Associations between Lesion Locations and Stroke Recurrence in Survivors of First-ever Ischemic Stroke:A Prospective Cohort Study
作者机构：Department of Epidemiology and Health StatisticsWest China School of Public Health and West China Fourh HospitalSichuan UniversityChengdu 610044China National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610044China The First Clinical College of Lanzhou UniversityLanzhou 730000China Department of Medical RecordWest China Second University SchoolChengdu 610044China Department of NeurologyWest China Hospital of Sichuan UniversitChengdu 610044China
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2020年第40卷第4期
页 面：708-718页
核心收录：
主 题：ischemic stroke lesion location prevention recurrence flexible parametric survival models survival analysis
摘 要：Summary:Several studies have indicated that stroke survivors with multiple lesions or with larger lesion volumes have a higher risk of stroke ***,the relationship between lesion locations and stroke recurrence is *** conducted a prospective cohort study of first-ever ischemic stroke survivors who were consecutively enrolled from January 2010 to December *** recurrence was assessed every 3 months after post-discharge via telephone interviews by trained *** locations were obtained from hospital-based MRI or CT scans and classified using two classification systems that were based on cerebral hemisphere or vascular territory and brain anatomical *** parametric survival models using the proportional hazards scale(PH model)were used to analyze the time-to-event *** 633 survivors,63.51%(n-402)had anterior circulation ischemia(ACI),and morc than half of all ACIs occurred in the *** a median follow-up of 2.5 years,117(18.48%)survivors developed a recurrent *** results of the multivariate PH model showed that survivors with non-brain lesions were at higher risk of recurrence than those with right-side lesions(HR,2.79;95%CI,1.53,5.08;P-0.001).There was no increase in risk among survivors with left-side lesions(HR,0.97;95%CI,0.53,1.75;P=0.914)or both-side lesions(HR,1.24;95%CI,0.75,2.07;P-0.401)compared to those with right-side ***,there were no associations between stroke ecurrence and lesion locations that were classified based on vascular territory and brain anatomical *** was concluded that first-ever ischemic stroke survivors with non-brain lesion had higher recurrence risk than those with right-side lesion,although no significant associations were found when the lesion locations were classified by vascular territory and brain anatomical structures.
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