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New translational and experimental insights into the role of proresolving lipid mediators in inflammatory bowel disease

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World Journal of experimental Medicine 2022年第1期12卷 1-15页

作者： Lívia Bitencourt Pascoal Bruna Biazon Palma fabio henrique Mendonça Chaim Marina Moreira de Castro Tiago andrade Damázio Ana Paula Menezes de Freitas Franceschini Marciane Milanski Lício AugustoVelloso Raquel Franco Leal Inflammatory Bowel Disease Research Laboratory Colorectal Surgery UnitDepartment of SurgerySchool of Medical SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Metabolic Disorders School of Applied SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Cell Signaling School of Medical SciencesUniversity of CampinasCampinas 13083-864São PauloBrazil

The resolution of inflammation is an active process,guided by specialized proresolution lipid mediators(SPMs).These mediators originate from polyunsaturated fatty acids,such as *** evidence suggests that the beneficial effects attributed to omega-3 are,at least in part,the result of the immunomodulatory action of the SPMs,which act systemically by overcoming inflammation and repairing tissue damage,without suppressing the immune *** studies suggest that an imbalance in the synthesis and/or activity of these compounds may be associated with the pathogenesis of several inflammatory conditions,such as inflammatory bowel disease(IBD).Thus,this review highlights the advances made in recent years with regard to the endogenous synthesis and the biological role of lipoxins,resolvins,protectins,and maresins,as well as their precursors,in the regulation of inflammation;and provides an update on the participation of these mediators in the development and evolution of IBD and the therapeutic approaches that these immunomodulating substances are involved in this context.

关键词： Pro-resolving lipid mediators Anti-inflammatory cytokines Omega-3 Chronic inflammation Pro-inflammatory cytokines Inflammatory bowel disease

Molecular approaches for spinal cord injury treatment

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Neural Regeneration Research 2023年第1期18卷 23-30页

作者： Fernanda Martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos Santos Caio andrade Prins Fellipe Soares dos Santos Cardoso Luiza dos Santos Heringer henrique Rocha Mendonça Ana Maria Blanco Martinez Laboratório de Neurodegeneração e Reparo Programa de Pós-Graduação em Medicina:Anatomia PatológicaDepartamento de PatologiaFaculdade de MedicinaHospital Universitário Clementino Fraga FilhoCentro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Ciências Biomédicas Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Biologia Departamento de NeurobiologiaLaboratório de Regeneração Neural e FunçãoUFFRio de JaneiroBrazil Laboratório Integrado de Morfologia Instituto de Biodiversidade e Sustentabilidade NUPEMPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisCentro Multidisciplinar UFRJ-MacaéUniversidade Federal do Rio de JaneiroMacaéBrazil

Injuries to the spinal cord result in permanent disabilities that limit daily life *** main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic *** decades of research,there is still no efficient treatment for spinal cord *** strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord *** these,molecular compounds are currently being used for neurological recovery,with promising *** molecules target the axon collapsed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost *** this review we focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,growth and neurotrophic factors,enzymes,and *** mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans.

关键词： axonal regeneration drugs enzymes growth factors molecular therapy neurotrophic factors purines spinal cord injury

Role of lysophosphatidic acid and its receptors in health and disease:novel therapeutic strategies

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Signal Transduction and Targeted Therapy 2021年第3期6卷 630-647页

作者： Luiz henrique Medeiros Geraldo Tania Cristina Leite de Sampaio Spohr Rackele Ferreira do Amaral Anna Carolina Carvalho da Fonseca Celina Garcia fabio de Almeida Mendes Catarina Freitas Marcos fabio dosSantos Flavia Regina Souza Lima Institute de Ciencias BiomedicasUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Universite de Paris PARCCINSERMF-75015 ParisFrance Institute estadual do Cerebro Paulo Niemeyer-Secretaria de estado de Saude Rio de JaneiroBrazil Instituto de Saiide de Nova Friburgo Universidade Federal Fluminense28625-650 Nova FriburgoBrazil

Lysophosphatidic acid(LPA)is an abundant,bioactive phospholipid,with multiple functions both in development and in pathological ***,we review the literature about the differential signaling of LPA through its specific receptors,which makes this lipid a versatile signaling *** differential signaling is important for understanding how this molecule can have such diverse effects during central nervous system development and angiogenesis;and also,how it can act as a powerful mediator of pathological conditions,such as neuropathic pain,neurodegenerative diseases,and cancer ***,we review the preclinical and clinical uses of Autotaxin,LPA,and its receptors as therapeutic targets,approaching the most recent data of promising molecules modulating both LPA production and *** review aims to summarize the most update knowledge about the mechanisms of LPA production and signaling in order to understand its biological functions in the central nervous system both in health and disease.

关键词： therapeutic clinical diseases

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Health 2014年第21期6卷 2966-2972页

作者： Helena andrade Figueira Rodrigo Gomes de Souza Vale Wilma Ferreira Guedes Rodrigues Alan andrade Figueira Joana andrade Figueira estélio henrique Martin Dantas Laboratory of Biomedical Human Kinetics (LABIMH) Rio de Janeiro Federal University (UNIRIO) Rio de Janeiro Brazil

Background: Pregnancy-related low back pain (LBP) impacts pregnancy. Flexibilizing facilitates movements providing posture correction and pain relief. Objective: To analyze effects of a maximum static flexibility program on pregnancy’s LBP. Methods: Clinical prospective randomized controlled trial. Setting: Brazilian Governmental Health Program’s prenatal care. Participants: 40 volunteer of pregnant women, gestational age between 20 and 31 weeks, with/without LBP randomly assigned to experimental group (eG) or control group (CG): eG n = 20 (e1 with LBP and e2 without LBP) and CG n = 20 (C1 with LBP and C2 without LBP). Interventions: eG intervention was sessions of static flexion. CG received conventional medical treatment. Pain intensity was measured by visual analog scale (VAS) of pain. Chi-square, Wilcoxon and the Kruskal-Wallis statistical tests were adopted. Results: Concerning percent variation (Δ%) e1 presented 56.4% reduction of LBP while e2, C1, C2 increased LBP by 2.9%, 0.1%, 0.5% respectively. Wilcoxon test outcome comparing pre- and post-test of experimental and control groups on pain intensity levels presented significant e1 p est comparing post-test C1 with e1 with e2 and C2 presented p e1 post: p = 0.006;C1 post vs. e2 post: p effect of the experimental treatment. Conclusion: Gains on LBP for eG show that the static flexibilizing exercises reduce and prevent pregnancy-related LBP.

关键词： Pregnancy Flexibility Low Back Pain exercise

Numerical Study of the Influence of elements inside the Wheelhouse on the Passenger Vehicle Aerodynamic

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Open Journal of Fluid Dynamics 2015年第2期5卷 199-207页

作者： edvaldo Angelo Gabriel Angelo Pedro henrique Di Giovanni Santos Delvonei Alves de.andrade Grupo de Simulaç o Numérica (GSN) Universidade Presbiteriana Mackenzie S&#227 o Paulo Brazil Department of Mechanical engineering Centro Universitário da Funda&#231 o educacional Inaciana Padre Sabóia de Medeiros (FeI) S&#227 o Bernardo do Campo Brazil Instituto de Pesquisas energéticas e Nucleares IPEN CNEN/SP Universidade de S&#227 o Paulo S&#227 o Paulo Brazil

Models for the study of computational fluid dynamics in vehicles to determine aerodynamic loads usually take into account only the geometry of the body. Several constructive elements such as the wheel geometry or suspension components are disregarded in the computational models. This work presents the study of the aerodynamics of a one-fourth model passenger vehicle, which contains the wheelhouse interior elements. The goal is to identify the aerodynamic loads produced by these components and their effect on the flow dynamics. Wheel and tire set, brake components, suspension and drive shaft are contemplated. Computer simulations were performed to the vehicle speed varying from 0 to 120 km/h and included the rotation of the tire and wheel assembly, considering the tire geometry in dynamic conditions. The computational model is solved by the finite volume method, wherein the computational domain is divided into tetrahedral and hexahedral elements. The turbulence model used is the standard k −ε.

关键词： Computational Fluid Dynamics Wheelhouse Aerodynamics Vehicle Aerodynamics

Comparison of Three experimental Models for Rat Osteoarthritis Induction

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Journal of Biosciences and Medicines 2016年第12期4卷 62-69页

作者： henrique Ribeiro Rodrigues-Neto edilson Ferreira andrade-Junior Denilson Jose Silva Feitosa-Junior André Lopes Valente Thiago Cesar Xavier Bianca Caroline do Nascimento Alho Renan Kleber Costa Teixeira fabio Vidal Moriya Rui Sérgio Monteiro de Barros Department of Orthopaedics and Traumatology Porto Dias Hospital Bel&eacute m Brazil experimental Surgery Laboratory Par&aacute State University Bel&eacute m Brazil

Background: Osteoarthritis is a slowly progressive and debilitating disease with high prevalence in adult population. Knee is one of the joints most affected by this disorder. There are several models for animals’ osteoarthritis induction, however it is not identified any paper that compares these techniques. The present study was aimed to define the most appropriate model for rats osteoarthritis induction. Material and Methods: 40 Wistar rats were distributed into 4 groups of 10 animals each: normality group (NG);meniscectomy group (MG);quinolone group (QG) and iodoacetate group (IG). Radiographic images of the rat’s knees were analyzed as well as the amount of chondrocytes in the epiphyseal and articular cartilage. Results: In the radiographic analysis, there was a low correlation between the raters. Regarding the amount of chondrocytes in the epiphyseal cartilage, it was noticed that the IG and QG groups had fewer chondrocytes than NG, in contrast to MG that reported similar results to normality (p > 0.05). There was no significant difference between IG and QG groups (p > 0.05). Regarding the amount of chondrocytes in articular cartilage, it was noticed that the IG group showed fewer chondrocytes than NG (p 0.05). There was no significant difference between QG and MG groups (p > 0.05). Conclusion: Intraarticular injection of iodoacetate in rats is the model with greatest effect on reduction of chondrocytes amount.

关键词： Osteoarthritis Knee Joint experimental Arthritis Animal Disease Models Rats

Design, Development and Geometric error Analysis of an Aerostatic Rotary Table

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Journal of Mechanics engineering and Automation 2016年第3期6卷 133-147页

作者： Verilton Nunes da Silva Luiz henrique Melo Silva Nobrega fabio de.andrade Barroso Rafael Franklin Alves Silva Jobson Francisco da Silva Jose Carlos de Lima JUnior and Joaio Bosco de Aquino Silva

The engineering Professional and the Labor Market Demands： electronic engineer and Mechanical engineer

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Journal of Mechanics engineering and Automation 2014年第7期4卷 616-624页

作者： Aldair Oliveira de.andrade Antonio Marcos de Oliveira Siqueira Lucas henrique Figueiredo Prates Instituto de educacao Agricultura e Ambiente Universidade Federal do Amazonas Humaita 69800-000 Brazil Department of Chemistry Universidade Federal de Vicosa Vicosa 36570-900 Brazil

The purpose of this study is to present results of a jobs classified survey from a newspaper in circulation in the city of Manaus (AM, Brazil), between late 1990s and early 2000s. The structure and functionality of the CBO (Brazilian Occupational Classification) 2002, fundamental tool for data analysis was used, followed by collection, diagnosis and data analysis to identify the characteristics and transformations of the occupational tasks of the electronic and mechanical engineer. The analysis was based on CBO data in three distinct steps described in the methodology section, compared with a study conducted in the early 1990s, and finally, the overall prevailing trend required in professional engineering training in times of complexity and in the knowledge era was presented.

关键词：机械工程师市场需求工程专业电子劳动力数据分析工程训练知识时代

Thyroid Nodule: Alpha Score 2.0 Classification for FNAB Selection, Multicentric Study in Latin America

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Open Journal of Radiology 2021年第4期11卷 160-174页

作者： Glenn Mena Maria Cristina Chammas Carlos Mario Gonzalez Vasquez Lylian Rocío Villagómez Marco Alfredo Muñoz Pico Patricio Alejandro Montalvo Santiago Mena-Bucheli Julio Olmedo elizabeth Quintero Pedro henrique de Marqui Moraes Osmar Cassio Saito Hubertino Diaz Denise Romero Gabriela Velalcazar Angel Ramón Sosa Fleitas Yamil Oliver Quevedo Ontaneda Victor Ricardo Chara Alpha Imagen Radiología e Intervencionismo Quito Ecuador Hospital das Clínicas Faculdade de Medicina da Universidade de Sã o Paulo S&#227 o Paulo Brasil Hospital Pablo Tobón Uribe Medellin Colombia Hospital del Instituto ecuatoriano de Seguridad Social Quito Sur Quito Ecuador Hospital San Francisco de Quito Quito Ecuador Hospital edgardo Rebagliati Martins Lima Perú Hospital Carlos andrade Marín Quito Ecuador Hospital de Clínicas San José de San Martín Buenos Aires Argentina Hospital Universitario de Los Andes Mérida Venezuela Hospital de la Policía Quito Ecuador Hospital Sisol Tacna Perú

Introduction: To perform a Latin-American multicentric study for the prediction of benign and malignant thyroid nodules using Alpha Score, and to compare it with ACR TIRADS® and Bethesda®. Materials and Methods: A prospective multicentric study in 10 radiological hospitals and institutions of Latin America was performed and 818 thyroid nodules were analyzed by ultrasound and classified by using both ACR TIRADS® and Alpha Score;fine-needle aspiration biopsy was performed when needed and classified with Bethesda. The relationships between predictors were analyzed by using binary logistic regression, statistical significance was defined by a p-value of 0.05, with an error margin of 4% and 95% confidence intervals. Results: Alpha Score 2.0 establishes five types of malignant predictors: microcalcifications, irregular borders, taller-than-wide shape, predominant solid texture and hypoechogenicity;a diameter equal to or greater than 1.5 cm adds an extra point to the final score. Resulting classification divides TNs into 4 categories: benign (1.9%), low suspicion (8.7%), mild suspicion (13.6%) and high suspicion (75.7%) of malignancy probability;sensitivity of 82%, specificity of 74%, the positive predictive value of 94%, the negative predictive value of 51%, the statistical accuracy of 81%, odds ratio of 108.89 and correlation with ACR TIRADS of 0.77 and Bethesda of 0.91. Conclusions: Alpha Score 2.0 has superior diagnostic accuracy and performance compared to the previously published Alpha Score and is able to classify a benign TN in a precise, safe and accurate way, avoiding unnecessary FNABs or determining the necessity of FNAB in cases of moderate to high suspicion of malignancy.

关键词： Thyroid Cancer-Clinical Radiology-Imaging Thyroid Nodule Alpha Score TIRADS® Thyroid Ultrasonography