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TT virus infection in patients with chronic hepatitis B and response of TTV to lamivudine

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World Journal of Gastroenterology 2003年第6期9卷 1261-1264页

作者： Javier Moreno Garcia rafael Barcena Marugan Gloria Moraleda Garcia M Luisa Mateos Lindeman Jesus Fortun Abete Santos del campo Terron Department of Gastroenterology Hospital Ramony CajalMadridSpain Department of Microbiology Hospital Ramony CajalMadridSpain Department of Infectious Diseases Hospital Ramony CajalMadridSpain

AIM: To investigate the responses of TT virus (TTV) and hepatitis B virus (HBV) to a long-term lamivudine ***: Sixteen patients infected with both TTV and HBV were treated with lamivudine 100 mg daily for 30 months. Blood samples were drawn at the beginning of the therapy and subsequently at month 3, 6, 9, 12 and *** TTV was quantified by real time PCR and serum HBV was detected by hybridization assay and nested polymerase chain ***: TTV infection was detected in 100 % of HBV-infected patients. Loss of serum TTV DNA after one year of treatment occurred in 1/16 (6 %) patients. At the end of therapy, TTV DNA was positive in 94 % of them. The decline of HBV viremia was evident at 3 months after therapy and the response rate was 31%, 44 %, 63 %, 50 % and 50 %at month 3, 6, 9, 12 and 30, ***: TTV replication is not sensitive to lamivudine and is highly prevalent in HBV-infected patients.

关键词： Torque teno virus Adult Aged DNA Virus Infections Female Hepatitis B, Chronic Humans Lamivudine Male Middle Aged Prevalence Reverse Transcriptase Inhibitors Virus Replication

Prevention of de novo HBV infection by the presence of anti-HBs in transplanted patients receiving core antibody-positive livers

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World Journal of Gastroenterology 2006年第13期12卷 2070-2074页

作者： rafael Barcena Gloria Moraleda Javier Moreno M Dolores Martín Emilio de Vicente Jesús Nuo M Luisa Mateos Santos del campo Department of Gastroenterology Hospital Ramón y Cajal Facultad de MedicinaUniversidad de AlcaláCtra. Colmenar Km 9.128034 MadridSpain Digestive Diseases Hospital Universitario La Paz 28034 MadridSpain Department of Surgery Hospital Ramón y Cajal Facultad de MedicinaUniversidad de Alcalá28034 MadridSpain Department of Microbiology Hospital Ramón y Cajal Facultad de MedicinaUniversidad de Alcalá28034 MadridSpain

AIM： To analyze whether the presence of anti-HBs in liver transplant recipients is effective in preventing HBV infection. METHODS： Twenty-three patients receiving anti-HBc positive liver were studied. Nine recipients were anti-HBc positive as a result of previous HBV infection. Of them, one also received HBV vaccine during the pre-liver transplantation period. Fourteen recipients were anti-HBs positive due to HBV vaccine administered during the pretransplant period. Liver biopsy was obtained in 10/14 anti-HBc negative/anti-HBs positive recipients and in 4/9 anti-HBc positive recipients. RESULTS： After a mean foUow-up period of 46 months, 1 recipient with protective serum anti-HBs levels developed de novo HBV infection as a consequence of immune escape HBV mutants. Among the 14 vaccinated anti-HBc negative/anti-HBs positive recipients, 1/10 patients with available liver biopsy （10%） had liver HBV-DNA at 13 mo post-liver transplantation without serum viral markers and did not develop de novo HBV *** vaccinated anti-HBc positive recipient without HBV vaccine response was HBV-DNA positive in serum and liver, viral DNA was continuously negative in the following tests, so a spontaneous seroconversion was diagnosed. CONCLUSION： The presence of anti-HBs as a result of HBV vaccine or past HBV infection seems to be effective at protecting patients receiving livers from anti-HBc positive donors. However, the emergence of immune escape HBV mutants, which can evade the anti-HBs protection, should be considered as a risk of HBV infection.

关键词： HBV vaccine Liver transplantation De novo HBV infection Hepatitis B core antibody

Review of the El Soplao Amber Outcrop,Early Cretaceous of Cantabria,Spain

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Acta Geologica Sinica(English Edition) 2010年第4期84卷 959-976页

作者： María NAJARRO Enrique PENALVER Ricardo PEREZ-DE LA FUENTE Jaime ORTEGA-BLANCO Cesar MENOR-SALVAN eduardo BARRON Carmen SORIANO Idoia ROSALES rafael LOPEZ del VALLE Francisco VELASCO Fernando TORNOS Véronique DAVIERO-GOMEZ Bernard GOMEZ Xavier delCLOS Instituto Geologico y Minero de Espana E-28003MadridSpain Departament d'Estratigrafia Paleontologia i Geociencies MarinesFacultat de GeologiaUniversitat de BarcelonaE-08071BarcelonaSpain Centro de Astrobiologia(CSIC-INTA) E-28850Torrejon de ArdozSpain European Synchrotron Radiation Facilities F-38000 GrenobleFrance/Geosciences Rennes-Universite de Rennes 1F-35042 RennesFrance El Soplao S.L. Prao El CollaoE-39553CantabriaSpain Universidad del Pais Vasco Dpto.Mineralogia y PetrologiaE-48080 BilbaoSpain CNRS-UMR 5125 PEPS Universite Lyon 1GeodeF-69622 VilleurbanneFrance

El Soplao outcrop, an Early Cretaceous amber deposit recently discovered in northern Spain （Cantabria）, has been shown to be the largest site of amber with arthropod inclusions that has been found in Spain so far. Relevant data provided herein for biogeochemistry of the amber, palynology, taphonomy and arthropod bioinclusions complement those previously published. This set of data suggests at least two botanical sources for the amber of El Soplao deposit. The first （type A amber） strongly supports a source related to Cheirolepidiaceae, and the second （type B amber） shows non-specific conifer biomarkers. Comparison of molecular composition of type A amber with Frenelopsis leaves （Cheirolepidiaceae） strongly suggests a biochemical affinity and a common botanical origin. A preliminary palynological study indicates a regional high taxonomical diversity, mainly of pteridophyte spores and gymnosperm pollen grains. According to the preliminary palynological data, the region was inhabited by conifer forests adapted to a dry season under a subtropical climate. The abundant charcoalified wood associated with the amber in the same beds is evidence of paleofires that most likely promoted both the resin production and an intensive erosion of the litter, and subsequent great accumulation of amber plus plant cuticles. In addition, for the first time in the fossil record, charcoalified plant fibers as bioinclnsions in amber are reported. Other relevant taphonomic data are the exceptional presence of serpulids and bryozoans on the surfaces of some amber pieces indicating both a long exposure on marine or brackish-water and a mixed assemblage of amber. Lastly, new findings of insect bioiuclusions, some of them uncommon in the fossil record or showing remarkable adaptations, are reported. In conclusion, a documented scenario for the origin of the El Soplao amber outcrop is provided.

关键词： fossil resin chemotaxonomy paleobotany charcoal arthropod bioinclusions taphonomy EarlyAlbian

From liver to hormones:The endocrine consequences of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1073-1095页

作者： Juan eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio María del Carmen Durand-Vásquez Luciana del Pilar rafael-Robles Jhean Gabriel Gonzáles-Yovera María Alejandra Quispe-Flores Luis Alberto Concepción-Urteaga Alejandro Román-González José Paz-Ibarra Marcio José Concepción-Zavaleta Non-communicable Diseases Endocrinology Research LineHospital de Apoyo ChepénChepén 13871Peru Department of Endocrinology Hospital Víctor Lazarte EchegarayTrujillo 13006Peru Department of Endocrinology Clínica Javier PradoLima 15046Peru Department of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyénLima 15018Peru Department of Endocrinology Hospital de Emergencias GrauLima 15001Peru Internal Medicine Hospital Regional Docente de TrujilloTrujillo 13011Peru Department of Endocrinology Hospital Universitario de San Vicente FundaciónMedellin 050010Colombia Internal Medicine Universidad de AntioquiaMedellín 050010Colombia School of Medicine Universidad Nacional Mayor de San MarcosLima 15081Peru Department of Endocrinology Hospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Carrera de Medicina Humana Universidad Científica del SurLima 15067Peru

Hepatocrinology explores the intricate relationship between liver function and the endocrine *** liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis *** its importance,assessing endocrine issues in cirrhotic patients is frequently *** article provides a comprehensive review of the epidemiology,pathophysiology,diagnosis,and treatment of endocrine disturbances in liver *** review was conducted using the PubMed/Medline,EMBASE,and Scielo databases,encompassing 172 *** cirrhosis is associated with endocrine disturbances,including diabetes,hypoglycemia,sarcopenia,thyroid dysfunction,hypogonadotropic hypogonadism,bone disease,adrenal insufficiency,growth hormone dysfunction,and secondary *** optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system,*** can be assessed through imaging and functional tests,while other endocrine disorders are evaluated using hormonal assays and imaging *** options include metformin,glucagon-like peptide-1 analogs,sodium-glucose co-transporter-2 inhibitors,and insulin,which are effective and safe for diabetes *** standards are followed for managing hypoglycemia,and hormone replacement therapy is often necessary for other endocrine *** transplantation can address some of these problems.

关键词： Diabetes mellitus Hypoglycemia Thyroid diseases Hypogonadism Metabolic bone diseases Liver cirrhosis

Conifer establishment after the eruption of the Paricutin volcano in central Mexico

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Forest Ecosystems 2022年第1期9卷 71-82页

作者： Jesús eduardo Sáenz-Ceja Blanca Lizeth Sáenz-Ceja J.Trinidad Sáenz-Reyes Diego rafael Pérez-Salicrup Instituto de Investigaciones en Ecosistemas y Sustentabilidad Universidad Nacional Autéonoma de MéxicoAntigua Carretera a Patzcuaro 8701 Col.Ex hacienda San Joséde la Huerta58190MoreliaMexico Escuela Nacional de Estudios Superiores Unidad Morelia Universidad Nacional Autónoma de MéxicoAntigua Carretera a Patzcuaro 8701 Col.Ex hacienda San Joséde la Huerta58190MoreliaMexico Instituto Nacional de Investigaciones Forestales Agrícolas y PecuariasCampo Experimental UruapanAv.Latinoamericana 1101Col.Revolución60500UruapanMexico

Background:Volcanic eruptions have large effects on forest ecosystems and create new substrates,triggering primary succession *** Paricutín volcano,born in central-western Mexico,erupted between 1943 and *** the cessation of the eruptive activity,plant colonization began on the lava flows and tephra deposits,including the conifer species that dominate the surrounding mature *** study aims to reconstruct the history of the establishment of conifer trees on the substrates created by the Paricutín ***:16 sampling plots were established along three transects with northern,southern,and south-western aspects,located every 250 m from the preserved forest to the volcanic *** cores from 400 conifer trees were extracted and their age was determined by cross-dating annual tree *** order of the species colonization and the tree establishment,abundance,and dominance patterns were ***,the influence of the distance from the mature forests and the inter-annual climatic conditions on the temporal tree establishment pattern was ***:Eight pine and one fir species have been established since 1970,only 18 years after the end of the eruptive ***,tree establishment increased by 12.9%annually after 1995,with the youngest tree in our sample getting established in *** did not find a well-defined temporal and spatial pattern of species arrival,which suggests that colonization occurred randomly,although the four pine species that were established early became the most abundant and *** establishment was not influenced by the distance from the mature forest,and wet inter-annual conditions did not enhance pulses of tree recruitment,exhibiting a continuous tree establishment ***:Conifer species have shown a great capacity for colonizing volcanic substrates created by the Paricutín eruption,which suggests that tropical montane conifers can regenerate rapidly under high-magni

关键词： Age structure Dendrochronology Lava flow Primary succession Tropical montane forest

Prognostic Factors for Mortality in Severe Traumatic Brain Injury at HGZ 46, Villahermosa, Tabasco, Period from March 1, 2021 to December 31, 2022

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Open Journal of Emergency Medicine 2024年第1期12卷 1-9页

作者： América del Carmen Flores Jiménez eduardo Guillermo Aguilar López rafael Blanco De La Vega Pérez Juan Manuel Hernández Vázquez Emergency Room at General Zone Hospital #46 (HGZ46) “Dr. Bartolomé Reynés Berezaluce” from Mexican Institute of Social Security Tabasco Mexico Intensive Care Unit at General Zone Hospital #46 (HGZ46) “Dr. Bartolomé Reynés Berezaluce” from Mexican Institute of Social Security Tabasco Mexico

Introduction: A traumatic brain injury (TBI) is caused by a forceful bump, blow, or jolt to the head or body, or by an object that pierces the skull and interrupts the normal function of the brain. Severe TBI is estimated at 73 cases per 100,000 people. The mortality of severe TBI can be reduced if a timely diagnosis and treatment of the injuries are made through prognostic factors. Objective: To determine the prognostic factors related to mortality in severe traumatic brain injury at the Hospital General de Zona No. 46. Material and Methods: Retrospective, cross-sectional and descriptive study in beneficiaries admitted to the Hospital General de Zona (HGZ) No. 46 of the Mexican Institute of Social Security (IMSS by its acronym in Spanish), with a diagnosis of severe TBI;the possible prognostic factors related to mortality of severe TBI were obtained from their records. Measures of central tendency and chi square were used for data analysis. Results: The study sample consisted of 60 subjects diagnosed with severe traumatic brain injury, of which 5 (8%) were women and 55 (92%) were men, and all 60 (100%) patients died. The average age of the sample was 26 with a standard deviation of 9 years. The variables that had a p value less than or equal to 0.05 were: Mydriasis, seizures, Hyperglycemia, Normoglycemia, Hypothermia and Hypotension. This means that these variables were associated with mortality. Conclusion: Statistical significance is demonstrated in prognostic factors of mortality in severe traumatic brain injury with p < 0.05 in the case of mydriasis, seizures, hyperglycemia, normoglycemia, hypothermia and hypotension.

关键词： Traumatic Brain Injury Prognostic Factors Mortality Severity

Variable-top stem biomass equations at tree-level generated by a simultaneous density-integral system for second growth forests of roble, raulí,and coigüe in Chile

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Journal of Forestry Research 2019年第3期30卷 993-1010页

作者： Carlos Valenzuela eduardo Acuna Alicia Ortega Geronimo Quinonez-Barraza Jose Corral-Rivas Jorge Cancino Departamento Manejo de Bosques y Medio Ambiente Facultad de Ciencias ForestalesUniversidad de Concepcion Victoria 631Barrio Universitario4070386 ConcepcionChile Instituto de Bosques y Sociedad Facultad de Ciencias Forestales y Recursos NaturalesUniversidad Austral de ChileCampus Isla Teja5110566 ValdiviaChile campo Experimental Valle del Guadiana Instituto Nacional de Investigaciones Forestales Agricolas y Pecuarias (INIFAP)km 4.5 Carretera Durango-Mezquital34170 DurangoDGOMexico Instituto de Silvicultura e Industria de la Madera Universidad de Juarez del Estado de Durango34120 DurangoMexico

Variable-top stem biomass models at the tree level for second growth forests of roble (Nothofagus obliqua), rauli(Nothofagus alpina), and coigüe (Nothofagus dombeyi) were fitted by a simultaneous density-integral system, which combines a stem taper model and a wood basic density model. For each model, an autoregressive structure of order 2 and a power equation of residual variance were incorporated to reduce residual autocorrelation and heteroscedasticity, respectively. By using dummy variables in the regression analysis, zonal effects on the parameters in the variable-top stem biomass equations were detected in roble. Consequently, equations for clusters of zones were obtained. These equations presented significant parameters and a high precision in both fitting and validation processes (i.e., CV<11.5% and CVp<11.9%, respectively), demonstrating that they are unbiased. The advantage of these types of functions is that they provide estimates of volume and biomass of sections of the stem, defined between any two points of the stem in the three species. Thus, depending on the final use of the wood and the dimensions of the tree, a stem fraction can be quantified in units of volume and the remaining fraction in units of weight.

关键词： Autocorrelation Density-integral Dummy variables Autoregressive error structure Heteroscedasticity

The first record of dermochelyid turtles in the Eocene of Tierra del Fuego:new insights on the evolution of the Weddellian faunas

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Advances in Polar Science 2024年第1期35卷 63-77页

作者： Paula BONA Juliana STERLI Marcelo Saúl de la FUENTE eduardo OLIVERO Marta S.FERNÁNDEZ Marcelo REGUERO División Paleontología Vertebrados Museo de La Plata-Anexo IIFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1900FWAArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Ciudad Autónoma de Buenos Aires C1425FQBArgentina Museo Paleontológico Egidio Feruglio Trelew U9100Argentina Instituto de Evolución Ecología Histórica y Ambiente-CONICETSan Rafael CP5600Argentina Centro Austral de Investigaciones Científicas-CONICET Universidad Nacional de Tierra del FuegoUshuaia CP 9410Argentina División Paleontología Vertebrados Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The Antarctic Paleogene marine fossil record has been the key to reconstructing the evolution of the Weddellian Sea and final dismemberment of Southern *** this context,Eocene marine vertebrates from Seymour(Marambio)Island have provided valuable *** present the first Eocene record of marine reptiles from the southern Atlantic Coast of South *** corresponds to several postcranial turtle remains represented by a proximal end of the right humerus,three caudal and one thoracic vertebrae,a fragment of the left pubis,and ten ossicles of the dorsal carapace,coming from the Leticia Formation(late-mid Eocene)at Cabo Tiburones,Tierra del Fuego,*** materials show severalfeatures such as the size and general morphology of the humerus and vertebrae,and the presence of relatively small,irregular,smooth,and unkeeled ossicles,which allow us to assign them to Dermochelyidae *** are a cosmopolitan group ofcryptodiran turtles,registered from the late Cretaceous up to the recent,with some physiological-biological peculiarities(e.g.,endothermy and an exclusive jellyfish-based diet)and characterized by the presence of an osseous carapace formed by *** new finding from the Leticia Formation is an addition to the scarce and extremely fragmentary record of Eocene dermochelyids from the southern seas like those from the La Meseta and Submeseta formations(Antarctica)and the Waihao and Burnside formations(New Zealand).This new information allows us to discuss the presence of these turtles in such high latitudes in the past and its implication in the evolution of the Weddellian fauna.

关键词： marine reptiles sea turtles Dermochelyidae Paleogene La Meseta Formation Submeseta Formation Leticia Formation

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The Genome of Cucurbita argyrosperma (Silver- Seed Gourd) Reveals Faster Rates of Protein- Coding Gene and Long Noncoding RNA Turnover and Neofunctionalization within Cucurbita

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Molecular Plant 2019年第4期12卷 506-520页

作者： Josue Barrera-Red on do Enrique Ibarra-Laclette Alejandra Vazquez-Lobo Yocelyn T. Gutierrez-Guerrero Guillermo Sanchez de la Vega Daniel Pinero Salvador Montes-Hernandez rafael Lira-Saade Luis E. Eguiarte Departamento de Ecologia Evolutiva Instituto de Ecologia Universidad Nacional Aut6noma de Mexico Circuito Exterior s/n Anexo al Jardin Bot合nico 04510 Ciudad de Mexico Mexico Departamento de Estudios Moleculares Avanzados Instituto de Ecologia A.C. Carretera Antigua a Coatepec No. 351 Col. El Haya. C.P. Xalapa Veracruz 91070 Mexico Centro de Investigaciones en Biodiversidad y Conservacion Universidad Autdnoma del Estado de Morelos Av. Universidad 1001 Col. Chamilpa Cuernavaca Morelos 62209 Mexico campo Experimental Bajio Instituto Nacional de In vestigaciones Forestales Agricolas y Pecuarias (INIFAP) Km 6.5 Carretera Celaya-San Miguel de Allen de Celaya Guanajuato 38110 Mexico UBIPRO Facultad de Estudios Superiores Iztacala Universidad Nacional Autdnoma de Mexico Av. de los Barrios #1 Col. Los Reyes Iztacala Tlanepantla Edo. de Mex 54090 Mexico

Whole-genome duplications are an important source of evolutionary novelties that change the mode and tempo at which genetic elements evolve within a genome. The Cucurbita genus experienced a wholegenome duplication around 30 million years ago, although the evolutionary dynamics of the coding and noncoding genes in this genus have not yet been scrutinized. Here, we analyzed the genomes of four Cucurbita species, in eluding a newly assembled genome of Cucurbita argyrosperma, and compared the gene con tents of these species with those of five other members of the Cucurbitaceae family to assess the evolutionary dynamics of protein-coding and long intergenic noncoding RNA (lincRNA) genes after the genome duplication. We report that Cucurbita genomes have a higher protein-coding gene birth-death rate compared with the genomes of the other members of the Cucurbitaceae family. C. argyrosperma gene families associated with pollination and transmembrane transport had significantly faster evolutionary rates. lincRNA families showed high levels of gene turnover throughout the phylogeny, and 67.7% of the lincRNA families in Cucurbita showed evidence of birth from the neofunctionalization of previously existing protein-coding genes. Collectively, our results suggest that the whole-genome duplication in Cucurbita resulted in faster rates of gene family evolution through the neofunctionalization of duplicated genes.

关键词： Cucurbita argyrosperma, comparative genomics molecular evolution neofunctionalization long noncoding RNA whole-genome duplication