Molecular basis of cranial suture biology and disease:Osteoblastic and osteoclastic perspectives

作     者：Maureen Beederman Evan M.Farina Russell R.Reid 

作者机构：Section of Plastic&Reconstructive SurgeryDepartment of SurgeryThe University of Chicago Medical Center5841 South Maryland AvenueMC 6035ChicagoIL 60637USA Pritzker School of Medicineand The Laboratory of Craniofacial BiologyUniversity of Chicago MedicineChicagoIL 60637USA 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2014年第1卷第1期

页      面：120-125页

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基　　金：The authors thank Justine C.Lee MD PhD of UCLA for providing the artwork for the figures.The reported work was supported in part by research grants from The American Society of Plastic Surgeons/Plastic Surgery Foundation’s(PSF)Pilot Research Grant Program and the American Society of Craniofacial Surgeons/Komedyplast Foundation Award.MB and EMF were recipients of the Pritzker Research Fellowship funded through a NIH T-35 training grant(NIDDK).MB was a recipient of the Alpha Omega Alpha Carolyn L.Kuckein Research Fellowship.RRR was a recipient of the Clinical Investigator Award/Mentored Research Award DE020140-01(NIDCR)from the National Institutes of Health 

主　　题：Cranial sutures Craniosynostosis Dura mater Osteoblasts Osteoclasts 

摘      要：The normal growth and development of the skull is a tightly regulated process that occurs along the osteogenic interfaces of the cranial ***,the borders of the calvarial bones and neighboring tissues above and below,function as a *** coordinated remodeling efforts of bone deposition and resorption,the cranial sutures maintain a state of patency from infancy through early adulthood as the skull continues to grow and accommodate the developing brain’s demands for ***,when this delicate balance is disturbed,a number of pathologic conditions ensue;and if left uncorrected,may result in visual and neurocognitive impairments.A prime example includes craniosynostosis,or premature fusion of one or more cranial and/or facial suture(s).At the present time,the only therapeutic measure for craniosynostosis is surgical correction by cranial vault ***,elegant studies performed over the past decade have identified several genes critical for the maintenance of suture patency and induction of suture *** deeper understandings of the pathogenesis and molecular mechanisms that regulate suture biology may provide necessary insights toward the development of non-surgical therapeutic alternatives for patients with cranial suture *** this review,we discuss the intricate cellular and molecular interplay that exists within the suture among its three major components:dura mater,osteoblastic related molecular pathways and osteoclastic related molecular pathways.