检索结果-南通市图书馆

Duodenal-type follicular lymphoma more than 10 years after treatment intervention:A retrospective single-center analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2022年第8期14卷 1552-1561页

作者： Makoto Saito Akio Mori Shihori Tsukamoto Takashi Ishio emi yokoyama Koh Izumiyama Masanobu Morioka Takeshi Kondo Hirokazu Sugino Blood Disorders Center Aiiku HospitalSapporo 064-0804Japan Department of Cancer Pathology Hokkaido UniversityFaculty of MedicineSapporo 060-8638Japan

BACKGROUND Duodenal-type follicular lymphoma(D-FL)has been recognized as a rare entity that accounts for approximately 4%of primary gastrointestinal lymphomas.D-FL follows an indolent clinical course compared with common nodal FL and is generally considered to have a better ***,the“watch and wait”approach is frequently adopted as the treatment ***,there is an option to actively intervene in ***,the long-term outcomes of such cases are poorly *** To clarify the clinical outcomes after long-term follow-up in cases of D-FL with treatment *** We retrospectively analyzed patients who met the following criteria:the lesion was confirmed by endoscopy,the diagnosis of D-FL was confirmed histopathologically,and the patient was followed-up for more than 10 years after the intervention at our *** We identified 5 cases of *** patients showed a small amount of bone marrow involvement(Stage IV).Rituximab was used as a treatment for remission in all 5 *** was also used in combination with chemotherapy in 2 Stage IV patients as well as for maintenance *** therapy was performed in 2 cases,which was followed by complete remission(CR).Eventually,all 5 patients achieved CR and survived for more than 10 ***,3 patients experienced *** patient achieved a second CR by retreatment,and in another case,the lesion showed spontaneous *** remaining patient had systemic widespread recurrence 13 years after the first *** results suggested that the FL lesions were transformed into diffuse large B-cell *** patient died 4 years later despite receiving various *** In this study,the treatment for patients of D-FL in Stage IV was *** the future,criteria for how to treat“advanced”D-FL should be established based on additional *** study of patients with D-FL indicates that whole-body follow-up examinations shou

关键词： Duodenal-type follicular lymphoma Treatment Long-term follow-up Radiation Rituximab Chemotherapy

Transformed gastric mucosa-associated lymphoid tissue lymphoma originating in the colon and developing metachronously after Helicobacter pylori eradication:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第10期16卷 4281-4288页

作者： Makoto Saito Zen-Ichi Tanei Masumi Tsuda Toma Suzuki emi yokoyama Minoru Kanaya Koh Izumiyama Akio Mori Masanobu Morioka Takeshi Kondo Blood Disorders Center Aiiku HospitalSapporo 064-0804HokkaidoJapan Department of Cancer Pathology Faculty of MedicineHokkaido UniversitySapporo 060-8638HokkaidoJapan

BACKGROUND Helicobacter pylori(***)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been ***,t(11;18)(q21;q21)/API2-MALT1 translocation-positive lesions are a type of primary gastric MALT lymphoma in which a response to eradication treatment is difficult to *** addition,trisomy 18 may be associated with diffuse large B-cell lymphoma(DLBCL)transformation of gastric MALT *** SUMMARY A 66-year-old man was diagnosed with MALT lymphoma in the ascending colon by colonoscopy and *** years later,esophagogastroduodenoscopy revealed chronic atrophic gastritis that was positive for ***,and eradication treatment was *** years and nine months later(at the age of 70),a new ulcerative lesion suggestive of MALT lymphoma appeared in the gastric body,and six months later,a similar lesion was also found in the *** year later(4 years and 3 months after *** eradication),at the age of 72,the lesion in the gastric body had become deeper and had propagated.A biopsy revealed a pathological diagnosis of *** MALT lymphoma lesions in the ascending colon and DLBCL lesions in the stomach were positive for the t(11;18)(q21;q21)/API2-MALT1 translocation,and trisomy 18q21 was also *** 6 courses of R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine and prednisone)chemotherapy,all of the above lesions disappeared[complete remission(CR)],and CR has been maintained for more than 3 *** addition,both the colonic and gastric lesions were proven to have the same *** Because the patient had a MALT1 translocation with trisomy 18q21,it was thought that this gastric MALT lymphoma developed independently of *** infection and progressed.

关键词： Gastric mucosa-associated lymphoid tissue lymphoma Transform Diffuse large B-cell lymphoma Colonic mucosa-associated lymphoid tissue lymphoma Helicobacter pylori eradication MALT1 translocation Case report

Helicobacter pylori eradication treatment for primary gastric diffuse large B-cell lymphoma:A single-center analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第27期11卷 6424-6430页

作者： Makoto Saito Akio Mori Sayaka Kajikawa emi yokoyama Minoru Kanaya Koh Izumiyama Masanobu Morioka Takeshi Kondo Zen-Ichi Tanei Ai Shimizu Blood Disorders Center Aiiku HospitalSapporo 064-0804HokkaidoJapan Department of Cancer Pathology Faculty of MedicineHokkaido UniversitySapporo 060-8638HokkaidoJapan Department of Surgical Pathology Hokkaido University HospitalSapporo 060-8648HokkaidoJapan

BACKGROUND Unlike the already established effect of Helicobacter pylori(***)eradication on gastric mucosa-associated lymphoid tissue(MALT)lymphoma,its therapeutic effect on primary gastric diffuse large B-cell lymphoma(DLBCL)is still *** To clarify the efficacy of *** eradication treatment for primary gastric *** We reported on 3 new cases,and added them to 3 previously reported *** analyzed the usefulness of *** eradication treatment for gastric DLBCL for a total of 6 cases at our *** Of the 6 patients(27-90 years old,3 males and 3 females),all 3 patients with single lesions(one transformed from MALT lymphoma)achieved complete remission(CR)after *** *** the 2 newly reported cases,CR was maintained for more than 6 years with eradication treatment *** contrast,none of the 3 patients with 2 lesions achieved *** 1 newly reported case,endoscopic CR was achieved in one lesion,while stable disease was obtained in the other *** patients with progressive disease responded to standard chemo therapy±radiation and remained in CR for more than 6 *** We believe it is worthwhile to attempt *** eradication for elderly patients with primary gastric DLBCL in a single lesion with a small tumor burden.

关键词： Primary gastric diffuse large B-cell lymphoma Treatment Helicobacter pylori Eradication

CD34+ dermal dendritic cells and mucin deposition in dermatomyositis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Dermatology 2016年第2期5卷 65-71页

作者： emi yokoyama Yoshitaka Nakamura Tomoko Okita Nobuyuki Nagai Masahiko Muto Department of Dermatology Yamaguchi University Graduate School of Medicine

Dermal mucinosis is often associated with collagen diseases such as rheumatoid arthritis, lupus erythematosus, and dermatomyositis, in addition to autoimmune thyroiditis. We report eight cases of dermal mucin deposition secondary to typical dermatomyositis with cutaneous lesions known as heliotrope rash and Gottron's papules. Striking mucin deposition was observed in both the papillary dermis and reticular dermis of all biopsy specimens. Immunohistochemical analysis showed that CD34+ dermal dendritic cells(DDCs) in the perilesional area in combination with vimentin+ cells within the mucinous lesion might be important in giving rise to abnormal deposition of dermal mucin. On the other hand, numbers of factor ⅩⅢa+ DDCs and tryptase+ mast cells were reduced within and surrounding the mucin deposition, as compared with those in the dermis of normal controls. A pathogenic mechanism of dermal mucin deposition is proposed.

关键词： Mucin deposition Dermatomyositis CD34+dermal dendritic cell

Self-/conspecific discrimination and superparasitism strategy in the ovicidal parasitoid Echthrodelphax fairchildii （Hymenoptera： Dryinidae）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2014年第6期21卷 741-749页

作者： emi Ito Yoshihiro Y. Yamada Insect Ecology Laboratory Graduate School of Bioresources Mie University Tsu Mie Japan

Superparasitism in solitary parasitoids results in fatal competition between the immature parasitoids, and consequently only one individual can emerge. In the semisoli- tary ovicidal parasitoid Echthrodelphaxfairchildii （Hymenoptera： Dryinidae）, 2 adults can emerge under superparasitism with a short interval （〈24 h） between the first and second ovipositions. We determined the female parasitoid＇s behavioral responses under self- and conspecific superparasitism bouts with first-to-second oviposition intervals of 〈2 h. The self- and conspecific superparasitizing frequencies increased up to an oviposition interval of 0.75 h, with the former remaining lower than the latter, particularly for oviposition intervals of _〈0.25 h, suggesting the existence of self-/conspecific discrimination. The superparasitizing frequency plateaued for oviposition intervals of _〉0.75 h, with no dif- ference between self- and conspecific superparasitism. The ovicidal-probing frequency did not differ under self- and conspecific superparasitism, and was usually 〈20%. The females exhibited no preference for the oviposition side （i.e., ovipositing on the side with or without the first progeny） and almost always laid female eggs for any oviposition in- terval under self- and conspecific superparasitism. The sex ratio was not affected by the type of superparasitism, oviposition sides, or the occurrence of ovicidal probing. These observed results about the oviposition side, ovicidal probing, and sex ratios differed from the predictions obtained assuming that the females behave optimally. Possible reasons for the discrepancies are discussed： likely candidates include the high cost of selecting oviposition sides and ovicidal probing, and, for the sex ratio, the low frequency of encountering suitable hosts before superparasitism bouts.

关键词： infanticide ovicide plant hopper self-recognition sex ratio

Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第9期27卷 574-593页

作者： Henry F.Duncan Yoshifumi Kobayashi Michaela Kearney emi Shimizu Division of Restorative Dentistry&Periodontology Dublin Dental University HospitalTrinity College DublinUniversity of DublinLincoln PlaceDublinIreland Department of Oral Biology Rutgers School of Dental MedicineNewarkNJUSA

This opinion-led review paper highlights the need for novel translational research in vital-pulp-treatment(VPT),but also discusses the challenges in translating evidence to *** dentistry is expensive,invasive and relies on an outmoded mechanical understanding of dental disease,rather than employing a biological perspective that harnesses cell activity and the *** research has focussed on developing minimally-invasive biologically-based‘fillings’that preserve the dental pulp;research that is shifting the paradigm from expensive high-technology dentistry,with high failure rates,to smart restorations targeted at biological *** VPTs promote repair by recruiting odontoblast-like cells in a material-dependent ***,exciting opportunities exist for development of next-generation biomaterials targeted at regenerative processes in the dentin-pulp *** article analyses recent research using pharmacological-inhibitors to therapeutically-target histone-deacetylase(HDAC)enzymes in dental-pulp-cells(DPCs)that stimulate pro-regenerative effects with limited loss of ***,HDAC-inhibitors have the potential to enhance biomaterial-driven tissue responses at low concentration by influencing the cellular processes with minimal side-effects,providing an opportunity to develop a topically-placed,inexpensive bio-inductive pulp-capping *** positive results,clinical translation of these innovations requires enterprise to counteract regulatory obstacles,dental-industry priorities and to develop strong academic/industry *** aim of this opinion-led review paper is to discuss the potential role of therapeutically-targeting epigenetic modifications as part of a topical VPT strategy in the treatment of the damaged dental pulp,while considering the next steps,material considerations,challenges and future for the clinical development of epigenetic therapeutics or other‘smart’restora

关键词： Epigenetics Vital pulp treatment Histone deacetylase inhibitors Regenerative endodontics Pulp capping

Seemingly maladaptive refraining from infanticidal probing at the third parasitism attack by the semi-solitary parasitoid Echthrodelphax fairchildii （Hymenoptera： Dryinidae）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2006年第3期13卷 229-233页

作者： emi ITO YOSHIHIRO Y. YAMADA Insect Ecology Laboratory Faculty of Bioresources Mie University Tsu Mie Japan

We assessed the adaptiveness of refraining from infanticidal probing at the third attack under triple parasitism in the parasitoid Echthrodelphaxfairchildii Perkins, by comparing fitness returns from the third attack with and without probing. Fitness returns were assessed in terms of the survival rate, mean developmental time, and mean adult head width of the progenies. Not probing was maladaptive under triple parasitism with oviposition intervals of 1/24 and 24/24 hours （where the numbers before and after the slash refer to the first-to-second and second-to-third oviposition intervals, respectively）, although no significant difference was detected in fitness returns for oviposition intervals of 24/1 hours. We suggest that the cost of probing （especially the decrease in the chance of future ovipositions） is a reason for the seemingly maladaptive absence of probing.

关键词： cost of reproduction Echthrodelphax fairchildii infanticide ovicide,superparasitism triple parasitism

Formation of Edge Crack in 1.4%Si Non-oriented Electrical Steel during Hot Rolling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2014年第2期21卷 269-274页

作者： Ai-hua CHEN Hai-rong GUO Hua-long LI Toshihiko emi Institute of Research of Iron and Steel Shasteel

Microstructure evolution, dynamic recrystallization, high temperature oxidation and hot ductility of 1.4 % Si non-oriented electrical steel sheets were investigated to reduce edge cracking. The causes of cracking were found to be coarse as-cast microstructure, grain boundary oxidation in reheating furnace, lack of dynamic recrystallization during hot rolling and increase of temperature, resulting in reduced hot ductility in strip edge region. Countermeas- ures against the edge crack are proposed accordingly. Lowering reheating temperature and reducing holding time re- duced oxidation and decarburization. Hot charging temperature was increased to decrease reheating temperature. And using an edger can refine microstructure in strip edge region. Finally, edge heater can be added to increase edge re- gion formability by inducing dynamic reerystallization and ductility by increasing temperature.

关键词： edge crack non-oriented electrical steel hot rolling

Identification of county-level health factors associated with COVID-19 mortality in the United States

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Journal of Biomedical Research 2020年第6期34卷 437-445,I0014页

作者： Wei Pan Yasuo Miyazaki Hideyo Tsumura emi Miyazaki Wei Yang School of Nursing Duke UniversityDurhamNC 27710USA Department of Population Health Sciences School of MedicineDuke UniversityDurhamNC 27708USA School of Education Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA School of Community Health Sciences University of NevadaRenoNV 89557USA.

Many studies have investigated causes of COVID-19 and explored safety measures for preventing COVID-19 ***,these studies fell short to address disparities in health status and resources among decentralized communities in the United *** this study,we utilized an advanced modeling technique to examine complex associations of county-level health factors with COVID-19 mortality for all 3141 counties in the United *** results indicated that counties with more uninsured people,more housing problems,more urbanized areas,and longer commute are more likely to have higher COVID-19 *** on the nationwide population-based data,this study also echoed prior research that used local data,and confirmed that county-level sociodemographic factors,such as more Black,Hispanic,and older subpopulations,are attributed to high risk of COVID-19 *** hope that these findings will help set up priorities on high risk communities and subpopulations in future for fighting the novel virus.

关键词： COVID-19 mortality health factors health disparity hierarchical generalized linear model