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Alteration of sister chromatid exchange frequencies in gastric cancer and chronic atrophic gastritis patients with and without H pylori infection

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World Journal of Gastroenterology 2008年第16期14卷 2534-2539页

作者： Ali Karaman dogan nasir binici Mehmet Esref Kabalar Hakan Dursun Ali Kurt Department of Medical Genetics State Hospital Department of Internal Medicine State Hospital Department of Pathology State Hospital Department of Gastroenterology State Hospital

AIM: To determine, by counting sister chromatid exchange (SCE) frequencies, whether genetic impairment and DNA damage have an effect on the pathogenesis of gastric cancer (GC). METHODS: Analysis of SCE is a cytogenetic technique used to show DNA damage as a result of an exchange of DNA fragments between sister chromatids. We analyzed SCE frequency in 24 patients with GC, 26 patients with chronic atrophic gastritis (CAG), and 15 normal controls. The presence of H pylori was confirmed by urease test, toluidine-blue stain and hematoxylin-eosin stain. RESULTS: SCE was significantly increased in H pylori- negative GC patients, and in H pylori-negative CAG patients compared with controls (7.41 ± 1.36 and 6.92 ± 1.20, respectively, vs 5.54 ± 0.8, P 0.05). On other hand, the SCE frequencies in H pylori-positive GC patients were higher than those in H pylori-positive CAG patients (9.20 ± 0.94 vs 7.93 ± 0.81, P < 0.01). Furthermore, H pylori-positive GC patients had a higher SCE frequency than H pylori- negative GC patients (9.20 ± 0.94 vs 7.41 ± 1.36, P < 0.001). Similarly, a significant difference was detected between H pylori-positive CAG patients and H pylori-negative CAG patients (7.93 ± 0.81 vs 6.92 ± 1.20, P < 0.05). CONCLUSION: We suggest the increased SCE in patients reflects a genomic instability that may be operative in gastric carcinogenesis.

关键词： Gastric carcinoma Chronic atrophic gastritis Pathogenesis Helicobacter pylori infection Sisterchromatid exchange

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Intraperitoneal dedifferentiated liposarcoma:A case report

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World Journal of Gastroenterology 2008年第38期14卷 5927-5929页

作者： Ali Karaman Mehmet Esref Kabalar nder zcan Timur Koca dogan nasir binici Department of Medical Genetics State HospitalErzurum 25240 Turkey Department of Pathology State HospitalErzurum 25240 Turkey Department of General Surgery State HospitalErzurum 25240 Turkey Department of Radiation Oncology State HospitalErzurum 25240 Turkey Department of Internal Medicine State HospitalErzurum 25240 Turkey

Dedifferentiated liposarcoma is a variant of liposarcoma with a more aggressive course. Mutations of the p53 gene have been found in different types of soft tissue sarcoma. It is generally accepted that p53 mutations in human malignant tumors are often related to a poor prognosis. In our case, analysis of p53 gene mutation in tumor samples was performed. p53 gene mutation was observed in dedifferentiated tumor tissue samples but not in well-differentiated tumor tissue samples. It has been reported that p53 gene mutation occurs most commonly in the retroperitoneum and rarely in other anatomic locations. Herein we report a case of dedifferentiated liposarcoma located at intraperitoneum.

关键词： Dedifferentiated liposarcoma p53 gene Mutation Intraperitoneum

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Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps

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World Journal of Gastroenterology 2008年第44期14卷 6835-6839页

作者： Ali Karaman dogan Nas■r binici Mehmet E■ref Kabalar Züleyha ■al■ku■u Department of Medical Genetics Erzurum Training and Research HospitalErzurum 25240Turkey Department of Internal Medicine Erzurum Training and Research HospitalErzurum 25240Turkey Department of Pathology Erzurum Training and Research HospitalErzurum 25240Turkey Department of Medical Oncology Erzurum Training and Research HospitalErzurum 25240Turkey

AIM:To determine,by counting micronucleus (MN) frequencies,whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). METHODS:We analyzed MN frequencies in 21 patients with CRC,24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls. RESULTS:MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 ± 1.34,3.58 ± 1.21 vs 1.97 ± 0.81,P 0.05). Similarly,there was no difference in the MN frequency between NNP patients (2.06 ± 0.85) and controls (P > 0.05). CONCLUSION:Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC.

关键词： Colorectal adenocarcinoma Colon polyp Micronucleus Genetic instability

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