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Nano Research 2016年第12期9卷 3828-3838页

作者： Zhixiong Li Ruizheng Liang Simin Xu Wendi Liu Dongpeng Yan Min Wei David g. Evans Xue Duan State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China

Fluorescence resonance energy transfer （FRET） systems have broad applications in visual detection, intelligent materials, and biological imaging, all of which favor the transmission of light through multiple dimensions and in diverse directions. Herein, we have demonstrated multi-dimensional （0D and 2D） FRET within a multi-layer ultrathin film （UTF） by employing a layer-by-layer （LBL） assembly technique. The anionic block copolymer micelle poly（tert-butyl acrylate- co-ethyl acrylate-co-methacrylic acid）（PTBEM） is chosen as a molecular carrier for the incorporation of bis（8-hydroxyquinolate） zinc （Znq2） and open-ring merocyanine （MC）（denoted as （Znq2/MC）@PTBEM）. Alternatively, electrostatic assembly is performed with cationic layered double hydroxide （LDH） nanosheets （denoted as [（Znq2/MC）@PTBEM/LDH]n）. This [（Znq2/MC）@PTBEM/ LDH]n system offers a multi-dimensional propagation medium and ensures that the FRET donor and acceptor are located within their F6rster radii in each direction. The system demonstrates a FRET process that can be switched via alternating ultraviolet/visible （UV/vis） irradiation, with tunable blue-green/red fluorescence, resulting in a FRET efficiency as high as 81.7%. It is expected that this assembly method, which uses 0D micelles on a 2D layered material, can be extended to other systems for further development of multi-dimensional FRET.

关键词： bis(8-hydroxyquinolate)zinc (Znq2) open-ring merocyanine layered double hydroxide layer-by-layerself-assembly multi-dimensionalfluorescence resonanceenergy transfer

Oxypred:Prediction and Classification of Oxygen-Binding Proteins

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genomics, Proteomics & Bioinformatics 2007年第3期5卷 250-252页

作者： S.Muthukrishnan Aarti garg g.P.S.Raghava Institute of Microbial Technology Sector 39-AChandigarh 160036India.

This study describes a method for predicting and classifying oxygen-binding proteins. Firstly, support vector machine （SVM） modules were developed using amino acid composition and dipeptide composition for predicting oxygen-binding proteins, and achieved maximum accuracy of 85.5% and 87.8%, respectively. Secondly, an SVM module was developed based on amino acid composition, classifying the predicted oxygen-binding proteins into six classes with accuracy of 95.8%, 97.5%, 97.5%, 96.9%, 99.4%, and 96.0% for erythrocruorin, hemerythrin, hemocyanin, hemoglobin, leghemoglobin, and myoglobin proteins, respectively. Finally, an SVM module was developed using dipeptide composition for classifying the oxygen-binding proteins, and achieved maximum accuracy of 96.1%, 98.7%, 98.7%, 85.6%, 99.6%, and 93.3% for the above six classes, respectively. All modules were trained and tested by five-fold cross validation. Based on the above approach, a web server Oxypred was developed for predicting and classifying oxygen-binding proteins （available from http：//***/raghava/oxypred/）.

关键词： oxygen-binding proteins SVM modules hemoglobin web server prediction

VgIchan:Prediction and Classification of Voltage-gated Ion Channels

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genomics, Proteomics & Bioinformatics 2006年第4期4卷 253-258页

作者： Sudipto Saha Jyoti Zack Balvinder Singh g.P.S.Raghava Institute of Microbial Technology Chandigarh 160036India.

This study describes methods for predicting and classifying voltage-gated ion channels. Firstly, a standard support vector machine （SVM） method was developed for predicting ion channels by using amino acid composition and dipeptide composition, with an accuracy of 82.89% and 85.56%, respectively. The accuracy of this SVM method was improved from 85.56% to 89.11% when combined with PSIBLAST similarity search. Then we developed an SVM method for classifying ion channels （potassium, sodium, calcium, and chloride） by using dipeptide composition and achieved an overall accuracy of 96.89%. We further achieved a classification accuracy of 97.78% by using a hybrid method that combines dipeptidebased SVM and hidden Markov model methods. A web server VgIchan has been developed for predicting and classifying voltage-gated ion channels using the above approaches. VgIchan is freely available at ***/raghava/vgichan/.

关键词： ion channels prediction VgIchan SVM HMM

Ion population fraction calculations using improved screened hydrogenic model with l-splitting

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Chinese Physics B 2018年第10期27卷 424-432页

作者： Amjad Ali g Shabbir Naz Rukhsana Kouser ghazala Tasneem M Saleem Shahzad Aman-ur-Rehman M H Nasim Department of Physics and Applied Mathematics Pakistan Institute of Engineeringand Applied Sciences Department of Nuclear Engineering Pakistan Institute of Engineeringand Applied Sciences

Ion population fraction（IPF） calculations are very important to understand the radiative spectrum emitted from the hot dense matter. IPF calculations require detailed knowledge of all the ions and correlation interactions between the electrons of an ion which are present in a plasma environment. The average atom models, e.g., screened hydrogenic model with l-splitting（SHML）, now have the capabilities for such calculations and are becoming more popular for in line plasma calculations. In our previous work [Ali A, Shabbir Naz g, Shahzad M S, Kouser R, Rehman A and Nasim M H 2018 High Energy Density Phys. 26 48], we have improved the continuum lowering model and included the exchange and correlation effects in SHML. This study presents the calculation of IPF using classical theory of fluctuation for our improved screened hydrogenic model with l-splitting（I-SHML） under local thermodynamic equilibrium conditions for iron and aluminum plasma over a wide range of densities and temperatures. We have compared our results with other models and have found a very good agreement among them.

关键词： self-consistent average atom model average ionization state ion population

Using machine learning to expound energy poverty in the global south:Understanding and predicting access to cooking with clean energy

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Energy and AI 2023年第4期14卷 426-438页

作者： M.D.Mukelabai K.g.U.Wijayantha R.E.Blanchard Centre for Renewable Energy Systems Technology(CREST) Wolfson School of MechanicalElectricaland Manufacturing EngineeringLoughborough UniversityEpinal WayLoughboroughLeicestershire LE113TUUK Centre for Renewable and Low-Carbon Energy Cranfield UniversityCollege RoadCranfieldBedfordshire MK430ALUK

Efforts towards achieving high access to cooking with clean energy have not been transformative due to a limited understanding of the clean-energy drivers and a lack of evidence-based clean-energy policy *** study addresses this gap by building a high-performing machine learning model to predict and understand the mechanisms driving energy poverty-specifically access to cooking with clean *** a first-of-a-kind,the estimated cost of US$14.5 trillion to enable universal access to cooking with clean energy encompasses all the intermediate inputs required to build self-sufficient ecosystems by creating value-addition *** pre-vious studies,the data-driven clean-cooking transition pathways provide foundations for shaping policy and building energy models that can transform the complex energy and cooking *** these path-ways is necessary to increase people’s financial resilience to tackle energy *** findings also show the absence of a linear relationship between electricity access and clean cooking-evidencing the need for a rapid paradigm shift to address energy poverty.A new fundamental approach that focuses on improving and sustaining the financial capacity of households through a systems approach is required so that they can afford electricity or fuels for cooking.

关键词： Energy modeling Artificial intelligence Explainable AI Developing world Hydrogen economy

Upgraded role of autophagy in colorectal carcinomas

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World Journal of gastrointestinal Oncology 2018年第11期10卷 367-369页

作者： Evangelos Koustas Panagiotis Sarantis Athanassios g Papavassiliou Michalis V Karamouzis Division of Molecular Oncology Department of Biological Chemistry Medical SchoolNational and Kapodistrian University of Athens

Autophagy is a basic catabolic process closely asso-ciated with degradation of cellular components. The role of autophagy in colorectal cancer(CRC) remains controversial. The mechanism of autophagy has been identified as protecting mechanism against tumorige-nesis by isolation of damaged organelles or as cytopro-tective provides energy in hypoxic regions of CRC tumors. Mutations in proto-oncogenes, such as RAS and BRAF, have been associated with autophagy initiation through signaling pathways of BRAF/MEK/ERK and PI3 K/AKT/m TOR. A combination therapy of chemotherapeutic agents and autophagy inhibitors such as hydroxychloroquine or immunotherapy might represent a major step that could be evaluated as a putative novel therapeutic strategy in CRC patients.

关键词： Autophagy Tumorigenesis Clinical trials Autophagy inhibitors Colorectal cancer

"Commissural drop"wiring technique facilitates catheter crossing of severely stenotic aortic valve

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Chinese Medical Journal 2021年第2期134卷 245-246页

作者： Yu Du Paul Sorajja Miho Fukui go Hashimoto Aisha Ahmed Mario gössl Valve Science Center Minneapolis Heart Institute FoundationAbbott Northwestern HospitalMN 55407USA Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

To the Editor:An 82-year-old man with symptomatic severe calcific aortic valve stenosis(peak velocity:5.19 m/s;mean gradient:78.0 mmHg;aortic valve area:0.48 cm2)underwent transfemoral transcatheter aortic valve *** the procedure,a 0.035-inch straight-tip glide wire(Terumo,Somerset,NJ,USA)supported by a 6 Fr Judkins Right 4(JR4)coronary catheter(Medtronic,Minneapolis,MN,USA)were used to cross the severely stenotic aortic ***,the JR4 catheter could not pass the aortic valve because the wire crossed the aortic valve in the left/right coronary commissure creating an unfavorable angle and limited pushability for the *** of switching to a differently shaped catheter(eg,an Amplatz left 1 catheter),we advanced the glide wire and therefore the more supportive portion of the wire further through the aortic ***,both wire and JR4 catheter dropped into the non/left coronary commissure,allowing the JR4 catheter to cross the valve ***,a 34 mm self-expanding Evolut R valve(Medtronic)was implanted,and the patient was discharged uneventfully(Figure 1A-E and Supplementary Video 1,http://***/CM9/A353["Commissural drop"wiring technique.]).

关键词： catheter valve Figure

Thermodynamic properties of 3C-SiC

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Chinese Physics B 2013年第10期22卷 429-435页

作者： B.Y.Thakore S.g.Khambholja A.Y.Vahora N.K.Bhatt A.R.Jani Department of Physics Sardar Patel UniversityVallabh Vidyanagar388120GujaratIndia Indus University Ahmedabad 380001GujaratIndia

In the present paper, we report on the results of various thermodynamic properties of 3C-SiC at high pressure and temperature using first principles calculations. We use the plane-wave pseudopotential density functional theory as im- plemented in Quantum ESPRESSO code for calculating various cohesive properties in ambient condition. Further, ionic motion at a finite temperature is taken into account using the quasiharmonic Debye model. The calculated thermody- namic properties, phonon dispersion curves, and phonon densities of states at different temperatures and structural phase transitions at high pressures are found to be in good agreement with experimental and other theoretical results.

关键词： phase transition phonon dispersion curve Debye model thermodynamic property

Simulation model for electron irradiated IgZO thin film transistors

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Journal of Semiconductors 2018年第2期39卷 17-21页

作者： g K Dayananda C Shantharama Rai A Jayarama Hyun Jae Kim Department of E&C Engineering Canara Engineering College Mangalore 574219 India Department of E&C Engineering AJIET Mangalore 575009 India Department of Physics SCEM Adyar Mangalore 575007 India Yonsei University Seoul 120-749 Republic of Korea

An efficient drain current simulation model for the electron irradiation effect on the electrical parameters of amorphous In–ga–Zn–O（IgZO） thin-film transistors is developed. The model is developed based on the specifications such as gate capacitance, channel length, channel width, flat band voltage etc. Electrical parameters of un-irradiated IgZO samples were simulated and compared with the experimental parameters and 1 kgy electron irradiated parameters. The effect of electron irradiation on the IgZO sample was analysed by developing a mathematical model.

关键词： simulation model IgZO TFT electron irradiation

大气压下He和N2辉光放电等离子体对生物用薄膜表面改性的研究

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高电压技术 2012年第5期38卷 1106-1113页

作者：柳晶晶 Kong Michael g 广州大学机械与电气工程学院广州510006 Department of Electronic and Electrical Engineering Loughborough University Leics LE11 3TU UK

生物用薄膜双向拉伸聚丙烯(BOPP)表面的惰性特性影响了其更为广泛的应用,为解决这一问题,需要在不改变薄膜主体特性的情况下对其表面特性进行改性。采用大气压下He和N2辉光放电等离子体对该薄膜进行了表面改性,并研究了等离子体各种参... 详细信息

生物用薄膜双向拉伸聚丙烯(BOPP)表面的惰性特性影响了其更为广泛的应用,为解决这一问题,需要在不改变薄膜主体特性的情况下对其表面特性进行改性。采用大气压下He和N2辉光放电等离子体对该薄膜进行了表面改性,并研究了等离子体各种参数对表面改性的影响。通过对该等离子体放电特性和光谱特性的研究,验证了其低温和均匀特性。大肠杆菌*** K12在等离子体处理后的BOPP表面的粘附性实验表明,N2体积流量和处理时间对BOPP表面改性有重要影响,加入N2的等离子体能提升BOPP膜表面的细菌粘附性。为进一步研究等离子体BOPP表面改性的机理,对等离子体处理后的BOPP进行了接触角测量、X射线光电子能谱(XPS)、原子力显微镜(AFM)分析。分析表明,等离子体改性后薄膜的亲水性、活性化学功能团、表面结构发生了显著变化。

关键词： He和N2辉光放电双向拉伸聚丙烯(BOPP)表面改性粘附性实验亲水性活性化学功能团表面结构