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Congenital absence of the splenic artery and splenic vein accompanied with a duodenal ulcer and deformity

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World Journal of Gastroenterology 2009年第11期15卷 1401-1403页

作者： eun Kyung Shin Won Moon Seun Ja Park Moo In Park Kyu Jong Kim Jee Suk Lee Jin Hwan kwon Department of Gastroenterology Kosin University College of MedicineBusanSouth Korea Department of Radiology Kosin University College of MedicineBusanSouth Korea

Congenital absence of the splenic artery is a very rare *** the best of our knowledge, congenital absence of the splenic artery accompanied with absence of the splenic vein has not been *** report a case of the absence of the splenic artery and vein in a 61-year-old woman who presented with postprandial epigastric discomfort. Upper gastrointestinal endoscopy showed a dilated, pulsatile vessel in the fundus and duodenal stenosis. An abdominal computed tomography(CT)scan revealed absence of the splenic vein with a tortuously engorged gastroepiploic ***-dimensional CT demonstrated the tortuously dilated left gastric artery and the left gastroepiploic artery with non-visualization of the splenic *** administration of a proton pump inhibitor,abdominal symptoms resolved without any recurrence of symptoms during 6 mo of follow-up.

关键词： Congenital Anomaly Splenic artery Splenic vein Duodenum Ulcer Deformity

Effects of Trekking Pole Use on Metabolic Cost in Novice Hikers on Steep Terrains

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Journal of Sports Science 2017年第5期5卷 256-264页

作者： Yong bin Han Ik Jin kwon Dae Taek Lee eun Jin Hwang Jong Kwang Kim eun Hyung Cho Graduate Program of Sports Engineering Convergence Kookmin University Seou102 707 Korea Department of Sports Health and Rehabilitation Kookmin University Seou102707 Korea Graduate School of Sports Natural Science Kookmin University Seou102707 Korea College of Sport Science Sung Kyun Kwan University Gyeonggi-do 16419 Korea

PURPOSE： This study examined whether the use of trekking poles alters metabolic cost in steep hiking by novice hikers and whether the response would be dependent on the grade of the terrain. METHODS： Twelve participants completed two trekking trials （with poles [WP] and without trekking poles [NP]） with round trips comprising three grades： 7.0 ± 0.7°, 12.9 ± 0.7°, and 18.8 ± 1.3°） over a steep mountain at self-paced speeds. During the trials, time spent for trekking （TT）, oxygen consumption （VO2）, heart rate （HR）, ratings of perceived exertion （RPE）, and step frequency （Sf） were measured, and step efficiency （Se） and oxygen pulse （OP） were calculated. RESULTS： TT tended to be longer in the WP than NP for both terrains （P 〈 0.05）. HR, VO2, and RPE were the same for the WP and NP. Sfwas lower in WP going uphill （P 〈 0.05） but was unchanged going downhill. Se in the WP was higher than in the NP for both terrains （P 〈 0.01）. When analyzed by slope, VO2 during uphill at 18.8° was lower in WP （37.2 ± 6.3） than in NP （38.6 ± 7.1 ml .kg-1 .min-1, P 〈 0.05）, but no difference in VO2 was found between WP and NP at the 12.9° and 7.0°. TT during uphill was slower in WP than NP at 12.9°（7.9± 1.1 vs. 7.4 ± 1.0） and 18.8° （5.3 ± 1.3 vs. 4.9± 1.0 min, respectively, P 〈 0.05）. No differences were noticed in HR and OP during uphill at every grade. CONCLUSIONS： Pole use decreased metabolic cost in the novice hikers only in the highest grade but not in the other two lower grades.

关键词： Oxygen uptake heart rate uphill downhill.

Association of the neutrophil-to-lymphocyte ratio and prostate cancer detection rates in patients via contemporary multi-core prostate biopsy

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Asian Journal of Andrology 2016年第6期18卷 937-941页

作者： Jong Jin Oh Ohsung kwon Jung Keun Lee Seok-Soo Byun Sang eun Lee Sangchul Lee Sung Kyu Hong Department of Urology Seoul National University Bundang Hospital Seongnam Korea.

The aim of this study was to determine whether the neutrophil-to-lymphocyte ratio （NLR）, a measure of the systemic inflammatory response is associated with the overall prostate cancer detection rate in men who underwent contemporary multi （〉12）-core transrectal ultrasound （TRUS） biopsy. We reviewed the records of 3913 patients with initial prostate-specific antigen （PSA） levels ranging from 4 to 10 ng ml^-1 who underwent TRUS-guided prostate biopsy between April 2006 and May 2014. NLR was calculated by prebiopsy neutrophil and lymphocyte counts. We excluded patients who had evidence of acute prostatitis, a history of prostate surgery, and any systemic inflammatory disease. A multivariate logistic regression model was used to analyze prostate cancer detection. After adjusting for confounding factors, predictive values were determined according to the receiver operating characteristic-derived area under the curve, both including and excluding the NLR variable. In univariate analyses, NLR was a significant predictor of prostate cancer detection （P 〈 0.001）. In multivariate analyses, a higher NLR was significantly associated with prostate cancer detection after adjusting for other factors （OR = 1.372, P = 0.038）. The addition of NLR increased the accuracy from 0.712 to 0,725 （P = 0.005） in the multivariate model for prostate cancer detection. NLR may be a potentially useful clinical marker in the detection of prostate cancer among men with a PSA level in the 4-10 ng ml^-1 range. These findings are derived from a retrospective analysis and should be validated in larger populations through prospective studies.

关键词： inflammation lymphocyte neutrophil prostate biopsy prostate cancer

Highly impermeable and flexible silica encapsulation films synthesized by sol-gel process

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Nano Research 2022年第8期15卷 7476-7483页

作者： Si-Hoon Kim Gyeong-Seok Hwang Donghwan Koo Dong-Hyun Seo Ye-Pil kwon Hansuek Lee Hyesung Park eun-chae Jeon Ju-Young Kim School of Materials Science and Engineering University of UlsanTechno saneop-ro 55beon-gil 12Ulsan 44776Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)UNIST-gil 50Ulsan 44919Republic of Korea Department of Physics Korea Advanced Institute of Science and Technology(KAIST)Daehak-ro 291Deajeon 34141Republic of Korea Graduate School of Semiconductor Materials and Devices Ulsan National Institute of Science and Technology(UNIST)UNIST-gil 50Ulsan 44919Republic of Korea

Silica thin films synthesized sol–gel process are proposed as flexible encapsulation materials.A sol–gel process provides a dense and stable amorphous silica structure,yielding an extremely high elastic deformation limit of 4.9%and extremely low water vapor transmission rate(WVTR)of 2.90×10^(−4)g/(m^(2)∙day)at 60℃and relative humidity of 85%.The WVTR is not degraded by cyclic bending deformations for the bending radius corresponding to a tensile strain of 3.3%in the silica encapsulation film,implying that the silica thin film is robust against the formation of pinhole-type defects by cyclic bending *** organic solar cells encapsulated with the silica films operate without degradation in power conversion efficiency for 50,000 bending cycles for a bending radius of 6 mm.

关键词： silica thin film sol-gel flexible encapsulation mechanical reliability flexible organic solar cell

Effects of the Syzygium aromaticum L. extract on antioxidation and inhibition of matrix metalloproteinase in human dermal fibroblast

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Asian Pacific Journal of Tropical Biomedicine 2019年第2期9卷 53-59页

作者： Da eun Kim Yeon Sil Hwang Bo Yoon Chang Dae Sung Kim Hyoung kwon Cho Sung Yeon Kim Institute of Pharmaceutical Research and Development College of PharmacyWonkwang University Hanpoong Pharm.CO. Ltd

Objective: To investigate cosmetic potential of Syzygium aromaticum L.(S. aromaticum L.) and to determine its antioxidant and anti-wrinkling effects. Methods: Using highperformance liquid chromatography, eugenol component was quantitated. The antioxidant activity of S. aromaticum L. was analyzed by 2,2-diphenyl-1-picrylhydrazyl radical scavenging and superoxide dismutase like activities. To determine cell viability, elastase and matrix metalloproteinase-1(MMP-1) activity, human dermal fibroblasts(HS68) were treated with S. aromaticum L. The inhibitory effect of S. aromaticum L. on tumor necrosis factor alpha induced MMPs expression in HS68 was analyzed by realtime-PCR. Results: The eugenol content was confirmed in S. aromaticum L. S. aromaticum L. was observed to have high 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and superoxide dismutase like activity. S. aromaticum L. had no cytotoxicity against the HS68 and dose-dependently increased elastase inhibition. Moreover, S. aromaticum L. significantly decreased MMP-1 content and inhibited gene levels of MMP-1, MMP-2, MMP-3 and MMP-9. Conclusions: The findings suggest that S. aromaticum L. has great potential as a cosmeceutical ingredient with antioxidant and antiwrinkling effects.

关键词： Syzygium aromaticum L Antioxidant Anti-aging Elastase Matrix metalloproteinase-1

Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer

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Bioactive Materials 2023年第7期25卷 527-540页

作者： Hyosuk Kim Hyun-Ju Park Hyo Won Chang Ji Hyun Back Su Jin Lee Yae eun Park eun Hye Kim Yeonsun Hong Gijung Kwak Ick Chan kwon Ji eun Lee Yoon Se Lee Sang Yoon Kim Yoosoo Yang Sun Hwa Kim Medicinal Materials Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Functional Genomics KRIBB School of BioscienceKorea University of Science and Technology(UST)Daejeon34141Republic of Korea Department of Otolaryngology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul05505Republic of Korea Chemical&Biological Integrative Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul02841Republic of Korea Department of Life Sciences Korea UniversitySeoul02841Republic of Korea

Highly immunosuppressive tumor microenvironment containing various protumoral immune cells accelerates malignant transformation and treatment *** particular,tumor-associated macrophages(TAMs),as the predominant infiltrated immune cells in a tumor,play a pivotal role in regulating the immunosuppressive tumor *** a potential therapeutic strategy to counteract TAMs,here we explore an exosome-guided in situ direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type *** derived from M1-type macrophages(M1-Exo)promote a phenotypic switch from anti-inflammatory M2-like TAMs toward pro-inflammatory M1-type macrophages with high conversion *** M1 macrophages possessing protein-expression profiles similar to those of classically activated M1 macrophages display significantly increased phagocytic function and robust cross-presentation ability,potentiating antitumor immunity surrounding the ***,these M1-Exo also lead to the conversion of human patient-derived TAMs into M1-like macrophages that highly express MHC class II,offering the clinical potential of autologous and allogeneic exosome-guided direct TAM reprogramming for arming macrophages to join the fight against cancer.

关键词： Exosome Cancer therapy Tumor microenvironment Tumor-associated macrophage Direct conversion

Duodenal obstruction after successful embolization for duodenal diverticular hemorrhage: A case report

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World Journal of Gastroenterology 2009年第30期15卷 3819-3822页

作者： Yu Jin kwon Ji Hun Kim Seung Hyoung Kim Bong Soo Kim Heung Up Kim eun Kwang Choi In Ho Jeong Department of Surgery Seoul National University College of Medicine28 Yeongeon-dongSeoul 110-744South Korea Department of Surgery Ajou University School of MedicineSan-5WonchondongYeongtongguSuwon 442-749South Korea Department of radiology Jeju National University School of Medicine1753-3Ara 1-DongJeju 690-121South Korea Department of internal medicine Jeju National University School of Medicine1753-3Ara 1-DongJeju 690-121South Korea Department of surgery Jeju National University School of Medicine1753-3Ara 1-DongJeju 690-121South Korea

We present a 69-year-old woman with a duodenal obstruction after successful selective transcatheter arterial embolization (TAE) for a duodenal diverticular hemorrhage. Two weeks after TAE, the patient showed abrupt symptoms of duodenal obstruction. Resolving hematomas after successful selective transcatheter arterial embolization should be thoroughly observed because they might result in duodenal fibrotic encasement featuring inflammatory duodenal wall thickening, duodenal deformity, dysmotility, and fi nally obstruction.

关键词： Diverticulum Gastrointestinal hemorrhage Therapeutic embolization Duodenal obstruction

Effect of prenatal antioxidant intake on infants' respiratory infection is modified by a CD14 polymorphism

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World Journal of Pediatrics 2017年第2期13卷 173-182页

作者： Seo Ah Hong eun Lee Sung Ok kwon Kyung Won Kim Youn Ho Shin Kang Mo Ahn eun-Jin Kim Jeom-Gyu Lee Se-Young Oh Soo-Jong Hong ASEAN Institute for Health Development Mahidol UniversitySalayaPhutthamonthonNakhonpathomThailand Department of Pediatrics Inje University Haeundae Paik HospitalBusanKorea Department of Food and Nutrition Research Institute of Human EcologyKyung Hee UniversitySeoulKorea Department of Pediatrics Severance Children's HospitalCollege of MedicineYonsei UniversitySeoulKorea Department of Pediatrics CHA Medical CenterCHA University School of MedicineSeoulKorea Department of Pediatrics Samsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Allergy and Respiratory Diseases Korea National Institute of HealthOsong Health Technology Administration ComplexKorea Department of Pediatrics Childhood Asthma Atopy CenterEnvironmental Health CenterAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Background:Prenatal maternal diet may influence disease susceptibility in offspring with specific genetic *** hypothesized that interactions between prenatal antioxidant intake and polymorphisms in immunity genes influence respiratory tract infection (RTI) susceptibility in infants at 12 months of ***:This study included 550 *** the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort study,prenatal maternal diet was assessed by administering a food frequency ***' cord blood was genotyped for CD14 (rs2569190),TLR4 (rs1927911),and GSDMB (rs4794820) polymorphisms by the TaqMan ***:Higher prenatal intake of total fruit and vegetables (FV) was associated with the decreased risk of RTI in offspring (P-trend=0.0430).In children with TT genotype at rs2569190,a higher prenatal intake of vitamins A and C,fruits,and total FV decreased RTI risk (P-trend <0.05),while in infants with TC+CC genotype,a higher prenatal intake of fruit increased RTI risk (P-trend <0.05).When analyzing the 3 genotypes,children with TT genotype at rs2569190 were more protected against RTIs compared with those with CC genotype with respect to vitamin C and fruits [odds ratio (OR)=5.04 and OR=10.30,respectively].In children with CC genotype at rs1927911,RTI risk showed a dose-response association with a higher prenatal intake of vitamin C (P for interaction<0.05).A higher prenatal intake of fruits and total FV reduced RTI risk in infants with GA+AA genotype of rs4794820 (P for interaction<0.05).Conclusion:Prenatal antioxidant intake may reduce RTI risk in infants and this relationship may be modified by CD14,TLR4,and GSDMB polymorphisms.

关键词： antioxidants CD14 fruit polymorphism respiratory tract infection

Effects of Wind Fences on the Wind Environment around Jang Bogo Antarctic Research Station

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Advances in Atmospheric Sciences 2017年第12期34卷 1404-1414页

作者： Jang-Woon WANG Jae-Jin KIM Wonsik CHOI Da-Som MUN Jung-eun KANG Hataek kwon Jin-Soo KIM Kyung-Soo HAN Department of Environmental Atmospheric Sciences Pukyong National University 45Yongso-ro Korea Polar Research Institute 26 Songdomirae-ro Yeonsu-gu Department of Spatial Information Engineering Pukyong National University 45Yongso-ro

This study investigated the flow characteristics altered by Jang Bogo Antarctic Research Station using computational fluid dynamics(CFD) modeling. The topography and buildings around Jang Bogo Station were constructed with computeraided-design data in the CFD model domain. We simulated 16 cases with different inflow directions, and compared the flow characteristics with and without Jang Bogo Station for each inflow direction. The wind data recorded by the site’s automatic weather station(AWS) were used for comparison. Wind rose analysis showed that the wind speed and direction after the construction of Jang Bogo Station were quite different from those before construction. We also investigated how virtual wind fences would modify the flow patterns, changing the distance of the fence from the station as well as the porosity of the fence. For westerly inflows, when the AWS was downwind of Jang Bogo Station, the decrease in wind speed was maximized(-81% for west-northwesterly). The wind speed reduction was also greater as the distance of the fence was closer to Jang Bogo Station. With the same distance, the fence with medium porosity(25%–33%) maximized the wind speed *** results suggest that the location and material of the wind fence should be selected carefully, or AWS data should be interpreted cautiously, for particular prevailing wind directions.

关键词： Jang Bogo Antarctic Research Station CFD model observation environment wind fence porosity