检索结果-南通市图书馆

Novel Insight into Glial Biology and Diseases

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2023年第3期39卷 365-367页

作者： Cheng He shumin duan Key Laboratory of Molecular Neurobiology of Ministry of Education and the Collaborative Innovation Center for Brain Science Second Military Medical UniversityShanghai 200433China Department of Neurobiology MOE Frontier Science Center for Brain Research and Brain-Machine IntegrationZhejiang University School of MedicineHangzhou 310058China

In the central nervous system(CNS),there are mainly two types of nerve *** is neurons,the other is glial *** are electrically excitable,whereas glial cells are not,and this is the fundamental difference between the two types of *** cells,consisting of astrocytes,oligodendrocyte lineage cells,and microglia,contribute more than half of the total cells in the mammalian CNS.

关键词： cells. Diseases CNS

Trafficking pathway between plasma membrane and mitochondria via clathrin-mediated endocytosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2018年第6期10卷 539-548页

作者： Zhongya Wei Wenfeng Su Huifang Lou shumin duan Gang Chen Department of Neurobiology Key Laboratory of Medical Neurobiology of Ministry of Health of ChinaKey Laboratory of Neurobiology of Zhejiang Province Zhejiang University School of MedicineHangzhou 310058China Key Laboratory of Neuroregeneration of Jiangsu Province and the Ministry of Education Co-innovation Center of NeuroregenerationNantong University Nantong 226019China Department of Anesthesiology Affiliated Hospital of Nantong UniversityNantong 226001China

Endocytosis is a basic cellular process that describes a form of active transport across the plasma membrane into the *** endocytic pathway consists of distinct membrane compartments;internalized molecules are delivered to early endosomes,and some of them are recycled back to the surface,whereas other molecules are sent to late endosomes and lysosomes for ***,little is known about how mitochondria are involved in the endocytic ***,we report that FM dyes, membrane-impermeant fluorescent lipid probes,can traffic to mitochondria directly from the plasma membrane by clathrinmediated *** dye entry into mitochondria uses microtubule-dependent active transport,but the mechanism is different from the classical endocytic ***,this study reveals a previously unrealized lipid trafficking pathway from the plasma membrane to mitochondria.

关键词： endocytosis mitochondria FM dye clathrin

Frontiers and future perspectives of neuroimmunology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fundamental Research 2024年第2期4卷 206-217页

作者： Hai Qi shumin duan Yanying Xu Hongliang Zhang School of Medicine Tsinghua UniversityBeijing 100084China Faculty of Medicine and Pharmaceutical Sciences Zhejiang UniversityHangzhou 310014China Department of Life Sciences National Natural Science Foundation of ChinaBeijing 100085China

Neuroimmunology is an interdisciplinary branch of biomedical science that emerges from the intersection of studies on the nervous system and the immune *** complex interplay between the two systems has long been *** efforts directed at the underlying functional interface and associated pathophysiology,however,have garnered attention only in recent *** this narrative review,we highlight significant advances in research on neuroimmune interplay and modulation.A particular focus is on early-and middle-career neuroimmunologists in China and their achievements in frontier areas of"neuroimmune interface","neuro-endocrine-immune network and modulation","neuroimmune interactions in diseases","meningeal lymphatic and glymphatic systems in health and disease",and"tools and methodologies in neuroimmunology research".Key scientific questions and future directions for potential breakthroughs in neuroimmunology research are proposed.

关键词： Neuroimmunology Neuroimmune interplay Neuro-endocrine-immune network Basic research Key scientific questions

Special Issue Celebrating the 25^(th)Anniversary of the Institute of Neuroscience,CAS

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第11期40卷 1599-1601页

作者： Ting Lv Yefei Li Fei Dong shumin duan Editorial Office of Neuroscience Bulletin Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Department of Neurology of Second Affiliated Hospital and School of Brain Science and Brain Medicine Zhejiang University School of MedicineHangzhou 310058China

On November 27^(th),2024,the Center for Excellence in Brain Science and Intelligence Technology(Institute of Neuroscience,ION)at the Chinese Academy of Sciences(CAS)will commemorate its 25th Anniversary by reviewing its development and highlighting its research *** with the anniversary celebrations,Neuroscience Bulletin organized this special academic issue as part of these *** issue features curated and invited submissions from neuroscientists who are currently affiliated with or have previously studied or worked at the *** selected papers showcase the institute’s scientific achievements and academic impact,honoring its legacy while inspiring future advancements in the field of *** Original Articles,four Letters,one Insight,and three Reviews are *** contributions span multiple dimensions of neuroscience,from molecular mechanisms to cognitive and behavioral insights,each offering a unique perspective on the complexities of the brain.

关键词： offering dimensions Bulletin

Morphological Tracing and Functional Identification of Monosynaptic Connections in the Brain:A Comprehensive Guide

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第9期40卷 1364-1378页

作者： Yuanyuan Li Yuanyuan Fang Kaiyuan Li Hongbin Yang shumin duan Li Sun Affiliated Mental Health Center and Hangzhou Seventh People’s Hospital and School of Brain Science and Brain Medicine Zhejiang University School of MedicineHangzhou310058China Liangzhu Laboratory MOE Frontier Science Center for Brain Science and Brain-machine IntegrationState Key Laboratory of Brain-machine IntelligenceZhejiang UniversityHangzhou311121China NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang UniversityHangzhou310058China Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou310058China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100005China

Behavioral studies play a crucial role in unraveling the mechanisms underlying brain *** advances in optogenetics,neuronal typing and labeling,and circuit tracing have facilitated the dissection of the neural circuitry involved in various important *** identification of monosynaptic connections,both upstream and downstream of specific neurons,serves as the foundation for understanding complex neural circuits and studying behavioral ***,the practical implementation and mechanistic understanding of monosynaptic connection tracing techniques and functional identification remain challenging,particularly for inexperienced *** application of these methods and misinterpretation of results can impede experimental progress and lead to erroneous *** this paper,we present a comprehensive description of the principles,specific operational details,and key steps involved in tracing anterograde and retrograde monosynaptic *** outline the process of functionally identifying monosynaptic connections through the integration of optogenetics and electrophysiological techniques,providing practical guidance for researchers.

关键词： Trans-monosynaptic Retrograde Anterograde Viral tool Neural circuit Optogenetics Electrophysiology

Anterograde Trans-Synaptic Tagging Mediated by Adeno-Associated Virus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2017年第3期33卷 348-350页

作者： Fei Zhao Hai-Fei Jiang Wen-Bo Zeng Yousheng Shu Min-Hua Luo shumin duan State Key Laboratory of Virology Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Wuhan Institute of Virology Chinese Academy of Sciences State Key Laboratory of Cognitive Neuroscience and Learning IDG/Mc Govern Institute for Brain ResearchSchool of Brain and Cognitive Sciences the Collaborative Innovation Center for Brain Science Beijing Normal University Department of Neurobiology Key Laboratory of Medical Neurobiology of the Ministry of Health of China Key Laboratory of Neurobiology Zhejiang University School of Medicine

Trans-neuronal viral tracing is becoming one of the most important methods for mapping neuronal circuit connections,but an anterograde trans-synaptic tracer compatible with functional assays is still ***-associated virus（AAV）is replication-defective,and its production of offspring needs the help of adenovirus（AV）[1]or herpesvirus co-infection[2].The replication deficiency,non-pathogenicity,easy manipulability,

关键词： neuronal herpesvirus offspring replication pathogenicity synaptic tracing Associated adenovirus titer

Anxiolytic Effect of Increased NREM Sleep after Acute Social Defeat Stress in Mice

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第10期36卷 1137-1146页

作者： Xiang Feng Hui-Ying Zhao Yu-Jin Shao Hui-Fang Lou Li-Ya Zhu shumin duan Yan-Qin Yu Department of Neurobiology and Department of Neurology of The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China

Social defeat stress(SDS)plays a major role in the pathogenesis of psychiatric disorders like anxiety and *** is generally considered to involve recovery of the brain from prior experience during wakefulness and is altered after acute ***,the effect of acute SDS on sleep/wake behavior in mice varies between *** addition,whether sleep changes in response to stress contribute to anxiety is not well ***,we first investigated the effects of acute SDS on sleep/wake states in the active period in *** results showed that total sleep time(time in rapid eyemovement[REM]and non-REM[NREM]sleep)increased in the active period after acute *** sleep increased mainly during the first 3 h after SDS,while REM sleep increased at a later ***,we demonstrated that the increased NREM sleep had an anxiolytic benefit in acute *** deprived of sleep for 1 h or 3 h after acute SDS remained in a highly anxious state,while in mice with ad libitum sleep the anxiety rapidly faded ***,our findings suggest an anxiolytic effect of NREM sleep,and indicate a potential therapeutic strategy for anxiety.

关键词： Social defeat stress Sleep Sleep deprivation Anxiety Anxiolytic effect

Immunology reshapes neuroscience,and neuroscience reshapes immunology

在线全文

学校读者我要写书评

暂无评论

Fundamental Research 2024年第2期4卷 199-200页

作者： Bo Peng Yanxia Rao Yun Wang shumin duan Hai Qi Jing Yang Hongliang Zhang Department of Neurosurgery Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain ScienceMOE Innovative Center for New Drug Development of Immune Inflammatory DiseasesFudan UniversityShanghai 200040China Department of Laboratory Animal Science MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Neuroscience Research Institute and Department of Neurobiology School of Basic Medical SciencesKey Laboratory for NeuroscienceMinistry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeijing 100083China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Faculty of Medicine and Pharmaceutical Sciences Zhejiang UniversityHangzhou 310014China School of Medicine Tsinghua UniversityBeijing 100084China IDG/McGovern Institute for Brain Research Center for Life SciencesSchool of Life SciencesPeking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China Department of Life Sciences National Natural Science Foundation of ChinaBeijing 100085China

As a result of evolution,our body has evolved into a sophisticated system in which various tissues and organs cooperate in a highly orchestrated *** tissues or organs operate in *** brain serves as the command center of our body and is relatively isolated from the peripheral system due to the presence of the blood-brain barrier(BBB).This barrier prevents direct and extensive interaction between blood cells,plasma molecules,and brain cells,contributing to the longstanding perception of the brain as an“immune-privileged”***,neuroscientists and immunologists historically conducted separate research with minimal overlap between these two ***,this perspective has undergone reconsideration over the past few decades.

关键词： organs overlap contributing

A Critical Time-Window for the Selective Induction of Hippocampal Memory Consolidation by a Brief Episode of Slow-Wave Sleep

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2018年第6期34卷 1091-1099页

作者： Yi Lu Zheng-Gang Zhu Qing-Qing Ma Yun-Ting Su Yong Han Xiaodong Wang shumin duan Yan-Qin Yu Department of Neurobiology Institute of NeuroscienceNational Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical NeurobiologyZhejiang University School of Medicine

Although extensively studied, the exact role of sleep in learning and memory is still not very clear. Sleep deprivation has been most frequently used to explore the effects of sleep on learning and memory, but the results from such studies are inevitably complicated by concurrent stress and distress. Furthermore, it is not clear whether there is a strict time-window between sleep and memory consolidation. In the present study we were able to induce time-locked slow-wave sleep(SWS) in mice by optogenetically stimulating GABAergic neurons in the parafacial zone(PZ), providing a direct approach to analyze the influences of SWS on learning and memory with precise time-windows. We found that SWS induced by light for 30 min immediately or 15 min after the training phase of the object-in-place task significantly prolonged the memory from 30 min to 6 h. However, induction of SWS 30 min after the training phase did not improve memory, suggesting a critical time-window between the induction of a brief episode of SWS and learning for memory *** of a gentle touch to the mice during light stimulation to prevent SWS induction also failed to improve memory, indicating the specific role of SWS,but not the activation of PZ GABAergic neurons itself, in memory consolidation. Similar influences of light-induced SWS on memory consolidation also occurred for Y-maze spatial memory and contextual fear memory, but not for cued fear memory. SWS induction immediately before the test phase had no effect on memory performance, indicating that SWS does not affect memory retrieval. Thus, by induction of a brief-episode SWS we have revealed a critical time window for the consolidation of hippocampusdependent memory.

关键词： Parafacial zone Slow-wave sleep Memory consolidation Hippocampus Optogenetics