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Global prevalence of hepatitis B virus serological markers among healthcare workers:A systematic review and meta-analysis

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World Journal of Hepatology 2021年第9期13卷 1190-1202页

作者： Gadji Mahamat Sebastien Kenmoe Etheline W Akazong Jean Thierry Ebogo-Belobo Donatien Serge Mbaga Arnol Bowo-Ngandji Joseph Rodrigue Foe-Essomba Marie Amougou-Atsama Chavely Gwladys Monamele Chris Andre Mbongue Mikangue Ginette Irma Kame-Ngasse Jeannette Nina Magoudjou-Pekam Cromwel Zemnou-Tepap Dowbiss Meta-Djomsi Martin Maidadi-Foudi Sabine Aimee Touangnou-Chamda Audrey Gaelle Daha-Tchoffo Abdel Aziz Selly-Ngaloumo Rachel Audrey Nayang-Mundo Jacqueline Felicite Yengue Jean Bosco Taya-Fokou Lorraine K M Fokou Raoul Kenfack-Momo dimitri Tchami Ngongang Efietngab Atembeh Noura Herve Raoul Tazokong Cynthia Paola Demeni Emoh Cyprien Kengne-Nde Jean Joel Bigna Onana Boyomo Richard Njouom Department of Microbiology The University of Yaounde IYaounde 00237Cameroon Department Centre Pasteur of CameroonYaounde 00237Cameroon Department of Biochemistry University of DschangDschang 00237Cameroon Medical Research Centre Institute of Medical Research and Medicinal Plants StudiesYaounde 00237Cameroon Department of Mycobacteriology Centre Pasteur of CameroonYaounde 00237Cameroon Centre de Recherche sur les Maladies Emergentes et Re-Emergentes Institut de Recherches Medicales et d'Etudes des Plantes MedicinalesYaounde 00237Cameroon Department of Biochemistry The University of Yaounde IYaounde 00237Cameroon Department of Medical Biochemistry The University of Yaounde IYaounde 00237Cameroon Department of Microbiology Protestant University of Central AfricaYaounde 00237Cameroon Department of Animals Biology and Physiology The University of Yaounde IYaounde 00237Cameroon Evaluation and Research Unit National AIDS Control CommitteeYaounde 00237Cameroon Department of Epidemiology and Public Health Centre Pasteur of CameroonYaounde 00237Cameroon

BACKGROUND The hepatitis B virus(HBV)infection is a global public health concern that affects about 2 billion people and causes 1 million people deaths *** is a bloodborne disease and healthcare workers(HCWs)are a high-risk group because of occupational hazard to patients’*** regions of the world show a highly variable proportion of HCWs infected and/or immunized against *** data on serologic markers of HBV infection and immunization in HCWs are very important to improve strategies for HBV *** To determine the worldwide prevalence of HBV serological markers among *** In this systematic review and meta–analyses,we searched PubMed and Excerpta Medica Database(Embase)to identify studies published between 1970 and 2019 on the prevalence of HBV serological markers in HCWs *** also manually searched for references of relevant *** independent investigators selected studies and included those on the prevalence of each of the HBV serological markers including hepatitis B surface antigen(HBsAg),hepatitis e antigen(HBeAg),immunoglobulin M anti-HBc,and *** quality of eligible studies was assessed and random-effect model meta-analysis resulted in the pooled prevalence of HBV serological markers HBV infection in ***(I²)was assessed using theχ²test on Cochran’s Q statistic and H ***’sources were explored through subgroup and metaregression *** study is registered with PROSPERO,number *** We reviewed 14059 references,out of which 227 studies corresponding to 448 prevalence data among HCWs(224936 HCWs recruited from 1964 to 2019 in 71 countries)were included in this *** pooled seroprevalences of current HBsAg,current HBeAg,and acute HBV infection among HCWs were 2.3%[95% confidence interval(CI):1.9-2.7],0.2%(95%CI:0.0-1.7),and 5.3%(95%CI:1.4-11.2),*** pooled seroprevalences of total immunity against HBV and immu

关键词： Healthcare workers Hepatitis B virus Seroprevalence Hepatitis B surface antigen Hepatitis e antigen

Innovative Education and Training in high power laser plasmas(PowerLaPs) for plasma physics, high power laser-matter interactions and high energy density physics-theory and experiments

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High Power Laser Science and Engineering 2019年第2期7卷 22-26页

作者： John Pasley Georgia Andrianaki Andreas Baroutsos dimitri Batani Emmanouil P.Benis Marco Borghesi Eugene Clark Donna Cook Emmanuel D'Humieres Vasilios dimitriou Brendan Dromey Michael Ehret Ioannis Fitilis Anastasios Grigoriadis Satya Kar Evaggelos Kaselouris Ondrej Klimo Michel Koenig Kyriaki Kosma George Koundourakis Milan Kucharik Aveen Lavery Jiri Limpouch Yannis Orphanos Nektarios A.Papadogiannis Stelios Petrakis Dave Riley Maria Serena Rivetta Laura Tejada Pascual Joao Jorge Santos Alexandros Skoulakis Ioannis Tazes Vladimir Tikhonchuk Jocelain Trela Calliope Tsitou Luca Volpe Steven White Mark Yeung Michael Tatarakis York Plasma Institute University of York Technological Educational Institute of Crete School of Applied SciencesCentre for Plasma Physics and Lasers-CPPL Universitéde Bordeaux CNRSCEACELIA(Centre Lasers Intenses et Applications) Department of Physics University of Ioannina Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University Belfast Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in Prague LULI-CNRS Ecole Polytechnique CEA:UniversitéParis-Saclay UPMC Univ Paris 06:Sorbonne Universités CLPU Laser-Plasma Chair University of Salamanca Centro de Láseres Pulsados(CLPU) Edificio M5.Parque Cientfico.C/Adaja

The Erasmus Plus programme’Innovative Education and Training in high power laser plasmas’,otherwise known as PowerLaPs,is *** PowerLaPs programme employs an innovative paradigm in that it is a multi-centre programme where teaching takes place in five separate institutes with a range of different aims and styles of *** ’in class’ time is limited to four weeks a year,and the programme spans two *** aims to train students from across Europe in theoretical,applied and laboratory skills relevant to the pursuit of research in laserplasma interaction physics and inertial confinement fusion(ICF).Lectures are intermingled with laboratory sessions and continuous assessment *** programme,which is led by workers from the Technological Educational Institute(TEI)of Crete,and supported by co-workers from the Queen’s University Belfast,the University of Bordeaux,the Czech Technical-University in Prague,Ecole Polytechnique,the University of Ioannina,the University of Salamanca and the University of York,has just completed its first *** far three Learning Teaching Training(LTT)activities have been held,at the Queen’s University Belfast,the University of Bordeaux and the Centre for Plasma Physics and Lasers(CPPL)of TEI *** last of these was a two-week long Intensive Programme(IP),while the activities at the other two universities were each five days in *** far work has concentrated upon training in both theoretical and experimental work in plasma physics,high power laser-matter interactions and high energy density *** nature of the programme will be described in detail and some metrics relating to the activities carried out to date will be presented.

关键词： higher education inertial confinement fusion laser-plasma interactions post-graduate education

Innovative education and training in high power laser plasmas(PowerLaPs) for plasma physics, high power laser matter interactions and high energy density physics: experimental diagnostics and simulations

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High Power Laser Science and Engineering 2020年第1期8卷 30-36页

作者： John Pasley Georgia Andrianaki Andreas Baroutsos dimitri Batani Emmanouil PBenis Andrea Ciardi Donna Cook Vasilios dimitriou Brendan Dromey Ioannis Fitilis Giancarlo Gatti Anastasios Grigoriadis Marine Huault Jose Antonio Pérez Hernández Evaggelos Kaselouris Ondrej Klimo Michel Koenig George Koundourakis Milan Kucharik Jiri Limpouch Richard Liska Carlos Salgado Lopez Sophia Malko Susana Olmos-Miguelanez Yannis Orphanos Valeria Ospina Nektarios APapadogiannis Stelios Petrakis Jan Psikal Maria Serena Rivetta Maria-ose Rodriguez-Conde Joao Jorge Santos Milan Sinor Alexandros Skoulakis Ioannis Tazes Laura Tejada Pascual Calliope Tsitou Pavel Vachal Luca Volpe Jiri Vyskocil Steven White Mark Yeung Ghassan Zerouli Michael Tatarakis York Plasma Institute University of YorkHeslingtonYork YO105DQUK Hellenic Mediterranean University Institute of Plasma Physics and Lasers-IPPL74100 Rethymnon73133 ChaniaCreteGreece University of Bordeaux CNRSCEACELIA(Centre Lasers Intenses et Applications)UMR 5107F-33405 TalenceFrance Department of Physics University of IoanninaGR 45110 IoanninaGreece LULI-CNRS CEASorbonne UniversiesEcole PolytechniqueInstitut Polytechnique de Paris-F-91128 Palaiseau CedexFrance Observatoire de Paris 5 Place J JanssenMeudon 92195France Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUK Centro de Láseres Pulsados(CLPU) Edificio M5Parque CientficoC/Adaja 837185 VillamayorSalamancaSpain University of Salamanca 37008 SalamancaSpain Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in PragueBrehova 711519Prague 1Czech Republic University Institute for Educational Sciences University of Salamanca37008 SalamancaSpain Group of Research“Interaction and e Learning”(GRIAL) University of Salamanca37008 SalamancaSpain CLPU Laser-Plasma Chair at University of Salamanca 37008 SalamancaSpain

The second and final year of the Erasmus Plus programme’Innovative Education and Training in high power laser plasmas’,otherwise known as PowerLaPs,is *** PowerLaPs programme employs an innovative paradigm in that it is a multi-centre programme,where teaching takes place in five separate institutes with a range of different aims and styles of ***’in-class’time is limited to 4 weeks a year,and the programme spans 2 *** aims to train students from across Europe in theoretical,applied and laboratory skills relevant to the pursuit of research in laser plasma interaction physics and inertial confinement *** are intermingled with laboratory sessions and continuous assessment *** programme,which is led by workers from the Hellenic Mediterranean University and supported by co-workers from the Queen’s University Belfast,the University of Bordeaux,the Czech Technical University in Prague,Ecole Polytechnique,the University of Ioannina,the University of Salamanca and the University of York,has just finished its second and final *** Learning Teaching Training activities have been held at the Queen’s University Belfast,the University of Bordeaux,the Czech Technical University,the University of Salamanca and the Institute of Plasma Physics and Lasers of the Hellenic Mediterranean *** last of these institutes hosted two 2-week-long Intensive Programmes,while the activities at the other four universities were each 5 days in *** addition,a’Multiplier Event’was held at the University of Ioannina,which will be briefly *** this second year,the work has concentrated on training in both experimental diagnostics and simulation techniques appropriate to the study of plasma physics,high power laser matter interactions and high energy density *** nature of the programme will be described in detail,and some metrics relating to the activities carried out will be *** particular,this paper will f

关键词： laser plasma interactions postgraduate education

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白树,蒙彼利埃,法国

世界建筑 2020年第10期 30-35,137页

作者：无尼古拉斯·莱斯内迪米特里·鲁塞尔天妮(译) Iwan Baan(摄影) 藤本壮介建筑设计事务所尼古拉斯•莱斯内建筑师事务所 DREAM事务所 OXO建筑师事务所不详

起源独特的项目,2013年,蒙彼利埃市议会发起了一项名为“Folie Richter”的竞赛。竞赛旨在征集一个标志性的塔楼方案以丰富城市的建筑传统。任务书强调,这个宏大的项目必须能够融入其周边环境,同时需要涵盖一系列商业及居住空间。导则... 详细信息

起源独特的项目,2013年,蒙彼利埃市议会发起了一项名为“Folie Richter”的竞赛。竞赛旨在征集一个标志性的塔楼方案以丰富城市的建筑传统。任务书强调,这个宏大的项目必须能够融入其周边环境,同时需要涵盖一系列商业及居住空间。导则还清楚地指出:市政厅想要年轻建筑师及有经验的团队……马纳尔·拉赫迪和尼古拉斯•莱斯内是两位都创办了独立事务所的建筑师,他们决定拜访曰本建筑师藤本壮介。

关键词：居住空间蒙彼利埃藤本壮介任务书尼古拉斯市议会市政厅竞赛

Correction to:Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

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Protein & Cell 2022年第10期13卷 778-778页

作者： Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou dimitri Lavillette Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu State Key Laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430072China Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor EngineeringSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

CORRECTION TO:PROTEIN CELL 2020,11(10):723–739 HTTPS://***/10.1007/S13238-020-00768-W In the original publication the author’s name‘dimitri Lavillete’is published *** correct author name should be spelt as‘dimitri Lavillette’is provided in this *** ACCESS This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were *** images or other third party material in this article are included in the article's Creative Commons licence,unless indicated otherwise in a credit line to the *** material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright *** view a copy of this licence,visit http://***/licenses/by/4.0/.

关键词： ACCESS HTTPS otherwise

Microbial Assessment and Antibiotic Susceptibility Profile of Bacterial Fish Isolates in an Aquaculture Production Site in Mefou Afamba Division of Cameroon

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Journal of Environmental Science and Engineering(B) 2021年第1期10卷 20-30页

作者： Judith Julie Takadong Tsafack dimitri Alex Kamgain Tchuenchieu Hippolyte Tene Mouafo Manuela Annick Bengue Baomog Jorelle Jeanne Bimem Adjele Evrard Koupestchop Medjo Imelda Lucresse Nouteza Djuikoo Bridget Tata Ndakoh Chelea Matchawe James Sasanya Gabriel Nama Medoua Centre for Food and Nutrition Research IMPM(Institute of Medical Research and Medicinal Plant Studies)Yaounde 6163Cameroon Department of Microbiology University of Yaounde IYaounde 337Cameroon Department of Microbiology and Parasitology University of BueaBuea 99999Cameroon International Atomic Energy Agency Vienna International CentreVienna 1400Austria

The practice of integrated fish farming and the use of local fish meal and manure for fish feeding in Cameroon constitute potential sources of resistant pathogenic bacteria in the fish pond ***,a periodical and constant monitoring of the microbiological quality of fish pond is *** study was to assess the microbial contamination of Mfou aquaculture production site and evaluate the antibiotic resistance profile of bacterial fish *** of pond water(n=36),sediment(n=36),fishmeal(n=12)and African catfish(Clarias gariepinus),kanga(Heterotis niloticus)and Nile Tilapia(Oreochromis niloticus)(n=36,each)were collected to determine TVAC(Total Viable Aerobic Bacterial Count),FC(Fungal Count),SAC(Staphylococcus aureus count),TCC(Total Coliform Count)and FCC(Feacal Coliform Count).The fish skin isolates of ***,Enterobacter sakazakii,Citrobacter freundii,Serratia fonticola,Klebsiella oxytoca,Proteus spp.,Aeromonas hydrophila,Kluyvera spp.,Moraxella spp.,Pasteurella multocida and Pseudomonas fluorescens were tested against penicillin G(10μg),chloramphenicol(30μg),sulfamethoxazole/trimethoprim(25μg),erythromycin(15μg),tetracycline(30μg),using the disk diffusion *** reveal a heavy contamination of fish farms with microbial load above the recommended *** study indicates that fish ponds are sources of zoonotic pathogens underlining their epidemiological and clinical *** bacterial isolates were multiresistant with a multiple antibiotic resistance index above *** data raise concern about the microbial contamination of aquaculture and associated public health risks in Cameroon.

关键词： Microbial contamination antibiotic susceptibility profile aquaculture pond fish zoonotic pathogens Cameroon

一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)

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中华神经外科疾病研究杂志 2014年第5期13卷 433-433页

作者： Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P Laboratory of Oncology "IRCCS Casa Sollievo della Sofferenza" Laboratory of Genetics "IRCCS Casa Sollievo della Sofferenza" Department of Biosciences Biotechnology and BiopharmaceuticsUniversity of Bari "Aldo Moro" LTTA Department of MorphologySurgery and Experimental MedicineHuman Anatomy BranchUniversity of Ferrara Department of Neurosurgery "IRCCS Casa Sollievo della Sofferenza " Department of Pathology "IRCCS Casa Sollievo della Sofferenza" Unit of Biostatistics "IRCCS Casa Sollievo della Sofferenza" Department of Oncology "IRCCS Casa Sollievo della Sofferenza" CIR Laboratory for Molecular Medicine and Biotechnology University Campus Biomedico

Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade ***-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.

关键词：神经外科学疾病临床研究医学