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创伤骨科基础研究展望

中华创伤杂志 2000年第2期16卷 69-70页

作者：钟世镇第一军医大学临床解剖学研究所广州510515

回顾二十世纪的创伤医学,创伤救治带共性的基础研究取得显著成效,创伤骨科的早期救治取得很大的成功.我国的创伤骨科在组织瓣移植、断肢再植、断指再植等方面,已取得很高的成活率.但是,成活后功能的恢复尚不理想.为此,加强创伤骨科基础... 详细信息

回顾二十世纪的创伤医学,创伤救治带共性的基础研究取得显著成效,创伤骨科的早期救治取得很大的成功.我国的创伤骨科在组织瓣移植、断肢再植、断指再植等方面,已取得很高的成活率.但是,成活后功能的恢复尚不理想.为此,加强创伤骨科基础研究,将是提高功能恢复率,减少伤残率的关键.现就各领域的有关研究要点展望如下.

关键词：创伤骨科基础研究

内源性自由基与生命科学相关的若干物理有机化学问题

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中国科学基金 2008年第3期22卷 167-169页

作者：杜灿屏朱仕正陈拥军国家自然科学基金委员会化学科学部北京100085

随着后基因组时代的到来，化学界和生物学界对生物功能的主要体现者或执行者——蛋白质给予了空前的关注。众所周知，蛋白质特定功能的实现离不开蛋白质特定结构的构筑由于蛋白质的修饰加工、转运定位、代谢、蛋白质与蛋白质及其他生物... 详细信息

随着后基因组时代的到来，化学界和生物学界对生物功能的主要体现者或执行者——蛋白质给予了空前的关注。众所周知，蛋白质特定功能的实现离不开蛋白质特定结构的构筑由于蛋白质的修饰加工、转运定位、代谢、蛋白质与蛋白质及其他生物大分子的相互作用等均无法从基因组水平上的研究获得，因此，对蛋白质功能中心结构的研究以及蛋白质功能中心被内源性小分子自由基（如一氧化氮）修饰后的改变对其功能影响的研究成为人们认识生命奥秘的一种迫切的需求。

关键词：内源性自由基 DNA 蛋白质烟酰胺辅酶反应机理

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电厂大型风机的故障诊断和整机平衡

热能动力工程 1999年第5期14卷 376-378页

作者：贺世正浙江大学

叙述了离心式风机常见机械故障的类型，频谱特征和诊断及治理的方法，介绍了风机现场整机平衡技术，并通过实例说明此法的具体应用。

关键词：风机机械故障诊断动平衡锅炉

PGE2 receptor 3 subtype（EP3）regulates adipose metabolism in mice

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PGE2 receptor 3 subtype（EP3）regulates adipose metabolism i...

中国国家运动的形成与变异：基于政体的整体性解释

中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：徐虎 Yifei Miao Sha Li Jialin Fu shizheng Huang Shengnan du Jia Liu Xiaoyan Zhang Youfei Guan 北京大学 Department of Physiology and Pathophysiology Peking University Health Science Center Astra Zeneca-Shenzhen University Joint Institute of Nephrology Shenzhen University Health Science Center

Preadipocyte and adipocyte are two major cell types that exist in white adipose tissue（WAT）.The differentiation of preadipocyte increases the number of mature adipocyte and governs fat ***（TG）in adipose tissue is the main energy storage form in *** breakdown of TG,termed lipolysis,in adipocyte produces glycerol and free fatty acid（FFA）,which is released to circulatory system to supply energy for various *** imbalance of adipogenesis and adipocyte lipolysis and hypertrophy in WAT account for the development of obesity under over-nutrition *** development of obesity also depends on the function of brown adipose tissue（BAT）.Prostaglandin E2（PGE2）is the predominant prostaglandin produced in adipose tissue and plays an important role in the regulation of adipose tissue functions through its four receptors,i.e.,EP1,EP2,EP3,and *** study showed that the EP3 receptor deficient mice exhibited increased night eating frequency and developed obesity and insulin ***,the underlying mechanism remains *** aimed to investigate the impact of EP3 receptor on both WAT and BAT functions and its contribution to the development of *** demonstrated that global EP3 receptor gene deficiency in mice（EP3-/-）resulted in reduced locomotion,increased food intake and spontaneous obesity,with an enhanced ***3-/-mice also exhibited increased adipocyte size,WAT mass and body weight,mainly due to enhanced preadipocyte ***,the lipolysis process was also activated in the WAT of EP3-/-mice via the stimulation of the c AMP/protein kinase A（PKA）/hormone sensitive lipase（HSL）pathway,which promoted excessive lipid ectopic deposition in liver and mild insulin *** the condition of 24h fasting,EP3-/-mice displayed higher serum glycerol level but less lipid deposition in liver than that in EP3+/+*** also found that EP3-/-mice exhibited more BAT content and lower respiratory quotient（R

关键词： PGE2 receptor 3 subtype adipose lipogenesis lipolysis

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开放时代 2011年第1期 73-97页

作者：冯仕政中国人民大学社会学系

本文旨在把新中国成立以来所有形式的政治运动和"运动式治理"作为一个整体,即"国家运动"来研究,并力图以政体为中心为国家运动的形成和变异提供一个整体性解释。本文认为,继承革命遗产,并适应推进赶超型现代化的需要,新中国诞生的是革... 详细信息

本文旨在把新中国成立以来所有形式的政治运动和"运动式治理"作为一个整体,即"国家运动"来研究,并力图以政体为中心为国家运动的形成和变异提供一个整体性解释。本文认为,继承革命遗产,并适应推进赶超型现代化的需要,新中国诞生的是革命教化政体。基于该政体强烈的历史使命感和所面临的强大绩效合法性压力,以及该政体所提供的组织和合法性基础,国家能够不时打破制度、常规和专业分际,强力动员国家所需要的社会资源,于是形成国家运动。尽管国家能够根据社会改造需要而不时变换国家运动的基本取向、变革目标或动员范围,但由于目标置换、政治凌驾专业和异化等因素的制约,任何一个国家运动都不可能永续发展,而只能与常规社会治理方式交替发生。随着国家卡理斯玛权威的常规化,国家运动在总体趋势上会越来越温和,发生频率越来越低,直至消亡。

关键词：国家运动政治运动运动式治理革命教化政体

Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish

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Journal of Genetics and Genomics 2024年第3期51卷 359-362页

作者： Ao Zhang Jingao Lu Shachuan Feng Huapeng Yu Tao Yu shizheng Zhao Kemin Chen Zhibin Huang Jin Xu Jianan Y.Qu Zilong Wen Division of Life Science Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Department of Immunology and Microbiology School of Life ScienceSouthern University of Science and TechnologyShenzhenGuangdong 518055China Biomedical Research Institute Shenzhen Peking University-Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036China Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Greater Bay Biomedical Innocenter Shenzhen Bay LaboratoryShenzhenGuangdong 518067China

Macrophages and neutrophils are key components of myeloid cells and play critical roles in innate immune responses,organ formation,and tissue *** integrity of their functions heavily relies on the generation of a proper number of mature macrophages and neutrophils through embryonic and adult *** mammalian adult myelopoiesis,oligopotent common myeloid progenitors(CMPs)are known to be the earliest myeloid progenitors,which give rise to granulocyte-macrophage progenitors(GMPs),subsequently differentiate into unipotent neutrophil and macrophage precursors,and finally,mature macrophages and neutrophils(Orkin and Zon,2008).In contrast,the ontogeny of embryonic myelopoiesis and the mechanism underlying the formation of macrophages and neutrophils remainless understood.

关键词： fish macrophage homeostasis

Construction of Fast-growing and High-yielding Willow Forest and Its Utilization

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Chinese Forestry Science and Technology 2007年第4期6卷 38-46页

作者： SHI shizheng WANG Baosong PAN Mingjian GUO Qun Jiangsu Academy of Forestry Nanjing 211153 P.R.China

For the high biomass and adaptability, application of willow on cultivating bioenergy forest and phytoremediation had been gotten more recognition in the world wide. Integrated with our research practice, we introduced the germ plasm of high biomass willow in China, and the new varieties with high biomass and their cultivated techniques were summarized in this article. Moreover, we reported the development up to date in breeding and cultivation on well-bred willow with high biomass and analyzed the foreground of establishing industrial willow with high biomass in China.

关键词： willow varieties biomass utilization

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关于半无限规划的对偶间隙

数学物理学报（A辑） 2000年第1期20卷 1-5页

作者：李师正山东师范大学济南250014

该文对半无限凸规划（P）提出了一个对偶问题（D1），证明（D1）与（P）无对偶间隙当且仅当Lagrange对偶问题（D）与（P）之间无对偶间隙，作者还利用方向导数给出一个新的刻划鞍点准则的方法．

关键词：半无限规划对偶问题对偶间隙方向导数次微分

Retinal microvasculature is a potential biomarker for acute mountain sickness

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Science China(Life Sciences) 2023年第6期66卷 1290-1302页

作者： Yuan Xie Diya Yang Alex S.Huang Yiquan Yang Ying Han Yunxiao Sun Kai Cao Huaizhou Wang shizheng Wu Qiang Zhu Guozhong Wang Tianyi Wu Ningli Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Sciences Key LaboratoryBeijing100730China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing100005China The Viterbi Family Department of Ophthalmology Shiley Eye InstituteUniversity of CaliforniaSan DiegoCA92121USA Department of Ophthalmology University of CaliforniaSan FranciscoCA94143USA Institution of Geriatric Qinghai Provincial Hospital Xining810007China Department of Ultrasound Beijing Tongren HospitalCapital Medical UniversityBeijing100730China Department of Hyperbaric and Hypobaric Chamber Civil Aviation General HospitalBeijing100025China National Key Laboratory of High Altitude Medicine China High Altitude Medical Research InstituteXining810012China

Increased cerebral blood flow resulting from altered capillary level autoregulation at high altitudes leads to capillary overperfusion and then vasogenic cerebral edema,which is the leading hypothesis of acute mountain sickness(AMS).However,studies on cerebral blood flow in AMS have been mostly restricted to gross cerebrovascular endpoints as opposed to the *** study aimed to investigate ocular microcirculation alterations,the only visualized capillaries in the central neural system(CNS),during early-stage AMS using a hypobaric *** study found that after high altitude simulation,the optic nerve showed retinal nerve fiber layer thickening(P=0.004–0.018)in some locations,and the area of the optic nerve subarachnoid space(P=0.004)*** coherence tomography angiography(OCTA)showed increased retinal radial peripapillary capillary(RPC)flow density(P=0.003–0.046),particularly on the nasal side of the *** AMSpositive group had the largest increases in RPC flow density in the nasal sector(AMS-positive,?3.21±2.37;AMS-negative,?0.01±2.16,P=0.004).Among multiple ocular changes,OCTA increase in RPC flow density was associated with simulated early-stage AMS symptoms(beta=0.222,95%CI,0.009–0.435,P=0.042).The area under the receiver operating characteristics curve(AUC)for the changes in RPC flow density to predict early-stage AMS outcomes was 0.882(95%CI,0.746–0.998).The results further confirmed that overperfusion of microvascular beds is the key pathophysiologic change in early-stage *** OCTA endpoints may serve as a rapid,noninvasive potential biomarker for CNS microvascular changes and AMS development during risk assessment of individuals at high altitudes.

关键词： optical coherence tomography angiography retinal microvasculature acute mountain sickness