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New translational and experimental insights into the role of proresolving lipid mediators in inflammatory bowel disease

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World Journal of Experimental Medicine 2022年第1期12卷 1-15页

作者： Lívia Bitencourt Pascoal Bruna Biazon Palma Fabio Henrique Mendonça Chaim Marina Moreira de Castro Tiago Andrade Damázio Ana Paula Menezes de Freitas Franceschini Marciane Milanski Lício AugustoVelloso Raquel Franco leal Inflammatory Bowel Disease Research Laboratory Colorectal Surgery UnitDepartment of SurgerySchool of Medical SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Metabolic Disorders School of Applied SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Cell Signaling School of Medical SciencesUniversity of CampinasCampinas 13083-864São PauloBrazil

The resolution of inflammation is an active process,guided by specialized proresolution lipid mediators(SPMs).These mediators originate from polyunsaturated fatty acids,such as *** evidence suggests that the beneficial effects attributed to omega-3 are,at least in part,the result of the immunomodulatory action of the SPMs,which act systemically by overcoming inflammation and repairing tissue damage,without suppressing the immune *** studies suggest that an imbalance in the synthesis and/or activity of these compounds may be associated with the pathogenesis of several inflammatory conditions,such as inflammatory bowel disease(IBD).Thus,this review highlights the advances made in recent years with regard to the endogenous synthesis and the biological role of lipoxins,resolvins,protectins,and maresins,as well as their precursors,in the regulation of inflammation;and provides an update on the participation of these mediators in the development and evolution of IBD and the therapeutic approaches that these immunomodulating substances are involved in this context.

关键词： Pro-resolving lipid mediators Anti-inflammatory cytokines Omega-3 Chronic inflammation Pro-inflammatory cytokines Inflammatory bowel disease

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Lymphoid-biased hematopoietic stem cells and myeloid-biased hematopoietic progenitor cells have radioprotection activity

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Blood Science 2021年第4期3卷 113-121页

作者： Shanshan Zhang Aled O’Neill Miner Xie Peng Wu Xiaofang Wang Haitao Bai Fang Dong Jinhong Wang Qingyun Zhang Toshio Suda Hideo ema State Key Laboratory of Experimental Hematology National Clinical Research Center for Hematological DisordersInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjinChina Department of Cell Differentiation Sakaguchi Laboratories of Developmental BiologyKeio University School of MedicineTokyoJapan

Radioprotection was previously considered as a function of hematopoietic stem cells(HSCs).However,recent studies have reported its activity in hematopoietic progenitor cells(HPCs).To address this issue,we compared the radioprotection activity in 2 subsets of HSCs(nHSC1 and 2 populations)and 4 subsets of HPCs(nHPC1–4 populations)of the mouse bone marrow,in relation to their in vitro and in vivo colony-forming *** radioprotection activity was detected in the nHSC2 population enriched in lymphoid-biased *** radioprotection activity was detected in nHPC1 and 2 populations enriched in myeloid-biased *** radioprotection activity was detected in the nHSC1 enriched in myeloid-biased *** radioprotection activity was detected in the nHPC3 and 4 populations that included MPP4(LMPP).Single-cell colony assay combined with flow cytometry analysis showed that the nHSC1,nHSC2,nHPC1,and nHPC2 populations had the neutrophils/macrophages/erythroblasts/megakaryocytes(nmEMk)differentiation potential whereas the nHPC3 and 4 populations had only the nm differentiation *** day 12 spleen colony-forming units(day 12 CFU-S)were detected in the nHSC1,nHSC2,and nHPC1–3 populations,but very few in the nHPC4 *** data suggested that nmEMk differentiation potential and day 12 CFU-S activity are partially associated with radioprotection *** analysis showed that sufficient myeloid reconstitution around 12 to 14 days after transplantation was critical for *** study implied that radioprotection is specific to neither HSC nor HPC populations,and that lymphoid-biased HSCs and myeloid-biased HPCs as populations play a major role in radioprotection.

关键词： Hematopoietic progenitor cells(HPCs) Hematopoietic stem cells(HSCs) Lymphoid-biased hematopoietic stem cells Myeloid-biased hematopoietic progenitor cells lymphoid-primed multipotent progenitors(LMPPs) Myeloid-biased hematopoietic stem cells Radioprotection

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银河波装置

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城市环境设计 2012年第11期 223-223,222页

作者： Rolando Rodriguez-leal Natalia Wrzask AIDIA工作室

银河波装置是AIDIA工作室在2012北京设计周中展示的装置项目。1664个回收利用的酸奶罐被重新排列组合,构成了moebius光波的视觉效果。装置悬挂在历史悠久的北京大栅栏地区一个废弃的自行车工厂的楼梯井上。每个陶瓷罐的底部穿孔,安装一... 详细信息

银河波装置是AIDIA工作室在2012北京设计周中展示的装置项目。1664个回收利用的酸奶罐被重新排列组合,构成了moebius光波的视觉效果。装置悬挂在历史悠久的北京大栅栏地区一个废弃的自行车工厂的楼梯井上。每个陶瓷罐的底部穿孔,安装一个0.3瓦特的LED灯。一个钩子支架上连接一个钢张量杆。所有的瓷罐悬挂在不同的高度。游客在装置下方和中间穿行,一路上穿行过楼梯井。

关键词：银河设计者瓷罐装置

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Ferric carboxymaltose for anemia in Crohn’s disease patients at a tertiary center:A retrospective observational cohort study

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World Journal of Clinical Cases 2023年第12期11卷 2740-2752页

作者： Natália Souza Nunes Siqueira Livia Bitencourt Pascoal Bruno Lima Rodrigues Marina Moreira de Castro Alan Sidnei Corrêa Martins Dante Orsetti Silva Araújo Luis Eduardo Miani Gomes Michel Gardere Camargo Maria de Lourdes Setsuko Ayrizono Raquel Franco leal Inflammatory Bowel Disease Research Laboratory GastrocenterColorectal Surgery UnitSchool of Medical SciencesUniversity of Campinas(Unicamp)Campinas 13083-878São PauloBrazil

BACKGROUND Although the gastrointestinal tract is the most affected by Crohn’s disease(CD),the condition triggers other consequent manifestations,and iron deficiency anemia(IDA)is one of the most ***(IV)iron replacement is currently available through several drugs,such as ferric hydroxide sucrose and ferric carboxymaltose(FCM).However,the clinical management of these conditions can be *** To elucidate the drug’s effectiveness,the present study analyzed,through medical records,the clinical and epidemiological data of a cohort of patients with active CD who received IV FCM for the IDA *** This retrospective observational study included 25 patients with active CD,severe anemia,and refractory to previous conventional *** were evaluated two times:During the last treatment with ferric hydroxide sucrose and treatment with *** After treatment with FCM,parameters of IDA assessment significantly improved,serum hemoglobin(Hb)levels increased in 93%of patients(Pleal and colonic CD and use of biologics and a positive association with patients who developed CD later in life after the age of 40(A3)and with a stenosing(B2)and fistulizing(B3)*** values of Hb and hematocrit after ferric hydroxide sucrose treatment remained similar to those found before *** This study demonstrated that FCM is an important therapeutic strategy for treating IDA in CD patients,achieving satisfactory results in refractory cases.

关键词： Ferric carboxymaltose Iron deficiency anemia Crohn’s disease Inflammatory bowel disease Anemia Clinical management

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甘蔗眼点病毒素（长孺孢属）对甘蔗叶片和愈伤组织渗透性的影响

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国外农学（甘蔗） 1992年第4期 37-41页

作者： leal,MR 曾献军

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造血干细胞的谱系分化——巨核细胞来源

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中国实验血液学杂志 2020年第3期28卷 1044-1048页

作者：张森董芳刘子闲依马秀夫中国医学科学院血液病医院(中国医学科学院血液学研究所) 实验血液学国家重点实验室国家血液病临床医学研究中心天津300020

造血干细胞(hematopoietic stem cell,HSC)是一类具有自我更新和多向分化潜能的细胞。既往的研究表明,造血干细胞是一个在功能、细胞命运和分子水平上具有高度异质性的细胞群体。传统的造血分化理论认为,伴随着细胞增殖分化的过程HSC逐... 详细信息

造血干细胞(hematopoietic stem cell,HSC)是一类具有自我更新和多向分化潜能的细胞。既往的研究表明,造血干细胞是一个在功能、细胞命运和分子水平上具有高度异质性的细胞群体。传统的造血分化理论认为,伴随着细胞增殖分化的过程HSC逐渐丧失了自我更新能力,而这个过程是一个从多潜能到单潜能干细胞以及成熟细胞的分化过程。基于此理论,巨核细胞的发育路径依次为造血干细胞、共同髓系祖细胞、巨核红系祖细胞、巨核祖细胞直到巨核细胞最终成熟产板。随着技术方法的改进和研究水平的提高,有证据显示巨核细胞可以由HSC直接分化而来,而不需要经历多潜能或者双潜能的阶段,且HSC可能存在巨核细胞倾向的亚群。本文总结了近年来新的技术方法和动物模型,对巨核细胞的分化来源进行探讨。

关键词：造血干细胞巨核细胞血小板分化异质性

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Clinical implication of 14-3-3 epsilon expression in gastric cancer

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World Journal of Gastroenterology 2012年第13期18卷 1531-1537页

作者： Mariana Ferreira leal Danielle Queiroz Calcagno Smia Demachki Paulo Pimentel Assumpo Roger Chammas Rommel Rodríguez Burbano Marília de Arruda Cardoso Smith Genetics Division Department of Morphology and GeneticFederal University of So PauloSo Paulo 04023-900Brazil Pathology Service Joo de Barros Barreto University HospitalFederal University of ParáBelém 60673-000Brazil Surgery Service Joo de Barros Barreto University HospitalFederal University of ParáBelém 60673-000Brazil Laboratory of Experimental Oncology School of MedicineUniversity of So PauloSo Paulo 01246-903Brazil Human Cytogenetics Laboratory Institute of Biological SciencesFederal University of ParáBelém 66073-000Brazil

AIM:To evaluate for the first time the protein and mRNA expression of 14-3-3εin gastric ***:14-3-3εprotein expression was determined by western blotting,and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue ***:Authors observed a significant reduction of 14-3-3εprotein expression in gastric cancer(GC)samples compared to their matched non-neoplastic *** levels of 14-3-3εwere also associated with diffuse-type GC and early-onset of this *** data suggest that reduced 14-3-3εmay have a role in gastric carcinogenesis ***:Our results reveal that the reduced 14-3-3εexpression in GC and investigation of 14-3-3ε interaction partners may help to elucidate the carcino-genesis process.

关键词： Gastric cancer 14-3-3 epsilon YWHAE Geneexpression Protein expression

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Hispanidades Latinoamerica y los EE. UU.

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2005年

作者： David Curland Robert Davis Francisco Lomelí special contributor Luis leal.

来源：畅想之星图书光盘版（南... 评论

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Understanding Tremor in Rapid Upper Limb Movements Using 3D Accelerometers Data

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Neuroscience & Medicine 2014年第5期5卷 205-213页

作者： Paula Pascoal-Faria Miguel Patrício Adriana leal Francisco Caramelo António Freire Cristina Januário Miguel Castelo-Branco Center for Rapid and Sustainable Product Development (CDRSP) School of Technology and Management (ESTG) of the Polytechnic Institute of Leiria (IPLeiria) Leiria Portugal IBILI Faculty of Medicine University of Coimbra Coimbra Portugal Laboratory of Biostatistics and Medical Informatics IBILI Faculty of Medicine University of Coimbra Coimbra Portugal Neurology Department Coimbra University Hospital Centre (CHUC) Coimbra Portugal

Tremor is a manifestation of a variety of human neurodegenerative diseases, notably Parkinson’s disease (PD) and Essential Tremor (ET), both affecting millions worldwide. PD is primarily caused by a progressive loss of dopamine neurons in the nigrostriatal system that leads to widespread motor symptoms such as bradykinesia, rigidity, tremor and postural instability. ET typically involves a tremor of the arms, hands or fingers. No definitive test or biomarker is yet available for PD or ET, so the rate of misdiagnosis is relatively high. As tremor is a very common feature at the onset of both diseases, it is crucial to be able to characterize it. This is made possible using acce?lerometers to quantify the tremor amplitude and frequency. In this work we aim to find tasks involving upper limb movements that are suitable to modulate both types of tremor. Four tasks were tested, differing on whether the arms moved together or alternatingly and whether loads were added. Significant differences in tremor measures were found when patients were asked to perform simultaneous rapid arms movements with loads placed on their wrists. These results may allow the design of an efficient fMRI protocol for identifying the cortical circuits responsible for the modulation of tremor.

关键词： Disease Essential Tremor Tremor Quantification Tremor Modulation Accelerometers

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Air Quality Regarding to TSP in Six Cities of Sonora,Mexico,a Criticism to the NOM-025-SSA1-1993 and a Proposed Criterion for Its Non-Compliance

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Journal of Environmental Protection 2014年第10期5卷 862-873页

作者： Martin Eusebio Cruz-Campas Agustin Gomez-Alvarez Margarito Quintero-Nunez Roberto Ramirez-leal Jaime Varela-Salazar Onofre Monge-Amaya Engineering Institute Autonomous University of Baja CaliforniaMexicaliMexico Environmental Industrial Engineering Program Sonora State UniversityHermosilloMexico Chemical Engineering and Metallurgy Department University of SonoraHermosilloMexico

In the present study, the air quality is assessed for the year 2010 regarding to the Total Suspended Particles (TSP) for six cities of Sonora, Mexico, representing the first regional study in Sonora in air quality. The assessment used performance indicators and indicators of compliance with the regulations. It is established that in all the cities the maximum limit value of daily concentration of 210 μg/m3 is exceeded, being the percentage of days above the rule of 30%, 78%, 76%, 6%, 3% and 62% for Agua Prieta, Nogales, Puerto Penasco, Hermosillo, Guaymas and Obregón respectively, classifying these days with poor air quality. According to the annualized index used, the air quality was not satisfactory for the period of study in the six cities. Nogales and Puerto Penasco presented the most adverse conditions of air quality with annual average values of TSP of 363 and 345 μg/m3 and maximum daily of 1047 and 1239 μg/m3 (498% and 590% above the norm) respectively. The requirements of coverage that establishes the Mexican Official Standard NOM-025-SSA1-1993 (SSA, 2005) are questioned for its compliance, proposing in this paper a criterion of non-compliance by prioritizing the protection of health and the precautionary principle. It is recommended to implement air quality management programs (PROAIRE) in these cities.

关键词： Particles TSP Air Quality NOM-025-SSA1-1993 Sonora Mexico

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