Human immunodeficiency virus patients with low CD4 counts are more likely to have precancerous polyps identified during index colonoscopy

作     者：Michelle Likhtshteyn Evan Marzouk Fray M Arroyo-Mercado Gurasees Chawla Sabrina Rosengarten Renata Lerer Hector Ojeda-Martinez Savanna Thor 

作者机构：Department of GastroenterologySUNY Downstate Health Sciences UniversityBrooklynNY 11203United States Department of Internal Medicine and PediatricsBaystate Medical CenterSpringfieldIL 01199United States Department of GastroenterologyUniversity of New MexicoAlbuquerqueNM 87106United States Department of Emergency MedicineNew York-Presbyterian Queens HospitalQueensNY 11355United States Department of GastroenterologyUniversity of PennsylvaniaPhiladelphiaPA 19104United States Department of Infectious DiseaseNuvance Health-Vassar Brothers Medical CenterPoughkeepsieNY 12601United States 

出 版 物：《世界胃肠内镜杂志:英文版(电子版)》 (World Journal of Gastrointestinal Endoscopy)

年 卷 期：2023年第15卷第9期

页      面：545-552页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The project “Adenoma prevalence characteristics and outcomes on screening colonoscopy in patients with HIV in an Urban Safety Net Hospital and Urban University Hospital”was approved by SUNY Downstate Health Sciences IRB on October 13 2020 No.1306045 

主　　题：Colonoscopy Non-acquired immunodeficiency syndromes defining malignancies Human immunodeficiency virus Adenoma detection rate Antiretroviral treatment Advanced adenoma 

摘      要：BACKGROUND Antiretroviral treatment(ART)has improved the life expectancy of patients living with human immunodeficiency virus(HIV).As these patients age,they are at increased risk for developing non-acquired immunodeficiency syndrome defining malignancies(NADMs)such as colon *** To determine which factors are associated with the development of precancerous polyps on screening colonoscopy in patients with HIV and to investigate whether HIV disease status,measured by viral load and CD4 count,might influence precancerous polyp *** A retrospective review of records at two urban academic medical centers was performed for HIV patients who had a screening colonoscopy between *** with a history of colorectal cancer or polyps,poor bowel preparation,or inflammatory bowel disease were *** data such as sex,age,race,and body mass index(BMI)as well as information regarding the HIV disease status such as CD4 count,viral load,and medication regimen were ***-controlled patients were defined as those that had viral load500(P=0.0276).In patients with CD4500,53.85%of patients were female,and 70.87%of patients with CD