Effect of prenatal antioxidant intake on infants' respiratory infection is modified by a CD14 polymorphism

作     者：Seo Ah Hong Eun Lee Sung Ok Kwon Kyung Won Kim Youn Ho Shin Kang Mo Ahn Eun-Jin Kim Jeom-Gyu Lee Se-Young Oh Soo-Jong Hong 

作者机构：ASEAN Institute for Health DevelopmentMahidol UniversitySalayaPhutthamonthonNakhonpathomThailand Department of PediatricsInje University Haeundae Paik HospitalBusanKorea Department of Food and NutritionResearch Institute of Human EcologyKyung Hee UniversitySeoulKorea Department of PediatricsSeverance Children's HospitalCollege of MedicineYonsei UniversitySeoulKorea Department of PediatricsCHA Medical CenterCHA University School of MedicineSeoulKorea Department of PediatricsSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Allergy and Respiratory DiseasesKorea National Institute of HealthOsong Health Technology Administration ComplexKorea Department of PediatricsChildhood Asthma Atopy CenterEnvironmental Health CenterAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2017年第13卷第2期

页      面：173-182页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by fundings from Research of Korea Centers for Disease Control and Prevention 

主　　题：antioxidants CD14 fruit polymorphism respiratory tract infection 

摘      要：Background:Prenatal maternal diet may influence disease susceptibility in offspring with specific genetic *** hypothesized that interactions between prenatal antioxidant intake and polymorphisms in immunity genes influence respiratory tract infection (RTI) susceptibility in infants at 12 months of ***:This study included 550 *** the Cohort for Childhood Origin of Asthma and Allergic Diseases (COCOA) birth cohort study,prenatal maternal diet was assessed by administering a food frequency *** cord blood was genotyped for CD14 (rs2569190),TLR4 (rs1927911),and GSDMB (rs4794820) polymorphisms by the TaqMan ***:Higher prenatal intake of total fruit and vegetables (FV) was associated with the decreased risk of RTI in offspring (P-trend=0.0430).In children with TT genotype at rs2569190,a higher prenatal intake of vitamins A and C,fruits,and total FV decreased RTI risk (P-trend 0.05),while in infants with TC+CC genotype,a higher prenatal intake of fruit increased RTI risk (P-trend 0.05).When analyzing the 3 genotypes,children with TT genotype at rs2569190 were more protected against RTIs compared with those with CC genotype with respect to vitamin C and fruits [odds ratio (OR)=5.04 and OR=10.30,respectively].In children with CC genotype at rs1927911,RTI risk showed a dose-response association with a higher prenatal intake of vitamin C (P for interaction0.05).A higher prenatal intake of fruits and total FV reduced RTI risk in infants with GA+AA genotype of rs4794820 (P for interaction0.05).Conclusion:Prenatal antioxidant intake may reduce RTI risk in infants and this relationship may be modified by CD14,TLR4,and GSDMB polymorphisms.