Clinical implication of 14-3-3 epsilon expression in gastric cancer

作     者：Mariana Ferreira Leal Danielle Queiroz Calcagno Smia Demachki Paulo Pimentel Assumpo Roger Chammas Rommel Rodríguez Burbano Marília de Arruda Cardoso Smith 

作者机构：Genetics DivisionDepartment of Morphology and GeneticFederal University of So PauloSo Paulo 04023-900Brazil Pathology ServiceJoo de Barros Barreto University HospitalFederal University of ParáBelém 60673-000Brazil Surgery ServiceJoo de Barros Barreto University HospitalFederal University of ParáBelém 60673-000Brazil Laboratory of Experimental OncologySchool of MedicineUniversity of So PauloSo Paulo 01246-903Brazil Human Cytogenetics LaboratoryInstitute of Biological SciencesFederal University of ParáBelém 66073-000Brazil 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第13期

页      面：1531-1537页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq Chammas R,Smith MAC and Burbano RR) Fundao de Amparoà Pesquisa do Estado de So Paulo (FAPESP Leal MF and Calcagno DQ) 

主　　题：Gastric cancer 14-3-3 epsilon YWHAE Geneexpression Protein expression 

摘      要：AIM:To evaluate for the first time the protein and mRNA expression of 14-3-3εin gastric ***:14-3-3εprotein expression was determined by western blotting,and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue ***:Authors observed a significant reduction of 14-3-3εprotein expression in gastric cancer(GC)samples compared to their matched non-neoplastic *** levels of 14-3-3εwere also associated with diffuse-type GC and early-onset of this *** data suggest that reduced 14-3-3εmay have a role in gastric carcinogenesis ***:Our results reveal that the reduced 14-3-3εexpression in GC and investigation of 14-3-3ε interaction partners may help to elucidate the carcino-genesis process.