Intraperitoneal dedifferentiated liposarcoma:A case report

作     者：Ali Karaman Mehmet Esref Kabalar nder zcan Timur Koca Dogan Nasir Binici 

作者机构：Department of Medical Genetics State HospitalErzurum 25240 Turkey Department of Pathology State HospitalErzurum 25240 Turkey Department of General Surgery State HospitalErzurum 25240 Turkey Department of Radiation Oncology State HospitalErzurum 25240 Turkey Department of Internal Medicine State HospitalErzurum 25240 Turkey 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2008年第14卷第38期

页      面：5927-5929页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：腹膜内反分化脂肪肉瘤 p53基因 基因突变 基因治疗 

摘      要：Dedifferentiated liposarcoma is a variant of liposarcoma with a more aggressive course. Mutations of the p53 gene have been found in different types of soft tissue sarcoma. It is generally accepted that p53 mutations in human malignant tumors are often related to a poor prognosis. In our case, analysis of p53 gene mutation in tumor samples was performed. p53 gene mutation was observed in dedifferentiated tumor tissue samples but not in well-differentiated tumor tissue samples. It has been reported that p53 gene mutation occurs most commonly in the retroperitoneum and rarely in other anatomic locations. Herein we report a case of dedifferentiated liposarcoma located at intraperitoneum.