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Antimalarial potency of the leaf extract of Aspilia africana(Pers.) ***

Asian Pacific Journal of Tropical Medicine 2012年第2期5卷 126-129页

作者： Akuodor Godwin Christian Amos Grace Mfon essien a.gustine dick essien David-Oku Akpan Joseph Linus Ezeokpo Basil Chukwuma Department Pharmacology College of Medical SciencesUniversity of CalabarNigeria Department of Pharmacology and Toxicology National Institute for Pharmaceutical Research and Development(NIPRD)AbujaNigeria Department of Biochemistry College of Medical SciencesUniversity of CalabarNigeria Department of Pharmacology and Therapeutics Faculty of Clinical MedicineEbonyi State UniversityAbakalikiNigeria

Objective:To investigate the antimalarial activity of ethanol extract of Aspilin africana (***) ***:The ethanol extract of *** leaf(100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei(P. berghei) in mice both in early and established models of antimalarial ***:The leaf extract exhibited significant(P<0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug,chloroquine(10 mg/kg).Conclusions:The findings show thai ethanol extract of *** leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy.

关键词： Aspilia africana Herbal medicine Plasmodium berghei Mice

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In vivo antiplasmodial activity of Bombax buonopozense root bark aqueous extract in mice infected by Plasmodium berghei

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Journal of Traditional Chinese Medicine 2017年第4期37卷 431-435页

作者： Akuodor Godwin Christian Ezeonu Chinonyelum Thecla essien a.gustine dick Asika Ebere Chile Chilaka Kingsley Chimsorom Nwachukwu Daniel Ckukwu Nwobodo Ndubuisi Nwobodo Department of Pharmacology and Therapeutics Faculty of Medicine Ebonyi State UniversityAbakaliki P.M.B. 053 Nigeria Department of Paediatrics Faculty of Medicine Ebonyi State University Abakaliki RM.B.053 Nigeria Department of Pharmacology College of Medical Sciences University of Calabar Calabar P.M.B. 1115 Nigeria Department of Pharmacology and Therapeutics College of Health Sciences Nnamdi Azikiwe University Awka P.M.B. 5025 Nigeria Department of Physiology College of Medicine University of Nigeria Enugu P.M.B. 1011 Nigeria

OBJECTIVE: To evaluate the in vivo antiplasmodial activity and the oral acute toxicity of the Bombax buonopozense root bark aqueous ***: The in vivo antiplasmodial activity of the root bark aqueous extract of Bombax buonopozense against early and established rodent malaria infections in chloroquine sensitive Plasmodium berghei strain in mice was investigated, and oral acute toxicity of the aqueous root bark extract of Bombax buonopozense was also evaluated in ***: The findings of this study revealed significant(P < 0.05) and dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses of the extract(50-200 mg/kg p.o.) in both suppressive and curative tests. There was also significant decrease in parasitaemia density in the chloroquine treated group. The aqueous extract was found no toxicity in mice and the oral LD50 was determined to be greater than 5000 mg/***: Bombax buonopozense root bark aqueous extract possesses potent antiplasmodial activity and may therefore, serve as potential sources of new antimalarial agents.

关键词： Plasmodium berghei Bombax Plant extracts Phytochemicals Toxicity tests, acute

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Analgesic,anti-inflammatory and antipyretic activities of methanolic leaf extract of Maerua crassifolia

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Journal of Coastal Life Medicine 2016年第3期4卷 225-230页

作者： Godwin Christian Akuodor a.gustine dick essien Joseph Linus Akpan Kingsley Chimsorom Chilaka Nkemjika Jane Ikodiya Uwaezuoke Kenneth Ikechukwu Nwadike Ndubuisi Nwobodo Nwobodo Basil Chukwuma Ezeokpo Department of Pharmacology and Therapeutics Faculty of MedicineEbonyi State UniversityAbakalikiNigeria Department of Pharmacology College of Medical SciencesUniversity of CalabarCalabarNigeria Department of Pharmacology and Therapeutics College of Health SciencesNnamdi Azikiwe UniversityAwkaNigeria Department of Pharmacology and Therapeutics College of MedicineUniversity of NigeriaEnugu CampusNigeria Department of Internal Medicine Faculty of MedicineEbonyi State UniversityAbakalikiNigeria

Objective:To investigate the the analgesic,anti-inflammatory and antipyretic activities of the methanolic leaf extract of Maerua crassifolia in mice and ***:Acetic acid-induced writhing and tail immersion methods were used to assess analgesic activity,while xylene and carrageenan-induced paw oedema methods were used to evaluate the anti-inflammatory effect of the leaf *** and amphetamine-induced pyrexia were used to investigate the antipyretic *** phytochemical analysis and oral acute toxicity of the methanolic leaf extract of Maerua crassifolia were also ***:The leaf extract(100,200,and 400 mg/kg)showed a dose dependent and significant(P<0.05)inhibition of pain in acetic acid-induced writhing and tail immersion *** extract also produced significant(P<0.05)anti-inflammatory activity in both paradigms.A significant(P<0.05)reduction in hyperpyrexia was also observed with the leaf *** phytochemical screening revealed the presence of alkaloids,flavonoids,terpenoids,tannins,steroids,resins,saponins and cardiac *** oral median lethal dose of the leaf extract was estimated to be greater than 5000 mg/kg in ***:The findings confirmed its ethnomedical use in the treatment of pains and feverish conditions.

关键词： Maerua crassifolia Leaf Analgesia Inflammation Pyrexia Rodents

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