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Neuropsychological features of progranulin-associated frontotemporal dementia: a nested case-control study

Neural Regeneration Research 2021年第5期16卷 910-915页

作者： Marisa Lima Miguel Tábuas-Pereira Diana Duro João Durães daniela vieira Inês Baldeiras Maria Rosário Almeida Isabel Santana Neurology Department Centro Hospitalar e Universitário de CoimbraCoimbraPortugal University of Coimbra Faculty of MedicineCoimbraPortugal University of Coimbra Center for Neuroscience and Cell BiologyCoimbraPortugal University of Coimbra Center for Research in Neuropsychology and Cognitive Behavioral Intervention(CINEICC)Faculty of Psychology and Educational SciencesCoimbraPortugal

The distinction between sporadic and genetic behavioural-variant frontotemporal dementia(bvFTD)regarding some neuropsychological(NP)features remains ***,progranulin(GRN)-associated bvFTD frequently presents with early episodic memory impairment and some degree of parietal dysfunction which are supporters of Alzheimer’s disease(AD)*** this context,we aimed to characterize the NP profile of GRN-bvFTD as compared to sporadic-bvFTD and AD in patients with mild dementia(Mini-Mental State Examination score≥17 and Clinical Dementia Rating Scale score≤*** identified 21 patients at Centro Hospitalar e Universitário de Coimbra,Portugal with GRN mutations belonging to fifteen different *** our focus was bvFTD variants,FTD-related aphasic forms(3 patients)were *** remaining 18 GRN-bvFTD were further matched with 18 sporadic-bvFTD and 18 AD patients according to disease staging,age and *** patients completed the Mini-Mental State Examination,Montreal Cognitive Assessment(MoCA)and a comprehensive NP assessment *** were converted into *** between groups in individual NP measures and NP domains were assessed through non-parametric tests(Kruskal-Wallis test analysis)and eta squared(ŋ2)was calculated as a measure of effect *** comparisons show that GRN patients have worse performances on verbal retrieval processes(P=0.039,ŋ2=0.110)and visuoconstructive abilities(P=0.039,ŋ2=0.190)than sporadic bvFTD *** compared to AD,GRN patients present a higher impairment in frontal(P=0.001,ŋ2=0.211)and parietal(P=0.041,ŋ2=0.129)measures and a better performance in memory tasks(P=0.020,ŋ2=0.120).Sporadic-bvFTD forms are worse than AD in frontal measures(P=0.032,ŋ2=0.200),being better in both memory(P=0.010,ŋ2=0.131)and visuospatial skills(P=0.023,ŋ2=0.231).Considering these results,we conclude that GRN-bvFTD patients present a NP profile that associates the typical patterns of FTD and AD ***

关键词： Alzheimer’s disease behavioral variant frontotemporal dementia cognitive profile frontotemporal dementia genetics memory neuropsychology progranulin visuoconstructive ability

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Anatomophysiological relationships and clinical considerations of taste and smell loss in patients with COVID-19

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World Journal of Virology 2022年第5期11卷 362-374页

作者： Maria Fernanda Rossi Vigliar Karina Torres Pomini daniela vieira Buchaim Rogerio Leone Buchaim Biological Sciences Bauru School of DentistryUniversity of São PauloBauru 17012901São PauloBrazil University of Marilia Marilia 17525902São PauloBrazil University Center of Adamantina Adamantina 17800000São PauloBrazil Faculty of Veterinary Medicine and Animal Science University of São PauloSão Paulo 05508270São PauloBrazil

BACKGROUND There are numerous conflicting discussions about the outbreak of the new coronavirus 2019(COVID-19).AIM To present some anatomical and physiological considerations about two of the symptoms reported by patients:The loss or reduction of smell and *** The loss or reduction of smell and taste is presented in a peculiar way,with some cases of persistence even after *** this,it was searched in three databases,PubMed/MEDLINE,Web of Science,and Scopus,using the following keywords:"Smell","Taste","Smell AND COVID-19","Taste AND COVID-19",with no publication time restriction,only in English with full text available,excluding also brief communications,letters to the editor,editorials,reviews,comments,and conference *** The search found 776 articles in the PubMed/MEDLINE database,1018 in the Web of Science database,and 552 in the Scopus database,from which duplicates were removed(104 articles).Finally,17 studies were selected for detailed analysis within the eligibility criteria,with titles and abstracts related to central nervous system lesions responsible for smell and *** review suggests that viral mechanisms of action may be related to lesions both at the local level and at the level of the central nervous system,lasting up to 3 to 4 *** is considered persistent if it exceeds this period,as reported in one case in this *** are still few studies about the treatment,and among those addressed in this review,only two studies reported possible treatments and emphasized the scarcity of data,with the best option being treatments that do not cause harm,such as gustatory and olfactory physiotherapy CONCLUSION Given the scarcity of data,this review emphasizes the importance of prevention,through the correct use of personal protective equipment by health professionals and respect for local behavioral *** is also emphasized,through five studies,that there is a predominance of such symptoms in patients with COVID-

关键词： SARS-CoV-2 COVID-19 Coronavirus Olfactory nerve Smell Taste

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Gene expression analysis of cytokines and MMPs in melatonin and rhBMP-2 enhanced bone remodeling

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World Journal of Orthopedics 2024年第11期15卷 1075-1087页

作者： Marina Ribeiro Paulini Letícia Ferreira Montarele Dimitrius Leonardo Pitol Gisele Giannocco Bruno Fiorelini Pereira daniela vieira Buchaim Carlos Henrique Bertoni Reis Rogério Leone Buchaim Joao Paulo Mardegan Issa Department of Basic and Oral Biology University of São PauloRibeirao Preto 14040-904Brazil Instituto de Ciências Ambientais Químicas e FarmacêuticasFederal University of São PauloDiadema 09972-270Brazil Medical School University Center of AdamantinaAdamantina 17800-000Brazil Postgraduate Program in Structural and Functional Interactions in Rehabilitation University of MariliaMarilia 17525-902Brazil Department of Biological Sciences Bauru School of DentistryUniversity of São PauloBauru 17012-901Brazil Department of Basic and Oral Biology Ribeirão Preto School of DentistryUniversity of São PauloRibeirao Preto 14040-904Brazil

BACKGROUND In the medical and dental fields,there is a need for studies of new therapeutic approaches for the treatment of bone defects that cause extensive bone *** may be an important endogenous biological factor for bone remodeling,and growth factors may enhance the repair *** To evaluate the gene expression of cytokines(IL-1β,IL-6,IL-10 and TNF-α),markers of osteoclastogenesis(RANK,RANKL and OPG)and MMPs(MMP-1,MMP-2,MMP-8 and MMP-13)from the treatment of melatonin associated with an osteogenic membrane and rhBMP-2 on the recovery of a bone *** Sixty-four rats were used and divided into 9 experimental groups and were formed according to the treatment carried out in the region of the bone lesion,which varied between the combination of 1,10 and 100μmol/L of *** Expression analysis was performed using real time-PCR by reading the concentration of total RNA and reverse *** There were differences between groups when compared with clot or scaffold control,and improvement with a higher concentration of melatonin or *** combination melatonin(1μg)with 5μg of rhBMP-2,using the guided bone regeneration technique,demonstrated some effects,albeit mild,on bone repair of critical bone *** This indicates that the approach for administering these substances needs to be reassessed,with the goal of ensuring their direct application to the affected ***,future research must be carried out,seeking to produce materials with these ideal characteristics.

关键词： Bone repair Melatonin Gene expression Rhbmp-2 Scaffold Tissue engineering Guided bone regeneration

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Chronic Diseases of Childhood and the International Classification of Functioning, Disability, and Health: A Systematic Review

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Health 2022年第7期14卷 751-765页

作者： daniela Koeller Rodrigues vieira Carla Trevisan M. Ribeiro Roseane de Lima Ribeiro Lara Carolina Januário Cabral Center for Assistive Technology and Health Products National Institute for Women Children and Adolescents Fernandes Figueira Oswaldo Cruz Foundation (IFF-Fiocruz) Rio de Janeiro Brazil

The increase in chronic diseases in childhood highlights the need for a biopsychosocial approach to deal with the complexity of these health conditions. The International Classification of Functioning, Disability, and Health (ICF) results from the need to implement new explanatory evaluative and therapeutic models. Thus, the present systematic review aims to identify published studies on the use of the ICF in chronic childhood diseases. As a secondary objective, to map the themes that have already been studied in the area to support the discussion on the expansion of the use of this classification in health services. The systematic review followed the PRISMA protocol, and the model was the PICO acronym, where Population was children and adolescents with chronic diseases, Intervention/Exposure was evaluation based on ICF concepts, Comparator was any tool, instrument, or intervention, and outcome was direct or indirect use of the ICF. We selected eight articles, five of which used the ICF as a conceptual tool and three as a classification system, divided into the following themes: quality of life, evaluation of patients (without using coding) and mapping the inclusion of the activity’s results and participation in clinical trials. Thus, use of the ICF in clinical practice is still incipient, although it has been recommended in guidelines. Further studies are necessary to expand the number of contributions by the ICF and to develop the necessary approaches for understanding the classification’s use.

关键词： Chronic Diseases International Classification of Functioning Disability and Health Child Adolescent Disabled Children

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Update on the use of 45S5 bioactive glass in the treatment of bone defects in regenerative medicine

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World Journal of Orthopedics 2024年第3期15卷 204-214页

作者： Dayane Maria Braz Nogueira Marcelie Priscila de Oliveira Rosso daniela vieira Buchaim Mariana Schutzer Ragghianti Zangrando Rogério Leone Buchaim Department of Prosthodontics and Periodontics Bauru School of DentistryUniversity of São PauloBauru 17012-901Brazil Department of Biological Sciences Bauru School of DentistryUniversity of São PauloBauru 17012-901Brazil Medical School University Center of AdamantinaAdamantina 17800-000Brazil Postgraduate Program in Structural and Functional Interactions in Rehabilitation Postgraduate DepartmentUniversity of MaríliaMarília 17525-902Brazil

Bone regeneration is a critical area in regenerative medicine,particularly in orthopedics,demanding effective biomedical materials for treating bone defects.45S5 bioactive glass(45S5 BG)is a promising material because of its osteoconductive and bioactive *** research in this field continues to advance,keeping up-to-date on the latest and most successful applications of this material is *** achieve this,we conducted a comprehensive search on Pub-Med/MEDLINE,focusing on English articles published in the last *** search used the keywords“bioglass 45S5 AND bone defect”in *** found 27 articles,and after applying the inclusion criteria,we selected 15 studies for detailed *** of these studies compared 45S5 BG with other cement or scaffold *** comparisons demonstrate that the addition of various composites enhances cellular biocompatibility,as evidenced by the cells and their osteogenic ***,the use of 45S5 BG is enhanced by its antimicrobial properties,opening avenues for additional investigations and applications of this biomaterial.

关键词： Biocompatible materials Bioglass Bone regeneration

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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos J.Arauzo-Bravo daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

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Development of Aircraft Maintenance Glossaries in Higher Education:Exploring Methodological Paths to Corpus-Driven Analysis of Key Keywords

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中国科技术语 2025年第1期27卷 83-93页

作者： Malila PRADO daniela TERENZI Diego BRITO BNU-HKBU United International College Zhuhai 519087 Federal Institute of Education Science and Technology of São PauloSão Carlos 13.565-820

This paper presents a project aimed at developing a trilingual visual dictionary for aircraft maintenance professionals and *** project addresses the growing demand for accurate communication and technical terminology in the aviation industry,particularly in Brazil and *** study employs a corpus-driven approach,analyzing a large corpus of aircraft maintenance manuals to extract key technical terms and their *** specialized subcorpora and a comparative analysis,this paper demonstrates challenges and solutions into the identification of high-frequency keywords and explores their contextual use in aviation documentation,emphasizing the need for clear and accurate technical *** incorporating these findings into a trilingual visual dictionary,the project aims to enhance the understanding and usage of aviation terminology.

关键词： aircraft maintenance corpus keyword extraction

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Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation

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International Journal of Oral Science 2023年第2期15卷 229-240页

作者： Paola Dongiovanni Marica Meroni Sara Casati Riccardo Goldoni Douglas vieira Thomaz Nermin Seda Kehr daniela Galimberti Massimo Del Fabbro Gianluca MTartaglia Medicine and Metabolic Diseases Fondazione IRCCS CàGranda Ospedale Maggiore Policlinico Department of Biomedical Surgical and Dental SciencesUniversity of Milan Department of Electronics Information and Bioengineering(DEIB) Istituto di Elettronica e di Ingegneria dell'Informazione e delle Telecomunicazioni CNR Laboratory of Medicinal Pharmaceutical Chemistry Faculty of PharmacyFederal University of Goiás Department of Chemistry ?zmir Institute of TechnologyGülbah?e Kampüsü Neurology-Neurodegenerative Diseases Fondazione IRCCS CàGrandaOspedale Maggiore Policlinico UOC Maxillo-Facial Surgery and Dentistry Fondazione IRCCS CàGranda Ospedale Maggiore Policlinico

Several chronic disorders including type 2 diabetes(T2D),obesity,heart disease and cancer are preceded by a state of chronic lowgrade *** for the early assessment of chronic disorders encompass acute phase proteins(APP),cytokines and chemokines,pro-inflammatory enzymes,lipids and oxidative stress *** substances enter saliva through the blood flow and,in some cases。

关键词： inflammation acute chronic

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Nano-confinement of biomolecules： Hydrophilic confinement promotes structural order and enhances mobility of water molecules

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Nano Research 2016年第2期9卷 273-281页

作者： Bachir Aoun daniela Russo Argonne National Laboratory Chicago IL 60439 USA CNR-IOM c/o Institut Laue-Langevin 38400 Grenoble France Institut Lumiere Matiere Universite de Lyon 69622 Lyon France

Molecular dynamics simulations have been used to investigate the confinement packing characteristics of small hydrophilic （N-acetyl-glycine-methylamide, Nagma） and hydrophobic （N-acetyl-leucine-methylamide, Nalma） biomolecules in large diameter single-wall carbon nanotubes （SWCNTs）. We find that hydrophilic biomolecules easily fill the nanotube and self organize into a geometrical configuration which reminds the water structural organization under SWCNT confinement. The packing of hydrophilic biomolecules inside the cylinder confines all water molecules in its core, which enhances their mobility. Conversely, hydrophobic biomolecules accommodate into the nanotubes with a trend for homogeneous filling, which generate unstable small pockets of water and drive toward a state of dehydration. These results shed light on key parameters important for the encapsulation of biomolecules with direct relevance for long-term storage and prevention of degradation.

关键词： nano-confinement protein folding hydration water carbon nanotube drug delivery

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Characterising populations living close to intensive farming and composting facilities in England

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Frontiers of Environmental Science & Engineering 2021年第3期15卷 97-109页

作者： Philippa Douglas daniela Fecht Deborah Jarvis National Heart and Lung Institute MRC Centre for Environment and HealthImperial College LondonLondonSW36LZUK Centre for Radiation Chemical and Environmental HazardsPublic Health EnglandHarwell CampusDidcotOxfordshireOX 11 ORQUK UK Small Area Health Statistics Unit MRC Centre for Environment and HealthSchool of Public HealthImperial College LondonLondonW2 IPGUK

Bioaerosol exposure has been linked to adverse respiratory *** farming and composting facilities are important anthropogenic sources of *** aimed to characterise populations living close to intensive farming and composting *** also infer whether the public are becoming more concerned about anthropogenic bioaerosol emissions,using reports of air pollution related incidents attributed to *** mapped the location of 1,257 intensive farming and 310 composting facilities in England in relation to the resident population and its characteristics(sex and age),area characteristics(deprivation proxy and rural/urban classification)and school locations stratified by pre-defined distance bands from these bioaerosol *** also calculated the average number of air pollution related incidents per year per *** found that more than 16%of the population and 15%of schools are located within 4,828 m of an intensive farming facility or 4,000 m of a composting facility;few people(0.01%)live very close to these sites and tend to be older *** to composting facilities,populations are more likely to be urban and more *** number of incidents were attributed to a small proportion of facilities;population characteristics around these facilities were *** indicate that populations living near composting facilities(particularly>250 to≤4,000 m)are mostly located in ur6an areas(80188%of the population),which supports the need for more community health studies to be *** could also be used to inform risk management strategies at facilities with higher numbers of incidents.

关键词： Composting Intensive farming Bioaerosol Population characteristics Public health

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