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Albuminuria as a marker of arterial stiffness in chronic kidney disease patients

World Journal of Nephrology 2015年第3期4卷 406-414页

作者： Rigas G Kalaitzidis despina p karasavvidou Athina Tatsioni Kosmas pappas Giorgos Katatsis Angelos Liontos Moses S Elisaf Outpatient Renal and Hypertension Clinic University Hospital of Ioannina Department of Internal Medicine Medical SchoolUniversity of Ioannina

AIM:To access the association between albuminuria levels and arterial stiffness in non-diabetic patients with hypertension and chronic kidney disease(CKD) stages 1-2,treated with renin angiotensin blockade agents plus other hypertensive drugs when ***:One hundred fifteen patients [median age 52 years(68% males)] were consequently enrolled in the *** each patient,we recorded gender,age,body mass index(BMI),peripheral systolic blood pressure(p SBp),peripheral diastolic blood pressure,peripheral pulse pressure,central systolic blood pressure(c SBp),central diastolic blood pressure(c DBp),central pulse pressure(c pp),hematocrit,hemoglobin,hs CRp,total cholesterol triglycerides,high-density lipoprotein-C,low-density lipoprotein-C,calcium,phosphorus,parathormone,and albumin,as well as 24 h urine albumin *** to 24-h urine albumin collection,patients were then classified as those with moderately increased albuminuria(formerly called macroalbuminuria)(≤ 300 mg/d) and those with severely increased albuminuria(formerly called macroaluminuria(> 300 mg/d).We considered aortic stiffness(AS) indices [carotid femoral pulse wave velocity(pWVc-f) and augmentation index(AIx)] as primary outcomes ofthe *** explored potential correlations between severely increased albuminuria and AS indices using a multiple linear regression ***:Fifty-eight patients were included in the moderately increased albuminuria group and 57 in the severely increased *** pressure measurements of the study population were 138 ± 14/82 ± 1.3 mm Hg(systolic/diastolic).There were no significant differences in age,sex,and Bp measurements between the two *** with severely increased albuminuria had higher pWV and AIx than patients with moderately increased albuminuria(p p pectively).In addition these patients exhibited higher BMI(p p(p p pared to patients with moderately incr

关键词：慢性肾脏病血红素治疗方法临床分析

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Importance of serum phosphate in elderly patients with diabetes mellitus

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World Journal of Diabetes 2020年第10期11卷 416-424页

作者： Vaia D Raikou despina Kyriaki Sotiris Gavriil Department of Nephrology Doctors’HospitalAthens 11257Greece Department of Nuclear Medicine General Hospital“LAΪKO”Athens 11527Greece Department of Bariatric Surgery Doctors’HospitalAthens 11257Greece

BACKGROUND Metabolic disturbances including changes in serum calcium,magnesium or phosphate(p)influence the prevalence of type 2 diabetes mellitus(DM).We assessed the importance of serum p in elderly patients with type 2 DM vs nondiabetes mellitus(non-DM)in relation to renal *** To determine the association between serum p and serum glucose or insulin resistance in diabetic and non-diabetic *** One hundred-ten subjects with a mean age of 69.02±14.3 years were ***-nine of the participants had type 2 DM(26.4%).The incidence of hypertension,smoking and receiving vitamin D(vitD)derivates were *** participants were classified by both estimated glomerular filtration rate(eGFR)and albuminuria categories according to the Kidney Disease Improving Global Outcomes 2012 *** We divided the patients in two groups according to the p cut-off point related to DM value.A comparison between high and low p showed that body mass index 30.2±6.3 vs 28.1±4.6(p=0.04),mean glucose 63.6 vs 50.2(p=0.03),uric acid 6.7±1.6 vs 6.09±1.7(p=0.05),mean intact-parathyroid hormone 68.06 vs 47.4(p=0.001),systolic blood pressure 147.4±16.7 vs 140.2±16.1(p=0.02),mean albuminuria 63.2 vs 50.6(p=0.04)and eGFR 45.6±22.1 vs 55.4±21.5(p=0.02)were significantly different.χ^2 tests showed a significant association between high p and DM,hypertension,receiving vitD,smoking and eGFR stage(χ^2=6.3,p=0.01,χ^2=3.9,p=0.03,χ^2=6.9,p=0.009,χ^2=7.04,p=0.01 andχ^2=7.36,p=0.04,respectively).The adjusted model showed that older age,female gender and increased body mass index were significant predictors of type 2 DM when entering the *** High serum p contributes to vascular and metabolic disturbances in elderly patients with type 2 DM and renal impairment.

关键词： Serum phosphate Diabetes mellitus Renal disease Old age Albuminuria Vitamin D

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Management of carbon tetrachloride-induced acute liver injury in rats by syngeneic hepatocyte transplantation in spleen and peritoneal cavity

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World Journal of Gastroenterology 2004年第14期10卷 2099-2102页

作者： Charalampos pilichos despina perrea Maria Demonakou Athena preza Ismini Donta Third Department of propaudeutic Surgery University of AthensSotiria HospitalAthensHellas Laboratory of Experimental Surgery University of AthensHellas Laboratory of pathological Anatomy Sismanogleion General HospitalAthensHellas

AIM: Acute hepatitis may seldom have a fulminant *** the treatment of this medical emergency, potential liver support measure must provide immediate and sufficient assistance to the hepatic function. The goal of our study was to study the adequacy of hepatocyte transplantation (HCTx) in two different anatomical sites, splenic parenchyma and peritoneal cavity, in a rat model of reversible acute hepatitis induced by carbon tetrachloride (CCl4).METHODS: After CCl4 intoxication, 84 male Wistar rats used as recipients were divided in to four experimental groups accordingly to their treatment: Group A (n=24): intrasplenic transplantation of 10±10^6 isolated hepatoo/tes, Group B (n=24):intrapedtoneal transplantation of 20×10^6 isolated hepatocytes attached on plastic microcarriers, Group C (n= 18): intrasplenic injection of 1 mL normal saline (sham-operated controls),Group D (n=18): intraperitoneal injection of 2.5 mL normal saline (sham-operated controls). Survival, liver function tests (LIT) and histology were studied in all four groups, on d 2,5 and 10 ***: The ten-day survival (and mean survival) in the 4 groups was 72.2% (8.1±3.1), 33.3% (5.4±3.4), 0%(3.1±1.3) and 33.3% (5.4±3.6) in groups A, B, C, D,respectively (pAB＜0.05, pAc＜0.05, p80=NS). In the final survivors, LIT (except alkaline phosphatase) and hepatic histology retumed to normal, independently of their previous therapy. Viable hepatocytes were identified within splenic parenchyma (in group A on d 2) and both in the native liver and the fatty tissue of abdominal wall (in group B on d 5).CONCLUSION: A significantly better survival of the intrasplenically transplanted animals has been demonstrated,Intraperitoneal hepatocytes failed to promptly engraft. A different timing between liver injury and intraperitoneal HCTx may give better results and merits further investigation.

关键词：碳氧化物急性肝损害老鼠同源性肝细胞移植脾脏腹膜腔 HCTx

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Serum Calprotectin and prealbumin Levels among Ovarian Cancer patients Aged 30 - 45 Years

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Open Journal of Obstetrics and Gynecology 2017年第3期7卷 303-311页

作者： Anastasia petsa Vasilios pergialiotis panagiotis Konstantopoulos Athanasia Katsichti Kyriakos petrou Athanasios Giannopoulos Dimitrios Botsis despina perrea Laboratory of Experimental Surgery and Surgical Research N.S. Christeas National and Kapodistrian University of Athens Athens Greece 1st Department of General Surgery “Laikon” General Hospital of Athens Athens Greece 2nd Department of Obstetrics-Gynecology “Aretaieion” Hospital Athens Greece

purpose: Serum calprotectin and prealbumin have been previously linked with ovarian cancer. However, to date, their effectiveness in the diagnosis of the disease remains uncertain. The purpose of the present study is to determine whether serum prealbumin and calprotectin correlate with the stage and type of histologic diagnosis. Materials-Methods: In the present study, we included 80 women aged 30 - 45 years that had either primary ovarian cancer (Stages 1 and 2) with elevated levels of CA-125 (n = 40) or were healthy (n = 40). Serum calprotectin and prealbumin levels were assessed using ELISA kits. Statistical analysis was performed with SpSS v.20.0 statistical software. Results: Both plasma prealbumin and calprotectin levels were significantly different in patients with ovarian cancer compared to healthy controls. Specifically, serum prealbumin levels showed a level towards decreasing as the stage of the disease advanced (21.2 (15.5 - 30.6) in healthy controls, 12.8 (6.9 - 16) for patients with stage 1 disease and 9.9 (4.0 - 15.5) for patients with stage 2 disease p p Conclusions: Both prealbumin and calprotectin seem to be useful markers for the identification of patients suffering from ovarian cancer.

关键词： CA-125 Calprotectin Ovarian Cancer prealbumin

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Mechanical behavior of colonic anastomosis in experimental settings as a measure of wound repair and tissue integrity

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World Journal of Gastroenterology 2006年第35期12卷 5668-5673页

作者： Konstantinos A Ekmektzoglou Georgios C Zografos Stavros K Kourkoulis Ismene A Dontas panagiotis K Giannopoulos Κaterina A Marinou Maria V poulakou despina N perrea Laboratory of Experimental Sur- gery and Surgical Research "NS Christeas" University of Athens Medical School Athens Greece 1st Univer- sity Department of General Surgery Athens School of Medicine Hippocration Hospital Athens Greece Laboratory of Testing and Materials De- partment of Mechanics National Technical University of Athens Greece BVMS MVM Laboratory of Experimen- tal Surgery and Surgical Research "NS Christeas" University of Athens Medical School Athens Greece and Greek Ministry of Rural Development and Food General Directorate of Veterinary Services

AIM: To determine the mechanical properties of anasto- motic colonic tissue in experimental settings and there- fore give a measure of wound healing. METHODS: Thirty-six male Wistar rats were used as ex- perimental models of anastomotic tissue integrity. On the 5th post-operative day, the tensile strength was measured by application of an axial force, providing a quantitative measure of anastomotic dehiscence and leakage. RESULTS: Diagrams of the load as a function of the time [p = p (t)] and of the displacement also as a func- tion of time [Δs = Δs (t)] were recorded for each test, permitting the design of the load versus the displace- ment diagram and thus providing significant data about the critical values of anastomotic failure. Quantitative data were obtained concerning the anastomotic strength of both control specimens (healthy rats), as well as spec- imens from non-healthy rats for comparison. CONCLUSION: This experimental model provides an excellent method of measuring anastomotic strength. Despite the relative small number of specimens used, this method provides an accurate way of measuring wound repair. More experimental measurements need to be performed to correlate emerging tensile strength val-ues to anastomotic failure.

关键词：机械行为结肠吻合术实验研究组织结构

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Biomechanical characteristics of bone in streptozotocin-induced diabetic rats:An in-vivo randomized controlled experimental study

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World Journal of Orthopedics 2013年第3期4卷 124-129页

作者： Nektarios Korres Eleftherios Tsiridis George pavlou Athanasios Mitsoudis despina N perrea Aristedes B Zoumbos KAT First Department of Orthopaedics and Trauma 14561 AthensGreece Academic Orthopaedics and Trauma Unit Division of SurgeryAristotle University Medical School54124 ThessalonikiGreece Department of Orthopaedics Robert Jones and Agnes Hunt Orthopaedic HospitalOswestry SY10 7AGUnited Kingdom Department of Biomechanics School of Applied Mathematical and Physical SciencesNational Technical University of Athens14561 AthensGreece Department of Experimental Surgical Research "N.S.Christeas" Athens University Medical School14561 AthensGreece Department of Orthopaedics Academic Orthopaedic Department "Attikon" HospitalAthens University Medical School14561 AthensGreece

AIM: To investigate the in vivo effects of type Ⅰdiabetes on the mechanical strength of tibial bone in a rodent ***: The biomechanical effect of diabetes on the structural integrity of the tibia in streptozotocin induced diabetic Wistar rats was analysed. Induction of diabetes was achieved by an intra-peritoneal injection and confirmed by measuring serial blood glucose levels(> 150 mg/d L). After 8 wk the tibiae were harvested and compared to a control group. Biomechanical analysis of harvested tibiae was performed using a threepoint bending technique on a servo hydraulic MTS 858 MiniB ionix frame. Maximum force applied to failure(N), stiffness(N × mm) and energy absorbed(N/mm) were recorded and plotted on load displacement curves. A displacement control loading mode of 1 mm/min was selected to simulate quasi-static loading conditions. Measurements from load-displacement curves were directly compared between ***: Fourteen streptozotocin induced diabetic Wistar rats were compared against nineteen non-diabetic controls. An average increase of 155.2 g in body weight was observed in the control group compared with only 5 g in the diabetic group during the experimental study period. Levels of blood glucose increased to 440.25 mg/d L in the diabetic group compared to 116.62 mg/d L in the control *** biomechanical results demonstrate a highly significant reduction in the maximum load to failure from 69.5 N to 58 N in diabetic group compared to control(p = 0.011). Energy absorption to fracture was reduced from 28.2 N in the control group to 23.5 N in the diabetic group(p = 0.082). No significant differences were observed between the groups for bending ***: Streptozotocin-induced diabetes in rodents reduces the maximum force and energy absorption to failure of bone, suggesting a predisposition for fracture risk.

关键词： Streptozotocin Rodent Bone Biomechanics

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分子细胞遗传学技术在确诊9p三体综合征中的应用

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中华医学遗传学杂志 1999年第6期16卷 383-385页

作者：丁秀原杨凤堂陈虹 despinaSanoudou 首都儿科研究所遗传研究室北京100020 首都儿科研究所临床兽医学系北京100020 首都儿科研究所生化免疫研究室北京100020 英国剑桥大学病理系人类分子遗传研究室

目的　用分子细胞遗传学技术鉴别常规细胞遗传学难以确定的染色体异常。方法　用染色体涂染、比较基因组杂交(com parative genom ic hybridization,CGH)和多色显带分析技术(colorbandingchrom osom e analysis,RxFISH),对一例G 显带提... 详细信息

目的　用分子细胞遗传学技术鉴别常规细胞遗传学难以确定的染色体异常。方法　用染色体涂染、比较基因组杂交(com parative genom ic hybridization,CGH)和多色显带分析技术(colorbandingchrom osom e analysis,RxFISH),对一例G 显带提示为9 号染色体结构异常的病例进行研究。结果　患儿核型为46,XX,9p+ ,染色体涂染显示两条9 号染色体(包括短臂额外片段)被均匀涂染,CGH 和RxFISH证实为9 号短臂完全重复,核型准确描述为46,XX,dup 9p(p11→p24∷p24→qter)。结论　这些技术手段可以鉴别常规细胞遗传学难以进行诊断的、复杂的染色体结构异常,在基础及临床医学研究领域中。

关键词：三体综合征分子细胞遗传学诊断

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