Flattening the biological age curve by improving metabolic health:to taurine or not to taurine,that’s the question

作     者：Kwok M.Ho Anna Lee William Wu Matthew T.V.Chan Lowell Ling Jeffrey Lipman Jason Roberts Edward Litton Gavin M.Joynt Martin Wong Kwok M.Ho;Anna Lee;William Wu;Matthew T.V.Chan;Lowell Ling;Jeffrey Lipman;Jason Roberts;Edward Litton;Gavin M.Joynt;Martin Wong

作者机构：Department of Intensive Care MedicineFiona Stanley HospitalPerthAustralia Medical SchoolThe University of Western AustraliaPerthAustralia School of Veterinary&Life SciencesMurdoch UniversityPerthAustralia Department of Anaesthesia&Intensive CarePrince of Wales HospitalChinese University of Hong KongHong KongChina Jamieson Trauma InstituteRoyal Brisbane and Women’s HospitalBrisbaneQueenslandAustralia Division of Anaesthesiology Critical Care Emergency and Pain MedicineNîmes University HospitalUniversity of MontpellierNîmesFrance University of Queensland Centre for Clinical ResearchFaculty of MedicineThe University of QueenslandBrisbaneAustralia Herston Infectious Diseases Institute(HeIDI)Metro North HealthBrisbaneAustralia Departments of Pharmacy and Intensive Care MedicineRoyal Brisbane and Women’s HospitalBrisbaneAustralia JC School of Public Health and Primary CareCentre for Health Education and Health PromotionChinese University of Hong KongHong KongChina School of Public HealthPeking UniversityBeijingChina School of Public HealthFudan UniversityShanghaiChina 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2023年第20卷第11期

页      面：813-823页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100403[医学-营养与食品卫生学] 10[医学] 

基　　金：Department of Anaesthesia & Intensive Care of the Chinese University of Hong Kong 

主　　题：rational meaningful Taurine 

摘      要：The aging population is an important issue around the world especially in developed *** med-ical advances have substantially extended life span,the same cannot be said for the duration of health *** are seeing in-creasing numbers of elderly people who are frail and/or have multiple chronic conditions;all of these can affect the quality of life of the elderly population as well as increase the burden on the healthcare *** is mechanistically related to common medical conditions such as diabetes mellitus,ischemic heart disease,cognitive decline,and frailty.A recently accepted concept termed‘Accelerated Biological Aging’can be diagnosed when a person’s biological age—as measured by biomarkers of DNA methylation—is older than their corresponding chronological ***,a conditionally essential amino acid,has received much attention in the past few years.A substantial number of animal studies have provided a strong scientific foundation sug-gesting that this amino acid can improve cellular and metabolic health,including blood glucose control,so much that it has been labelled one of the‘longevity amino acids’.In this review article,we propose the rationale that an adequately powered random-ized-controlled-trial(RCT)is needed to confirm whether taurine can meaningfully improve metabolic and microbiome health,and biological *** trial should incorporate certain elements in order to provide the much-needed evidence to guide doctors,and also the community at large,to determine whether this promising and inexpensive amino acid is useful in improving human metabolic health.