Antimalarial potency of the leaf extract of Aspilia africana(Pers.) ***

作     者：Akuodor Godwin Christian Amos Grace Mfon Essien Augustine Dick Essien David-Oku Akpan Joseph Linus Ezeokpo Basil Chukwuma 

作者机构：Department PharmacologyCollege of Medical SciencesUniversity of CalabarNigeria Department of Pharmacology and ToxicologyNational Institute for Pharmaceutical Research and Development(NIPRD)AbujaNigeria Department of BiochemistryCollege of Medical SciencesUniversity of CalabarNigeria Department of Pharmacology and TherapeuticsFaculty of Clinical MedicineEbonyi State UniversityAbakalikiNigeria 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2012年第5卷第2期

页      面：126-129页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Aspilia africana Herbal medicine Plasmodium berghei Mice 

摘      要：Objective:To investigate the antimalarial activity of ethanol extract of Aspilin africana (***) ***:The ethanol extract of *** leaf(100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei(P. berghei) in mice both in early and established models of antimalarial ***:The leaf extract exhibited significant(P0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug,chloroquine(10 mg/kg).Conclusions:The findings show thai ethanol extract of *** leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy.