Serum Calprotectin and Prealbumin Levels among Ovarian Cancer Patients Aged 30 - 45 Years

作     者：Anastasia Petsa Vasilios Pergialiotis Panagiotis Konstantopoulos Athanasia Katsichti Kyriakos Petrou Athanasios Giannopoulos Dimitrios Botsis Despina Perrea 

作者机构：Laboratory of Experimental Surgery and Surgical Research N.S. Christeas National and Kapodistrian University of Athens Athens Greece 1st Department of General Surgery “Laikon” General Hospital of Athens Athens Greece 2nd Department of Obstetrics-Gynecology “Aretaieion” Hospital Athens Greece 

出 版 物：《Open Journal of Obstetrics and Gynecology》 (妇产科期刊（英文）)

年 卷 期：2017年第7卷第3期

页      面：303-311页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：CA-125 Calprotectin Ovarian Cancer Prealbumin 

摘      要：Purpose: Serum calprotectin and prealbumin have been previously linked with ovarian cancer. However, to date, their effectiveness in the diagnosis of the disease remains uncertain. The purpose of the present study is to determine whether serum prealbumin and calprotectin correlate with the stage and type of histologic diagnosis. Materials-Methods: In the present study, we included 80 women aged 30 - 45 years that had either primary ovarian cancer (Stages 1 and 2) with elevated levels of CA-125 (n = 40) or were healthy (n = 40). Serum calprotectin and prealbumin levels were assessed using ELISA kits. Statistical analysis was performed with SPSS v.20.0 statistical software. Results: Both plasma prealbumin and calprotectin levels were significantly different in patients with ovarian cancer compared to healthy controls. Specifically, serum prealbumin levels showed a level towards decreasing as the stage of the disease advanced (21.2 (15.5 - 30.6) in healthy controls, 12.8 (6.9 - 16) for patients with stage 1 disease and 9.9 (4.0 - 15.5) for patients with stage 2 disease p p Conclusions: Both prealbumin and calprotectin seem to be useful markers for the identification of patients suffering from ovarian cancer.