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Low-intensity pulsed ultrasound reduces alveolar bone resorption during orthodontic treatment via Lamin A/C-Yes-associated protein axis in stem cells

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World Journal of Stem Cells 2024年第3期16卷 267-286页

作者： Tong Wu Fu Zheng Hong-Yi Tang Hua-Zhi Li Xin-Yu Cui Shuai Ding duo Liu Cui-Ying Li Jiu-Hui Jiang Rui-Li Yang Department of Orthodontics Peking University School and Hospital of StomatologyNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China Department of Central Laboratory Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China

BACKGROUND The bone remodeling during orthodontic treatment for malocclusion often requires a long duration of around two to three years,which also may lead to some complications such as alveolar bone resorption or tooth root ***-intensity pulsed ultrasound(LIPUS),a noninvasive physical therapy,has been shown to promote bone fracture *** is also reported that LIPUS could reduce the duration of orthodontic treatment;however,how LIPUS regulates the bone metabolism during the orthodontic treatment process is still *** To investigate the effects of LIPUS on bone remodeling in an orthodontic tooth movement(OTM)model and explore the underlying *** A rat model of OTM was established,and alveolar bone remodeling and tooth movement rate were evaluated via micro-computed tomography and staining of tissue *** vitro,human bone marrow mesenchymal stem cells(hBMSCs)were isolated to detect their osteogenic differentiation potential under compression and LIPUS stimulation by quantitative reverse transcription-polymerase chain reaction,Western blot,alkaline phosphatase(ALP)staining,and Alizarin red *** expression of Yes-associated protein(YAP1),the actin cytoskeleton,and the Lamin A/C nucleoskeleton were detected with or without YAP1 small interfering RNA(siRNA)application via *** The force treatment inhibited the osteogenic differentiation potential of hBMSCs;moreover,the expression of osteogenesis markers,such as type 1 collagen(COL1),runt-related transcription factor 2,ALP,and osteocalcin(OCN),*** could rescue the osteogenic differentiation of hBMSCs with increased expression of osteogenic marker inhibited by ***,the expression of LaminA/C,F-actin,and YAP1 was downregulated after force treatment,which could be rescued by ***,the osteogenic differentiation of hBMSCs increased by LIPUS could be attenuated by YAP siRNA ***,LIPUS increased alveolar

关键词： Low-intensity pulsed ultrasound Bone resorption Osteogenesis Cytoskeleton-Lamin A/C-Yes-associated protein axis Bone marrow mesenchymal stem cells Orthodontic tooth movement

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马克思主义文化领导权与资本主义意识形态控制的实质论析——兼评“西方马克思主义”的误区及其危害

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毛泽东邓小平理论研究 2024年第3期 73-87,F0003页

作者：孙夺内蒙古大学中华民族共同体研究中心

1970年代以来,借助葛兰西的文本,众多“西方马克思主义”思想家对文化领导权与资本主义意识形态控制问题进行了广泛讨论。这一命题实际上是由列宁在20世纪初提出来的。在列宁那里,自发性、领导权、先锋队等问题构成了一个完整的理论框架... 详细信息

1970年代以来,借助葛兰西的文本,众多“西方马克思主义”思想家对文化领导权与资本主义意识形态控制问题进行了广泛讨论。这一命题实际上是由列宁在20世纪初提出来的。在列宁那里,自发性、领导权、先锋队等问题构成了一个完整的理论框架,从理论上论证了以伯恩施坦为代表的民主社会主义必然内化于资本主义体制的历史结局。葛兰西总体上坚持了列宁主义的政治战略,强调由于西方市民社会的“牢固防线”,欧洲革命需要比俄国十月革命更加注重持久的阵地战,更加重视发挥无产阶级阶级意志和政治组织的作用。然而,“西方马克思主义”总体上不是按照马克思列宁主义,而是按照伯恩施坦主义的理论框架处理葛兰西文本,将伯恩施坦式的回避阶级议题的改良主义从议会选举转移到市民社会,转移到女权、种族、性少数人群、环保等领域。

关键词：公共关系产业意识形态控制文化领导权伯恩施坦主义西方马克思主义

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Leveraging Zibo Barbecue’s Success to Develop Hebei’s Culinary Brand:A Strategic Path

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Proceedings of Business and Economic Studies 2024年第3期7卷 48-52页

作者： Chengguo E Yang Yang Ali Mao duo Pan Foundation Department Hebei University of Environmental EngineeringQinhuangdao 066102China Hebei Institute of International Business and Economics Qinhuangdao 066311China

In 2023,Zibo barbecue culture exploded across the entire country,allowing people nationwide to experience and enjoy Zibo *** phenomenon injected new vitality into the economic development of *** promote the economic development of Hebei Province,this paper fully analyzes the reasons behind the popularity of Zibo barbecue,combines these insights with the characteristics of traditional cuisine in Hebei,and draws lessons from Zibo barbecue’s success as a business card for *** paper then outlines a strategy for building a culinary business card for Hebei.

关键词： Zibo barbecue Hebei traditional food Online platform City business card Government-enterprise cooperation

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《三国演义》英译者的“译入”行为特征探析

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外语学刊 2024年第3期 64-70页

作者：许多南京师范大学外国语学院南京210023

纵观《三国演义》二百余年的英译史,外籍译者占比接近八成。26位外籍译者中,主要以英美籍译者为主,同时也包括德国籍译者。他们呈现出的“译入”行为存在一定的共性,具有其显著特征。本文聚焦于《三国演义》英译者的“译入”行为,通过... 详细信息

纵观《三国演义》二百余年的英译史,外籍译者占比接近八成。26位外籍译者中,主要以英美籍译者为主,同时也包括德国籍译者。他们呈现出的“译入”行为存在一定的共性,具有其显著特征。本文聚焦于《三国演义》英译者的“译入”行为,通过翻译内外因素、文本与副文本的分析,揭示外籍译者译入行为的3个主要特征:以读者接受为中心、“重文轻武”的文本内容选择倾向以及注重翻译与研究的互动。这些外籍译者既是《三国演义》的译者,又是学者,他们在翻译和研究《三国演义》时,充分体现了对中国传统文化的热爱和尊重,以及对翻译工作的认真和严谨。探究外籍译者“译入”行为特征,以期为《三国演义》在英语世界的持续译介和广泛传播提供助力。

关键词：《三国演义》译入行为译者英译本副文本

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Preliminary exploration of animal models of congenital choledochal cysts

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World Journal of Gastroenterology 2024年第10期30卷 1420-1430页

作者： Shu-Hao Zhang Yue-Bin Zhang duo-Te Cai Tao Pan Ken Chen Yi Jin Wen-Juan Luo Zong-Wei Huang Qing-Jiang Chen Zhi-Gang Gao Department of General Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Various animal models have been used to explore the pathogenesis of choledochal cysts(CCs),but with little convincing *** surgical techniques can achieve satisfactory outcomes for treatment of ***,recent studies have focused more on clinical issues rather than basic ***,we need appropriate animal models to further basic *** To establish an appropriate animal model that may contribute to the investigation of the pathogenesis of *** Eighty-four specific pathogen-free female Sprague-Dawley rats were randomly allocated to a surgical group,sham surgical group,or control group.A rat model of CC was established by partial ligation of the bile *** reliability of the model was confirmed by measurements of serum biochemical indices,morpho-logy of common bile ducts of the rats as well as molecular biology experiments in rat and human *** Dilation classified as mild(diameter,≥1 mm to<3 mm),moderate(≥3 mm to<10 mm),and severe(≥10 mm)was observed in 17,17,and 2 rats in the surgical group,respectively,while no dilation was observed in the control and sham surgical *** levels of alanine aminotransferase,aspartate aminotrans-ferase,total bilirubin,direct bilirubin,and total bile acids were significantly elevated in the surgical group as compared to the control group 7 d after surgery,while direct bilirubin,total bilirubin,and gamma-glutamyltransferase were further increased 14 d after *** of the biochemical indices gradually decreased to normal ranges 28 d after *** protein expression trend of signal transducer and activator of transcription 3 in rat model was consistent with the human CC *** The model of partial ligation of the bile duct of juvenile rats could morphologically simulate the cystic or fusiform CC,which may contribute to investigating the pathogenesis of CC.

关键词： Choledochal cyst Animal model Partial ligation Cystic and fusiform dilation Juvenile rats

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径向进气旋转盘腔换热特性试验研究

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航空发动机 2014年第5期40卷 18-22页

作者：于霄吕多李红莲夏梦中航工业沈阳发动机设计研究所沈阳110015 北京航空航天大学航空发动机气动热力国防科技重点实验室北京100083

为分析流量系数和旋转雷诺数对径向进气旋转盘换热效果的影响,采用试验方法对径向进气旋转盘腔的换热特性进行了研究。通过测试不同工况下的旋转盘表面温度,获得了局部努赛尔数分布和平均努赛尔数的变化规律。试验结果表明:由于径向进... 详细信息

为分析流量系数和旋转雷诺数对径向进气旋转盘换热效果的影响,采用试验方法对径向进气旋转盘腔的换热特性进行了研究。通过测试不同工况下的旋转盘表面温度,获得了局部努赛尔数分布和平均努赛尔数的变化规律。试验结果表明:由于径向进气旋转盘腔内流动复杂,旋转盘面局部对流换热系数受流动影响出现多头分布的规律;同时,随着旋转雷诺数和流量系数的增大,转盘的平均努赛尔数增大,平均换热效果增强。

关键词：旋转盘径向进气换热特性流量系数旋转雷诺数燃气轮机

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Potential application of Nardostachyos Radix et Rhizoma-Rhubarb for the treatment of diabetic kidney disease based on network pharmacology and cell culture experimental verification

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World Journal of Diabetes 2024年第3期15卷 530-551页

作者： Meng-Ying Che Ling Yuan Jiao Min duo-Jie Xu Dou-Dou Lu Wen-Jing Liu Kai-Li Wang Yan-Yan Wang Yi Nan Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Endocrinology Yinchuan Hospital of Traditional Chinese MedicineYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetic kidney disease(DKD)is one of the serious complications of diabetes mellitus,and the existing treatments cannot meet the needs of today's *** Chinese medicine has been validated for its efficacy in DKD after many years of clinical ***,the specific mechanism by which it works is still *** the molecular mechanism of the Nardostachyos Radix et Rhizoma-rhubarb drug pair(NRDP)for the treatment of DKD will provide a new way of thinking for the research and development of new *** To investigate the mechanism of the NRDP in DKD by network pharmacology combined with molecular docking,and then verify the initial findings by in vitro *** The Traditional Chinese Medicine Systems Pharmacology(TCMSP)database was used to screen active ingredient targets of *** for DKD were obtained based on the Genecards,OMIM,and TTD *** VENNY 2.1 database was used to obtain DKD and NRDP intersection targets and their Venn diagram,and Cytoscape 3.9.0 was used to build a"drug-component-target-disease"*** String database was used to construct protein interaction *** Encyclopedia of Genes and Genomes(KEGG)enrichment analysis and Gene Ontology analysis were performed based on the DAVID *** selecting the targets and the active ingredients,Autodock software was used to perform molecular *** experimental validation using renal tubular epithelial cells(TCMK-1),we used the Cell Counting Kit-8 assay to detect the effect of NRDP on cell viability,with glucose solution used to mimic a hyperglycemic *** cytometry was used to detect the cell cycle progression and *** blot was used to detect the protein expression of STAT3,p-STAT3,BAX,BCL-2,Caspase9,and *** A total of 10 active ingredients and 85 targets with 111 disease-related signaling pathways were obtained for *** analysis of KEGG pathways was performed to determ

关键词： Nardostachyos Radix et Rhizoma-rhubarb Diabetic kidney disease Molecular docking Network pharmacology Experimental validation

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用于高风险环境安全监测和可调热管理的具有分层核壳结构的耐化学品纱线

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Engineering 2024年第1期32卷 217-225页

作者： duo Xu Yingcun Liu Can Ge Chong Gao Ze Chen Ziyi Su Haoran Gong Weilin Xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200China

Chemical resistant textiles are vital for safeguarding humans against chemical hazards in various *** as industrialproduction,chemicalaccidents,laboratory activities,and road ***,the ideal integration of chemical resistance,thermal and moisture management,and wearer condition monitoring in conventional chemically protective textiles remains ***,the design,manufacturing,and use of stretchable hierarchical core-shell yarns(HCSYs)for integrated chemical resistance,moisture regulation,and smart sensing textiles are *** yarns con-tain helically elastic spandex,wrapped silver-plated nylon,and surface-structuredpolytetrafluo-roethylene(PTFE)yarns and are designed and manufactured based on a scalable fabrication *** addition to their ideal chemical resistance performance,HCSYs can function as multifunctional stretch-able electronics for real-time human motion monitoring and as the basic element of intelligent ***,a desirable dynamic thermoregulation function is achieved by exploiting the fabric structure with stretching *** HCSYs may provide prospective opportunities for the future development of smart protective textiles with high durability,flexibility,and scalability.

关键词： Hierarchical core-shell structure Chemical resistant yam Wearable strain sensor Thermoregulation

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解读《涉及人的生命科学和医学研究伦理审查办法》发展负责任研究与创新

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中国医学伦理学 2024年第4期37卷 377-383页

作者：魏琳许多西安交通大学马克思主义学院陕西西安710049

《涉及人的生命科学和医学研究伦理审查办法》的出台,回应了科学技术、社会和伦理发展引发的伦理审查新问题,以及法律法规对伦理审查的要求,适应了科技创新研究投入持续加大和生物技术发展的趋势,扩展了伦理审查制度适用机构和研究类型... 详细信息

《涉及人的生命科学和医学研究伦理审查办法》的出台,回应了科学技术、社会和伦理发展引发的伦理审查新问题,以及法律法规对伦理审查的要求,适应了科技创新研究投入持续加大和生物技术发展的趋势,扩展了伦理审查制度适用机构和研究类型。面对涉及人的生命科学和医学研究,伦理审查是负责任研究与创新的保障形式之一。因此,要建立并完善伦理审查制度,落实涉及人的生命科学和医学研究的“主体责任”,开展分类分层次的生命伦理教育,增强科研人员、研究管理人员和学生的负责任研究与创新的意识。

关键词：生命科学医学研究伦理审查负责任研究与创新

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Classification of congenital cataracts based on multidimensional phenotypes and its association with visual outcomes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 473-479页

作者： Yuan Tan Ying-Shi Zou Ying-Lin Yu Le-Yi Hu Ting Zhang Hui Chen Ling Jin duo-Ru Lin Yi-Zhi Liu Hao-Tian Lin Zhen-Zhen Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

●AIM:To establish a classification for congenital cataracts that can facilitate individualized treatment and help identify individuals with a high likelihood of different visual outcomes.●METHODS:Consecutive patients diagnosed with congenital cataracts and undergoing surgery between January 2005 and November 2021 were *** on visual outcomes and the phenotypic characteristics of ocular biometry and the anterior and posterior segments were extracted from the patients’medical records.A hierarchical cluster analysis was *** main outcome measure was the identification of distinct clusters of eyes with congenital cataracts.●RESULTS:A total of 164 children(299 eyes)were divided into two clusters based on their ocular *** 1(96 eyes)had a shorter axial length(mean±SD,19.44±1.68 mm),a low prevalence of macular abnormalities(1.04%),and no retinal abnormalities or posterior *** 2(203 eyes)had a greater axial length(mean±SD,20.42±2.10 mm)and a higher prevalence of macular abnormalities(8.37%),retinal abnormalities(98.52%),and posterior cataracts(4.93%).Compared with the eyes in Cluster 2(57.14%),those in Cluster 1(71.88%)had a 2.2 times higher chance of good best-corrected visual acuity[<0.7 logMAR;OR(95%CI),2.20(1.25–3.81);P=0.006].●CONCLUSION:This retrospective study categorizes congenital cataracts into two distinct clusters,each associated with a different likelihood of visual *** innovative classification may enable the personalization and prioritization of early interventions for patients who may gain the greatest benefit,thereby making strides toward precision medicine in the field of congenital cataracts.

关键词： classification congenital cataract phenotype visual acuity cluster analysis

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