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Immune mediators in the tumor microenvironment of prostate cancer

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Chinese Journal of Cancer 2017年第3期36卷 131-138页

作者： Jinlu Dai Yi Lu Hernan Roca Jill M. Keller Jian Zhang Laurie K. McCauley evan T. Keller Department of Urology and Biointerfaces Institute University of MichiganAnn Arbor MI 48109 USA Center for Translational Medicine Guangxi Medical University Nanning Guangxi 520021 P. R. China Periodontics and Oral Medicine School of Dentistry University of Michigan Ann Arbor MI 48109 USA Department of Urology University of Michigan Ann Arbor MI 48109.8940 USA

Prostate cancer tissue is composed of both cancer cells and host *** milieu of host components that compose the tumor is termed the tumor microenvironment(TME).Host cells can be those derived from the tissue in which the tumor originates(e.g.,fibroblasts and endothelial cells)or those recruited,through chemotactic or other factors,to the tumor(e.g.,circulating immune cells).Some immune cells are key players in the TME and represent a large proportion of non-tumor cells found within the *** cells can have both anti-tumor and pro-tumor *** addition,crosstalk between prostate cancer cells and immune cells affects immune cell *** this review,we focus on immune cells and cytokines that contribute to tumor *** discuss T-regulatory and T helper17 cells and macrophages as key modulators in prostate cancer *** addition,we discuss the roles of interleukin-6 and receptor activator of nuclear factor kappa-B ligand in modulating prostate cancer *** review highlights the concept that immune cells and cytokines offer a potentially promising target for prostate cancer therapy.

关键词： Prostate cancer Tumor microenvironment Macrophage T-regulatory cell Th17 cell Interleukin-6 Receptor activator of nuclear factor kappa-B ligand

Human immunodeficiency virus patients with low CD4 counts are more likely to have precancerous polyps identified during index colonoscopy

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世界胃肠内镜杂志:英文版(电子版) 2023年第9期15卷 545-552页

作者： Michelle Likhtshteyn evan Marzouk Fray M Arroyo-Mercado Gurasees Chawla Sabrina Rosengarten Renata Lerer Hector Ojeda-Martinez Savanna Thor Department of Gastroenterology SUNY Downstate Health Sciences UniversityBrooklynNY 11203United States Department of Internal Medicine and Pediatrics Baystate Medical CenterSpringfieldIL 01199United States Department of Gastroenterology University of New MexicoAlbuquerqueNM 87106United States Department of Emergency Medicine New York-Presbyterian Queens HospitalQueensNY 11355United States Department of Gastroenterology University of PennsylvaniaPhiladelphiaPA 19104United States Department of Infectious Disease Nuvance Health-Vassar Brothers Medical CenterPoughkeepsieNY 12601United States

BACKGROUND Antiretroviral treatment(ART)has improved the life expectancy of patients living with human immunodeficiency virus(HIV).As these patients age,they are at increased risk for developing non-acquired immunodeficiency syndrome defining malignancies(NADMs)such as colon *** To determine which factors are associated with the development of precancerous polyps on screening colonoscopy in patients with HIV and to investigate whether HIV disease status,measured by viral load and CD4 count,might influence precancerous polyp *** A retrospective review of records at two urban academic medical centers was performed for HIV patients who had a screening colonoscopy between *** with a history of colorectal cancer or polyps,poor bowel preparation,or inflammatory bowel disease were *** data such as sex,age,race,and body mass index(BMI)as well as information regarding the HIV disease status such as CD4 count,viral load,and medication regimen were ***-controlled patients were defined as those that had viral load500(P=0.0276).In patients with CD4>500,53.85%of patients were female,and 70.87%of patients with CD

关键词： Colonoscopy Non-acquired immunodeficiency syndromes defining malignancies Human immunodeficiency virus Adenoma detection rate Antiretroviral treatment Advanced adenoma

Weave geometry generation avoiding interferences for mesoscale RVEs

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Journal of Materials Science & Technology 2019年第12期35卷 2869-2882页

作者： Daniel Höwer Shengkai Yu Trenton M.Ricks Brett A.Bednarcyk evan J.Pineda Bertram Stier Stefanie Reese Jaan-Willem Simon Institute of Applied Mechanics RWTH Aachen University52074 AachenGermany NASA Glenn Research Center ClevelandOH 44135USA Collier Research and Development Corporation Newport NewsVA 23606USA

An algorithm which allows the generation of representative volume elements(RVEs) for complex woven and warp-interlaced fiber-reinforced composite topologies while avoiding unphysical tow intersections is presented. This is achieved by extending an existing RVE generation strategy in two significant ways:(1) the local cross section shape of the tow is adjusted depending on the local tow curvature in a way that preserves the cross sectional area of the tow, and(2) the elementary crimp interval is separated into a planar and a transition region. The modifications facilitate the generation of a wide range of elaborate textile topologies without tow intersections, which are present without the proposed modifications unless complex tow to tow contact models are introduced. The mechanical properties of plain weaves were predicted based on the topology generated with the proposed algorithm as well as based on RVEs which were constructed based on actual micrographs, i.e. a "digital twin" of the actual microstructure. A comparison of the predicted mechanical properties based on finite element and Multiscale Generalized Method of Cells techniques shows close agreement. However, some differences exist with respect to experimentally determined material parameters due to the finite dimensions of the specimens. Lastly,mechanical properties of multilayered weaves are predicted with the finite element method. The considered material systems are carbon fiber in epoxy matrix as well as C/C-SiC. However, the procedure is applicable to a wide range of material systems.

关键词： RVE generation Multiscale analysis Composites

Atlas of Essential Orthopaedic Procedures 1

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Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

2013年

作者： American Academy of Orthopaedic Surgeons evan Flatow Alexis Chiang Colvin

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四川生理科学杂志 2020年第4期42卷 468-468页

作者： evan J Anderson From the Center for Childhood Infections and Vaccines of Children’s Healthcare of Atlanta and the Department of Pediatrics Emory University School of Medicine (E.J.A. V.V.E. K.F. M.S.S. C.A.R.) and Emory Vaccine Center Yerkes National Primate Research Center Emory University (M.S.S.) Atlanta and Hope Clinic Department of Medicine Emory University School of Medicine Decatur (E.J.A. N.G.R. V.K.P.) — both in Georgia the Vaccine Research Center (A.T.W. A.B.M. B.F. B.C.L. N.A.D.-R. S.O. S.D.S. K.S.C. P.A.S. M.P. J.E.L. B.S.G.) and the Division of Microbiology and Infectious Diseases (P.C.R. M. Makhene W.B. C.J.L. J.H.B.) National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda the University of Maryland School of Medicine Baltimore (K.M.N.) and the Emmes Company Rockville (M. Makowski J.A. K.C.) — all in Maryland Kaiser Permanente Washington Health Research Institute Seattle (L.A.J.) the Department of Pediatrics (J.D.C. M.R.D. L.J.S. A.J.P.) the Vanderbilt Institute for Infection Immunology and Inflammation (J.D.C. M.R.D. A.J.P.) and the Departments of Pathology Microbiology and Immunology (M.R.D.) Vanderbilt University Medical Center Nashville Moderna Cambridge MA (H.B. B.L.) and the Departments of Epidemiology and Microbiology and Immunology University of North Carolina at Chapel Hill Chapel Hill (D.R.M. R.B.).

Background:Testing of vaccine candidates to prevent infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in an older population is important,since increased incidences of illness and death from co... 详细信息

关键词： vaccine acute respiratory

The Expedition of Humphry Clinker

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The Expedition of Humphry Clinker

Uniformly dispersed FeOx atomic clusters by pulsed arc plasma deposition： An efficient electrocatalyst for improving the performance of Li-O2 battery

作者： Tobias Smollet Edited by evan Gottlieb Oregon State University.

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Nano Research 2016年第7期9卷 1913-1920页

作者： Xiangyi Luo Jun Lu evan Sohm Lu Ma Tianpin Wu Jianguo Wen Dantong Qiu YunKai Xu Yang Ren Dean J. Miller Khalil Amine Material Sciences Division Argonne National Laboratory Argonne IL 60439 USA Chemical Sciences and Engineering Division Argonne National Laboratory Argonne IL 60439 USA ULVAC Technologies Inc. Methuen MA 01844 USA Center for N anoscale Materials Nanoscience and Technology Argonne National Laboratory Argonne IL 60439 USA Advanced Photon Source Argonne National Laboratory Argonne IL 60439 USA Center for Nanoscale Materials Nanoscience and Technology Argonne Notional Laboratory Argonne IL 60439 USA

The present study explored a new method to improve the catalytic activity of non-precious metals, especially in electrochemical reactions. Highly ionized Fe plasma produced by arc discharge was uniformly deposited on a porous carbon substrate and formed atomic clusters on the carbon surface. The as-prepared FeO~/C material was tested as a cathode material in a rechargeable Li-02 battery under different current rates. The results showed significant improvement in battery performance in terms of both cycle life and reaction rate. Furthermore, X-ray diffraction （XRD） and scanning electron microscopy （SEM） results showed that the as-prepared cathode material stabilized the cathode and reduced side reactions and that the current rate was a critical factor in the nucleation of the discharge products.

关键词： Li-O2 battery FeOx atomic cluster electrocatalyst pulsed arc plasmadeposition (APD)

Biomolecular hydration dynamics probed with 2D-IR spectroscopy:From dilute solution to a macromolecular crowd

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Chinese Chemical Letters 2015年第4期26卷 435-438页

作者： John T.King evan J.Arthur Derek G.Osborne Charles L.Brooks Ⅲ Kevin J.Kubarych Department of Chemistry University of Michigan LSA Biophysics University of Michigan Department of Materials Science and Engineering University of Illinois

Although it is well known that water is essential for biological function, it has been a challenge to determine how water behaves near biomacromolecular interfaces, and what role water plays in influencing the dynamics of the biochemical machinery. By adopting a vibrational labeling strategy coupled with ultrafast two-dimensional infrared （2D-IR） spectroscopy, it has recently become possible to study hydration dynamics, site specifically at the surface of proteins and model membranes. We review our recent progress in measuring hydration dynamics in contexts ranging from small-molecule solutes to biomacromolecules in dilute, viscous, and crowded environments.

关键词： Protein hydration dynamicsMembrane dynamicsUltrafast infrared spectroscopy

Prostate cancer tends to metastasize in the bone-mimicking microenvironment via activating NF-κB signaling

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The Journal of Biomedical Research 2018年第5期32卷 343-353页

作者： Haibo Tong Chunlin Zou Siyuan Qin Jie Meng evan T.Keller Jian Zhang Yi Lu Key Laboratory of Longevity and Aging-related Diseases Guangxi Medical University Ministry of Education Nanning Guangxi 530021 China Southern University of Science and Technology School of Medicine Shenzhen Guangdong 518055 China Department of Pathology and Internal Medicine University of Michigan Ann Arbor MI 48109 USA

Prostate cancer preferentially metastasizes to the bone. However, the underlying molecular mechanisms are still unclear. To explore the effects of a bone-mimicking microenvironment on PC3 prostate cancer cell growth and metastasis, we used osteoblast differentiation medium（ODM; minimal essential medium alpha supplemented with L-ascorbic acid） to mimic the bone microenvironment. PC3 cells grown in ODM underwent epithelial-mesenchymal transition and showed enhanced colony formation, migration, and invasion abilities compared to the cells grown in normal medium. PC3 cells grown in ODM showed enhanced metastasis when injected in mice. A screening of signaling pathways related to invasion and metastasis revealed that the NF-κB pathway was activated, which could be reversed by Bay 11-7082, a NF-κB pathway inhibitor. These results indicate that the cells in different culture conditions manifested significantly different biological behaviors and the NF-κB pathway is a potential therapeutic target for prostate cancer bone metastasis.

关键词： prostate cancer metastasis NF-κB Bay 11-7082 EMT