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Sheep numbers required for dry matter digestibility evaluations when fed fresh perennial ryegrass or forage rape

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Animal Nutrition 2017年第1期3卷 61-66页

作者： Xuezhao Sun Linda Krijgsman Garry C.Waghorn Holly Kjestrup John Koolaard david pacheco Grasslands Research Centre Agresearch Limited DairyNZ Limited

Research trials with fresh forages often require accurate and precise measurement of digestibility and variation in digestion between individuals, and the duration of measurement periods needs to be established to ensure reliable data are obtained. The variation is likely to be greater when freshly harvested feeds are given, such as perennial ryegrass(Lolium perenne L.) and forage rape(Brassica napus L.),because the nutrient composition changes over time and in response to weather conditions. Daily feed intake and faeces output data from a digestibility trial with these forages were used to calculate the effects of differing lengths of the measurement period and differing numbers of sheep, on the precision of digestibility, with a view towards development of a protocol. Sixteen lambs aged 8 months and weighing 33 kg at the commencement of the trial were fed either perennial ryegrass or forage rape(8/treatment group) over 2 periods with 35 d between measurements. They had been acclimatised to the diets, having grazed them for 42 d prior to 11 days of indoor measurements. The sheep numbers required for a digestibility trial with different combinations of acclimatisation and measurement period lengths were subsequently calculated for 3 levels of imposed precision upon the estimate of mean dry matter(DM) digestibility. It is recommended that if the standard error of the mean for digestibility is equal to or higher than 5 g/kg DM, and if sheep are already used to a fresh perennial ryegrass or forage rape diet,then a minimum of 6 animals are needed and 4 acclimatisation days being fed individually in metabolic crates followed by 7 days of measurement.

关键词： Sheep Digestibility Fresh forage Sample size

Impaired immune reaction and increased lactate and C-reactive protein for early prediction of severe morbidity and pancreatic fistula after pancreatoduodenectomy

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 58-67页

作者： Mario Rodriguez-Lopez Francisco J.Tejero-Pintor Martin Bailon-Cuadrado Asterio Barrera-Rebollo Baltasar Perez-Saborido david pacheco-Sanchez General and Digestive Surgery Department Rio-Hortega University Hospital

Background: Prediction of complications after pancreatoduodenectomy (PD) remains of interest. Blood parameters and biomarkers during rst and second postoperative days (POD1, POD2) may be early indi- cators of complications. Methods: This case-control study included 50 patients. Baseline, POD1 and POD2 values of leukocytes, neutrophils, lymphocytes, platelets, hemoglobin, C-reactive protein (CRP), procalcitonin and arterial lactate were compared between individuals presenting Clavien ≥ III morbidity, pancreatic stula (PF) or clinically relevant PF (CRPF) and those without these morbidities. Common variables reaching signi cance were further analyzed in order to calculate a predictive score. Results: Severe morbidity, PF and CRPF rates were 28.0%, 26.0% and 14.0%, respectively. Patients with severe morbidity had lower leukocytes on POD2 (P=0.04). Patients with PF presented higher CRP on POD2 (P=0.001), higher lactate on POD1 (P=0.007) and POD2 (P=0.008), and lower lymphocytes on POD1 (P=0.007) and POD2 (P=0.008). Patients with CRPF had lower leukocytes and neutrophils on POD1 (P =0.048, P =0.038), lower lymphocytes on POD1 (P =0.001) and POD2 (P =0.003), and higher CRP on POD2 (P =0.001). Baseline parameters and procalcitonin obtained no statistical associations. Score was de ned according to lymphocytes on POD1 < 650/μL and CRP on POD2 ≥ 250 mg/L allocating patients in 3 risk categories. PF and CRPF rates were statistically higher as risk category increased (P<0.001). Receiver operating characteristic curves and Hosmer Lemeshow tests showed a good accuracy. Conclusions: Impaired immunological reaction during early postoperative period (lower leukocytes and, particularly, lymphocytes) in response to surgical aggression would favor complications after PD. Likewise, acidosis (higher arterial lactate) could behave as risk factor of PF. An elevated CRP on POD2 is also an early biomarker of PF. Our novel score based on postoperative lymphocyte count and CRP seems reliable

关键词： Pancreatoduodenectomy Morbidity Pancreatic fistula Biomarker Prediction Score

Severe morbidity after pancreatectomy is accurately pre dicte d by preoperative pancreatic resection score(PREPARE): A prospective validation analysis from a medium-volume center

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Hepatobiliary & Pancreatic Diseases International 2018年第6期17卷 559-565页

作者： Mario Rodriguez-Lopez Francisco J. Tejero-Pintor Baltasar Perez-Saborido Asterio Barrera-Rebollo Martin Bailon-Cuadrado david pacheco-Sanchez General and Digestive Surgery Department Rio-Hortega University Hospital

Background: Major morbidity in pancreatic surgery remains high. Different scores for predicting complications have been described. Preoperative pancreatic resection(PREPARE) score is based on objective preoperative variables and offers good predictive accuracy for Clavien ≥ III complications. This study aimed to validate this score and analyze other preoperative variables in a prospective study performed in a medium-volume center. Methods: A total of 50 pancreatic resections were included. Preoperative variables were registered and PREPARE was calculated. The main outcome was severe morbidity(Clavien ≥ III) up to 30 days after discharge. The secondary outcomes were length of stay(LOS) and readmission. Statistical validation was performed to compare severe morbidity rate among the scores categories. Association with other preoperative variables(not included in PREPARE) was also tested. Results: Of the 50 pancreatic resections, the severe morbidity was 34.0%, with median LOS of 11 days. Readmission rate was 25.5%. Severe morbidity rates according to PREPARE categories were 18.5% in lowrisk group, 41.7% in intermediate-risk group, and 63.6% in high-risk group, respectively( P = 0.023). The accuracy was 72%(Hosmer–Lemeshow, P = 0.86). ROC curve was obtained both for PREPARE score expressed as incremental values and categorized as the three risk groups, showing an area under curve(AUC) of 0.736(95% CI: 0.586–0.887; P = 0.007) and 0.712(95% CI: 0.555–0.869; P = 0.015), respectively. PREPARE was significant in multivariate analysis. Median LOS was statistically higher as PREPARE category increases(9, 11 and 15 days in low-, intermediate-and high-risk groups, respectively; P = 0.009). Readmission was not associated with any variables. Conclusions: PREPARE behaves as an independent risk factor for severe morbidity after pancreatic surgery. Score validation shows good accuracy prediction. Increasing PREPARE category is also associated with longer LOS.

关键词： Pancreatic surgery Morbidity Complications Preoperative pancreatic resection score Validation

The significance of N-carbamoylglutamate in ruminant production.

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Role of sex on psychological distress,quality of life,and coping of patients with advanced colorectal and non-colorectal cancer

畜牧与生物技术杂志(英文版) 2023年第5期

作者： Susan A. McCoard david pacheco

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2025-2037页

作者： Vilma pacheco-Barcia david Gomez Berta Obispo Luka Mihic Gongora Raquel Hernandez San Gil Patricia Cruz-Castellanos Mireia Gil-Raga Vicente Villalba Ismael Ghanem Paula Jimenez-Fonseca Caterina Calderon Department of Medical Oncology School of MedicineAlcala University(UAH)Hospital Central de la Defensa Gómez UllaMadrid 28047Spain Department of Medical Oncology Hospital Universitario de NavarraPamplona 31008Spain Department of Medical Oncology Hospital Universitario Infanta LeonorMadrid 28031Spain Department of Medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain Department of Medical Oncology Hospital Universitario de CanariasTenerife 38320Spain Department of Medical Oncology Hospital Universitario La PazMadrid 28046Spain Department of Medical Oncology Hospital General Universitario de ValenciaCIBERONCValencia 46014Spain Department of Clinical Psychology and Psychobiology Faculty of PsychologyUniversity of BarcelonaBarcelona 08007Spain Department of Medical Oncology Hospital Universitario Central de AsturiasISPAOviedo 33007Spain Department of Clinical Psychology and Psychobiology University of BarcelonaBarcelona 08007Spain

BACKGROUNDPatients with advanced gastrointestinal cancer must cope with the negative effects of cancer and *** To evaluate psychological distress,quality of life,and coping strategies in patients with advanced colorectal cancer compared to non-colorectal cancer based on *** A prospective,transversal,multicenter study was conducted in 203 patients;101(50%)had a colorectal and 102(50%)had digestive,non-colorectal advanced *** completed questionnaires evaluating psychological distress(Brief Symptom Inventory-18),quality of life(EORTC QLQ-C30),and coping strategies(Mini-Mental Adjustment to Cancer)before starting systemic cancer *** The study included 42.4%*** exhibited more depressive symptoms,anxiety,functional limitations,and anxious preoccupation than *** with non-colorectal digestive cancer and women showed more somatization and physical symptoms than subjects with colorectal cancer and *** with colorectal cancer reported the best health *** The degree of disease acceptance in gastrointestinal malignancies may depend on sex and location of the primary digestive *** interventions should specifically address sex and tumor site differences in individuals with advanced digestive cancer.

关键词： Anxiety Colorectal cancer Depression Gastrointestinal cancer Sex

Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle

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Nano Research 2015年第10期8卷 3307-3315页

作者： Daniela P. Lobo Alan M. Wemyss david J. Smith Anne Straube Kai B. Betteridge Andrew H. J. Salmon Rebecca R. Foster Hesham E. Elhegni Simon C. Satchell Haydn A. Little Raul pacheco-Gomez Mark J. Simmons Matthew R. Hicks david O. Bates Alison Rodger Timothy R. Dafforn Kenton P. Arkill DepartmentofChemistryandWarwickAnalyticalScienceCentre UniversityofWarwickCoventryCV47ALUK MOACDoctoralTrainingCentre UniversityofWarwickCoventryCV47ALUK Mathematics UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK CentreforMechanochemicalCellBiology WarwickMedicalSchoolUniversityofWarwickCoventryCV47ALUK PhysiologyandPharmacology UniversityofBristolUniversityWalkBristolBS81TDUK ClinicalSciences WhitsonStreetUniversityofBristolBristolBS13NYUK SchoolofChemistry UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK Biosciences UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK ChemicalEngineering UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK SchoolofMedicine UniversityofNottinghamQueen'sMedicalCentreNottinghamNG27UHUK Biochemistry UniversityofBristolUniversityWalkBristolBS81TDUK

The wall shear stress （WSS） that a moving fluid exerts on a surface affects many processes including those relating to vascular function. WSS plays an important role in normal physiology （e.g. angiogenesis） and affects the microvasculature＇s primary function of molecular transport. Points of fluctuating WSS show abnormalities in a number of diseases; however, there is no established technique for measuring WSS directly in physiological systems. All current methods rely on estimates obtained from measured velocity gradients in bulk flow data. In this work, we report a nanosensor that can directly measure WSS in microfluidic chambers with sub-micron spatial resolution by using a specific type of virus, the bacteriophage M13, which has been fluorescently labeled and anchored to a surface. It is demonstrated that the nanosensor can be calibrated and adapted for biological tissue, revealing WSS in micro-domains of cells that cannot be calculated accurately from bulk flow measurements. This method lends itself to a platform applicable to many applications in biology and microfluidics.

关键词： microfluidics nanoparticle M13 bacteriophage wall shear stress fluorescent microscopy

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橄榄林中的乡村酒店

现代装饰 2021年第2期 138-145页

作者： david Melero Herrera Fausto Santarosa Jua Francisco Mata Dlaz Angel Gabriel pacheco Rodado Daniel Montoya Lopez Francisco Torreblanca Herrero(摄影) 郭映琴(编译) 不详

该项目将乡间小屋开发成酒店,旨在让其成为乡村旅游热潮的一部分。设计面临的挑战是改造历史悠久的、位于橄榄林中心的建筑。人们在安达卢西亚旅游时,很难不留意到街道上排列有序的绿植,当地人深信其价值并引以为傲。该酒店对当地独特... 详细信息

关键词：安达卢西亚室内外空间原有建筑旅游热潮自然环境酒店印象深刻橄榄

Undergraduate Design and Analysis of a LEED Certified Building

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Journal of Civil Engineering and Architecture 2022年第5期16卷 227-234页

作者： Lance Narcida Madison O’Dell Mynor pacheco Carlos Perla Victor Ramirez Damian Sanchez Jillian Shoemaker Louisa Songco Tadeh Zirakian david Boyajian Department of Civil Engineering and Construction Management California State UniversityNorthridgeCAU.S.A.

In this technical and educational research endeavor, a diverse group of civil engineering students took on the role of creating the means and methods of producing a successful building design. Architectural, structural, and environmental designs were primarily performed. This was followed by detailed cost analysis with the intent of providing a realistic cost comparison by pricing the intended building, using traditional material and typical building methods, versus pricing the building using recycled material and new present-day technology. Some green features needed to achieve a LEED (Leadership in Energy and Environmental Design) gold certification were considered and applied. It is shown that producing a green building is more costly in present circumstances;however, the additional cost due to greenification pays itself off throughout the years giving in return saving features. Even though the design of a green building comes with detailed planning and costly material, it does generate benefits for the building owner, the society, and most importantly the environment.

关键词： Structural design LEED certification green building design cost analysis engineering education

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橄榄林中的乡村酒店

现代装饰 2021年第4期 138-145页

作者： Antonio José Galisteo Espartero álvaro Fernández Navarro Francisco Jesús Camacho Gómez david Melero Herrera.Arquitecto Fausto Santarosa.Arquitecto Juan Francisco Mata Díaz.Ingeniero ángel Gabriel pacheco Rodado.Ingeniero Daniel Montoya López.Aparejador Francisco Torreblanca Herrero 郭映琴

该项目将乡间小屋开发成酒店,旨在让其成为乡村旅游热潮的一部分。设计面临的挑战是改造历史悠久的、位于橄榄林中心的建筑。人们在安达卢西亚旅游时,很难不留意到街道上排列有序的绿植,当地人深信其价值并引以为傲。该酒店对当地独特...

该项目将乡间小屋开发成酒店,旨在让其成为乡村旅游热潮的一部分。设计面临的挑战是改造历史悠久的、位于橄榄林中心的建筑。人们在安达卢西亚旅游时,很难不留意到街道上排列有序的绿植,当地人深信其价值并引以为傲。该酒店对当地独特的自然环境致以最真诚的敬意,四周的美景令人印象深刻。设计的关键在于使室内外空间相互渗透,不破坏原有建筑的特质。城市规划发展组织将与酒店相连的另一栋用于农业开发的仓库一并纳入了该项目,复杂的行政程序使得这两栋建筑只能进行简单的改造,而该项目的翻新和扩建的设计方案有效地满足了此需求。

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