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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han deyang zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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二维功能填料尺寸对BN/EPDM柔性中子防护复合材料性能的影响

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核技术 2024年第9期47卷 102-111页

作者：宗波曾德洋王凯凯唐文偲付嘉佳常树全何佳霖陈芳雷李自平李达国家核安保技术中心北京102401 南京航空航天大学材料科学与技术学院南京211100

柔性中子防护复合材料对于异形构件和人员防护具有重要意义,其性能与功能填料的性质密切相关,但二维功能填料尺寸对材料性能的影响尚不明确。以性能良好的三元乙丙橡胶(Ethylene Propylene Diene Monomer,EPDM)作为柔性基体,以热中子吸... 详细信息

柔性中子防护复合材料对于异形构件和人员防护具有重要意义,其性能与功能填料的性质密切相关,但二维功能填料尺寸对材料性能的影响尚不明确。以性能良好的三元乙丙橡胶(Ethylene Propylene Diene Monomer,EPDM)作为柔性基体,以热中子吸收截面较高的层状氮化硼(Boron Nitride,BN)作为二维功能填料并作表面改性,通过开炼工艺将BN均匀分散于EPDM中,热压硫化后得到BN/EPDM柔性中子防护复合材料,对其微观结构进行表征分析。研究了BN尺寸对复合材料综合性能的影响,结果表明:减小BN尺寸有利于提升复合材料的拉伸强度和热中子屏蔽性能,当材料厚度为2 mm时,其拉伸强度最高可达8.13 MPa,热中子屏蔽率最高可提升约5%。该研究可为聚合物基柔性中子防护复合材料的设计与制备提供基础。

关键词：中子防护复合材料柔性二维功能填料氮化硼

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Exploring the psychological impact of the 2022 SARS-CoV-2 Omicron variant outbreak in China

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General Psychiatry 2023年第6期36卷 541-546页

作者： Gangbin Han Guirong Cheng Feifei Hu Chunli Li Dan Liu Juan Zhou Jing Liu Linya Huang Xiaochang Liu Qianqian Nie Dan Song deyang zeng Lang Xu Jinquan Li Yushan Chen Zhen Wei Qiong Wu Xiaoming He Qingming Wu Wei Tan Yufei Mei Xingxing Chen Yangming Ou Jingjing ZhangYafu Yu Mengliu Yang Pengfei Lian Fukai Zhou Renjia Fan Hong Wan Chenlu Hu Yidi Fu Shiyue Li Junyi Wang Cheng Cai Mengdie Pei Yuyang Cui Wanying Cai Yiqing Li Shiyao Pan Chang Chen Yan He Zhaoxia Wu Liu Hu Liang Tao Hongyan Xiao Xinyan Xie Yan zeng Institute of Brain Science and Advanced Technology Wuhan University of Science and TechnologyWuhanHubeiChina Department of Neurology Geriatric Hospital Affiliated to Wuhan University of Science and TechnologyWuhan University of Science and TechnologyWuhanHubeiChina Department of Neurology Tianyou Hospital Affiliated to Wuhan University of Science and TechnologyWuhan University of Science and TechnologyWuhanHubeiChina Institute of Infection Immunology and Tumor MicroenvironmentHubei Province Key Laboratory of Occupational Hazard Identification and ControlMedical CollegeWuhan University of Science and TechnologyWuhanHubeiChina Department of Anesthesiology Zhongnan HospitalWuhan UniversityWuhanHubeiChina Department of Neurology Wuchang Hospital afiliated to Wuhan University of Science and TechnologyWuhan University of Science and TechnologyWuhanHubeiChina Department of neurology Asian Heart HospitalWuhan University of Science and TechnologyWuhanHubeiChina School of Public Health Wuhan University of Science and TechnologyWuhanHubeiChina

To the editor:The impact of the coronavirus disease 2019(COVID-19)pandemic in 2020 on mental health was substantialin Chinai2and various other countries.34 Beyond the direct consequences of COVID-19,the pandemic created an environment in which many determinants of mental health were *** associated with the pandemic,such as loss of livelihood,limited access to medical services,reduced social interactions,and economic downturn,could potentially have adverse effects on the population's mental well-being.5 In November 2021,the World Health Organization(WHO)designated the new variant of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),variant B.1.1.529,as a variant of concern and named it Omicron;its rapid mutation and spread raised a new global health concern.

关键词： acute impact consequences

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高产林可霉素链霉菌的筛选及发酵条件的优化

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中国酿造 2015年第11期34卷 99-102页

作者：邓加聪施潇蕊曾德样张文森徐慧诠唐慧华郑虹福建师范大学福清分校海洋与生化工程学院福建福清350300 福建师范大学福清分校朗姆多果酒研究所福建福清350300

采用平板划线,摇瓶复筛等方法从福清近海海域泥土中分离筛选到一株林可霉素产率较高的链霉菌株6204;采用单因素试验和正交设计试验,从葡萄糖添加量、磷酸二氢钾条件两及金属离子对菌株6204产林可霉素影响,并对其发酵条件进行优化。结果... 详细信息

采用平板划线,摇瓶复筛等方法从福清近海海域泥土中分离筛选到一株林可霉素产率较高的链霉菌株6204;采用单因素试验和正交设计试验,从葡萄糖添加量、磷酸二氢钾条件两及金属离子对菌株6204产林可霉素影响,并对其发酵条件进行优化。结果表明,最适的发酵条件为葡萄糖添加量10.0%,镁离子质量浓度0.10 g/L,磷酸二氢钾添加量0.020%,在此优化发酵条件下,菌株6204产林可霉素的含量可达3 907.738μg/m L,与优化前相比较,林可霉素的含量提高了1 823.082μg/m L。

关键词：链霉菌选育林可霉素发酵条件优化

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中年心血管危险因素增加阿尔茨海默病相关痴呆的流行病学和机制研究进展

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中华脑血管病杂志（电子版） 2024年第1期18卷 6-13页

作者：曾德阳董贺千禧陶凉肖红艳曾燕鄢华武汉科技大学亚洲心脏病医院心内科 430022 武汉科技大学医学部 430081

尽管越来越多的流行病学研究证明,中年心血管风险因素,如高血压、糖尿病、肥胖、缺乏运动和吸烟,通过脑动脉粥样硬化、脑灌注不足和神经退行性变等病理机制,增加阿尔茨海默病相关痴呆(ADRD)的发病率,但心血管危险因素和亚临床动脉粥样... 详细信息

尽管越来越多的流行病学研究证明,中年心血管风险因素,如高血压、糖尿病、肥胖、缺乏运动和吸烟,通过脑动脉粥样硬化、脑灌注不足和神经退行性变等病理机制,增加阿尔茨海默病相关痴呆(ADRD)的发病率,但心血管危险因素和亚临床动脉粥样硬化对ADRD临床前阶段的纵向影响尚未完全阐明。本篇综述系统阐述了心血管风险因素,亚临床或症状前动脉粥样硬化与ADRD之间的关系,提出识别心血管危险因素并确定预防和延迟ADRD发作的关键时间窗至关重要,开展大规模多中心的心血管危险因素预防试验将有助于确定血管因素是否对亚临床动脉粥样硬化有明显影响,并阐明中年心血管风险因素对大脑的影响。

关键词：危险因素心血管疾病动脉粥样硬化阿尔茨海默病痴呆

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Strategy of preparing SmCo based films with high coercivity and remanence ratio achieved by temperature and chemical optimization

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Journal of Rare Earths 2024年第7期42卷 1289-1297,I0004页

作者： Yansong Gong Zhaoguo Qiu Sizhe Liang Xinrui Zheng Hongxia Meng Zhigang Zheng deyang Chen Shengfu Yuan Weixing Xia Dechang zeng J.P.Liu School of Materials Science and Engineering South China University of TechnologyGuangzhou510640China Zhongshan R&D Center for Materials Surface and Thin Films Technology of the South China University of Technology Gent Materials Surface Technology(Guangdong)Co.Ltd.Zhongshan528437China Institute for Advanced Materials South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou510006China Yangjiang Branch Guangdong Laboratory Materials Science and Technology Yangjiang Advanced Alloys LaboratoryYangjiang529500China Laboratory of Rare-Earth Magnetic Functional Materials Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China Department of Physics University of Texas at ArlingtonArlingtonTX76019USA

SmCo based films with excellent intrinsic magnetic properties have promising applications in micro-electro-mechanical system(MEMS).However,due to the complexity of phase composition and uncontrollable crystallization degree of SmCo hard magnetic phase in the film,both the coercivity(Hc)and remanence(Mr)of films are difficult to enhance *** this paper,SmCo based films were deposited with a Cr underlayer and capping layer on single crystal Si substrates via magnetron sputtering *** effects of annealing parameters and Sm/Co atomic ratio on the phase structure and coercivity of films are *** adjusting the Sm/Co atomic ratio from 1:5 to 1:4,Co soft magnetic phase disappears and the single phase SmCo5 is obtained,leading to the increase of coercivity of the films from 30 to 34 *** influence of deposition temperature and Cu doping on magnetic properties of SmCo based films was *** the deposition temperature increases from room temperature to 250℃,the coercivity will further increase from 34 to 51 ***,a severe kink is observed in the demagnetization curves due to the poor exchanged *** analysis of transmission electron microscopy(TEM)confirms that the average size of non-hard magnetic amorphous phase exceeds the effective exchanged coupling length of SmCo5,which contributes to the decoupling and low remanence ***,doping Cu and applying a post-annealing process can significantly improve the crystallization degree of the *** the coercivity and the remanence ratio of the demagnetization curves are greatly *** propose a plausible strategy to prepare the SmCo based films with high coercivity and remanence ratio by temperature and chemical optimization,which can be utilized in high performed MEMS devices.

关键词： Rare earths SmCo based films Phase composition Crystallization conditions Coercivity Remanence ratio

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Creation and erasure of polar bubble domains in PbTiO_(3)films by mechanical stress and light illuminations

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Journal of Materiomics 2023年第4期9卷 626-633页

作者： Xingchen Zhang Hongying Chen Guo Tian Wenda Yang Zhen Fan Zhipeng Hou deyang Chen Min zeng Minghui Qin Jinwei Gao Xingsen Gao Jun-Ming Liu Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials and Institute for Advanced Materials South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou510006China Laboratory of Solid-State Microstructures and Innovation Center of Advanced Microstructures Nanjing UniversityNanjing210093China National Laboratory of Solid State Microstructures Department of Materials Science and EngineeringJiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjing210093China

The controllable manipulation of polar topological structures(*** bubble)in ferroelectric materials have been considered as a cornerstone for future programmable ***,we present the effective creation and erasure of polar bubble states PbTiO_(3)(PTO)multilayers trigged by mechanical stress and light illumination,*** was found that applying atomic force microscope(AFM)tip force can induced formation of nanoscale bubble domains from the initial monodomain ***,the created bubble domain can be eliminated by exposure to ultraviolet or infrared light *** above results can be understood by modulation of depolarization screening charges and bias fields,as reflected by scanning Kelvin potential microscopic(SKPM)observations,whereby the flexoelectric effect from the tip force tends to remove the screening charges on top surface and modulate the bias field that favors the formation of bubble state while light illumination tends to recover the screen charges and favor the monodomain *** results provide a good example for multi-field manipulation of polar topologies,which might create a new avenue towards the immerging new concept electronic devices.

关键词： Ferroelectric films Polar topologies Piezoresponse force microscopy

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Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space

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Science China(Life Sciences) 2022年第2期65卷 227-235页

作者： deyang Yao Yukun Li Sheng zeng Zhifan Li Zahir Shah Bigui Song Jinglei Liu Yi Wu Liang Yang Qi Long Wenqian Wang Zhijuan Hu Haite Tang Xingguo Liu School of Life Sciences University of Science and Technology of ChinaHefei 230027China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) CAS Key Laboratory of Regenerative BiologyJoint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou Medical UniversityGuangzhou 510530China Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Institute for Stem Cell and RegenerationGuangzhou Institutes of Biomedicine and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesGuangzhou 510530China Centre for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong SARChina

Mitochondria,double-membrane organelles,are known to participate in a variety of metabolic and signal transduction *** intermembrane space(IMS)of mitochondria is proposed to subject to multiple damages emanating from the respiratory *** optic atrophy 1(OPA1),an important protein for mitochondrial fusion,is cleaved into soluble short-form(S-OPA1)under *** we report that S-OPA1 could function as a molecular chaperone in *** purified the S-OPA1(amino acid sequence after OPA1 isoform 5 S1 site)protein and showed it protected substrate proteins from thermally and chemically induced aggregation and strengthened the thermotolerance of Escherichia coli(***).We also showed that S-OPA1 conferred thermotolerance on IMS proteins,e.g.,*** chaperone activity of S-OPA1 may be required for maintaining IMS homeostasis in mitochondria.

关键词： mitochondria OPA1 chaperone mitochondrial homeostasis heat shock

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Enhanced ferroelectric polarization with less wake-up effect and improved endurance of Hf_(0.5)Zr_(0.5)O_(2)thin films by implementing W electrode

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Journal of Materials Science & Technology 2022年第9期104卷 1-7页

作者： Dao Wang Yan Zhang Jiali Wang Chunlai Luo Ming Li Wentao Shuai Ruiqiang Tao Zhen Fan deyang Chen Min zeng Jiyan Y.Dai Xubing B.Lu J-M.Liu Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials and Institute for Advanced Materials South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China Department of Applied Physics The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Laboratory of Solid State Microstructures and Innovation Centre of Advanced Microstructures Nanjing UniversityNanjing 210093China

This paper reports the improvement of electrical,ferroelectric and endurance of Hf_(0.5)Zr_(0.5)O_(2)(HZO)thinfilm capacitors by implementing W *** W/HZO/W capacitor shows excellent pristine 2 P_(r)values of 45.1 gC/cm^(2)at±6 V,which are much higher than those of TiN/HZO/W(34.4μC/cm^(2))and W/HZO/TiN(26.9μC/cm^(2))***,the maximum initial 2 P_(r)value of W/HZO/W capacitor can reach as high as 57.9μC/cm^(2)at±7.5 *** strong ferroelectric polarization effects are ascribed to the W electrode with a fairly low thermal expansion coefficient which provides a larger in-plane tensile strain compared with TiN electrode,allowing for enhancement of o-phase ***,the W/HZO/W capacitor also exhibits higher endurance,smaller wake-up effect(10.1%)and superior fatigue properties up to 1.5×10^(10)cycles compared to the TiN/HZO/W and W/HZO/TiN *** improvements of W/HZO/W capacitor are mainly due to the decreased leakage current by more than an order of magnitude compared to the W/HZO/TiN *** results demonstrate that capping electrode material plays an important role in the enhancement of o-phase formation,reduces oxygen vacancies,mitigates wake-up effect and improves reliability.

关键词： Hf_(0.5)Zr_(0.5)O_(2)films Ferroelectric polarization Endurance properties Thermal expansion coefficient W electrode

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Ferroelectricity in dopant-free HfO_(2) thin films prepared by pulsed laser deposition

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Journal of Materiomics 2022年第2期8卷 311-318页

作者： Yongjian Luo Zhenxun Tang Xiaozhe Yin Chao Chen Zhen Fan Minghui Qin Min zeng Guofu Zhou Xingsen Gao Xubing Lu Jiyan Dai deyang Chen Jun-Ming Liu Institute for Advanced Materials South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou510006China Guangdong Provincial Key Laboratory of Optical Information Materials and Technology South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou510006China Department of Applied Physics The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Laboratory of Solid State Microstructures and Innovation Center of Advanced Microstructures Nanjing UniversityNanjing210093China

As a high-k material,hafnium oxide(HfO_(2))has been used in gate dielectrics for *** the discovery of polar phase in Si-doped HfO_(2) films,chemical doping has been widely demonstrated as an effective approach to stabilize the ferroelectric phase in HfO_(2) based thin ***,the extra capping layer deposition,post-growth annealing and wake-up effect are usually required to arouse the ferroelectricity in HfO_(2) based thin films,resulting in the increase of complexity for sample synthesis and the impediment of device *** this study,the ferroelectricity is observed in non-capped dopant-free HfO_(2) thin films prepared by pulsed laser deposition(PLD)without post-growth *** adjusting the deposited temperature,oxygen pressure and thickness,the maximum polarization up to 14.7 m C/cm^(2) was obtained in 7.4 nm-thick *** fraction of orthorhombic phase,concentrations of defects and size effects are considered as possible mechanisms for the influences of ferroelectric *** study indicates that PLD is an effective technique to fabricate high-quality ferroelectric HfO_(2) thin films in the absence of chemical doping,capping layer deposition and post-growth annealing,which may boost the process of nonvolatile memory device application.

关键词： Hafnium oxide Pulsed laser deposition Ferroelectricity Orthorhombic phase

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