Analgesic,anti-inflammatory and antipyretic activities of methanolic leaf extract of Maerua crassifolia

作     者：Godwin Christian Akuodor Augustine Dick Essien Joseph Linus Akpan Kingsley Chimsorom Chilaka Nkemjika Jane Ikodiya Uwaezuoke Kenneth Ikechukwu Nwadike Ndubuisi Nwobodo Nwobodo Basil Chukwuma Ezeokpo 

作者机构：Department of Pharmacology and TherapeuticsFaculty of MedicineEbonyi State UniversityAbakalikiNigeria Department of PharmacologyCollege of Medical SciencesUniversity of CalabarCalabarNigeria Department of Pharmacology and TherapeuticsCollege of Health SciencesNnamdi Azikiwe UniversityAwkaNigeria Department of Pharmacology and TherapeuticsCollege of MedicineUniversity of NigeriaEnugu CampusNigeria Department of Internal MedicineFaculty of MedicineEbonyi State UniversityAbakalikiNigeria 

出 版 物：《Journal of Coastal Life Medicine》 (海岸生命医学杂志（英文版）)

年 卷 期：2016年第4卷第3期

页      面：225-230页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：The authors are grateful to Dr.(Mrs) Jamilat A. Ibrahim  Department of Medicinal Plant Research and TraditionalMedicine  NIPRD Abuja Nigeria for her botanical assistance 

主　　题：Maerua crassifolia Leaf Analgesia Inflammation Pyrexia Rodents 

摘      要：Objective:To investigate the the analgesic,anti-inflammatory and antipyretic activities of the methanolic leaf extract of Maerua crassifolia in mice and ***:Acetic acid-induced writhing and tail immersion methods were used to assess analgesic activity,while xylene and carrageenan-induced paw oedema methods were used to evaluate the anti-inflammatory effect of the leaf *** and amphetamine-induced pyrexia were used to investigate the antipyretic *** phytochemical analysis and oral acute toxicity of the methanolic leaf extract of Maerua crassifolia were also ***:The leaf extract(100,200,and 400 mg/kg)showed a dose dependent and significant(P0.05)inhibition of pain in acetic acid-induced writhing and tail immersion *** extract also produced significant(P0.05)anti-inflammatory activity in both paradigms.A significant(P0.05)reduction in hyperpyrexia was also observed with the leaf *** phytochemical screening revealed the presence of alkaloids,flavonoids,terpenoids,tannins,steroids,resins,saponins and cardiac *** oral median lethal dose of the leaf extract was estimated to be greater than 5000 mg/kg in ***:The findings confirmed its ethnomedical use in the treatment of pains and feverish conditions.