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女性便秘病因探讨

中国肛肠病杂志 2024年第3期44卷 78-80页

作者：程爱阳樊文彬林文霞重庆市丰都县暨龙镇卫生院重庆408224 重庆中医药学院重庆402760

便秘临床比较常见,以排便受阻、排便次数减少或排便不尽感、粪质干结为主要临床表现征。史慧慧等[1]针对上海部分社区人群的流行病学调查显示,慢性便秘的患病率为4.6%,杨直等[2]通过Meta分析,结果显示,男性和女性便秘患病率分别为7.0%和... 详细信息

便秘临床比较常见,以排便受阻、排便次数减少或排便不尽感、粪质干结为主要临床表现征。史慧慧等[1]针对上海部分社区人群的流行病学调查显示,慢性便秘的患病率为4.6%,杨直等[2]通过Meta分析,结果显示,男性和女性便秘患病率分别为7.0%和11.5%。便秘可引起直肠和肛周疾病、胃肠疾病和心脑血管等疾病,严重危害女性身心健康,部分患者由于反复就医或滥用药物造成沉重的经济和心理负担[3]。

关键词：便秘女性病因综述

Rabi Oscillations in Realistic Superlattice with Finite Bloch Bands

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Chinese Physics Letters 2001年第3期18卷 425-428页

作者： fan wen-bin ZHANG Ping LUO Ying ZHAO Xian-Geng Graduate School China Academy of Engineering PhysicsP.O.Box 2101Beijing 100088 Institute of Applied Physics and Computational Mathematics P.O.Box 8009Beijing 100088

We investigate the dynamical processes taking place in nanodevices by high-frequency dc-ac *** found that Rabi oscillations between minibands are clearly identified under theoretical resonant conditions derived by an ideal two bands superlattice model,the resonant conditions have broadened,and the amount of broadening is about four times of the Rabi oscillation *** also want to elucidate the role of different mechanisms that could lead to loss of quantum *** results show how the dephasing effects of disorder of interface roughness and doping fluctuation that destroy after some periods coherent oscillations,such as Rabi oscillations,can be reduced dramatically if we apply a bias static electric field to the superlattice *** fluctuation's dephasing effect is much stronger than that of interface roughness in coherent process of realistic superlattices.

关键词： bands resonant roughness

Generation of Maximally Entangled Bell State in a Coupled Quantum Dot

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Chinese Physics Letters 2001年第10期18卷 1304-1307页

作者： ZHANG Ping fan wen-bin DUAN Su-Qing ZHAO Xian-Geng Institute of Applied Physics and Computational Mathematics P.O.Box 8009Beijing 100088

We show how the two interacting electrons in a field-driven coupled quantum dot can be used to prepare maximally entangled Bell states. The time durations of the oscillatory electric field for producing and maintaining such highly entangled states are identified by both analytic and exact numerical solutions of the quantum dynamical equations.

关键词： equations. quantum maximal

Catalytic effect in lithium metal batteries: From heterogeneous catalyst to homogenous catalyst

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Journal of Energy Chemistry 2024年第3期90卷 305-326,I0008页

作者： Haining fan Xuan-wen Gao Hailong Xu Yichun Ding Shi-Xue Dou wen-bin Luo School of Fashion and Textiles The Hong Kong Polytechnic UniversityHong Kong 100872China Institute for Energy Electrochemistry and Urban Mines Metallurgy School of MetallurgyNortheastern UniversityShenyang 110819LiaoningChina Institute of Energy Materials Science University of Shanghai for Science and TechnologyShanghai 200000China State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710000ShaanxiChina

Lithium metal batteries are regarded as prominent contenders to address the pressing needs owing to the high theoretical *** the broader implementation,the primary obstacle lies in the intricate multi-electron,multi-step redox reaction associated with sluggish conversion kinetics,subsequently giving rise to a cascade of parasitic *** order to smooth reaction kinetics,catalysts are widely introduced to accelerate reaction rate via modulating the energy *** past decades,a large amount of research has been devoted to the catalyst design and catalytic mechanism exploration,and thus the great progress in electrochemical performance has been ***,it is necessary to make a comprehensive review toward key progress in catalyst design and future development *** this review,the basic mechanism of lithium metal batteries is provided along with corresponding advantages and existing challenges detailly *** main catalysts employed to accelerate cathode reaction with emphasis on their catalytic mechanism are summarized as ***,the rational design and innovative direction toward efficient catalysts are suggested for future application in metal-sulfur/gas battery and *** review is expected to drive and benefit future research on rational catalyst design with multi-parameter synergistic impacts on the activity and stability of next-generation metal battery,thus opening new avenue for sustainable solution to climate change,energy and environmental issues,and the potential industrial economy.

关键词： Energy storage and conversion Metal battery Sulfur battery Air battery Catalytic effect Heterogeneous catalyst Homogeneous catalyst

补充与替代疗法治疗帕金森病相关便秘的研究进展

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中国肛肠病杂志 2024年第5期44卷 64-68页

作者：倪嘉淳陶美樊文彬江琼蔡增进上海中医药大学附属岳阳中西医结合医院上海200437 重庆市巴南区中医院肛肠科重庆400055 重庆中医药学院重庆402760 重庆医科大学中医药学院重庆400016 江苏省中医院重庆医院(重庆市永川区中医院)肛肠科重庆402160

帕金森病(Parkinson's disease,PD)是以静止性震颤、肌肉僵硬、运动迟缓等运动症状为主要表现的一种常见进行性神经退行性疾病[1]。胃肠功能紊乱是PD常见的非运动症状(nonmotor symptoms,NMS),其中便秘最为多见[2,3]。流行病学研究表明,... 详细信息

帕金森病(Parkinson's disease,PD)是以静止性震颤、肌肉僵硬、运动迟缓等运动症状为主要表现的一种常见进行性神经退行性疾病[1]。胃肠功能紊乱是PD常见的非运动症状(nonmotor symptoms,NMS),其中便秘最为多见[2,3]。流行病学研究表明,P D患者便秘发生率达24.6%~63%,且便秘为PD危险因素之一[4,5]。PD相关便秘(Parkinson's disease related constipation,PDC)不仅会降低患者生活质量,还会影响药物吸收,引发肠梗阻、肠扭转、肠穿孔、巨结肠等严重并发症.

关键词：帕金森病相关便秘补充与替代疗法治疗

Atomic layer deposition in advanced display technologies:from photoluminescence to encapsulation

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International Journal of Extreme Manufacturing 2024年第2期6卷 65-82页

作者： Rong Chen Kun Cao Yanwei wen fan Yang Jian Wang Xiao Liu bin Shan State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiPeople’s Republic of China

Driven by the growing demand for next-generation displays,the development of advanced luminescent materials with exceptional photoelectric properties is rapidly accelerating,with such materials including quantum dots and phosphors,***,the primary challenge preventing the practical application of these luminescent materials lies in meeting the required durability *** layer deposition(ALD)has,therefore,been employed to stabilize luminescent materials,and as a result,flexible display devices have been fabricated through material modification,surface and interface engineering,encapsulation,cross-scale manufacturing,and *** addition,the appropriate equipment has been developed for both spatial ALD and fluidized ALD to satisfy the low-cost,high-efficiency,and high-reliability manufacturing *** strategic approach establishes the groundwork for the development of ultra-stable luminescent materials,highly efficient light-emitting diodes(LEDs),and thin-film ***,this significantly enhances their potential applicability in LED illumination and backlighted displays,marking a notable advancement in the display industry.

关键词： atomic layer deposition display luminescent encapsulation

Active Template Synthesis of Protein[n]Catenanes Using Engineered Peptide–Peptide Ligation Tools

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CCS Chemistry 2024年第2期6卷 377-389页

作者： fan Zhang Yajie Liu Yu Shao wen-bin Zhang Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871 Beijing Academy of Artificial Intelligence Beijing 100084

The expansion of protein topological diversity requires new and efficient synthetic ***,we report the second and third generations of the SpyStapler-mediated SpyTag/BDTag ligation system for the efficient synthesis of 4-arm star proteins and the repurposing of the third generation as an active template to enable the synthesis of higher-order protein[n]catenanes(n=3,4,and 5).SpyStapler003 has a higher affinity to its cognate SpyTag and BDTag reactive pairs relative to the original ***,it can overcome much more profound steric hindrance in protein ligation and improve the efficiency of the resulting active template tool to facilitate the construction of radial protein[n]*** proteins of interest,such as dihydrofolate reductase and the nanobody KN035,can be modularly incorporated into the[n]catenanes with intact *** of passive and active template strategies gives rise to linear protein[4]catenanes,which further expands the current topological ***,higher-order protein catenation not only leads to enhanced thermal stability and proteolytic resistance but also higher affinity of the nanobody via multivalent *** study provides tools useful for bioconjugation and new topological protein scaffolds for the multivalent display of enzymes and antibodies.

关键词： SpyTag SpyCatcher catenane topology active template ligation

Toward Selective Synthesis of Protein Olympiadanes via Orthogonal Active Templates in One Step

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CCS Chemistry 2024年第4期6卷 1047-1059页

作者： fan Zhang Yajie Liu Xiao-Di Da wen-bin Zhang Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871 Beijing Academy of Artificial Intelligence Beijing 100084

Unlike small molecules,the topological complexity of macromolecules remains largely unexplored due to the huge synthetic ***,we report the development of orthogonal active templates for concise and selective synthesis of protein[n]heterocatenanes toward protein *** active template(AT-Snoop)was first developed based on the isopeptide-bond-forming RrgA domain with comparable efficiency and excellent orthogonality to the previously reported active template(AT-Spy)based on the CnaB2 *** combination facilitated the selective synthesis of protein[n]catenanes from multiple components in one step and the resulting structures were verified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis,size exclusion chromatography,liquid chromatography-mass spectrometry,and proteolytic digestion *** results offered a promising solution to tackling the daunting challenge of precision synthesis of protein olympiadane with five distinct ring *** only did the success provide new tools for proteintopology engin eering but alsospurred and fueled the future exploitation of topology-related functional benefits in protein science.

关键词： catenane topology active template SnoopTag SnoopCatcher SpyTag SpyCatcher

METTL5 promotes cell proliferation,invasion,and migration by up-regulating Toll-like receptor 8 expression in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2006-2017页

作者： Ling-Shang Kong Ran Tao Yi-fan Li wen-bin Wang Xue Zhao Department of General Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Vascular Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230002Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina Anhui Public Health Clinical Center Hefei 230012Anhui ProvinceChina Department of Scientific Research Anhui Public Health Clinical CenterHefei 230012Anhui ProvinceChina Department of Scientific Research The First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina

BACKGROUND N6-methyladenosine(m6A)modification represents the predominant alteration found in eukaryotic messenger RNA and plays a crucial role in the progression of various ***,despite its significance,the comprehensive investigation of METTL5,a key m6A methyltransferase,in colorectal cancer(CRC)remains *** To investigate the role of METTL5 in *** We assessed METTL5 expression levels in clinical samples obtained from CRC patients as well as in CRC cell *** elucidate the downstream targets of METTL5,we performed RNA-sequencing analysis coupled with correlation analysis,leading us to identify Toll-like receptor 8(TLR8)as a potential downstream *** vitro functional assessments of METTL5 and TLR8 were conducted using CCK-8 assays,scratch assays,as well as assays measuring cell migration and *** Our findings reveal a pronounced upregulation of METTL5 expression in both CRC cells and tissues,which correlated significantly with an unfavorable *** vitro experiments unequivocally demonstrated the oncogenic role of METTL5,as evidenced by its promotion of CRC cell proliferation,invasion,and ***,we identified TLR8 as a downstream target of METTL5,and subsequent down-regulation of TLR8 led to a significant inhibition of CRC cell proliferation,invasion,and tumor *** The heightened expression of METTL5 in CRC is strongly associated with clinicopathological features and a poor prognosis,thereby underscoring its potential utility as a critical marker for facilitating early diagnosis and prognostication in CRC.

关键词： METTL5 Toll-like receptor 8 Colorectal cancer