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The association of type and number of high-risk criteria with cancer-specific mortality in prostate cancer patients treated with radical prostatectomy

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Current Urology 2024年第2期18卷 128-132页

作者： Francesco Chierigo Rocco Simone Flammia GabrieleSorce Benedikt hoeh Lukas hohenhorst Andrea Panunzio Zhe Tian Fred Saad Marcus Graefen Michele Gallucci Alberto Briganti Francesco Montorsi felix k.h.chun Shahrokh F.Shariat Alessandro Antonelli Giovanni Guano Guglielmo Mantica Marco Borghesi Nazareno Suardi Carlo Terrone Pierre I.karakiewicz Department of Surgical and Diagnostic Integrated Sciences University of GenovaGenovaItaly IRCCS Ospedale Policlinico San Martino GenovaItaly Cancer Prognostics and health Outcomes Unit Division of UrologyUniversity ofMontréal Health CenterMontréalQuébecCanada Department of Urology IRCCS Policlinico San MartinoGenovaItaly Department of Maternal-Child and Urological Sciences Sapienza Rome UniversityPoliclinico Umberto I HospitalRomeItaly Department of Urology University Hospital FrankfurtFrankfurt am MainGermany Martini-klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany Department of Urology University of VeronaAzienda Ospedaliera Universitaria Integrata di VeronaVeronaItaly Division of Experimental Oncology/Unit of Urology URIUrological Research InstituteIRCCS San Raffaele Scientific InstituteMilanItaly Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Department of Urology Weill Cornell Medical CollegeNew YorkNYUSA Department of Urology University of Texas SouthwesternDallasTXUSA Department of Urology Second Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of Urology Department of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan

Objectives:This study aimed to test the association between of type and number of D'Amico high-risk criteria(DhRCs)with cancer-specific mortality(CSM)in high-risk prostate cancer patients treated with radical *** and methods:In the Surveillance,Epidemiology,and End Results database(2004–2016),we identified 31,281 radical prostatectomy patients with at least 1 DhRC,namely,prostate-specific antigen(PSA)>20 ng/mL(hrPSA),biopsy Gleason Grade Group(hrGGG)score of 4 and 5,or clinical tumor stage≥T3(hrcT).Multivariable Cox regression models and competing risks regression models(adjusting for other cause mortality)tested the association between DhRCs and 5-year ***:Of 31,281 patients,14,394(67%)exclusively harbored hrGGG,3189(15%)harbored hrPSA,and 1781(8.2%)harbored *** 2132 patients(6.8%)harbored a combination of the 2 DhRCs,and 138(0.6%)had all 3 ***-year CSMrates ranged from 0.9%to 3.0%when any individual DhRC was present(hrcT,hrPSA,and hrGGG,in that order),1.6%to 5.9%when 2 DhRCs were present(hrPSA-hrcT,hrcT-hrGGG,and hrPSA-hrGGG,in that order),and 8.1%when all 3 DhRCs were *** regression models and competing risks regression confirmed the independent predictor status of DhRCs for 5-year CSM that was observed in univariable analyses,with hazard ratios from 1.00 to 2.83 for 1 DhRC,2.35 to 5.88 for combinations of 2 DhRCs,and 7.13 for all 3 ***:Within individual DhRCs,hrcT and hrPSA exhibited weaker effects than hrGGG ***,a dose-response effect was identified according to the number of ***,the type and number of DhRCs allow further risk stratification within the high-risk subgroup.

关键词： high risk prostate cancer Radical prostatectomy Cancer-specific mortality Staging SEER

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Comparison of survival outcomes between laparoscopic versus open radical nephroureterectomy in upper tract urothelial cancer patients:Experiences of a tertiary care single center

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Current Urology 2023年第4期17卷 292-298页

作者： Benedikt hoeh Marina kosiba Mike Wenzel Nicola Meister felix Preisser Shahrokh F.Shariat Jan Lukas hohenhorst Andreas Becker Philipp Mandel Severine Banek Frederik Roos Pierre I.karakiewicz felix k.h.chun Luis A.kluth Department of Urology University Hospital FrankfurtGoethe University Frankfurt am MainFrankfurt am Main60590Germany Cancer Prognostics and health Outcomes Unit Division of UrologyUniversity of Montreal Health CenterMontrealQuebecCanada Department of Urology Comprehensive Cancer CenterMedical University of ViennaViennaAustria Department of Urology Weill Cornell Medical CollegeNew YorkNYUSA Department of Urology University of Texas SouthwesternDallasTXUSA Department of Urology Second Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive health I.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of Urology Department of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan Martini-klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburgGermany

Objectives:To test for differences in overall and recurrence-free survival between laparoscopic and open surgical approaches in patients undergoing radical nephroureterectomy(RNU)for upper tract urothelial carcinoma(UTUC).Materials and methods:We retrospectively identified patients treated for UTUC from 2010 to 2020 from our institutional *** undergoing laparoscopic or open RNU with no suspicion of metastasis(cM0)were for the current study *** with suspected metastases at diagnosis(cM1)or those undergoing other surgical treatments were *** was performed according to the laparoscopic versus open surgical ***-Meier plots were used to test for differences in overall and recurrence-free survival with regard to the surgical ***,separate kaplan-Meier plots were used to test the effect of preoperative ureterorenoscopy on overall and recurrence-free survival within the overall study ***:Of the 59 patients who underwent nephroureterectomy,29%(n=17)underwent laparoscopic nephroureterectomy,whereas 71%(n=42)underwent open *** and tumor characteristics were comparable between groups(p≥0.2).The median overall survival was 93 and 73 months in the laparoscopic nephroureterectomy group compared to the open nephroureterectomy group(p=0.5),*** median recurrence-free survival did not differ between open and laparoscopic nephroureterectomies(73 months for both groups;p=0.9).Furthermore,the median overall and recurrence-free survival rates did not differ between patients treated with and without preoperative ***:The results of this retrospective,single-center institution showed that overall and recurrence-free survival rates did not differ between patients with UTUC treated with laparoscopic and open ***,preoperative ureterorenoscopy before RNU was not associated with higher overall or recurrence-free survival rates.

关键词： Upper tract urothelial carcinoma Laparoscopic radical nephroureterectomy Open radical nephroureterectomy Overall survival

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Radical prostatectomy in patients aged 75 years or older:review of the literature

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Asian Journal of Andrology 2019年第1期21卷 32-36页

作者： Philipp Mandel Thenappan Chandrasekar felix k chun hartwig huland Derya Tilki Martini-klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburg 20246Germany Division of Urology Department of Surgical Oncology Princess Margaret Cancer CentreUniversity Health Network and the University of TorontoTorontoOntario M5G 2M9Canada Department of Urology University Hospital Hamburg-EppendorfHamburg 20246Germany

Given the demographic trends toward a considerably longer life expectancy,the percentage of elderly patients with prostate cancer will increase further in the upcoming ***,the question arises,should patients ≥75 years old be offered radical prostatectomy and under which circumstances? For treatment decision-making,life expectancy is more important than biological *** a result,a patient's health and mental status has to be determined and radical treatment should only be offered to those who are *** perioperative morbidity and mortality in these patients is increased relative to younger patients,patient selection according to comorbidities is a key issue that needs to be *** is known from the literature that elderly men show notably worse tumor characteristics,leading to worse oncologic outcomes after ***,elderly patients also demonstrate worse postoperative recovery of continence and erectile *** the absolute rates of both oncological and functional outcomes are still very reasonable in patients ≥75 years,a radical prostatectomy can be offered to highly selected and healthy elderly patients. Nevertheless,patients clearly need to be informed about the worse outcomes and higher perioperative risks compared to younger patients.

关键词： age functional outcome oncological outcome prostate cancer radical prostatectomy

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Novel biomarkers of acute kidney injury: Evaluation and evidence in urologic surgery

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World Journal of Nephrology 2015年第2期4卷 160-168页

作者： Marianne Schmid Deepansh Dalela Rana Tahbaz Jessica Langetepe Marco Randazzo Roland Dahlem Margit Fisch Quoc-Dien Trinh felix k.h.chun Center for Surgery and Public health and Division of Urologic Surgery Brigham and Women’s HospitalHarvard Medical School Department of Urology University Hospital Hamburg-Eppendorf Center for Surgery and Public health and Division of Urologic Surgery Brigham and Women’s Hospital Harvard Medical School Center for Outcomes Research Analytics and Evaluation Vattikuti Urology Institute Henry Ford Health System Department of Urology Cantonal Hospital Aarau Center for Surgery and Public health and Division of Urologic Surgery Brigham and Women’s Hospital Harvard Medical School

atients undergoing urologic surgery are at risk of acute kidney injury （AkI） and consequently long-term deterioration in renal function. AkI is further associated with signifcantly higher odds of perioperative complications, prolonged hospital stay, higher mortality and costs. Therefore, better awareness and detection of AkI, as well as identifcation of AkI determinants in the urological surgery setting is warranted to pre-empt and mitigate further deterioration of renal function in patients at special risk. New consensus criteria provide precise definitions of diagnosis and description of the severity of AkI. however, they rely on serum creatinine （SCr）, which is known to be an inaccurate marker of early changes in renal function. Therefore, several newurinary and serum biomarkers promise to address the gap associated with the use of SCr. Novel biomarkers may complement SCr measurement or most likely improve the diagnostic accuracy of AkI when used in combinations. however, novel biomarkers have to prove their clinical applicability, accuracy, and cost effectiveness prior to implementation into clinical practice. Most preferably, novel biomarkers should help to positively improve a patient’s long-term renal functional outcomes. The purpose of this review is to discuss currently available biomarkers and to review their clinical evidence within urologic surgery settings.

关键词： Acute kidney injury Urology Outcome Renal function Biomarker Surgery

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The wound healing potential of collagen peptides derived from the jellyfish Rhopilema esculentum

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Chinese Journal of Traumatology 2019年第1期22卷 12-20页

作者： Fatuma felix Felician Rui-he Yu Meng-Zhen Li chun-Jie Li hui-Qin Chen Ying Jiang Tao Tang Wei-Yan Qi han-Mei Xu The Engineering Research Center of Peptide Drug Discovery and Development China Pharmaceutical University Nanjing 211198 China Department of Marine Pharmacy College of Life Science and Technology China Pharmaceutical University Nanjing 211198 China

Purpose: Wound represents a major health challenge as they consume a large amount of healthcare resources to improve patient's quality of life. Many scientific studies have been conducted in search of ideal biomaterials with wound-healing activity for clinical use and collagen has been proven to be a suitable can didate biomaterial. This study in tended to investigate the wound healing activity of collagen peptides derived from jellyfish following oral administration. Methods: In this study, collagen was extracted from the jellyfish-Rhopilema esculentum using 1% pepsin. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and fourier transform infrared (FTIR) were used to identify and determine the molecular weight of the jellyfish collagen. Collagenase II, papain and alkaline proteinase were used to breakdown jellyfish collagen into collagen peptides. Wound scratch assay (in vitro) was done to determine migration potential of human umbilical vein endothelial cells (hUVEC) covering the artificial wound created on the cell monolayer following treatment with collagen peptides. In vivo studies were con ducted to determine the effects of collagen peptides on wound healing by examining wound contraction, re-epithelialization, tissue regeneration and collagen deposition on the wounded skin of mice. Confidence level (p hPad Prism software. Results: The yield of collagen was 4.31%. The SDS-PAGE and FTIR showed that extracted collagen from jellyfish was type I. Enzymatic hydrolysis of this collagen using collagenase II produced collagen peptides (CPi) and hydrolysis with alkaline proteinase/papain resulted into collagen peptides (CP2). Tricine SDSPAGE revealed that collagen peptides consisted of protein fragments with molecular weight kDa. Wound scratch assay showed that there were significant effects on the scratch closure on cells treated with collagen peptides at a concentration of 6.25 μg/mL for 48 h as com

关键词： Collagen Collagen peptides Wound healing Jellyfish

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短链碳氢化合物应用于页岩气烃基无水压裂液的研究现状

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应用化工 2020年第5期49卷 1293-1296页

作者：孙孟莹荣继光杨双春 FAMUWAGUN felix OLUWABUSUYI 张秋实李沼萱辽宁石油化工大学石油天然气工程学院辽宁抚顺113001 辽宁石油化工大学国际教育学院辽宁抚顺113001 东北石油大学石油工程学院黑龙江大庆163000

主要介绍短链碳氢化合物在烃基压裂体系中的应用,包括基液和添加剂,并按基液组分的复杂程度分为三种类型,即单一纯液态丙烷、液态丙烷混合物(LPG)和复杂碳氢化合物的混合物(油基),分析了体系的组成及短链碳氢结构在其中所起到的作用,介... 详细信息

主要介绍短链碳氢化合物在烃基压裂体系中的应用,包括基液和添加剂,并按基液组分的复杂程度分为三种类型,即单一纯液态丙烷、液态丙烷混合物(LPG)和复杂碳氢化合物的混合物(油基),分析了体系的组成及短链碳氢结构在其中所起到的作用,介绍体系中主剂合成及优化,列表对比各压裂体系性能参数,阐述当前技术存在的优势与不足,并从微观的角度对短链碳氢化合物类无水压裂体系提出研究与发展建议,以期能更好地适用于非常规页岩地层。

关键词：烃基无水压裂液非常规页岩气 LPG 石油环境

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南通地区24例成人恙虫病患者诊治分析

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中华传染病杂志 2014年第1期32卷 35-38页

作者：刘春袁鼎山黄中伟南通大学附属医院急诊内科 226001

目的探讨南通地区成人恙虫病临床特点和治疗方法，以期降低对该病的误诊和漏诊。方法回顾性分析南通大学附属医院急诊内科2010年至2012年收治的24例成人恙虫病患者临床资料，其中男13例，女11例，年龄25～70岁。治疗首选米诺环素口服。... 详细信息

目的探讨南通地区成人恙虫病临床特点和治疗方法，以期降低对该病的误诊和漏诊。方法回顾性分析南通大学附属医院急诊内科2010年至2012年收治的24例成人恙虫病患者临床资料，其中男13例，女11例，年龄25～70岁。治疗首选米诺环素口服。结果24例恙虫病患者就诊时均有发热，以高热为主。其中体温≥39℃者23例，38．O～38．9℃者1例。患者有咽痛咳嗽3例、心悸胸闷I例、焦痂或溃疡（i枚）2i例、焦痂或溃疡（2枚）1例、淋巴结肿大21例、皮疹11例、肝脏肿大3例、脾脏肿大4例。焦痂或溃疡在患者腋窝、腹股沟、外生殖器及肛周、腰部、胭窝、女性乳房下缘与胸壁皮肤皱褶处、腕关节内侧、踝部、颈部、耳后、胸背部、臀部均有发现。血常规白细胞计数（2．5～3．9）×10^9／L者4例，白细胞计数（10．1～18．6）×10^9／L者3例；血小板减少1例。尿蛋白阳性4例。血清ALT升高2例、血肌酐升高1例、心肌钙蛋白I轻度升高i例、C反应蛋白升高19例。外斐试验OXk效价1：160～1：320者17例。4例患者胸部x线片检查提示双肺纹理增粗、局限性炎性浸润影、严重者有少量胸腔积液。2例患者心电图示室性早搏及ST段轻度改变。给予患者口服米诺环素治疗有明显效果。结论恙虫病临床表现多样，除发热外，可见多脏器受损表现。皮肤焦痂或溃疡是本病的重要特征，若不仔细询问病史和体榆极易漏诊和误诊。

关键词：丛林斑疹伤寒误诊米诺环素

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“被黄金锁缚的女子”——论欧也妮·葛朗台的人生悲剧

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怀化学院学报 2009年第12期28卷 83-85页

作者：戴春雷吉林师范大学文学院吉林四平136000

国内对《欧也妮.葛朗台》的流行评论多聚焦于对老葛朗台吝啬性格的剖析,是一种选择性误读。该小说中心主人公是欧也妮,主要内容是欧也妮的人生悲剧。老葛朗台对金钱的狂热追逐和贪婪占有,是欧也妮悲剧的主要原因。欧也妮所代表的温情主... 详细信息

国内对《欧也妮.葛朗台》的流行评论多聚焦于对老葛朗台吝啬性格的剖析,是一种选择性误读。该小说中心主人公是欧也妮,主要内容是欧也妮的人生悲剧。老葛朗台对金钱的狂热追逐和贪婪占有,是欧也妮悲剧的主要原因。欧也妮所代表的温情主义与老葛朗台代表的金钱崇拜形成两种价值观的冲突;面对金钱魔力的挤压,欧也妮的生存空间和心理空间逐渐萎缩恶化;欧也妮的生活轨迹展示了金钱对人生命运的改写,成为"被黄金锁缚的女子"。

关键词：《欧也妮·葛朗台》金钱价值观冲突悲剧

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再认识阿司匹林

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中华全科医师杂志 2006年第4期5卷 231-234页

作者：张涓杨新春北京朝阳医院心脏中心 100020

1897年德国化学家felix hoffmann博士首次合成出乙酰水杨酸,由此引出了阿司匹林的经典传奇.除解热镇痛外,阿司匹林主要用于血管性疾病的一级和二级预防.其作用的主要环节是通过与血小板的环氧化酶活性位点丝氨酸产生共价键性乙酰化而使... 详细信息

1897年德国化学家felix hoffmann博士首次合成出乙酰水杨酸,由此引出了阿司匹林的经典传奇.除解热镇痛外,阿司匹林主要用于血管性疾病的一级和二级预防.其作用的主要环节是通过与血小板的环氧化酶活性位点丝氨酸产生共价键性乙酰化而使该酶受到抑制,从而阻断花生四烯酸通过环氧化酶途径转变为前列腺素内过氧化物(PGG1、PGh2),进而减少血栓素A2(TXA2)的形成,持续抑制血小板激活和血栓形成[1].但目前这样一个普遍使用的简单药物,却仍存在着在适用人群中使用率低、使用剂量不足等严重问题。

关键词：阿司匹林 hoffmann 血小板激活再认环氧化酶乙酰水杨酸血管性疾病花生四烯酸解热镇痛二级预防

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宿迁地区32例恙虫病临床特征分析

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中国血吸虫病防治杂志 2013年第6期25卷 639-641页

作者：孙明汪东亮赵春云陈秋香江苏省南京鼓楼医院集团宿迁市人民医院宿迁223800

目的分析宿迁地区恙虫病临床特征,为临床诊断与治疗提供参考。方法对宿迁市人民医院急诊中心近2年来诊治的32例恙虫病患者的病例资料进行回顾性分析。结果恙虫病在每年8-11月高发,32例患者均有野外草地等接触史,均有高热及恙螨叮咬处焦... 详细信息

目的分析宿迁地区恙虫病临床特征,为临床诊断与治疗提供参考。方法对宿迁市人民医院急诊中心近2年来诊治的32例恙虫病患者的病例资料进行回顾性分析。结果恙虫病在每年8-11月高发,32例患者均有野外草地等接触史,均有高热及恙螨叮咬处焦痂、溃疡、淋巴结肿大等症状,其中30例出现不同程度肝损害(93.75%),14例有肺部损害(43.75%),9例有心脏损害(28.13%),6例有肾损害(18.75%),1例发生弥散性血管内凝血和多脏器功能障碍综合症(MODS)(3.1%);变形杆菌OX2和OX19均阴性,OXk凝集反应仅6例阳性(18.75%)。32例病例首诊误诊24例,误诊率高达75%。阿奇霉素治疗效果较好,治愈率为96.88%,仅1例死亡,病死率为3.13%。结论恙虫病临床表现比较复杂,且合并肝损害最常见,但是外斐氏试验结果对本地区恙虫病的早期诊断意义不大。临床医生尤其是急诊医生要对该病充分认识,对不明原因发热伴肝损害的患者,应考虑恙虫病的可能,减少误诊。

关键词：恙虫病临床特征外斐氏试验回顾性分析宿迁市

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