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Survival benefit with extended lymphadenectomy for advanced renal malignancy: A population-based analysis

Asian Journal of Urology 2020年第1期7卷 29-36页

作者： dean Laganosky Christopher P.Filson Dattatraya Patil Viraj A.Master Department of Urology Emory University School of MedicineAtlantaGAUSA Winship Cancer Institute AtlantaGAUSA Atlanta VA Medical Center DecaturGAUSA

Objective:We used population-based data to examine the possible benefit of extended lymphadenectomy for patients with renal malignancy in the setting of more advanced ***:The Surveillance,Epidemiology,and End Results(SEER)database was utilized to identify non-metastatic,T3-T4 renal cancer patients from 2004-2015 treated with removal of≥1 lymph node at the time of ***-parametric bivariate statistics were used to assess associations between covariates of interest and extended lymphadenectomy(≥10 lymph nodes removed).Cancer-specific survival(CSS)and overall survival(OS)benefit was evaluated using Kaplane-Meier ***:Of the 4397 patients identified,816(18.6%)underwent extended *** patients with T3a disease,5-year CSS and OS benefit with extended lymphadenectomy did not reach statistical significance(CSS:hazard ratio[HR]0.98,95%confidence interval[CI]0.77-1.24;OS:HR 0.96,95%CI 0.77-1.20).Conversely,for those with T3b-T3c disease,extended lymphadenectomy led to statistically significant improvements in both 5-year CSS and OS compared to non-extended lymphadenectomy(CSS:HR 0.78,95%CI 0.61-0.99;OS:HR 0.72,95%CI 0.58-0.90).Finally,for those with T4 disease,use of extended lymphadenectomy had OS benefit after 5 years(OS:HR 0.51,HR 0.29-0.90,p = 0.02).Conclusion:Based on population-level data,extended lymphadenectomy was associated with improved survival in select patients with advanced renal malignancy treated with surgical *** the basis of these real-world findings in the face of conflicting randomized trial results will be key,moving forward.

关键词： Extended lymphadenectomy Lymph node dissection Advanced renal malignancy Renal cell carcinoma

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连续冷却过程中的相变本构方程

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机械工程学报 2009年第2期45卷 301-307页

作者：阳代军宁林新林建国 dean T A 首钢技术研究院薄板研究所北京100041 伯明翰大学机械工程系英国伯明翰B15 2TT

如何有效地预测在不同工艺条件下材料的微观结构和力学性能,是许多钢铁公司非常关注的重要课题之一。以连续冷却过程中的自由能理论为基础,成功地开发出一套在连续冷却过程中统一的相变本构方程。该本构方程可用来预测钢材在不同的冷却... 详细信息

如何有效地预测在不同工艺条件下材料的微观结构和力学性能,是许多钢铁公司非常关注的重要课题之一。以连续冷却过程中的自由能理论为基础,成功地开发出一套在连续冷却过程中统一的相变本构方程。该本构方程可用来预测钢材在不同的冷却速度下从奥氏体到铁素体、珠光体或贝氏体的开始转变点和结束转变点,同时还可用来预测各相转变的体积分数。利用优化算法通过缩小试验数据和预测数据之间的误差来确定本构方程中的材料常数,得出DINSAE5140钢种相变本构方程的模型参数,并且利用该相变本构方程对DINSAE5140钢种的相变过程进行详细地研究。研究结果表明,利用所开发的模型参数得出的预测连续冷却转变(Continuous cooling transformation,CCT)曲线和相变过程中各相的转变体积分数与试验数据非常一致,该统一的本构方程的建立为预测相变过程提供了一种有效的方法。

关键词：连续冷却相变统一本构方程材料模型

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The East–West Divide in Response to COVID-19

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Engineering 2021年第7期7卷 936-947页

作者： dean T.Jamison Kin Bing Wu Department of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCA 98158USA Independent Consultant AthertonCA 94027USA

Coronavirus disease 2019(COVID-19)deaths per million population in the countries of the West had often exceeded those in the countries of the East by factor of 100 by May *** this paper,we refer to the West as represented by the United States plus the five most populous countries of Western Europe(France,Germany,Italy,Spain,and the United Kingdom),and the East as the 15 countries in East Asia and Oceania that are members of the Regional Comprehensive Economic Partnership,RCEP(Australia,Brunei,Cambodia,China,Indonesia,Japan,the Republic of Korea,Laos,Malaysia,Myanmar,New Zealand,Philippines,Singapore,Thailand,and Vietnam).This paper argues that currently available information points to the factors most responsible for the East–West *** by early January 2020 about an atypical viral pneumonia in Wuhan,China,prompted rapid responses in many jurisdictions in East *** of the virus’s genome on 10 January 2020 provided essential information for making diagnostic tests and launching vaccine ***’s lockdown of Wuhan on 23 January 2020 provided a final,decisive signal of the danger of the new *** late March 2020,China had fully controlled its epidemic,and many other RCEP countries had taken early and decisive measures,including restrictions on travel,that aborted serious *** during the critical month of February 2020 in the United States and most other Western countries allowed the disease to take hold and *** both the East and the West,stringent population-wide non-pharmaceutical interventions were widely implemented at great cost to societies,economies,and school *** these measures,the outcomes could have been even *** countries in the East also implemented tightly focused policies to isolate infectious *** today,most countries in the West allow infectious individuals to mingle with their families,coworkers,and *** of the East–West divide plausibly results from f

关键词： Coronavirus disease 2019 Isolation Non-pharmaceutical interventions Pandemic Vaccination

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High-resolution bone microstructure imaging based on ultrasonic frequency-domain full-waveform inversion

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Chinese Physics B 2021年第1期30卷 295-310页

作者： Yifang Li Qinzhen Shi Ying Li Xiaojun Song Chengcheng Liu dean Ta Weiqi Wang Department of Electronic Engineering Fudan UniversityShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina Academy for Engineering and Technology Fudan UniversityShanghaiChina

The main challenge in bone ultrasound imaging is the large acoustic impedance contrast and sound velocity differences between the bone and surrounding soft tissue. It is difficult for conventional pulse-echo modalities to give accurate ultrasound images for irregular bone boundaries and microstructures using uniform sound velocity assumption rather than getting a prior knowledge of sound speed. To overcome these limitations, this paper proposed a frequency-domain fullwaveform inversion(FDFWI) algorithm for bone quantitative imaging utilizing ultrasonic computed tomography(USCT).The forward model was calculated in the frequency domain by solving the full-wave equation. The inverse problem was solved iteratively from low to high discrete frequency components via minimizing a cost function between the modeled and measured data. A quasi-Newton method called the limited-memory Broyden–Fletcher–Goldfarb–Shanno algorithm(L-BFGS) was utilized in the optimization process. Then, bone images were obtained based on the estimation of the velocity and density. The performance of the proposed method was verified by numerical examples, from tubular bone phantom to single distal fibula model, and finally with a distal tibia-fibula pair model. Compared with the high-resolution peripheral quantitative computed tomography(HR-p QCT), the proposed FDFWI can also clearly and accurately presented the wavelength scaled pores and trabeculae in bone images. The results proved that the FDFWI is capable of reconstructing high-resolution ultrasound bone images with sub-millimeter resolution. The parametric bone images may have the potential for the diagnosis of bone disease.

关键词： quantitative imaging full-waveform inversion bone microstructure ultrasonic computed tomography high resolution

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甲苯甲醇烷基化制对二甲苯技术研究进展

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化学反应工程与工艺 2007年第4期23卷 359-364页

作者：曹德安中国石油化工股份有限公司催化剂上海分公司上海201208

甲苯甲醇烷基化反应选择性合成高浓度对二甲苯技术可提高甲苯利用率,显著降低异构化和吸附分离装置负荷。综述了近年来国内外有关甲苯甲醇烷基化制备对二甲苯的研究进展,包括甲苯甲醇烷基化反应机理、催化剂活性组分、元素改性方法和现... 详细信息

甲苯甲醇烷基化反应选择性合成高浓度对二甲苯技术可提高甲苯利用率,显著降低异构化和吸附分离装置负荷。综述了近年来国内外有关甲苯甲醇烷基化制备对二甲苯的研究进展,包括甲苯甲醇烷基化反应机理、催化剂活性组分、元素改性方法和现有工艺技术。沸石的孔口修饰和外表面酸性位的钝化是影响反应活性和对位选择性的主要因素,活性和选择性高、稳定性好的催化剂的开发是甲苯烷基化技术应用的关键。

关键词：甲苯甲醇烷基化对二甲苯改性

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Ultrasonic backscatter characterization of cancellous bone using a general Nakagami statistical model

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Chinese Physics B 2019年第2期28卷 313-320页

作者： Chengcheng Liu Rui Dong Boyi Li Ying Li Feng Xu dean Ta Weiqi Wang Institute of Acoustics School of Physics Science and EngineeringTongji University Department of Electronic Engineering Fudan University State Key Laboratory of ASIC and System Fudan University

The goal of this study is to analyze the statistics of the backscatter signal from bovine cancellous bone using a Nakagami model and to evaluate the feasibility of Nakagami-model parameters for cancellous bone characterization. Ultrasonic backscatter measurements were performed on 24 bovine cancellous bone specimens in vitro and the backscatter signals were compensated for the frequency-dependent attenuation prior to the envelope detection. The statistics of the backscatter envelope were modeled using the Nakagami distribution. Our results reveal that the backscatter envelope mainly followed pre-Rayleigh distributions, and the deviations of the backscatter envelope from Rayleigh distribution decreased with increasing bone density. The Nakagami shape parameter(i.e., m) was significantly correlated with bone densities(R = 0.78–0.81, p < 0.001) and trabecular microstructures(|R| = 0.46–0.78, p < 0.05). The scale parameter(i.e.,?) and signal-to-noise ratio(SNR) also yielded significant correlations with bone density and structural features. Multiple linear regressions showed that bone volume fraction(BV/TV) was the main predictor of the Nakagami parameters,and microstructure produced significantly independent contribution to the prediction of Nakagami distribution parameters,explaining an additional 10.2% of the variance at most. The in vitro study showed that statistical parameters derived with Nakagami model might be useful for cancellous bone characterization, and statistical analysis has potential for ultrasonic backscatter bone evaluation.

关键词： ultrasonic backscatter cancellous bone statistical analysis Nakagami model

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Radio Preaching in Southern Appalachia

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Journalism and Mass Communication 2017年第5期7卷 259-262页

作者： Rebecca dean University of Pittsburgh Pittsburgh Pennsylvania USA

Appalachian inspired Pentecostal radio preaching maintains the Protestant legacy of that region first settled through the medium of radio. These sermons are characterized by high levels of affect in delivery, and serve to differentiate ＂preacher culture＂ from those denominations that abandoned their original heritage for admittance into middle class status. Thus, preacher culture is an act of both religious and class descent because they are ＂inspired＂ by the Holy Spirit （that is, not composed before delivery）. Gramscian notions of hegemony are used to interpret how ＂preacher culture＂ has maintained itself since the settlement by the northern British and the Scots to Appalachia. The genre of melodrama and ＂preacher culture＂ share significant parallels and content, dynamics of presentational styles, and because of these basic parallels, theories of melodrama offer analytical methods for analysis of the content of the inspired sermons and the way of life they elaborate. Gramscian notions of negotiation and consent are used to analyze the maintenance of ＂preacher culture＂, which maintains both tradition and cultural specificity that is characteristic of southern Appalachia.

关键词： Preacher culture southern Appalachian inspired radio preaching cultural maintenance cultural specificity

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The Greatest Global Grand Challenge: Preparing Our Next Generations to Solve the Challenges of Tomorrow: International First and the National Academies Partnership

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Engineering 2016年第1期2卷 44-44页

作者： dean Kamen DEKA Research and Development Corporation

Franklin Roosevelt said, ＂We cannot always build the future for our youth, but we can build our youth for the future,＂ a statement and a calling that has never been more true and relevant as it is today. The Grand Challenges for Engineering are fourteen ambitious goals identified by some of this generation＇s leading technologi- cal thinkers and doers, These challenges are believed to be both achievable and necessary to help all of humanity and to ensure that our planet will survive. I was honored to be part of the Na- tional Academy group that met to identify and carefully select the most urgent issues to be solved.

关键词：合作伙伴学术国际决明球性罗斯福

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Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration

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International Journal of Oral Science 2023年第2期15卷 185-203页

作者： Milos Marinkovic Olivia N.Tran Hanzhou Wang Parveez Abdul-Azees David D.dean Xiao-Dong Chen Chih-Ko Yeh Department of Comprehensive Dentistry University of Texas Health Science Center at San AntonioTXUSA Research Service South Texas Veterans Health Care SystemTXUSA Department of Biomedical Engineering University of Texas at San AntonioTXUSA Geriatric Research Education and Clinical CenterSouth Texas Veterans Health Care SystemTXUSA

Salivary gland(SG)dysfunction,due to radiotherapy,disease,or aging,is a clinical manifestation that has the potential to cause severe oral and/or systemic diseases and compromise quality of ***,the standard-of-care for this condition remains palliative.A variety of approaches have been employed to restore saliva production,but they have largely failed due to damage to both secretory cells and the extracellular matrix(niche).

关键词： salivary clinical diseases

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Critical Considerations in the Immunochemical Detection and Quantitation of Antigenic Biomarkers

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Biomedical and Environmental Sciences 1991年第1期4卷 113-129页

作者： dean W.ROBERTS R.WAYNEBENSON JACK A.HINSON FRED F.KADLUBAR Division of Biochemical Toxicology National Center for Toxicological Research JeffersonDivision of Biochemical Toxicology National Center for Toxicological Research JeffersonDivision of Interdisciplinary Toxicology University of Arkansas for Medical Sciences. Little RockDivision of Biochemical Toxicology National Center for Toxicological Research Jefferson Arkansas 72079-9502Arkansas 72079-9502 Arkansas 72205Arkansas 72079-9502

The formation of covalent adducts as a result of the interaction of metabolically activated chemicals with host macromolecules is a common critical event in mutagenic, carcinogenic, and immunologic phenomena. Because of their antigenicity and their immunogenicity, covalent adducts may be detected using sensitive immunochemical techniques. The immunochemical approaches to biomonitoring and molecular dosimetry of DNA damage are particularly attractive because they allow sensitive quantitation of specific DNA adducts present in small samples and do not rely on the use of radiolabeled adducts. Two examples of biomarker immunoassay development are presented: an avidin/biotin-amplified ELISA for the major DNA adduct of the human bladder carcinogen 4-aminobiphenyl (ABP), and a particle concentration fluorescent immunoassay (PCFIA) for the major protein adduct associated with toxicity by the prototype hepatotoxin acetaminophen. The examples illustrate critical steps in the development of biomarker immunoassays which include selection of the relevant adduct, preparation of an appropriate immunogen, immunization, characterization of antisera, and development of application-specific sample processing techniques for biomarker quantitation. Immunochemical procedures may be combined with other analytical techniques to form hybrid systems which take advantage of both the antigenicity and the physical or chemical properties of a biomarker to achieve greater specificity and/or sensitivity. The future usefulness of these new tools of molecular epidemiology will depend on a compound-by-compound validation of methods and critical evaluation of the biologic importance of the particular antigenic biomarker as an indicator of exposure and as an indicator of risk.

关键词： Critical Considerations in the Immunochemical Detection and Quantitation of Antigenic Biomarkers ABP

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