Exosomal lncRNAs: the newest promising liquid biopsy
作者机构：RNA and Molecular Pathology(RAMP)Research GroupDepartment of Medical BiologyThe Artic University of Norway(Tromso)Tromso 9019Norway INSERMInstitut de Cancérologie de l’OuestLabCTU1232CRCINAUniversitéde NantesUniversitéd’AngersSaint Herblain 44805France
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2019年第2卷第4期
页 面：1002-1017页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Liquid biopsy long non-coding RNAs exosomes
摘 要：LncRNAs are defined as RNA transcripts greater than 200 nucleotides in length that have no or limited protein-coding *** expression of lncRNAs appeared important for various homeostatic processes,like gene imprinting cell differentiation and ***,it has been demonstrated that lncRNAs play an important role in tumorigenesis and *** lncRNAs were stably detected in exosomes,which are widely found in body *** studies validated the use of exosomal lncRNAs as minimally invasive diagnostic and prognostic markers in several types of *** addition,exosomal lncRNAs have been associated with drug resistance of tumor cells,suggesting a clinical application in cancer-targeted *** the recent increase of studies on exosomal lncRNAs,their clinical significance in cancer diagnosis,prognosis and treatment needs to be fully *** methodologies for their detection with high purity and accuracy must be also improved in order to implement their use in clinical *** review aims to summarize the main recent technologies available for the isolation of exosomal lncRNAs,their status as a liquid biopsy as well as their future perspectives.
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