The association of type and number of high-risk criteria with cancer-specific mortality in prostate cancer patients treated with radical prostatectomy

作     者：Francesco Chierigo Rocco Simone Flammia GabrieleSorce Benedikt Hoeh Lukas Hohenhorst Andrea Panunzio Zhe Tian Fred Saad Marcus Graefen Michele Gallucci Alberto Briganti Francesco Montorsi Felix K.H.Chun Shahrokh F.Shariat Alessandro Antonelli Giovanni Guano Guglielmo Mantica Marco Borghesi Nazareno Suardi Carlo Terrone Pierre I.Karakiewicz 

作者机构：Department of Surgical and Diagnostic Integrated SciencesUniversity of GenovaGenovaItaly IRCCS Ospedale Policlinico San MartinoGenovaItaly Cancer Prognostics and Health Outcomes UnitDivision of UrologyUniversity ofMontréal Health CenterMontréalQuébecCanada Department of UrologyIRCCS Policlinico San MartinoGenovaItaly Department of Maternal-Child and Urological SciencesSapienza Rome UniversityPoliclinico Umberto I HospitalRomeItaly Department of UrologyUniversity Hospital FrankfurtFrankfurt am MainGermany Martini-Klinik Prostate Cancer CenterUniversity Hospital Hamburg-EppendorfHamburgGermany Department of UrologyUniversity of VeronaAzienda Ospedaliera Universitaria Integrata di VeronaVeronaItaly Division of Experimental Oncology/Unit of UrologyURIUrological Research InstituteIRCCS San Raffaele Scientific InstituteMilanItaly Department of UrologyComprehensive Cancer CenterMedical University of ViennaViennaAustria Department of UrologyWeill Cornell Medical CollegeNew YorkNYUSA Department of UrologyUniversity of Texas SouthwesternDallasTXUSA Department of UrologySecond Faculty of MedicineCharles UniversityPragueCzech Republic Institute for Urology and Reproductive HealthI.M.Sechenov First Moscow State Medical UniversityMoscowRussia Division of UrologyDepartment of Special SurgeryJordan University HospitalThe University of JordanAmmanJordan 

出 版 物：《Current Urology》 (当代泌尿学（英文）)

年 卷 期：2024年第18卷第2期

页      面：128-132页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：High risk prostate cancer Radical prostatectomy Cancer-specific mortality Staging SEER 

摘      要：Objectives:This study aimed to test the association between of type and number of D Amico high-risk criteria(DHRCs)with cancer-specific mortality(CSM)in high-risk prostate cancer patients treated with radical *** and methods:In the Surveillance,Epidemiology,and End Results database(2004–2016),we identified 31,281 radical prostatectomy patients with at least 1 DHRC,namely,prostate-specific antigen(PSA)20 ng/mL(hrPSA),biopsy Gleason Grade Group(hrGGG)score of 4 and 5,or clinical tumor stage≥T3(hrcT).Multivariable Cox regression models and competing risks regression models(adjusting for other cause mortality)tested the association between DHRCs and 5-year ***:Of 31,281 patients,14,394(67%)exclusively harbored hrGGG,3189(15%)harbored hrPSA,and 1781(8.2%)harbored *** 2132 patients(6.8%)harbored a combination of the 2 DHRCs,and 138(0.6%)had all 3 ***-year CSMrates ranged from 0.9%to 3.0%when any individual DHRC was present(hrcT,hrPSA,and hrGGG,in that order),1.6%to 5.9%when 2 DHRCs were present(hrPSA-hrcT,hrcT-hrGGG,and hrPSA-hrGGG,in that order),and 8.1%when all 3 DHRCs were *** regression models and competing risks regression confirmed the independent predictor status of DHRCs for 5-year CSM that was observed in univariable analyses,with hazard ratios from 1.00 to 2.83 for 1 DHRC,2.35 to 5.88 for combinations of 2 DHRCs,and 7.13 for all 3 ***:Within individual DHRCs,hrcT and hrPSA exhibited weaker effects than hrGGG ***,a dose-response effect was identified according to the number of ***,the type and number of DHRCs allow further risk stratification within the high-risk subgroup.