检索结果-南通市图书馆

New translational and experimental insights into the role of proresolving lipid mediators in inflammatory bowel disease

引用

World Journal of Experimental Medicine 2022年第1期12卷 1-15页

作者： Lívia Bitencourt Pascoal Bruna Biazon Palma fabio henrique mendonça chaim Marina Moreira de Castro Tiago Andrade Damázio Ana Paula Menezes de Freitas Franceschini Marciane Milanski Lício AugustoVelloso Raquel Franco Leal Inflammatory Bowel Disease Research Laboratory Colorectal Surgery UnitDepartment of SurgerySchool of Medical SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Metabolic Disorders School of Applied SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Cell Signaling School of Medical SciencesUniversity of CampinasCampinas 13083-864São PauloBrazil

The resolution of inflammation is an active process,guided by specialized proresolution lipid mediators(SPMs).These mediators originate from polyunsaturated fatty acids,such as *** evidence suggests that the beneficial effects attributed to omega-3 are,at least in part,the result of the immunomodulatory action of the SPMs,which act systemically by overcoming inflammation and repairing tissue damage,without suppressing the immune *** studies suggest that an imbalance in the synthesis and/or activity of these compounds may be associated with the pathogenesis of several inflammatory conditions,such as inflammatory bowel disease(IBD).Thus,this review highlights the advances made in recent years with regard to the endogenous synthesis and the biological role of lipoxins,resolvins,protectins,and maresins,as well as their precursors,in the regulation of inflammation;and provides an update on the participation of these mediators in the development and evolution of IBD and the therapeutic approaches that these immunomodulating substances are involved in this context.

关键词： Pro-resolving lipid mediators Anti-inflammatory cytokines Omega-3 Chronic inflammation Pro-inflammatory cytokines Inflammatory bowel disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Time-Series Embeddings from Language Models:A Tool for Wind Direction Nowcasting

引用

Journal of Meteorological Research 2024年第3期38卷 558-569页

作者： Decio ALVES fabio mendonCA Sheikh Shanawaz MOSTAFA Fernando MORGADO-DIAS University of Madeira Campus Universitário da Penteada9020-105FunchalPortugal Interactive Technologies Institute/Laboratory for Robotics and Engineering Systems and Agência Regional para o Desenvolvimento da Investigação Tecnologia e InovaçãoEdif.Madeira TecnopoloCaminho da Penteada piso-29020-105FunchalPortugal

Wind direction nowcasting is crucial in various sectors,particularly for ensuring aviation operations and *** this context,the TELMo(Time-series Embeddings from Language Models)model,a sophisticated deep learning architecture,has been introduced in this work for enhanced wind-direction *** by using three years of data from multiple stations in the complex terrain of an international airport,TELMo incorporates the horizontal u(east-west)and v(north-south)wind components to significantly reduce forecasting *** a day with high wind direction variability,TELMo achieved mean absolute error values of 5.66 for 2-min,10.59 for 10-min,and 14.79 for 20-min forecasts,processed within a swift 9-ms/step *** degree-based analysis,in comparison,yielded lower performance,emphasizing the effectiveness of the u and v *** contrast,a Vanilla neural network,representing a shallow-learning approach,underperformed in all analyses,highlighting the superiority of deep learning methodologies in wind direction *** is an efficient model,capable of accurately forecasting wind direction for air traffic operations,with an error less than 20°in 97.49%of the predictions,aligning with recommended international *** model design enables its applicability across various geographical locations,making it a versatile tool in global aviation meteorology.

关键词： wind nowcasting wind components wind direction time series prediction deep learning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ultrastructural features of the hypopharyngeal glands in the social wasp Polistes versicolor （Hymenoptera： Vespidae）

引用

Insect Science 2008年第3期15卷 277-284页

作者： fabio Barros Britto Flavio henrique Caetano Universidade Estadual Paulista Julio de Mesquita Filho Instituto de Bioci~ncias de Rio Claro - Depto. de Biologia Rio Claro SP Brazil

The wasps of the genus Polistes have been considered the key to understanding the evolution of social behavior in Hymenoptera. Several studies have shown that the development of organized insect societies was accompanied by the evolution of structures like exocrine glands, which became specialized to perform specific functions. This article investigates the ultrastructural and cytochemical features of the hypopharyngeal glands of Polistes versicolor. These glands have been studied in depth in social bees, where they occur only in nurses and produce the royal jelly. Our results＇ revealed that these glands basically did not vary among individuals or between sexes. They are constituted by spherical cells, each with a large nucleus and well-developed rough endoplasmic reticulum. Secretion vesicles are abundant, but lipid droplets were not observed, indicating that these glands may not have a role in pheromone synthesis. Acid phosphatase was detected in lysosomes, and also flee in the cytosol, but did not seem to be related with cell death. Thus, our results suggest that the hypopharyngeal glands ofP. versicolor may not have a specialized social role, but could produce digestive enzymes.

关键词： cellular cycle cytochemistry hypopharyngeal glands morphology Polistes,wasps

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic retina and optic nerve:galectin-3 participation

引用

Neural Regeneration Research 2020年第4期15卷 625-635页

作者： henrique Rocha mendonca Raul Carpi-Santos Karin da Costa Calaza Ana Maria Blanco Martinez Laboratorio de Neurodegeneracao e Reparo Departamento de PatologiaPrograma de Pos-graduacao em Anatomia PatologicaFaculdade de MedicinaHospital Universitrio Clementino Fraga FilhoFederal University of Rio de JaneiroRio de JaneiroBrazil Polo Universitario Macae Unidade Integrada de Pesquisa em Produtos Bioativos e BiocienciasFederal University of Rio de JaneiroMacaeBrazil Laboratorio Integrado de Morfologia Instituto de Biodiversidade e SustentabilidadeNucleo de Pesquisas Ecologicas de MacaeFederal University of Rio de JaneiroMacaeBrazil Laboratorio de Neurobiologia Celular Instituto de Ciencias BiomedicasCentro de Ciencias da SaudeFederal University of Rio de JaneiroRio de JaneiroBrazil Laboratorio de Neurobiologia da Retina Departamento de NeurobiologiaPrograma de Pos-Graduacao em NeurocienciasFluminense Federal UniversityNiteroiBrazil

Diabetes is a lifelong disease characterized by glucose metabolic imbalance,in which low insulin levels or impaired insulin signaling lead to hyperglycemic *** 20 years of diabetes progression,95%of patients will have diabetic retinopathy,the leading cause of visual defects in working-age people *** diabetes is considered a microvascular disease,recent studies have shown that neurodegeneration precedes vascular changes within the diabetic visual system,albeit its mechanisms are still under *** and oxidative stress are intrinsically related phenomena,since macrophage/microglia and astrocytes are the main sources of reactive oxygen species during central nervous system chronic degenerative diseases,and both pathological processes are increased in the visual system during *** present review will focus on recent findings of the contribution of oxidative stress derived from neuroinflammation in the early neurodegenerative aspects of the diabetic visual system and their relationship with galectin-3.

关键词： diabetes diabetic retinopathy galectin-3 neurodegeneration neuroinflammation optic nerve oxidative stress retina

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Erratum to “Time-Series Embeddings from Language Models:A Tool for Wind Direction Nowcasting”

引用

Journal of Meteorological Research 2024年第4期38卷 844-844页

作者： Decio ALVES fabio mendonCA Sheikh Shanawaz MOSTAFA Fernando MORGADO-DIAS University of Madeira Campus Universitario da Penteada 9020-105 FunchalPortugal Interactive Technologies Institute/Laboratory for Robotics and Engineering Systems and Agencia Regional para o Desenvolvimento da Investigaao Tecnologia e InovagaoEdif.Madeira TecnopoloCaminho da Penteada piso-29020-105 FunchalPortugal

The article “Time-series embeddings from language models: A tool for wind direction nowcasting”, written by Décio ALVES, Fábio mendon?A, Sheikh Shanawaz MOSTAFA, and Fernando MORGADO-DIAS was originally published ... 详细信息

关键词： Embedding electronic Time

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of lysophosphatidic acid and its receptors in health and disease:novel therapeutic strategies

引用

Signal Transduction and Targeted Therapy 2021年第3期6卷 630-647页

作者： Luiz henrique Medeiros Geraldo Tania Cristina Leite de Sampaio Spohr Rackele Ferreira do Amaral Anna Carolina Carvalho da Fonseca Celina Garcia fabio de Almeida Mendes Catarina Freitas Marcos fabio dosSantos Flavia Regina Souza Lima Institute de Ciencias BiomedicasUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Universite de Paris PARCCINSERMF-75015 ParisFrance Institute Estadual do Cerebro Paulo Niemeyer-Secretaria de Estado de Saude Rio de JaneiroBrazil Instituto de Saiide de Nova Friburgo Universidade Federal Fluminense28625-650 Nova FriburgoBrazil

Lysophosphatidic acid(LPA)is an abundant,bioactive phospholipid,with multiple functions both in development and in pathological ***,we review the literature about the differential signaling of LPA through its specific receptors,which makes this lipid a versatile signaling *** differential signaling is important for understanding how this molecule can have such diverse effects during central nervous system development and angiogenesis;and also,how it can act as a powerful mediator of pathological conditions,such as neuropathic pain,neurodegenerative diseases,and cancer ***,we review the preclinical and clinical uses of Autotaxin,LPA,and its receptors as therapeutic targets,approaching the most recent data of promising molecules modulating both LPA production and *** review aims to summarize the most update knowledge about the mechanisms of LPA production and signaling in order to understand its biological functions in the central nervous system both in health and disease.

关键词： therapeutic clinical diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular approaches for spinal cord injury treatment

引用

Neural Regeneration Research 2023年第1期18卷 23-30页

作者： Fernanda Martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos Santos Caio Andrade Prins Fellipe Soares dos Santos Cardoso Luiza dos Santos Heringer henrique Rocha mendonça Ana Maria Blanco Martinez Laboratório de Neurodegeneração e Reparo Programa de Pós-Graduação em Medicina:Anatomia PatológicaDepartamento de PatologiaFaculdade de MedicinaHospital Universitário Clementino Fraga FilhoCentro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Ciências Biomédicas Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Biologia Departamento de NeurobiologiaLaboratório de Regeneração Neural e FunçãoUFFRio de JaneiroBrazil Laboratório Integrado de Morfologia Instituto de Biodiversidade e Sustentabilidade NUPEMPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisCentro Multidisciplinar UFRJ-MacaéUniversidade Federal do Rio de JaneiroMacaéBrazil

Injuries to the spinal cord result in permanent disabilities that limit daily life *** main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic *** decades of research,there is still no efficient treatment for spinal cord *** strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord *** these,molecular compounds are currently being used for neurological recovery,with promising *** molecules target the axon collapsed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost *** this review we focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,growth and neurotrophic factors,enzymes,and *** mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans.

关键词： axonal regeneration drugs enzymes growth factors molecular therapy neurotrophic factors purines spinal cord injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association between Ebstein Anomaly and Coronary Artery Disease： A Report Case

引用

Journal of Pharmacy and Pharmacology 2018年第5期6卷 488-494页

作者： Larissa Biolchini fabio Gouvea Isabela Furtado Walter Gusmao henrique Veiga Bruno Paolino Department of Cardiology Pedro Ernesto University Hospital State University of Rio de Janeiro Rio de Janeiro 20.551-030 Brazil

The intention of this article is to report a case of a 26 years old man presenting a rare combination of congenital heart disease （Ebstein anomaly） and coronary artery disease. EA （Ebstein anomaly） has a prevalence of 1% of all congenital heart diseases, as CAD （coronary artery disease） has a little evidence in literature＇s registries when occurred in individuals with 40 years old or less. Therefore, this case report rises attention to the rarity of those patologies, which individually are already considerably rare and, in this case, it comes associated what turns this diagnosis excepcional, highlighting the complexity of the treatment.

关键词： Ebstein infarction young.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-throughput phenotyping of two plant-size traits of Eucalyptus species using neural networks

引用

Journal of Forestry Research 2022年第2期33卷 591-599页

作者： Marcus Vinicius Vieira Borges Janielle de Oliveira Garcia Tays Silva Batista Alexsandra Nogueira Martins Silva fabio henrique Rojo Baio Carlos Antônio da Silva Junior Gileno Brito de Azevedo Glauce Taís de Oliveira Sousa Azevedo Larissa Pereira Ribeiro Teodoro Paulo Eduardo Teodoro Federal University of Mato Grosso Do Sul(UFMS) Chapadão Do SulMato Grosso Do Sul 79560000Brazil Department of Geography State University of Mato Grosso(UNEMAT)SinopMato Grosso 78555000Brazil

In forest modeling to estimate the volume of wood,artificial intelligence has been shown to be quite effi-cient,especially using artificial neural networks(ANNs).Here we tested whether diameter at breast height(DBH)and the total plant height(Ht)of eucalyptus can be pre-dicted at the stand level using spectral bands measured by an unmanned aerial vehicle(UAV)multispectral sensor and vegetation *** do so,using the data obtained by the UAV as input variables,we tested different configurations(number of hidden layers and number of neurons in each layer)of ANNs for predicting DBH and Ht at stand level for different Eucalyptus *** experimental design was randomized blocks with four replicates,with 20 trees in each experimental *** treatments comprised five Eucalyptus species(***,***,***,***-dis,and ***)and Corymbria *** and Ht for each plot at the stand level were measured seven times in separate overflights by the UAV,so that the multispectral sensor could obtain spectral bands to calculate vegetation indices(VIs).ANNs were then constructed using spectral bands and VIs as input layers,in addition to the categorical variable (species), to predict DBH and Ht at the stand level simultaneously. This report represents one of the first appli-cations of high-throughput phenotyping for plant size traits in Eucalyptus species. In general, ANNs containing three hidden layers gave better statistical performance (higher esti-mated r, lower estimated root mean squared error-RMSE) due to their greater capacity for self-learning. Among these ANNs, the best contained eight neurons in the first layer, seven in the second, and five in the third (8 − 7 − 5). The results reported here reveal the potential of using the gener-ated models to perform accurate forest inventories based on spectral bands and VIs obtained with a UAV multispectral sensor and ANNs, reducing labor and time.

关键词： Computational intelligence Diameter at breast height Forest inventory Remote sensing Vegetation indices

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Design, Development and Geometric Error Analysis of an Aerostatic Rotary Table

引用

Journal of Mechanics Engineering and Automation 2016年第3期6卷 133-147页

作者： Verilton Nunes da Silva Luiz henrique Melo Silva Nobrega fabio de Andrade Barroso Rafael Franklin Alves Silva Jobson Francisco da Silva Jose Carlos de Lima JUnior and Joaio Bosco de Aquino Silva

Rotary tables are equipments in precision machinery applied in five-axis Machine Tools and CMM （Coordinate Measuring Machines）, offering rotational （C-axis） and tilting motion （A-axis）, allowing the obtaining of several configurations for manufacturing or inspection of parts with complex geometries. The demand for high accuracy, high efficiency and fewer errors in the positioning of the part in precision machines increases every day, thus ensuring their high confidence and the use of aerostatic bearings enable constructive innovations to the equipment. In this context, this work presents the mechanical design, the development and error analysis of a prototype of an aerostatic rotary table. This study emphasizes the analysis of a prototype that uses the air as a working principle for reducing friction between moving parts, increasing the mechanical efficiency, and its influence of motion error is also discussed based on the experimental results. For the geometrical errors analysis, experimental tests were realized in laboratory using a DBB （Double Ballbar）. The tests are performed with only one axis moving, observing the behavior of the system for different feedrate at the C-axis.

关键词： Rotary tables aerostatic bearings double ballbar geometric errors coordinate measuring machines.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：