Autologous mesenchymal stem cells offer a new paradigm for salivary gland regeneration
作者机构:Department of Comprehensive DentistryUniversity of Texas Health Science Center at San AntonioTXUSA Research ServiceSouth Texas Veterans Health Care SystemTXUSA Department of Biomedical EngineeringUniversity of Texas at San AntonioTXUSA Geriatric ResearchEducation and Clinical CenterSouth Texas Veterans Health Care SystemTXUSA
出 版 物:《International Journal of Oral Science》 (国际口腔科学杂志(英文版))
年 卷 期:2023年第15卷第2期
页 面:185-203页
核心收录:
学科分类:1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学]
基 金:supported by NIDCR/NIH R01DE025286(C-K.Y.&X-D.C.),R21 DE028271A(C-K.Y.) VA Merit Review 1I01BX002145-01(X-D.C.) VA Career Development Award 1IK2BX005694-01(M.M.)
主 题:salivary clinical diseases
摘 要:Salivary gland(SG)dysfunction,due to radiotherapy,disease,or aging,is a clinical manifestation that has the potential to cause severe oral and/or systemic diseases and compromise quality of ***,the standard-of-care for this condition remains palliative.A variety of approaches have been employed to restore saliva production,but they have largely failed due to damage to both secretory cells and the extracellular matrix(niche).