand how chemical mixtures affect non-target organisms, our results suggest that it is first crucial to determine how these chemicals act independently in order to be able to identify consequences of individual pesticide exposure.

关键词： amphibian pesticide organ morphogenesis teratogenesis toxicology Xenopus laevis

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Extreme points, support points and the Loewner variation in several complex variables

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Science China Mathematics 2012年第7期55卷 1353-1366页

作者： GRAHAM Ian HAMADA Hidetaka KOHR gabriela KOHR Mirela Department of Mathematics University of Toronto Toronto Ontario M5S 2E4 Canada Faculty of Engineering Kyushu Sangyo University 3-1 Matsukadai 2-Chome Higashi-ku Fukuoka 8138503 Japan Faculty of Mathematics and Computer Science Babe s-Bolyai University 1 M. Koga lniceanu Str. Cluj-Napoca 400084 Romania Faculty of Mathematics and Computer Science Babes-Bolyai University 1 M. Kogǎlniceanu Str. Cluj-Napoca 400084 Romania

In this paper we consider extreme points and support points for compact subclasses of normalized biholomorphic mappings of the Euclidean unit ball Bn in Cn. We consider the class So（Bn） of biholomorphic mappings on Bn which have parametric representation, i.e., they are the initial elements f（-, O） of a Loewner chain f（x,t） = etz ＋ ... such that {e-tf（.,t）}t≥o is a normal family on Bn. We show that if f（.,O） is an extreme point （respectively a support point） of So（Bn）, then e-t f（., t） is an extreme point of So（Bn） for t≥0 （respectively a support point of So（Bn） for t C [O, t0] and some to〉 0）. This is a generalization to the n-dimensional case of work due to Pell. Also, we prove analogous results for mappings which belong to So（Bn） and which are bounded in the norm by a fixed constant. We relate the study of this class to reachable sets in control theory generalizing work of Roth. Finally we consider extreme points and support points for biholomorphic mappings of Bn generated by using extension operators that preserve Loewner chains.

关键词： biholomorphic mapping Loewner chain parametric representation reachable set starlike map-ping

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Decentralized control in active distribution grids via supervised and reinforcement learning

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Energy and AI 2024年第2期16卷 137-149页

作者： Stavros Karagiannopoulos Petros Aristidou gabriela Hug Audun Botterud Laboratory for Information and Decision Systems(LIDS) Massachusetts Institute of TechnologyCambridgeUSA EEH-Power Systems Laboratory ETH Zurichhysikstrasse 38092 ZurichSwitzerland Department of Electrical Engineering Computer Engineering&InformaticsCyprus

While moving towards a low-carbon, sustainable electricity system, distribution networks are expected to host a large share of distributed generators, such as photovoltaic units and wind turbines. These inverter-based resources are intermittent, but also controllable, and are expected to amplify the role of distribution networks together with other distributed energy resources, such as storage systems and controllable loads. The available control methods for these resources are typically categorized based on the available communication network into centralized, distributed, and decentralized or local. Standard local schemes are typically inefficient, whereas centralized approaches show implementation and cost concerns. This paper focuses on optimized decentralized control of distributed generators via supervised and reinforcement learning. We present existing state-of-the-art decentralized control schemes based on supervised learning, propose a new reinforcement learning scheme based on deep deterministic policy gradient, and compare the behavior of both decentralized and centralized methods in terms of computational effort, scalability, privacy awareness, ability to consider constraints, and overall optimality. We evaluate the performance of the examined schemes on a benchmark European low voltage test system. The results show that both supervised learning and reinforcement learning schemes effectively mitigate the operational issues faced by the distribution network.

关键词： Supervised learning Reinforcement learning Deep deterministic policy gradient Decentralized control Active distribution systems

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Circulating microRNAs as non-invasive biomarkers for hepatitis B virus liver fibrosis

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World Journal of Gastroenterology 2020年第11期26卷 1113-1127页

作者： Diana gabriela Iacob Adelina Rosca Simona Maria Ruta Infectious Diseases Department "Carol Davila"University of Medicine and PharmacyBucharest 050474Romania Bucharest Emergency University Hospital Bucharest 050098Romania Virology Department Carol Davila University of Medicine and PharmacyBucharest 050474Romania Viral Emerging Diseases Department Stefan S.Nicolau Institute of VirologyBucharest 030304Romania

Viruses can alter the expression of host microRNAs(miRNA s) and modulate the immune response during a persistent infection. The dysregulation of host miRNA s by hepatitis B virus(HBV) contributes to the proinflammatory and profibrotic changes within the liver. Multiple studies have documented the differential regulation of intracellular and circulating miRNA s during different stages of HBV infection. Circulating miRNA s found in plasma and/or extracellular vesicles can integrate data on viral-host interactions and on the associated liver injury. Hence, the detection of circulating miRNA s in chronic HBV hepatitis could offer a promising alternative to liver biopsy, as their expression is associated with HBV replication, the progression of liver fibrosis,and the outcome of antiviral treatment. The current review explores the available data on miRNA involvement in HBV pathogenesis with an emphasis on their potential use as biomarkers for liver fibrosis.

关键词： Hepatitis B virus MicroRNA Noncoding RNA Liver fibrosis Viral hepatitis Non-invasive biomarkers Extracellular vesicles Hepatitis management

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Effect of hepatic iron concentration reduction on hepatic fibrosis and damage in rats with cholestatic liver disease

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World Journal of Gastroenterology 2006年第2期12卷 240-245页

作者： Gil Peretz gabriela Link Orit Pappo Rafael Bruck Zvi Ackerman Department of Internal Medicine Hebrew University- Hadassah Medical CenterMount Scopus CampusJerusalemIsrael Department of Human Nutrition and Metabolism Hebrew University Hadassah Medical SchoolJerusalemIsrael Department of Pathology Hebrew University-Hadassah Medical CenterJerusalemIsrael Department of Gastroenterology and Hepatology The EWolfson Medical CenterHolonand Sackler School of MedicineTel Aviv UniversityTel AvivIsrael

AIM： TO assess the effect of iron reduction after phlebotomy in rats with ＂normal＂ hepatic iron concentration （HIC） on the progression of hepatic fibrosis, as a result of bile duct ligation （BDL）. METHODS： Rats underwent phlebotomy before or after sham operation or BDL. Animals undergone only BDL or sham operation served as controls. Two weeks after surgery, indices of hepatic damage and fibrosis were evaluated. RESULTS： Phlebotomy lowered HIC. Phlebotomy after BDL was associated with body weight increase, lower hepatic weight, less portal hypertension, less periportal necrosis, less portal inflammation, lower hepatic activity index score and higher albumin levels. On the other hand, phlebotomy before BDL was associated with body weight decrease and hepatic activity index score increase. Phlebotomy after sham operation was not associated with any hepatic or systemic adverse effects. CONCLUSION： Reduction of HIC after induction of liver damage may have beneficial effects in BDL rats. However, iron deficiency could induce impairment of liver function and may make the liver more susceptible to insults like BDL.

关键词： Iron Phlebotomy Bile duct ligation Hepatic activity index Rat.

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