Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space

作     者：Deyang Yao Yukun Li Sheng Zeng Zhifan Li Zahir Shah Bigui Song Jinglei Liu Yi Wu Liang Yang Qi Long Wenqian Wang Zhijuan Hu Haite Tang Xingguo Liu Deyang Yao;Yukun Li;Sheng Zeng;Zhifan Li;Zahir Shah;Bigui Song;Jinglei Liu;Yi Wu;Liang Yang;Qi Long;Wenqian Wang;Zhijuan Hu;Haite Tang;Xingguo Liu

作者机构：School of Life SciencesUniversity of Science and Technology of ChinaHefei 230027China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)CAS Key Laboratory of Regenerative BiologyJoint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou Medical UniversityGuangzhou 510530China Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineInstitute for Stem Cell and RegenerationGuangzhou Institutes of Biomedicine and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesGuangzhou 510530China Centre for Regenerative Medicine and HealthHong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong SARChina 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2022年第65卷第2期

页      面：227-235页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：the National Key Re-search and Development Program of China(2017YFA0106300) the Stra-tegic Priority Research Program of the Chinese Academy of Sciences(XDA16030505) the National Key Research and Development Program of China(2017YFA0102900,2019YFA09004500,2017YFC1001602,2016YFA0100300,2018YFA0107100) the National Natural Science Foundation of China(32025010,31801168,31900614,31970709,81901275,32070729) the Key Research Program of Frontier Sciences,CAS(QYZDB-SSW-SMC001) International Cooperation Program,CAS(154144KYSB20200006) Guangdong Province Science and Technol-ogy Program(2020B1212060052,2018A030313825,2018GZR110103002,2020A1515011200,2020A1515010919,2020A1515011410,2021A1515012513) Guangzhou Science and Technology Program(201807010067,202002030277,202102021250,202102020827,202102080066) CAS Youth Innovation Promotion Association 

主　　题：mitochondria OPA1 chaperone mitochondrial homeostasis heat shock 

摘      要：Mitochondria,double-membrane organelles,are known to participate in a variety of metabolic and signal transduction *** intermembrane space(IMS)of mitochondria is proposed to subject to multiple damages emanating from the respiratory *** optic atrophy 1(OPA1),an important protein for mitochondrial fusion,is cleaved into soluble short-form(S-OPA1)under *** we report that S-OPA1 could function as a molecular chaperone in *** purified the S-OPA1(amino acid sequence after OPA1 isoform 5 S1 site)protein and showed it protected substrate proteins from thermally and chemically induced aggregation and strengthened the thermotolerance of Escherichia coli(***).We also showed that S-OPA1 conferred thermotolerance on IMS proteins,e.g.,*** chaperone activity of S-OPA1 may be required for maintaining IMS homeostasis in mitochondria.