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Molecular Plant 2021年第3期14卷 40-60页

作者： Ling Jiang Simon Strobbe dominique Van Der Straeten Chunyi Zhang Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Laboratory of Functional Plant Biology Ghent UniversityK.L.Ledeganckstraat 359000 GhentBelgium These authors contributed equally to this work

Micronutrient deficiencies include shortages of vitamins and *** affect billions of people and are associated with long-range effects on health,learning ability,and huge economic *** of multiple micronutrients can play an important role in combating *** challenge,however,is to balance plant growth with nutrient requirements for ***,we summarize the major progress about vitamin biosynthesis and its response to the changing *** discuss the interactions among vitamins as well as possible strategies for vitamin ***,we propose to integrate new breeding technologies with metabolic pathway modification to facilitate the biofortification of crops,thereby alleviating the hidden hunger of target populations.

关键词： vitamins biosynthesis regulatory mechanisms biofortification hidden hunger

HLA and lung transplantation

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Frontiers of Medicine 2019年第3期13卷 298-313页

作者： Liya Ju Caroline Suberbielle Xiaofan Li Nuala Mooney dominique Charron HLA et Medecine "Jean Daus set" Laboratory NetworkHopital Saint-LouisParisFrance Laboratoire Histocompatibilité Hopital Saint-LouisParisFrance INSERM U1160 Hopital Saint-LouisUniversité Paris DiderotSorbonne Paris CitéFrance Labex Transplantex StrasbourgFrance Shanghai Jiao Tong University School of Medicine Shanghai 200025China

Lung transplantation is increasingly practiced for patients with end-stage lung *** successful outcome of solid organ transplantation today is severely impeded by the production of alloantibodies,mainly directed against the protein products of the HLA complex of the organ *** the association between antibody mediated rejection and ailograft damage has been well established in renal and heart transplantation,it has not yet been well characterized in lung *** review addresses the question of HLA matching in lung transplantation and current knowledge of the allogenicity of different HLA class Ⅰ and Ⅱ *** role of the antibody mediated immune response is discussed as well as the importance of pre-transplant or de novo posttransplant circulating ***,potential mechanisms,which may act individually or in combination,of antibody mediated damage to solid organ transplants are considered.

关键词： human leukocyte antigen class I and II lung transplantation mismatch obliterans bronchiolitis alloantibody antibody mediated rejection

PM_(2.5) source apportionment in a French urban coastal site under steelworks emission influences using constrained non-negative matrix factorization receptor model

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Journal of Environmental Sciences 2016年第2期28卷 114-128页

作者： Adib Kfoury Frederic Ledoux Cloe Roche Gilles Delmaire Gilles Roussel dominique Courcot Unite de Chimie Environnementale et Interactions sur le Vivant (UCEIV) EA4492 Universite du Littoral Cote d'Opale F-59140 Dunkerque France Laboratoire d'Informatique Signal et Image de la Cote d'Opale (LISIC) EA4491 Universite du Littoral Cote d'Opale F-52228 Calais France

The constrained weighted-non-negative matrix factorization（CW-NMF） hybrid receptor model was applied to study the influence of steelmaking activities on PM_（2.5）（particulate matter with equivalent aerodynamic diameter less than 2.5 μm） composition in Dunkerque,Northern France. Semi-diurnal PM_（2.5）samples were collected using a high volume sampler in winter 2010 and spring 2011 and were analyzed for trace metals, water-soluble ions, and total carbon using inductively coupled plasma – atomic emission spectrometry（ICP-AES）,ICP- mass spectrometry（ICP-MS）, ionic chromatography and micro elemental carbon analyzer. The elemental composition shows that NO_3^-, SO_4^（2-）, NH_4~＋and total carbon are the main PM_（2.5）constituents. Trace metals data were interpreted using concentration roses and both influences of integrated steelworks and electric steel plant were evidenced. The distinction between the two sources is made possible by the use Zn/Fe and Zn/Mn diagnostic ratios. Moreover Rb/Cr, Pb/Cr and Cu/Cd combination ratio are proposed to distinguish the ISW-sintering stack from the ISW-fugitive emissions. The a priori knowledge on the influencing source was introduced in the CW-NMF to guide the calculation. Eleven source profiles with various contributions were identified： 8 are characteristics of coastal urban background site profiles and 3 are related to the steelmaking activities. Between them,secondary nitrates, secondary sulfates and combustion profiles give the highest contributions and account for 93% of the PM_（2.5）concentration. The steelwork facilities contribute in about 2%of the total PM_（2.5）concentration and appear to be the main source of Cr, Cu, Fe, Mn, Zn.

关键词： PM_(2.5) Receptor modeling Non-negative matrix factorization Source apportionment Steelworks

Liquid encapsulation in a freezing sessile drop

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Droplet 2023年第4期2卷 120-126页

作者： Sijia Lyu Xun Zhu dominique Legendre Chao Sun Center for Combustion Energy Key Laboratory for Thermal Science and Power Engineering of Ministry of EducationDepartment of Energy and Power EngineeringTsinghua UniversityBeijingChina Institut de Mécanique des Fluides de Toulouse(IMFT) Universitéde ToulouseCNRS‐ToulouseFrance Department of Engineering Mechanics School of Aerospace EngineeringTsinghua UniversityBeijingChina

During the solidification of a sessile drop,the effect of heat exchange from the gaseous environmental medium is generally ***,by combining experimental observations,direct numerical simulations,and a theoretical model,we have demonstrated that the environmental medium,particularly one with high thermal conductivity such as a liquid,has nonnegligible heat exchange with both the drop and the substrate,leading to accelerated cooling of the outer surface of the sessile ***,it causes alterations in the geometry of the freezing front and ultimately results in the formation of a solidified shell that encloses the ***,the encapsulated liquid continues to solidify,which induces volume change and consequently changes the final outcome of the freezing *** study highlights the importance of considering the properties of the environmental medium and provides novel strategies to manipulate the freezing rate and reshape the morphology of the solidified drop.

关键词： solidification freezing outer

Exosomal lncRNAs: the newest promising liquid biopsy

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Cancer Drug Resistance 2019年第4期2卷 1002-1017页

作者： Marta Tellez-Gabriel dominique Heymann RNA and Molecular Pathology(RAMP)Research Group Department of Medical BiologyThe Artic University of Norway(Tromso)Tromso 9019Norway INSERM Institut de Cancérologie de l’OuestLabCTU1232CRCINAUniversitéde NantesUniversitéd’AngersSaint Herblain 44805France

LncRNAs are defined as RNA transcripts greater than 200 nucleotides in length that have no or limited protein-coding *** expression of lncRNAs appeared important for various homeostatic processes,like gene imprinting cell differentiation and ***,it has been demonstrated that lncRNAs play an important role in tumorigenesis and *** lncRNAs were stably detected in exosomes,which are widely found in body *** studies validated the use of exosomal lncRNAs as minimally invasive diagnostic and prognostic markers in several types of *** addition,exosomal lncRNAs have been associated with drug resistance of tumor cells,suggesting a clinical application in cancer-targeted *** the recent increase of studies on exosomal lncRNAs,their clinical significance in cancer diagnosis,prognosis and treatment needs to be fully *** methodologies for their detection with high purity and accuracy must be also improved in order to implement their use in clinical *** review aims to summarize the main recent technologies available for the isolation of exosomal lncRNAs,their status as a liquid biopsy as well as their future perspectives.

关键词： Liquid biopsy long non-coding RNAs exosomes

Correlation between Transcutaneous Bilirubinemia and Blood Bilirubinemia in Screening Term Newborn for Neonatal Jaundice at the Essos Hospital Centre (EHC), Yaoundé, Cameroon

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Open Journal of Pediatrics 2022年第3期12卷 594-605页

作者： Anne Esther Njom Nlend dominique Kamtchoua Ndjenje Arsène Brunelle Sandie Higher Institute of Medical Technology Nkolodom University of Douala Yaoundé Cameroon Essos Hospital Centre Yaoundé Cameroon African Population and Health Research Center Dakar Senegal

Background: Early and non-invasive diagnosis of neonatal hyperbilirubinemia remains critical in dark skinned babies of low resource settings. Objective: To assess correlation/agreement between transcutaneous bilirubin (Tcb) and serum bilirubin (Tsb) values in full term neonates with jaundice. Methodology: An analytical cross-sectional study was conducted at the neonatology unit of the Essos Hospital Centre (EHC) from January to June 2019. All full-term neonates aged 0 to 7 days with suspected jaundice who did not receive phototherapy were eligible for the study. The enrolled neonates in the study were assessed clinically, then with the MBJ20 transcutaneous bilirubinometer (TcB). The MBJ20 transcutaneous bilirubinometer highest measurement over the forehead and the sternum were compared to TsB. Data were entered and then analysed with the CsPro7.2 and R (version 3.6.0) software. Correlation was captured by Bland & Alman plots and Concordance Correlation Coefficient (CCC) estimates. The Pearson correlation coefficient and Student test for paired data were used for descriptions purposes, and the significance level was 5%. Results: We recruited 88 neonates. The sex ratio of the babies included was 1.25 favouring males. Median Post-natal age was 3 days with 62% aged 72 hours or more. The mean TcB corresponding to the maximum average between frontal and sternal measurement was 153 mg/dl ± 48 and the average Tsb was 123.80 mg/dl ± 50.48. A good linear correlation was found between TcB and total serum bilirubin level r = 0.86 [0.80;0.91]. Positive correlation was noted between both (forehead and sternum) TcB measurements sites, namely r = 0.78 and r = 0.86. The Bland & Altman plot measured the bias at -29.68 mg/l (confidence interval at 95%, 21.14 - 80.50). The CCC estimate was 0.2 varying from -0.22 to 0.76 according to TcB measurement threshold and post-natal age. The ROC area under the curve value for a threshold < 100 mg/l equals 90% proving to be a good predictor for t

关键词： Neonatal Jaundice Transcutaneous Bilirubin Measurement Total Serum Bilirubin Screening in Full Term Infant

Attitudes toward forest diversity and forest ecosystem services—a cross-cultural comparison between China and Switzerland

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Journal of Plant Ecology 2014年第1期7卷 1-9页

作者： Petra Lindemann-Matthies dominique Keller Xuefei Li Bernhard Schmid Institute of Evolutionary Biology and Environmental Studies University of ZurichWinterthurerstrasse 190CH-8057 ZurichSwitzerland Institute of Biology Karlsruhe University of EducationBismarckstrasse 10D-76060 KarlsruheGermany

Aims Despite the current interest in services provided by ecosystems and the role of biodiversity,the relationship among human attitudes,biodiversity and ecosystem services has hardly been ***,few studies have examined attitudes toward nature in cross-cultural *** study investigates the attitudes of Chinese and Swiss people,both environmental experts and laypersons,toward forest biodiversity and ecosystem *** Overall,640 people in China and Switzerland were interviewed with the help of a standardized *** each country,the study population was equally divided into an urban(80 city dwellers and 80 environmental science students)and a rural(80 forest visitors and 80 farmers)study *** 15-minute interviews took place in the cities of Beijing and Zurich and in the rural forested areas of Dujiangyan,Sichuan Province and Lake Sempach,canton *** toward forest biodiversity were investigated with the help of color photographs that depicted both monocultures and speciesrich forests typical for China and *** toward ecosystem services were investigated with the help of 13 statements on provisioning,regulating,cultural and supporting services of *** Findings On average,Chinese participants showed no strong preferences for biodiversity,whereas the Swiss clearly preferred species-rich forests over ***,Chinese environmental science students did prefer species-rich forests and attributed to them a higher conservation value because of their higher *** there were no strong preferences for Chinese versus Swiss forests,all participants correctly answered that Chinese forests are more species rich in terms of plants and animals and thus found them less boring and more interesting,but also less managed,than Swiss *** participants highly valued the ecosystem services provided by forests;especially the regulating and supporting ***

关键词： biodiversity preferences cross-cultural comparison forests valuation of ecosystem services

PM_(2.5)characterization of primary and secondary organic aerosols in two urban-industrial areas in the East Mediterranean

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Journal of Environmental Sciences 2021年第3期33卷 98-116页

作者： Marc Fadel Frédéric Ledoux Mariana Farhat Adib Kfoury dominique Courcot Charbel Afif Emissions Measurementsand Modeling of the Atmosphere(EMMA)LaboratoryCARFaculty of SciencesSaint Joseph UniversityBeirutLebanon Unitéde Chimie Environnementale et Interactions sur le Vivant UCEIV UR4492FR CNRS 3417University of Littoral Côte d Opale(ULCO)DunkerqueFrance Department of Environmental Sciences University of BalamandAl KourahLebanon Climate and Atmosphere Research Center The Cyprus InstituteNicosiaCyprus

Primary and secondary organic aerosols in PM_(2.5)were investigated over a one-year campaign at Zouk Mikael and Fiaa,*** n-alkanes concentrations were quite similar at both sites(26-29 ng/m^(3))and mainly explained by anthropogenic emissions rather than natural *** concentrations of total Polycyclic Aromatic Hydrocarbons(PAHs)were nearly three times higher at Zouk Mikael(2.56 ng/m^(3))compared to Fiaa(0.95 ng/m^(3)),especially for indeno[1,2,3-c,d]pyrene linked to the presence of the power plant.A characteristic indeno[1,2,3-c,d]pyrene/(indeno[1,2,3-c,d]pyrene+benzo[g,h,i]perylene)ratio in the range0.8-1.0 was determined for heavy fuel oil combustion from the power *** acids and hopanes were also investigated and were assigned to cooking activities and vehicular emissions *** were identified for the first time in Lebanon with high concentrations at Zouk and Fiaa(106.88 and 97.68 ng/m^(3) respectively).Moreover,the biogenic secondary aerosols revealed higher concentrations in *** total terpene concentration varied between 131 ng/m^(3) at Zouk Mikael in winter to 469 ng/m3 at Fiaa in ***,the concentrations of the dicarboxylic acids especially for adipic and phthalic acids were more influenced by anthropogenic *** analysis of molecular markers and diagnostic ratios indicated that the sites were strongly affected by anthropogenic sources such as waste open burning,diesel private generators,cooking activities,road transport,power plant,and industrial ***,results showed different pattern during winter and summer ***,higher concentrations of biogenic markers were clearly encountered during the summer period.

关键词： PM_(2.5) Secondary organic aerosols PAHs Phthalates Lebanon Urban-industrial sites

Soil bacterial communities under slash and burn in Mozambique as revealed by a metataxonomic approach

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Pedosphere 2023年第3期33卷 508-520页

作者： dominique SERRANI Ilario FERROCINO Cristiana GAROFALO Andrea OSIMANI Maria Rita CORVAGLIA Vesna MILANOVIĆ Lucia AQUILANTI Stefania COCCO Valeria CARDELLI Rogério Borguete Alves RAFAEL Elena FRANCIOSI Kieran TUOHY Francesca CLEMENTI Giuseppe CORTI Department of Agriculture Food and Environmental SciencesPolytechnic University of MarcheAncona 60131(Italy) Department of Agriculture Forest and Food SciencesUniversity of TurinGrugliasco 10095(Italy) Department of Rural Engineering Faculty of Agronomy and Forestry EngineeringUniversidade Eduardo MondlaneMaputo 257(Mozambique) Research and Innovation Center Fondazione Edmund Mach(FEM)San Michele all'Adige 38010(Italy)

The slash-and-burn system is a subsistence agronomical practice widespread in tropical areas *** system has been extensively studied,especially for its impacts on agronomical aspects and soil physicochemical properties;however,knowledge of soil microbial diversity under slash and bum is *** this study,for the first time,soil bacterial diversity of three locations from Central Mozambique,where slash and burn has been practiced for different durations of the forest fallow period(ca.25,35,and 50 years),was elucidated through a metataxonomic *** communities were evaluated in the genetic horizons of soils under charcoal kilns,crop fields,and *** aim of this study was to examine the influence of spatial(location and land use),temporal(forest fallow period),and vertical(horizon)variations on bacterial community structure in relation to soil physicochemical *** analysis detected 25 different phyla whose distribution varied horizontally and vertically in relation to soil properties(i.e.,p H,easily oxidizable organic carbon,total nitrogen,and available phosphorus),as well as particle size distribution and mineralogical *** properties were strongly affected and altered by land-use management;in particular,charcoal kilns exhibited better soil properties and greater differences in bacterial community than crop fields and forests,which were quite *** might suggest the inability of a forest fallow period shorter than 50 years to improve soil fertility and induce changes in bacterial *** uncommon application of the pedological approach for microbial evaluation facilitated the detection of a clear separation in bacterial composition along the soil profile,with eutrophic bacteria mainly located in the A horizon whereas oligotrophic bacteria were found in the Bo *** horizontal and vertical heterogeneities in the same study represent a novelty for bacterial metataxonomic analysis.

关键词： 16S rRNA gene agroforestry land use soil microbiota soil physicochemical property