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Associations between Lesion Locations and Stroke Recurrence in Survivors of First-ever Ischemic Stroke:A Prospective Cohort Study

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Current Medical Science 2020年第4期40卷 708-718页

作者： Pe-jing YANI Li-sha HOU Mi-er LI Zhen-xing LU feng-yu zhan Meng-dong RAN Ji-je LI Lu zhanG Rong YANG Mu-ke ZHOU Cai-rong ZHU Department of Epidemiology and Health Statistics West China School of Public Health and West China Fourh HospitalSichuan UniversityChengdu 610044China National Clinical Research Center for Geriatrics West China HospitalSichuan UniversityChengdu 610044China The First Clinical College of Lanzhou University Lanzhou 730000China Department of Medical Record West China Second University SchoolChengdu 610044China Department of Neurology West China Hospital of Sichuan UniversitChengdu 610044China

Summary:Several studies have indicated that stroke survivors with multiple lesions or with larger lesion volumes have a higher risk of stroke ***,the relationship between lesion locations and stroke recurrence is *** conducted a prospective cohort study of first-ever ischemic stroke survivors who were consecutively enrolled from January 2010 to December *** recurrence was assessed every 3 months after post-discharge via telephone interviews by trained *** locations were obtained from hospital-based MRI or CT scans and classified using two classification systems that were based on cerebral hemisphere or vascular territory and brain anatomical *** parametric survival models using the proportional hazards scale(PH model)were used to analyze the time-to-event *** 633 survivors,63.51%(n-402)had anterior circulation ischemia(ACI),and morc than half of all ACIs occurred in the *** a median follow-up of 2.5 years,117(18.48%)survivors developed a recurrent *** results of the multivariate PH model showed that survivors with non-brain lesions were at higher risk of recurrence than those with right-side lesions(HR,2.79;95%CI,1.53,5.08;P-0.001).There was no increase in risk among survivors with left-side lesions(HR,0.97;95%CI,0.53,1.75;P=0.914)or both-side lesions(HR,1.24;95%CI,0.75,2.07;P-0.401)compared to those with right-side ***,there were no associations between stroke ecurrence and lesion locations that were classified based on vascular territory and brain anatomical *** was concluded that first-ever ischemic stroke survivors with non-brain lesion had higher recurrence risk than those with right-side lesion,although no significant associations were found when the lesion locations were classified by vascular territory and brain anatomical structures.

关键词： ischemic stroke lesion location prevention recurrence flexible parametric survival models survival analysis

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang feng Gao yu-Gui Peng Peng Wu Zong-Lin Li Xue-feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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不同蛋白源对仔猪生长性能和健康状况的影响

饲料研究 2022年第12期45卷 19-22页

作者：袁书林王岩冯占雨淮安生物工程高等职业学校江苏淮安223200 江苏淮大科技集团有限公司江苏南京210019 定州市海丰养殖有限公司河北定州073011

试验旨在研究断奶仔猪饲料中不同蛋白质原料对仔猪生长和健康的影响,寻找可以替代喷雾干燥血浆蛋白粉和鱼粉的优质原料。选择35日龄断奶仔猪108头,按体重将其随机分为4组,每组4个重复,每个重复6~8头仔猪,公、母各半。处理1组蛋白原料为... 详细信息

试验旨在研究断奶仔猪饲料中不同蛋白质原料对仔猪生长和健康的影响,寻找可以替代喷雾干燥血浆蛋白粉和鱼粉的优质原料。选择35日龄断奶仔猪108头,按体重将其随机分为4组,每组4个重复,每个重复6~8头仔猪,公、母各半。处理1组蛋白原料为喷雾干燥血浆蛋白粉和鱼粉,处理2组为低水平的马铃薯蛋白和鱼粉,处理3组为高水平的马铃薯蛋白和鱼粉,处理4组为蚯蚓蛋白和鱼粉。试验期25 d。结果显示:日粮中添加喷雾干燥血浆蛋白粉和鱼粉的断奶仔猪生长和健康状况最佳。与马铃薯蛋白相比,日粮中添加蚯蚓蛋白的仔猪平均日增重(ADG)和平均日采食量(ADFI)较高。添加低水平的马铃薯蛋白比高水平添加对仔猪生长更好。研究表明,断奶仔猪日粮中,国产马铃薯蛋白和蚯蚓粉还不能完全替代血浆蛋白粉,蚯蚓粉替代血浆蛋白粉和鱼粉对仔猪生长性能的效果优于马铃薯蛋白粉。

关键词：蛋白源喷雾干燥血浆蛋白粉鱼粉马铃薯蛋白蚯蚓粉

小檗碱对断奶仔猪生长性能、腹泻、抗氧化指标和肠道生态的影响

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饲料研究 2022年第23期45卷 32-36页

作者：袁书林刘明王岩冯占雨淮安生物工程高等职业学校江苏淮安223200 江苏淮大科技集团有限公司江苏南京210019 北京农学院北京102206 定州市海丰养殖有限公司河北定州073011

试验旨在研究断奶仔猪日粮中添加小檗碱对其生长、腹泻、抗氧化指标和肠道生态的影响。选择体重(8.20±0.40)kg、30日龄的断奶仔猪96头,随机分为4组,每组4个重复,每个重复6头猪。处理1组(对照组)仔猪饲喂基础日粮,处理2组、处理3组、处... 详细信息

试验旨在研究断奶仔猪日粮中添加小檗碱对其生长、腹泻、抗氧化指标和肠道生态的影响。选择体重(8.20±0.40)kg、30日龄的断奶仔猪96头,随机分为4组,每组4个重复,每个重复6头猪。处理1组(对照组)仔猪饲喂基础日粮,处理2组、处理3组、处理4组分别在基础日粮中添加2000 mg/kg氧化锌以及40、80 mg/kg小檗碱。试验期30 d。结果显示,与对照组相比,处理3组仔猪平均日增重(ADG)、平均日采食量(ADFI)显著提高(P<0.05),料重比(F/G)显著降低(P<0.05);处理1组仔猪的ADFI显著升高(P<0.05)。对照组仔猪的腹泻情况最严重,腹泻指数和腹泻率均显著高于其他3组(P<0.05)。与对照组相比,处理3组仔猪血清总超氧化物歧化酶(T-SOD)活性显著提高(P<0.05);各处理组仔猪血清过氧化氢酶(CAT)活性均显著升高(P<0.05),丙二醛(MDA)含量均显著降低(P<0.05)。与对照组相比,3个处理组仔猪空肠和回肠的绒毛高度均显著提高(P<0.05),回肠的绒毛高度/隐窝深度显著提高(P<0.05);处理1组和处理3组空肠的绒毛高度/隐窝深度显著提高(P<0.05)。研究表明,断奶仔猪日粮中小檗碱添加量在80 mg/kg时效果最佳,添加40 mg/kg小檗碱对仔猪生长性能、腹泻状况、抗氧化指标和肠道指标的影响与添加2000 mg/kg ZnO相当。

关键词：小檗碱氧化锌仔猪生长性能肠道健康

EPA和DHA对断奶仔猪淋巴细胞转化和细胞内信号分子的影响

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畜牧兽医学报 2007年第10期38卷 1060-1065页

作者：刘玉兰李德发龚利敏冯占雨赵丽丹中国农业大学国家饲料工程技术研究中心

研究二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)对断奶仔猪外周血淋巴细胞转化及相关细胞内信号分子的影响。结果表明:(1)EPA和DHA剂量依赖性地抑制淋巴细胞转化(P<0.05);(2)EPA和DHA剂量依赖性地刺激一氧化氮(P<0.001)、环腺苷酸(P<0.001... 详细信息

研究二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)对断奶仔猪外周血淋巴细胞转化及相关细胞内信号分子的影响。结果表明:(1)EPA和DHA剂量依赖性地抑制淋巴细胞转化(P<0.05);(2)EPA和DHA剂量依赖性地刺激一氧化氮(P<0.001)、环腺苷酸(P<0.001)和环鸟苷酸(P<0.001)的产生,提高环腺苷酸/环鸟苷酸比例(P<0.05);(3)EPA和DHA使细胞内游离Ca2+浓度出现瞬间上升,其上升幅度有明显的剂量依赖关系;(4)EPA和DHA剂量依赖性地抑制蛋白激酶C活性(P<0.05),而对蛋白激酶A活性无影响。EPA和DHA抑制仔猪淋巴细胞功能,其作用可能是通过改变细胞内信号转导实现的。

关键词：断奶仔猪二十碳五烯酸二十二碳六烯酸淋巴细胞转化信号转导

Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-yu Bian yu-Fang feng Wen-Ting He Tong zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第01期 329-336页

作者： yuzhu Li yumeng Gao feng Tian yu Wang yuan Yao Shaoliang Lin Xiang Ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

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Advances in the Development of Gradient Scaffolds Made of Nano-Micromaterials for Musculoskeletal Tissue Regeneration

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NANO-MICRO LETTERS 2025年第1期17卷 1-46页

作者： Fang, Lei Lin, Xiaoqi Xu, Ruian Liu, Lu zhang, yu Tian, feng Li, Jiao Jiao Xue, Jiajia Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Beijing 100029 Peoples R China Univ Technol Sydney Fac Engn & IT Sch Biomed Engn Sydney NSW 2007 Australia

This review highlights the gradient variations in the structural composition of musculoskeletal tissues and comprehensively examines recent progress in the fabrication and application of biomimetic gradient scaffolds for musculoskeletal *** challenges and prospects of gradient scaffolds for clinical application are discussed. The intricate hierarchical structure of musculoskeletal tissues, including bone and interface tissues, necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered substitutes. This has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic outcomes. Building on the anatomical characteristics of bone and interfacial tissues, this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues, specifically focusing on methods used to construct compositional and structural gradients within the scaffolds. The latest applications of gradient scaffolds for the regeneration of bone, osteochondral, and tendon-to-bone interfaces are presented. Furthermore, the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed, as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： Hui-feng Wang Wen-Jie Shi yu-Xin Yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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