Importance of serum phosphate in elderly patients with diabetes mellitus

作     者：Vaia D Raikou Despina Kyriaki Sotiris Gavriil 

作者机构：Department of NephrologyDoctors’HospitalAthens 11257Greece Department of Nuclear MedicineGeneral Hospital“LAΪKO”Athens 11527Greece Department of Bariatric SurgeryDoctors’HospitalAthens 11257Greece 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2020年第11卷第10期

页      面：416-424页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Serum phosphate Diabetes mellitus Renal disease Old age Albuminuria Vitamin D 

摘      要：BACKGROUND Metabolic disturbances including changes in serum calcium,magnesium or phosphate(P)influence the prevalence of type 2 diabetes mellitus(DM).We assessed the importance of serum P in elderly patients with type 2 DM vs nondiabetes mellitus(non-DM)in relation to renal *** To determine the association between serum P and serum glucose or insulin resistance in diabetic and non-diabetic *** One hundred-ten subjects with a mean age of 69.02±14.3 years were ***-nine of the participants had type 2 DM(26.4%).The incidence of hypertension,smoking and receiving vitamin D(vitD)derivates were *** participants were classified by both estimated glomerular filtration rate(eGFR)and albuminuria categories according to the Kidney Disease Improving Global Outcomes 2012 *** We divided the patients in two groups according to the P cut-off point related to DM value.A comparison between high and low P showed that body mass index 30.2±6.3 vs 28.1±4.6(P=0.04),mean glucose 63.6 vs 50.2(P=0.03),uric acid 6.7±1.6 vs 6.09±1.7(P=0.05),mean intact-parathyroid hormone 68.06 vs 47.4(P=0.001),systolic blood pressure 147.4±16.7 vs 140.2±16.1(P=0.02),mean albuminuria 63.2 vs 50.6(P=0.04)and eGFR 45.6±22.1 vs 55.4±21.5(P=0.02)were significantly different.χ^2 tests showed a significant association between high P and DM,hypertension,receiving vitD,smoking and eGFR stage(χ^2=6.3,P=0.01,χ^2=3.9,P=0.03,χ^2=6.9,P=0.009,χ^2=7.04,P=0.01 andχ^2=7.36,P=0.04,respectively).The adjusted model showed that older age,female gender and increased body mass index were significant predictors of type 2 DM when entering the *** High serum P contributes to vascular and metabolic disturbances in elderly patients with type 2 DM and renal impairment.