Micronucleus analysis in patients with colorectal adenocarcinoma and colorectal polyps

作     者：Ali Karaman Dogan Nas■r Binici Mehmet E■ref Kabalar Züleyha ■al■ku■u 

作者机构：Department of Medical GeneticsErzurum Training and Research HospitalErzurum 25240Turkey Department of Internal MedicineErzurum Training and Research HospitalErzurum 25240Turkey Department of PathologyErzurum Training and Research HospitalErzurum 25240Turkey Department of Medical OncologyErzurum Training and Research HospitalErzurum 25240Turkey 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2008年第14卷第44期

页      面：6835-6839页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100214[医学-肿瘤学] 10[医学] 

主　　题：Colorectal adenocarcinoma Colon polyp Micronucleus Genetic instability 

摘      要：AIM:To determine,by counting micronucleus (MN) frequencies,whether chromosomal or DNA damage have an effect on the pathogenesis of early colorectal adenocarcinoma (CRC). METHODS:We analyzed MN frequencies in 21 patients with CRC,24 patients with colon polyps [10 neoplastic polyps (NP) and 14 non-neoplastic polyps (NNP)] and 20 normal controls. RESULTS:MN frequency was significantly increased in CRC patients and in NP patients compared with controls (3.72 ± 1.34,3.58 ± 1.21 vs 1.97 ± 0.81,P 0.05). Similarly,there was no difference in the MN frequency between NNP patients (2.06 ± 0.85) and controls (P 0.05). CONCLUSION:Our results suggest increased chromosome/DNA instabilities may be associated with the pathogenesis of early CRC.