Comparison of survival outcomes between laparoscopic versus open radical nephroureterectomy in upper tract urothelial cancer patients:Experiences of a tertiary care single center

作     者：Benedikt Hoeh Marina Kosiba Mike Wenzel Nicola Meister Felix Preisser Shahrokh F.Shariat Jan Lukas Hohenhorst Andreas Becker Philipp Mandel Severine Banek Frederik Roos Pierre I.Karakiewicz Felix K.H.Chun Luis A.Kluth 

作者机构：Department of UrologyUniversity Hospital FrankfurtGoethe University Frankfurt am MainFrankfurt am Main60590Germany Cancer Prognostics and Health Outcomes UnitDivision of UrologyUniversity of Montreal Health CenterMontrealQuebecCanada Department of UrologyComprehensive Cancer CenterMedical University of ViennaViennaAustria Department of UrologyWeill Cornell Medical CollegeNew YorkNYUSA Department of UrologyUniversity of Texas SouthwesternDallasTXUSA Department of UrologySecond Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive HealthI.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of UrologyDepartment of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan Martini-Klinik Prostate Cancer CenterUniversity Hospital Hamburg-EppendorfHamburgGermany 

出 版 物：《Current Urology》 (当代泌尿学（英文）)

年 卷 期：2023年第17卷第4期

页      面：292-298页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：awarded a scholarship by the STIFTUNG GIERSCH 

主　　题：Upper tract urothelial carcinoma Laparoscopic radical nephroureterectomy Open radical nephroureterectomy Overall survival 

摘      要：Objectives:To test for differences in overall and recurrence-free survival between laparoscopic and open surgical approaches in patients undergoing radical nephroureterectomy(RNU)for upper tract urothelial carcinoma(UTUC).Materials and methods:We retrospectively identified patients treated for UTUC from 2010 to 2020 from our institutional *** undergoing laparoscopic or open RNU with no suspicion of metastasis(cM0)were for the current study *** with suspected metastases at diagnosis(cM1)or those undergoing other surgical treatments were *** was performed according to the laparoscopic versus open surgical ***-Meier plots were used to test for differences in overall and recurrence-free survival with regard to the surgical ***,separate Kaplan-Meier plots were used to test the effect of preoperative ureterorenoscopy on overall and recurrence-free survival within the overall study ***:Of the 59 patients who underwent nephroureterectomy,29%(n=17)underwent laparoscopic nephroureterectomy,whereas 71%(n=42)underwent open *** and tumor characteristics were comparable between groups(p≥0.2).The median overall survival was 93 and 73 months in the laparoscopic nephroureterectomy group compared to the open nephroureterectomy group(p=0.5),*** median recurrence-free survival did not differ between open and laparoscopic nephroureterectomies(73 months for both groups;p=0.9).Furthermore,the median overall and recurrence-free survival rates did not differ between patients treated with and without preoperative ***:The results of this retrospective,single-center institution showed that overall and recurrence-free survival rates did not differ between patients with UTUC treated with laparoscopic and open ***,preoperative ureterorenoscopy before RNU was not associated with higher overall or recurrence-free survival rates.