检索结果-南通市图书馆

Description of two new species of Hemiphyllodactylus(Reptilia: Gekkonidae) from karst landscapes in Yunnan, China, highlights complex conservation needs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2022年第5期43卷 767-786页

作者： Ade Prasetyo Agung Ada Chornelia L.lee Grismer Jesse L.Grismer evan S.H.Quah Jian-Mei Lu Kyle W.Tomlinson Alice C.Hughes Landscape Ecology Group Center for Integrative ConservationXishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan 666303China University of Chinese Academy of Sciences Beijing 101408China Herpetology Laboratory Department of BiologyLa Sierra UniversityRiversideCalifornia 92515USA Institute for Tropical Biology and Conservation Universiti Malaysia SabahJalan UMSKota KinabaluSabah 88400Malaysia lee Kong Chian Natural History Museum National University of SingaporeSingapore 117377Singapore Community Ecology and Conservation Group Center for Integrative ConservationXishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan 666303China School of Biological Sciences University of Hong KongPokfulamHong Kong SARChina

Karst habitats are hotspots of diversity and endemism. Their naturally fragmented distributions across broad geographic landscapes have led to the complex array of smaller evolutionary ecosystems that present unique challenges from a conservation *** assessments of karst habitats have revealed that these ecosystems contain an almost unparalleled level of endemism, and many site-restricted species remain undescribed, thus posing considerable challenges for effective conservation *** rock-dwelling species, such as geckos, may be particularly prone to such isolation. In this paper, we discuss one such genus, i.e.,Hemiphyllodactylus, and explore its diversity across karst landforms in Yunnan Province, southwestern China. Based on morphological and genetic data, we describe two new species of Hemiphyllodactylus from karst habitats in Simao District and Yanshan County. A phylogenetic tree for Hemiphyllodactylus was constructed using 1?039 base pairs(bp) of the mitochondrial NADH dehydrogenase subunit 2 gene(ND2). The Simao and Yanshan specimens can be distinguished from all other congeners within their respective subclades based on uncorrected genetic pairwise distances greater than 6.3% and 4.3%respectively, as well as significant morphological differences. The discovery and description of these two new species brings the total number of described Hemiphyllodactylus species in China to 14and indicates many more undescribed species from unsurveyed karst regions await *** findings suggest that karst ecosystems in Yunnan support a higher diversity of Hemiphyllodactylus than previously *** study also highlights the importance of karst ecosystems as refugia for sitespecific endemic species and the need for heightened conservation efforts.

关键词： Discovery Endemism Geckos Reptiles South China

Mako:A Graph-based Pattern Growth Approach to Detect Complex Structural Variants

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2022年第1期20卷 205-218页

作者： Jiadong Lin Xiaofei Yang Walter Kosters Tun Xu Yanyan Jia Songbo Wang Qihui Zhu Mallory Ryan Li Guo Chengsheng Zhang The Human Genome Structural Variation Consortium Charles lee Scott E.Devine evan E.Eichler Kai Ye School of Automation Science and Engineering Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China MOE Key Lab for Intelligent Networks&Networks Security Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China Genome Institute the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Leiden Institute of Advanced Computer Science Faculty of ScienceLeiden UniversityLeiden 2311EZNetherland School of Computer Science and Technology Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China The Jackson Laboratory for Genomic Medicine FarmingtonCT 06032USA Precision Medicine Center the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Institute for Genome Sciences University of Maryland School of MedicineBaltimoreMD 21201USA Department of Genome Sciences University of Washington School of MedicineSeattleWA 98119USA Howard Hughes Medical Institute University of WashingtonSeattleWA 98195USA The School of Life Science and Technology Xi’an Jiaotong UniversityXi’an 710049China 不详

Complex structural variants(CSVs) are genomic alterations that have more than two breakpoints and are considered as the simultaneous occurrence of simple structural ***,detecting the compounded mutational signals of CSVs is challenging through a commonly used model-match *** a result,there has been limited progress for CSV discovery compared with simple structural ***,we systematically analyzed the multi-breakpoint connection feature of CSVs,and proposed Mako,utilizing a bottom-up guided model-free strategy,to detect CSVs from paired-end short-read ***,we implemented a graph-based pattern growth approach,where the graph depicts potential breakpoint connections,and pattern growth enables CSV detection without pre-defined *** evaluations on both simulated and real datasets revealed that Mako outperformed other ***,validation rates of CSVs on real data based on experimental and computational validations as well as manual inspections are around 70%,where the medians of experimental and computational breakpoint shift are 13 bp and 26 bp,***,the Mako CSV subgraph effectively characterized the breakpoint connections of a CSV event and uncovered a total of 15 CSV types,including two novel types of adjacent segment swap and tandem dispersed *** analysis of these CSVs also revealed the impact of sequence homology on the formation of *** is publicly available at https://***/xjtu-omics/Mako.

关键词： Next-generation sequencing Complex structural variant Pattern growth Graph mining Formation mechanism

Snapshot Mueller spectropolarimeter imager

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2023年第5期9卷 271-279页

作者： Tianxiang Dai Thaibao Phan evan W.Wang Soonyang Kwon Jaehyeon Son Myungjun lee Jonathan A.Fan Department of Electrical Engineering Stanford UniversityStanfordCA 94305USA Equipment R&D Team 4 Mechatronics ResearchSamsung Electronics Co.LtdGyeonggi-do 18848Republic of Korea

We introduce an imaging system that can simultaneously record complete Mueller polarization responses for a set of wavelength channels in a single image *** division-of-focal-plane concept combines a multiplexed illumination scheme based on Fourier optics together with an integrated telescopic light-field imaging ***-resolved imaging is achieved using broadband nanostructured plasmonic polarizers as functional pinhole *** recording of polarization and wavelength information on the image sensor is highly *** also develop a calibration approach based on a customized neural network architecture that can produce calibrated measurements in *** a proof-of-concept demonstration,we use our calibrated system to accurately reconstruct a thin film thickness map from a four-inch *** anticipate that our concept will have utility in metrology,machine vision,computational imaging,and optical computing platforms.

关键词： polarization image Snapshot

Molecular basis of cranial suture biology and disease:Osteoblastic and osteoclastic perspectives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2014年第1期1卷 120-125页

作者： Maureen Beederman evan M.Farina Russell R.Reid Section of Plastic&Reconstructive Surgery Department of SurgeryThe University of Chicago Medical Center5841 South Maryland AvenueMC 6035ChicagoIL 60637USA Pritzker School of Medicine and The Laboratory of Craniofacial BiologyUniversity of Chicago MedicineChicagoIL 60637USA

The normal growth and development of the skull is a tightly regulated process that occurs along the osteogenic interfaces of the cranial ***,the borders of the calvarial bones and neighboring tissues above and below,function as a *** coordinated remodeling efforts of bone deposition and resorption,the cranial sutures maintain a state of patency from infancy through early adulthood as the skull continues to grow and accommodate the developing brain’s demands for ***,when this delicate balance is disturbed,a number of pathologic conditions ensue;and if left uncorrected,may result in visual and neurocognitive impairments.A prime example includes craniosynostosis,or premature fusion of one or more cranial and/or facial suture(s).At the present time,the only therapeutic measure for craniosynostosis is surgical correction by cranial vault ***,elegant studies performed over the past decade have identified several genes critical for the maintenance of suture patency and induction of suture *** deeper understandings of the pathogenesis and molecular mechanisms that regulate suture biology may provide necessary insights toward the development of non-surgical therapeutic alternatives for patients with cranial suture *** this review,we discuss the intricate cellular and molecular interplay that exists within the suture among its three major components:dura mater,osteoblastic related molecular pathways and osteoclastic related molecular pathways.

关键词： Cranial sutures Craniosynostosis Dura mater Osteoblasts Osteoclasts

Air-Stable Ultrabright Inverted Organic Light-Emitting Devices with Metal Ion-Chelated Polymer Injection Layer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2022年第1期14卷 239-249页

作者： Shihao Liu Chunxiu Zang Jiaming Zhang Shuang Tian Yan Wu Dong Shen Letian Zhang Wenfa Xie Chun-Sing lee State Key Laboratory of Integrated Optoelectronics College of Electronics Science and EngineeringJilin University2699 Qianjin StreetChangchun 130012People’s Republic of China Department of Chemistry Center of Super-Diamond and Advanced Films(COSDAF)City University of Hong KongKowloonHong KongPeople’s Republic of China

Here,this work presents an air-stable ultrabright inverted organic lightemitting device(OLED)by using zinc ionchelated polyethylenimine(PEI)as electron injection *** zinc chelation is demonstrated to increase the conductivity of the PEI by three orders of magnitude and passivate the polar amine *** these physicochemical properties,the inverted OLED shows a record-high external quantum efficiency of 10.0% at a high brightness of 45,610 cd m^(-2) and can deliver a maximum brightness of 121,865 cd m^(-2).Besides,the inverted OLED is also demonstrated to possess an excellent air stability(humidity,35%)with a half-brightness operating time of 541 h@1000 cd m^(-2) without any protection nor encapsulation.

关键词： Air stability Ultrabright Electron injection Metal ion chelation Inverted organic light-emitting device

Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2017年第2期4卷 43-63页

作者： Cody S.lee Elliot S.Bishop Ruyi Zhang Xinyi Yu evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Laboratory of Craniofacial Biology and Development Section of Plastic and Reconstructive SurgeryDepartment of SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and the Affiliated Hospitals of Chongqing Medical UniversityChongqing 400016China Department of Laboratory Medicine and Clinical Diagnostics The Affiliated Yantai HospitalBinzhou Medical UniversityYantai 264100China Department of Immunology and Microbiology Beijing University of Chinese MedicineBeijing 100029China

With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted *** numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human *** is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene *** has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two *** all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue *** applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial *** fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral *** review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative *** challenges and future directions regarding the use of adenoviral vectors are also *** is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine.

关键词： Adenovirus Adenoviral vector Cell therapy Gene transfer Gene therapy Oncolytic virus Regenerative medicine Vaccine development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

卫星中导体的交调测量与分析

空间电子技术 1992年第2期 68-74页

作者： lee,jc 于洪喜

Total pancreatectomy with islet cell transplantation vs intrathecal narcotic pump infusion for pain control in chronic pancreatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第16期22卷 4160-4167页

作者： Mohamad Mokadem Lama Noureddine Thomas Howard lee Mc Henry Stuart Sherman evan L Fogel James L Watkins Glen A Lehman Division of Gastroenterology and Hepatology Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 United States Division of Nephrology and Hypertension Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa IA 52242 United States Community Health Network Indianapolis IN 46219 United States Division of Gastroenterology and Hepatology Indiana University Medical Center Indianapolis IN 46202 United States

AIM: To evaluate pain control in chronic pancreatitis patients who underwent total pancreatectomy with islet cell transplantation or intrathecal narcotic pump ***: We recognized 13 patients who underwent intrathecal narcotic pump(ITNP) infusion and 57 patients who underwent total pancreatectomy with autologous islet cell transplantation(TP + ICT) for chronic pancreatitis(CP) pain control between 1998 and 2008 at Indiana University Hospital. All patients had already failed multiple other modalities for pain control and the decision to proceed with either intervention was made at the discretion of the patients and their treating physicians. All patients were evaluated retrospectively using a questionnaire inquiring about their pain control(using a 0-10 pain scale), daily narcotic dose usage, and hospital admission days for pain control before each intervention and during their last follow-up. RESULTS: All 13 ITNP patients and 30 available TP + ICT patients were evaluated. The mean age was approximately 40 years in both groups. The median duration of pain before intervention was 6 years and 7 years in the ITNP and TP + ICT groups, respectively. The median pain score dropped from 8 to 2.5(on a scale of 0-10) in both groups on their last follow up. The median daily dose of narcotics also decreased from 393 mg equivalent of morphine sulfate to 8 mg in the ITNP group and from 300 mg to 40 mg in the TP + ICT group. No patient had diabetes mellitus(DM) before either procedure whereas 85% of those who underwent pancreatectomy were insulin dependent on their last evaluation despite ICT. CONCLUSION: ITNP and TP + ICT are comparable for pain control in patients with CP however with high incidence of DM among those who underwent TP + ICT. Prospective comparative studies and longer follow up are needed to better define treatment outcomes.

关键词： Chronic pancreatitis Intractable pain Total pancreatectomy Islet cell transplantation Intrathecal na

Flattening the biological age curve by improving metabolic health:to taurine or not to taurine,that’s the question

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2023年第11期20卷 813-823页

作者： Kwok M.Ho Anna lee William Wu Matthew T.V.Chan Lowell Ling Jeffrey Lipman Jason Roberts Edward Litton Gavin M.Joynt Martin Wong Department of Intensive Care Medicine Fiona Stanley HospitalPerthAustralia Medical School The University of Western AustraliaPerthAustralia School of Veterinary&Life Sciences Murdoch UniversityPerthAustralia Department of Anaesthesia&Intensive Care Prince of Wales HospitalChinese University of Hong KongHong KongChina Jamieson Trauma Institute Royal Brisbane and Women’s HospitalBrisbaneQueenslandAustralia Division of Anaesthesiology Critical Care Emergency and Pain Medicine Nîmes University HospitalUniversity of MontpellierNîmesFrance University of Queensland Centre for Clinical Research Faculty of MedicineThe University of QueenslandBrisbaneAustralia Herston Infectious Diseases Institute(HeIDI) Metro North HealthBrisbaneAustralia Departments of Pharmacy and Intensive Care Medicine Royal Brisbane and Women’s HospitalBrisbaneAustralia jc School of Public Health and Primary Care Centre for Health Education and Health PromotionChinese University of Hong KongHong KongChina School of Public Health Peking UniversityBeijingChina School of Public Health Fudan UniversityShanghaiChina

The aging population is an important issue around the world especially in developed *** med-ical advances have substantially extended life span,the same cannot be said for the duration of health *** are seeing in-creasing numbers of elderly people who are frail and/or have multiple chronic conditions;all of these can affect the quality of life of the elderly population as well as increase the burden on the healthcare *** is mechanistically related to common medical conditions such as diabetes mellitus,ischemic heart disease,cognitive decline,and frailty.A recently accepted concept termed‘Accelerated Biological Aging’can be diagnosed when a person’s biological age—as measured by biomarkers of DNA methylation—is older than their corresponding chronological ***,a conditionally essential amino acid,has received much attention in the past few years.A substantial number of animal studies have provided a strong scientific foundation sug-gesting that this amino acid can improve cellular and metabolic health,including blood glucose control,so much that it has been labelled one of the‘longevity amino acids’.In this review article,we propose the rationale that an adequately powered random-ized-controlled-trial(RCT)is needed to confirm whether taurine can meaningfully improve metabolic and microbiome health,and biological *** trial should incorporate certain elements in order to provide the much-needed evidence to guide doctors,and also the community at large,to determine whether this promising and inexpensive amino acid is useful in improving human metabolic health.

关键词： rational meaningful Taurine