Effect of hepatic iron concentration reduction on hepatic fibrosis and damage in rats with cholestatic liver disease

作     者：Gil Peretz Gabriela Link Orit Pappo Rafael Bruck Zvi Ackerman 

作者机构：Department of Internal MedicineHebrew University- Hadassah Medical CenterMount Scopus CampusJerusalemIsrael Department of Human Nutrition and MetabolismHebrew University Hadassah Medical SchoolJerusalemIsrael Department of PathologyHebrew University-Hadassah Medical CenterJerusalemIsrael Department of Gastroenterology and HepatologyThe EWolfson Medical CenterHolonand Sackler School of MedicineTel Aviv UniversityTel AvivIsrael 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2006年第12卷第2期

页      面：240-245页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Iron Phlebotomy Bile duct ligation Hepatic activity index Rat. 

摘      要：AIM： TO assess the effect of iron reduction after phlebotomy in rats with ＂normal＂ hepatic iron concentration （HIC） on the progression of hepatic fibrosis, as a result of bile duct ligation （BDL）. METHODS： Rats underwent phlebotomy before or after sham operation or BDL. Animals undergone only BDL or sham operation served as controls. Two weeks after surgery, indices of hepatic damage and fibrosis were evaluated. RESULTS： Phlebotomy lowered HIC. Phlebotomy after BDL was associated with body weight increase, lower hepatic weight, less portal hypertension, less periportal necrosis, less portal inflammation, lower hepatic activity index score and higher albumin levels. On the other hand, phlebotomy before BDL was associated with body weight decrease and hepatic activity index score increase. Phlebotomy after sham operation was not associated with any hepatic or systemic adverse effects. CONCLUSION： Reduction of HIC after induction of liver damage may have beneficial effects in BDL rats. However, iron deficiency could induce impairment of liver function and may make the liver more susceptible to insults like BDL.