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Helicobacter pylori infection- recent developments in diagnosis

World Journal of Gastroenterology 2014年第28期20卷 9299-9313页

作者： Ana Isabel Lopes filipa f vale Mónica Oleastro Centro Académico de Medicina de Lisboa Faculdade de Medicina da Universidade de Lisboa Centro de Patogénese Molecular Unidade dos Retrovírus e Infec??es AssociadasInstituto de Medicina Molecular e Instituto de Investiga??o do MedicamentoFaculdade de FarmáciaUniversidade de Lisboa Laboratório Nacional de Referência das Infe??es Gastrintestinais Departamento de Doen?as InfeciosasInstituto Nacional de Saúde Dr Ricardo Jorge

Considering the recommended indications for Helicobacter pylori(***)eradication therapy and the broad spectrum of available diagnostic methods,a reliable diagnosis is mandatory both before and after eradication *** highly accurate tests should be used in clinical practice,and the sensitivity and specificity of an adequate test should exceed 90%.The choice of tests should take into account clinical circumstances,the likelihood ratio of positive and negative tests,the cost-effectiveness of the testing strategy and the availability of the *** review concerns some of the most recent developments in diagnostic methods of *** infection,namely the contribution of novel endoscopic evaluation methodologies for the diagnosis of *** infection,such as magnifying endoscopy techniques and *** addition,the diagnostic contribution of histology and the urea breath test was explored recently in specific clinical settings and patient *** studies recommend enhancing the number of biopsy fragments for the rapid urease *** culture from the gastric biopsy is the gold standard technique,and is recommended for antibiotic susceptibility *** is used for initial screening and the stool antigen test is particularly used when the urea breath test is not available,while molecular methods have gained attention mostly for detecting antibiotic resistance.

关键词： Helicobacter pylori Diagnosis Endoscopy Histology Culture Urea breath test Stool antigen test Serology Molecular methods

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Overview of the phytomedicine approaches against Helicobacter pylori

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World Journal of Gastroenterology 2014年第19期20卷 5594-5609页

作者： filipa f vale Monica Oleastro Centro de Patogenese Molecular Unidade dos Retrovirus e Infeccoes AssociadasInstituto de Medicina Molecular e Instituto de Investigacao do Medicamento (iMed.ULisboa)Faculdade de FarmaciaUniversidade de LisboaLisboaPortugal Departamento de Doencas Infeciosas Instituto Nacional Saude Dr.Ricardo Jorge1649-016 LisboaPortugal

Helicobacter pylori(***)successfully colonizes thehuman stomach of the majority of the human *** infection always causes chronic gastritis,butmay evolve to serious outcomes,such as peptic ulcer,gastric carcinoma or mucosa-associated lymphoid tis-sue *** first line therapy recommend-ed by the Maastricht-4 Consensus Report comprises theuse of two antibiotics and a proton-pomp inhibitor,butin some regions failure associated with this treatmentis already undesirable ***,treatment failure isone of the major problems associated with *** in-fection and is mainly associated with bacterial *** order to counteract this situation,someeffort has been allocated during the last years in theinvestigation of therapeutic alternatives beyond *** include vaccines,probiotics,photodynamic inactivation and phage therapy,which are briefly revis-ited in this review.A particular focus on phytomedicine,also described as herbal therapy and botanical therapy,which consists in the use of plant extracts for medicinal purposes,is specifically addressed,namely considering its history,category of performed studies,tested com-pounds,active principle and mode of *** herbs already experienced are highly diverse and usually selected from products with a long history of employ-ment against diseases associated with *** infec-tion from each country own folk *** studies demonstrated that many phytomedicine products have an *** activity and gastroprotective ***-though the mechanism of action is far from being com-pletely understood,current knowledge correlates the beneficial action of herbs with inhibition of essential *** enzymes,modulation of the host immune system and with attenuation of inflammation.

关键词： Helicobacter pylori Alternative treatment Phytomedicine Herbal medicine Phytotherapy Botanical therapy Herb medicine Probiotics Antibiotic resistance

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Adenosine A_(2A) receptors in neuronal outgrowth:a target for nerve regeneration?

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Neural Regeneration Research 2016年第5期11卷 706-708页

作者： filipa f.Ribeiro Ana M.Sebastiao Instituto de farmacologia e Neurociencias Faculdade de MedicinaUniversidade de LisboaLisbonPortugal Instituto de Medicina Molecular Faculdade de MedicinaUniversidade de LisboaLisbonPortugal

Axonal and dendritic outgrowth are fundamental processes in the development of the nervous *** this period neurons change their morphology from a simple bipolar shape into a mature complex *** develop dendrites and extend long or short axons that travel through a complex path until reaching target cells and form functional and accurate neuronal circuits.

关键词： receptors in neuronal outgrowth Adenosine A BDNf

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Neuroinflammatory modulators of oligodendrogenesis

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 263-273页

作者： Ana Armada-Moreira filipa f.Ribeiro Ana M.Sebastião Sara Xapelli Instituto de farmacologia e Neurociências Faculdade de Medicina da Universidade de Lisboa1649-028 LisboaPortugal Instituto de Medicina Molecular Faculdade de Medicina da Universidade de Lisboa1649-028 LisboaPortugal

Oligodendrocytes are key neural cells that are responsible for producing myelin sheaths that wrap around neuronal axons in the central nervous *** is essential to insulate neurons and maintain a fast and saltatory propagation of action potentials along the ***,oligodendrocytes are very susceptible to damage,and thus demyelination may arise from a brain lesion or a neurodegenerative ***,demyelination produces a loss of axonal insulation leading to sensory or motor neuron *** adulthood,there are two main sources of oligodendrocytes:parenchymal oligodendrocyte precursor cells(OPCs)and subventricular zone derived *** this review,we will discuss oligodendrogenesis derived from these two sources,and also highlight their main extrinsic and intrinsic *** addition,the neuroinflammatory mediators of oligodendrogenesis will also be assessed.

关键词： Demyelination inflammation neural stem cells oligodendrocyte remyelination

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Characterization of monocarboxylate transporter activity in hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第33期20卷 11780-11787页

作者： Venncio Af Alves Céline Pinheiro filipa Morais-Santos Aloisio felipe-Silva Adhemar Longatto-filho fátima Baltazar Laboratory of Medical Investigation (LIM) 14 Department of Pathology University of S?o Paulo School of Medicine S?oPaulo SP 1246-903 Brazil Life and Health Sciences Research Institute (ICVS) School of Health Sciences University of Minho 4704-553 Braga Portugal ICVS/3B’s-PT Government Associate Laboratory 4710-057 Braga/ Guimar?es Portugal Barretos School of Health Sciences Dr. Paulo Prata-FACISB Barretos S?o Paulo SP 13083-970 Brazil Molecular Oncology Research Center Barretos Cancer Hospital Barretos Sao Paulo 14780-000 Brazil Molecular Oncology Research Center Barretos Cancer Hospital Pio XII Foundation Barretos 14780-000 Brazil

AIM: To assess the immunoexpression of hypoxia-related markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma (HCC).

关键词： Hepatocellular carcinoma Monocarboxylate transporters Glycolysis Cirrhosis Glucose transporter-1

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The neurosphere assay:an effective in vitro technique to study neural stem cells

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Neural Regeneration Research 2021年第11期16卷 2229-2231页

作者： Rita Soares filipa f.Ribeiro Diogo M.Lourenço Rui S.Rodrigues João B.Moreira Ana M.Sebastião Vanessa A.Morais Sara Xapelli Instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisboaPortugal Instituto de farmacologia e Neurociências Faculdade de MedicinaUniversidade de LisboaLisboaPortugal Instituto de Biologia Molecular Faculdade de MedicinaUniversidade de LisboaLisboaPortugal

Neural stem cells(NSCs)are known to be present in the adult mammalian brain where they constitutively differentiate into the neuronal,astroglial,and oligodendroglial lineages,in defined processes termed neurogenesis,ast rogl iogenesis and oligodendrogenesis,respectively(reviewed in Braun and Jessberger,2014).During brain development,NSCs are present throughout the brain,becoming progressively restricted to defined brain *** the adult brain,NSCs are mainly present in areas classically known as neurogenic niches,*** subventricular zone(SVZ),along the lateral walls of the lateral ventricles,and the subgranular zone,located in the dentate gyrus(DG)of the hippocampus.

关键词： walls neural becoming

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Skin models of cutaneous toxicity,transdermal transport and wound repair

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Burns & Trauma 2023年第1期11卷 393-407页

作者： Inês Vilela de Sousa Miguel J.S.ferreira Luís B.Bebiano Sandra Simões Ana filipa Matos Rúben f.Pereira Pedro L.Granja i3S-Instituto de Investigação e Inovação em Saúde Universidade do PortoRua Dr.Manuel Pereira da Silva4200-393 PortoPortugal INEB-Instituto de Engenharia Biomédica Universidade do PortoRua do Campo Alegre8234150-180 PortoPortugal ICBAS-Instituto de Ciências Biomédicas Abel Salazar Universidade do PortoRua de Jorge Viterbo Ferreira 2284050-313 PortoPortugal fEUP-faculdade de Engenharia da Universidade do Porto Rua Dr.Roberto Frias4200-465 PortoPortugal Department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringFaculty of Science and Engineering&Henry Royce InstituteEngineering Building AThe University of ManchesterOxford RoadManchester M139PLUK ISEP-Instituto Superior de Engenharia do Porto Universidade do PortoRua Dr.António Bernardino de Almeida 4314200-072 PortoPortugal iMed.ULisboa Faculty of PharmacyUniversidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal faculty of Pharmacy Universidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal

Skin is widely used as a drug delivery route due to its easy access and the possibility of using relatively painless methods for the administration of bioactive ***,the barrier properties of the skin,along with its multilayer structure,impose severe restrictions on drug transport and ***,bioengineered models aimed at emulating the skin have been developed not only for optimizing the transdermal transport of different drugs and testing the safety and toxicity of substances but also for understanding the biological processes behind skin *** though in vivo research is often preferred to study biological processes involving the skin,in vitro and ex vivo strategies have been gaining increasing relevance in recent ***,there is a noticeably increasing adoption of in vitro and ex vivo methods by internationally accepted ***,microfluidic organ-on-a-chip devices are nowadays emerging as valuable tools for functional and behavioural skin *** in miniaturization,automation and reliability still need to be addressed in order to create skin models that can predict skin behaviour in a robust,high-throughput manner,while being compliant with regulatory issues,standards and *** this review,skin models for transdermal transport,wound repair and cutaneous toxicity will be discussed with a focus on high-throughput *** microfluidic strategies driven by advancements in microfabrication technologies will also be revised as a way to improve the efficiency of existing models,both in terms of complexity and throughput.

关键词： Skin In vitro models Ex vivo models Transdermal transport assays Wound healing assays Toxicity assays Microfluidic chip Skin-on-a-chip

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Harvesting of Mouse Embryos at 0.5 Dpc as a Tool to Reduce Animal Use: Data from C57BL/6J, B6*129 and fVB/NJ Strains

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Open Journal of Animal Sciences 2020年第2期10卷 254-265页

作者： Sofia Lamas filipa franquinho Marlene Morgado fátima Gartner Irina Amorim Institute for Research and Innovation in Health (i3S) University of Porto Porto Portugal Animal facility i3S/IBMC Porto Portugal Institute for Molecular and Cell Biology (IBMC) Porto Portugal Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) Porto Portugal Department of Pathology and Molecular Immunology Institute of Biomedical Sciences Abel Salazar (ICBAS) University of Porto Porto Portugal

Superovulation is used to stimulate the production and release of large amounts of oocytes in mice by using two hormones that mimic fSH (PMSG) and LH (hCG) effects. Since superovulation can have a negative impact on oocyte and embryo development, this investigation aimed to compare two alternatives for 2-cells embryo collection in order to reduce the number of females and to benefit from the superovulation process. Data from mouse embryo collection from our facility was analyzed to compare the number of 2-cells embryos collected at 1.5 dpc and the number of 2-cells embryos obtained after overnight incubation of 1-cell embryos, collected at 0.5 dpc. Genetically modified mouse strains with a similar background (C57BL/6J, B6*129 and fVB/NJ) were analyzed and for strains at a C57BL/6J and B6*129 background, the number of 2-cells embryos obtained after incubation was significantly higher when compared to the number of 2-cells embryos collected at 1.5 dpc (1.4-fold and 1.7-fold, respectively). C57BL/6J wild type mice had similar results with a higher number of 2-cells embryos when collection was performed at 0.5 dpc followed by incubation (1.4-fold). These results can help the planning of 2-cells embryo harvesting by reducing the number of females needed for this procedure.

关键词： 0.5 Dpc Embryos 1.5 Dpc Embryos Incubation Superovulation

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Gastric cancer treated with pressurized intraperitoneal aerosol chemotherapy:revising an option for peritoneal carcinomatosis

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 104-109页

作者： filipa Macedo Katia Ladeira Adhemar Longatto-filho Sandra f.Martins Portuguese Oncology Institute-Coimbra Coimbra 3000-075Portugal Portuguese Oncology Institute-Lisbon Lisbon 1099-023Portugal Life and Health Science Research Institute School of Health SciencesUniversity of MinhoBraga 4710-057Portugal ICVS/3B's-PT Government Associate Laboratory Braga/GuimaraesBraga 4710-057Portugal Molecular Oncology Research Center Barretos Cancer HospitalBarretosSao Paulo 14784-400Brazil Laboratory of Medical Investigation 14 Faculty of MedicineUniversity of Sao PauloSao Paulo 01246-903Brazil Surgery Department Coloproctology UnitBraga HospitalBraga 4710-243Portugal

Aim:Gastric cancer is the cancer with the highest rate of peritoneal metastization and this type of spread is associated with a higher death rate compared to dista nt orga n *** systemic chemotherapy has a mini mal effect in peritoneal metastasis so new types of treatment have *** authors revised the main studies done in pressurized in traperit on eal aerosol chemotherapy(PIPAC)and prese nted the main con clusi ***:A PubMed search was con ducted focus ing on PIPAC in gastric can *** MeSH database was searched with the terms:"Gastric can cer[MeSH]and in traperit on eal aerosol chemotherapy".Results:Seve n studies were an *** the studies performed the tech nique with aerosol of doxorubic in and cisplat *** cases were well tolerated,with minor adverse *** presented resolution of their abdominal symptoms and regression of macroscopic *** surgery or hypertermic intraperitoneal chemotherapy could be performed in some patients with good response to *** peritonitis caused by the chemotherapy was well ***:PIPAC can induce remission in end-stage and resistant disease with acceptable side effects,good safety levels for patients and health professionals,and quality of life improvement.

关键词： Pressurized intraperitoneal aerosol chemotherapy gastric cancer peritoneal carcinomatosis

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Genotypic Assessment by RAPD Markers and Ultrastructural Characteristics of a NaCI-Tolerant Potato Cell Line

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Journal of Life Sciences 2012年第1期6卷 1-8页

作者： filipa Queiros Jose M. Almeida Domingos P.f. Almeida femanda fidalgo Biology Department Faculty of Science University of Porto Porto 4169-007 Portugal BiofIG-Center for Biodiversity Functional and Integrative Genomics Plant Molecular Biology ＆ Biotechnology Lab University of Porto Porto 4169-007 Portugal faculty of Science University of Porto Porto 4169-007 Portugal CBQf College of Biotechnology Portuguese Catholic University Porto 4200-072 Portugal

Salinity is a serious threat to agricultural production. Potato （Solanum tuberosum） is an important food crop characterised for having low to moderate salinity tolerance. Tissue cultures may be relevant to improve salt tolerance in potato through selection of salt-tolerant cell lines and subsequent regeneration of plants. In this work, the authors used the random amplified polymorphic DNA （RAPD） markers to investigate the occurrence of genetic polymorphism in a potato calli line tolerant to 150 mM NaCI. Out of 40 primers screened, eight generated polymorphic patterns that distinguished salt-tolerant line from the control. Although the macroscopic appearance was similar in both lines, ultrastructural study revealed alterations in salt-grown cells. These showed that plastids less differentiated with a lower number of grana had more and larger starch grains than control cells. In conclusion, RAPD analysis revealed that NaCl-adapted line is a somaclonal variant and the ultrastructural study showed changes essentially at the plastids.

关键词： Salt tolerance potato callus tissue polymorphism molecular marker RAPD markers ultrastructure.

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