Role of lysophosphatidic acid and its receptors in health and disease:novel therapeutic strategies

作     者：Luiz Henrique Medeiros Geraldo Tania Cristina Leite de Sampaio Spohr Rackele Ferreira do Amaral Anna Carolina Carvalho da Fonseca Celina Garcia Fabio de Almeida Mendes Catarina Freitas Marcos Fabio dosSantos Flavia Regina Souza Lima Luiz Henrique Medeiros Geraldo;Tânia Cristina Leite de Sampaio Spohr;Rackele Ferreira do Amaral;Anna Carolina Carvalho da Fonseca;Celina Garcia;Fabio de Almeida Mendes;Catarina Freitas;Marcos Fabio dosSantos;Flavia Regina Souza Lima

作者机构：Institutede Ciencias BiomedicasUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Universite de ParisPARCCINSERMF-75015 ParisFrance Institute Estadual do Cerebro Paulo Niemeyer-Secretaria de Estado de SaudeRio de JaneiroBrazil Instituto de Saiide de Nova FriburgoUniversidade Federal Fluminense28625-650 Nova FriburgoBrazil 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第3期

页      面：630-647页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Brazilian Funding agencies Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Fundacao de Amparo a Pesquisa do Rio de Janeiro (FAPERJ) Instituto Nacional de Neurociencia Translacional (INNT) Programa de Pos-Graduacao em Ciencias Morfologicas (PCM) financed by a fellowship of CNPq financed by fellowships of CAPES and of the European Society of Cardiology (ESC) 

主　　题：therapeutic clinical diseases 

摘      要：Lysophosphatidic acid(LPA)is an abundant,bioactive phospholipid,with multiple functions both in development and in pathological ***,we review the literature about the differential signaling of LPA through its specific receptors,which makes this lipid a versatile signaling *** differential signaling is important for understanding how this molecule can have such diverse effects during central nervous system development and angiogenesis;and also,how it can act as a powerful mediator of pathological conditions,such as neuropathic pain,neurodegenerative diseases,and cancer ***,we review the preclinical and clinical uses of Autotaxin,LPA,and its receptors as therapeutic targets,approaching the most recent data of promising molecules modulating both LPA production and *** review aims to summarize the most update knowledge about the mechanisms of LPA production and signaling in order to understand its biological functions in the central nervous system both in health and disease.